Category: 1877-71-0

Quality Control of 3-(Methoxycarbonyl)benzoic acidOn November 5, 2021 ,《Cobalt-Catalyzed Deprotection of Allyl Carboxylic Esters Induced by Hydrogen Atom Transfer》 appeared in Organic Letters. The author of the article were Li, Nan; Gui, Yizhen; Chu, Mengqi; You, Mengdi; Qiu, Xiaohan; Liu, Hejia; Wang, Shiang; Deng, Meng; Ji, Baoming. The article conveys some information:

A brief, efficient method has been developed for the removal of the allyl protecting group from allyl carboxylic esters RC(O)OCH2CH=CH2 (R = cyclohexyl, Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.) using a Co(II)/TBHP/(Me2SiH)2O catalytic system. This facile strategy displays excellent chemoselectivity, functional group tolerance, and high yields. This transformation probably occurs through the hydrogen atom transfer process, and a Co(III)-six-membered cyclic intermediate is recommended. The results came from multiple reactions, including the reaction of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Quality Control of 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Quality Control of 3-(Methoxycarbonyl)benzoic acid

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2020,Molecules included an article by Cao, Jiangying; Zhao, Wei; Zhao, Chunlong; Liu, Qian; Li, Shunda; Zhang, Guozhen; Chou, C. James; Zhang, Yingjie. Product Details of 1877-71-0. The article was titled 《Development of a bestatin-SAHA hybrid with dual inhibitory activity against APN and HDAC》. The information in the text is summarized as follows:

With five histone deacetylase (HDAC) inhibitors approved for cancer treatment, proteolysis-targeting chimeras (PROTACs) for degradation of HDAC are emerging as an alternative strategy for HDAC-targeted therapeutic intervention. Herein, three bestatin-based hydroxamic acids (P1, P2 and P3) were designed, synthesized and biol. evaluated to see if they could work as HDAC degrader by recruiting cellular inhibitor of apoptosis protein 1 (cIAP1) E3 ubiquitin ligase. Among the three compounds, the bestatin-SAHA hybrid P1 exhibited comparable even more potent inhibitory activity against HDAC1, HDAC6 and HDAC8 relative to the approved HDAC inhibitor SAHA. It is worth noting that although P1 could not lead to intracellular HDAC degradation after 6 h of treatment, it could dramatically decrease the intracellular levels of HDAC1, HDAC6 and HDAC8 after 24 h of treatment. Intriguingly, the similar phenomenon was also observed in the HDAC inhibitor SAHA. Cotreatment with proteasome inhibitor bortezomib could not reverse the HDAC decreasing effects of P1 and SAHA, confirming that their HDAC decreasing effects were not due to protein degradation Moreover, all three bestatin-based hydroxamic acids P1, P2 and P3 exhibited more potent aminopeptidase N (APN, CD13) inhibitory activities than the approved APN inhibitor bestatin, which translated to their superior anti-angiogenic activities. Taken together, a novel bestatin-SAHA hybrid was developed, which worked as a potent APN and HDAC dual inhibitor instead of a PROTAC. In the part of experimental materials, we found many familiar compounds, such as 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Product Details of 1877-71-0)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Product Details of 1877-71-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Kehan; Zhu, Yan; Fan, Weitai; Chen, Yujie; Xu, Xu; Zhang, Jingyu; Zhao, Yingsheng published their research in ACS Catalysis on August 2 ,2019. The article was titled 《Late-Stage Functionalization of Aromatic Acids with Aliphatic Aziridines: Direct Approach to Form β-Branched Arylethylamine Backbones》.HPLC of Formula: 1877-71-0 The article contains the following contents:

A palladium-catalyzed carboxylic acid-directed cross-coupling of an ortho-C(sp2) atom of aromatic acids with aliphatic aziridines to construct the β-arylethylamine skeleton via C-H activation was developed. The reaction proceeded under mild conditions with great substrate scope. Meanwhile, the β-arylethylamine skeleton in drugs or bioactive compounds could be easily generated in a single step. A catalytic amount of cesium carbonate was crucial to realizing the selective β-arylethylamine synthesis. After reading the article, we found that the author used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0HPLC of Formula: 1877-71-0)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.HPLC of Formula: 1877-71-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Name: 3-(Methoxycarbonyl)benzoic acidOn June 1, 2021, Joshi, Sumedh; Fedoseyenko, Dmytro; Sharma, Vishav; Nesbit, Mark A.; Britt, R. David; Begley, Tadhg P. published an article in Biochemistry. The article was 《Menaquinone Biosynthesis: New Strategies to Trap Radical Intermediates in the MqnE-Catalyzed Reaction》. The article mentions the following:

Aminofutalosine synthase (MqnE) is a radical SAM enzyme that catalyzes the conversion of 3-((1-carboxyvinyl)oxy)benzoic acid to aminofutalosine during the futalosine-dependent menaquinone biosynthesis. In this Communication, the authors report the trapping of a radical intermediate in the MqnE-catalyzed reaction using sodium dithionite, mol. oxygen, or 5,5-dimethyl-1-pyrroline-N-oxide. These radical trapping strategies are potentially of general utility in the study of other radical SAM enzymes. In the part of experimental materials, we found many familiar compounds, such as 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Name: 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Name: 3-(Methoxycarbonyl)benzoic acid

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Formula: C9H8O4On September 6, 2019 ,《Ring-Opening Ortho-C-H Allylation of Benzoic Acids with Vinylcyclopropanes: Merging Catalytic C-H and C-C Activation Concepts》 was published in Organic Letters. The article was written by Hu, Zhiyong; Hu, Xiao-Qiang; Zhang, Guodong; Goossen, Lukas J.. The article contains the following contents:

A Ru-catalyzed selective and atom-economic ortho-C-H allylation of aromatic acids with vinylcyclopropanes is reported. The reaction proceeds with selective cleavage of both a C-H and a C-C bond. A wide range of allylarenes were synthesized in high yields and stereoselectivities. The vinylcyclopropane substrates can optionally be generated in situ from a diazo compound and 1,3-butadiene. Concise syntheses of isocoumarin and 3,4-dihydroisocoumarin derivatives underline the synthetic utility of the reaction. The results came from multiple reactions, including the reaction of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Formula: C9H8O4)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Formula: C9H8O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 3-(Methoxycarbonyl)benzoic acidOn June 4, 2021, Zeng, Zhongyi; Goebel, Jonas F.; Liu, Xianming; Goossen, Lukas J. published an article in ACS Catalysis. The article was 《2,2′-Biaryldicarboxylate Synthesis via Electrocatalytic Dehydrogenative C-H/C-H Coupling of Benzoic Acids》. The article mentions the following:

2,2′-Biaryldicarboxylates are important functionalities in bioactive compounds, functional materials, and chiral catalysts. These compounds have been found to be conveniently accessible from benzoic acids via Rh-catalyzed electrooxidative C-H/C-H couplings, giving valuable dihydrogen as the byproduct. In an undivided cell with Pt electrodes, RhCl3·3H2O catalyzes the oxidative carboxylate-directed ortho-homocoupling of various aromatic acids with a current efficiency of 67%. The protocol is operationally simple, tolerates a wide variety of functional groups, and does not require the exclusion of air and moisture. Heterodimerizations via cross-dehydrogenative couplings of naphthyl-1-carboxylic acids with acrylic or benzoic acids were also shown to work. The experimental process involved the reaction of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Reference of 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Reference of 3-(Methoxycarbonyl)benzoic acid

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Catalyst- and additive-free sunlight-induced autoxidation of aldehydes to carboxylic acids》 were Shi, Hongwei; Li, Jun; Wang, Tao; Rudolph, Matthias; Hashmi, A. Stephen K.. And the article was published in Green Chemistry in 2022. Computed Properties of C9H8O4 The author mentioned the following in the article:

A catalyst- and additive-free sunlight-induced strategy for autoxidation of a wide range of aldehydes RCHO (R = Bu, cyclohexyl, Ph, pyridin-3-yl, etc.) to carboxylic acids RC(O)OH is described for the first time. In this oxidation system, air serves as the source of oxygen and sunlight as the light source, and the system includes the advantages of green, highly atom-efficient, and low-cost synthesis. This method was easily applied even at gram scale. The reaction proceeds smoothly even at lower temperature and in natural light. The experimental process involved the reaction of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Computed Properties of C9H8O4)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Computed Properties of C9H8O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of C9H8O4On March 15, 2021, Sessa, Francesco; Olsson, Martina; Soederberg, Fredrik; Wang, Fang; Rahm, Martin published an article in ChemPhysChem. The article was 《Experimental Quantum Chemistry: A Hammett-inspired Fingerprinting of Substituent Effects》. The article mentions the following:

The quantum mech. calculable Q descriptor is shown to be a potent quantifier of chem. reactivity in complex mols. – it shows a strong correlation to exptl. derived field effects in non-aromatic substrates and Hammett σm and σp parameters. Models for predicting substituent effects from Q are presented and applied, including on the elusive pentazolyl substituent. The presented approach enables fast computational estimation of substituent effects, and, in extension, medium-throughput screening of mols. and compound design. An exptl. dataset is suggested as a candidate benchmark for aiding the general development and comparison of electronic structure analyses. It is here used to evaluate the exptl. quantum chem. (EQC) framework for chem. bonding anal. in larger mols. In addition to this study using 3-(Methoxycarbonyl)benzoic acid, there are many other studies that have used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Synthetic Route of C9H8O4) was used in this study.

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters.Synthetic Route of C9H8O4 They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Computed Properties of C9H8O4On November 15, 2019 ,《Decarbonylative Phosphorylation of Carboxylic Acids via Redox-Neutral Palladium Catalysis》 appeared in Organic Letters. The author of the article were Liu, Chengwei; Ji, Chong-Lei; Zhou, Tongliang; Hong, Xin; Szostak, Michal. The article conveys some information:

We describe the direct synthesis of organophosphorus compounds from ubiquitous aryl and vinyl carboxylic acids via decarbonylative palladium catalysis. The catalytic system shows excellent scope and tolerates a wide range of functional groups (>50 examples). The utility of this powerful methodol. is highlighted in the late-stage derivatization directly exploiting the presence of the prevalent carboxylic acid functional group. DFT studies provided insight into the origin of high bond activation selectivity and P(O)-H isomerization pathway. In the experiment, the researchers used many compounds, for example, 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Computed Properties of C9H8O4)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Computed Properties of C9H8O4 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yanagi, Tomoyuki; Somerville, Rosie J.; Nogi, Keisuke; Martin, Ruben; Yorimitsu, Hideki published an article on February 7 ,2020. The article was titled 《Ni-Catalyzed Carboxylation of C(sp2)-S Bonds with CO2: Evidence for the Multifaceted Role of Zn》, and you may find the article in ACS Catalysis.Reference of 3-(Methoxycarbonyl)benzoic acid The information in the text is summarized as follows:

Nickel-catalyzed reductive carboxylation reactions of aryl electrophiles typically require the use of metallic reducing agents. At present, the prevailing perception is that these serve as both a source of electrons and as a source of Lewis acids that may aid CO2 insertion into the Ni-C bond. Herein, we provide evidence for the in situ formation of organometallic species from the metallic reductant, a step that has either been ruled out or has been unexplored in catalytic carboxylation reactions with metal powder reductants. Specifically, we demonstrate that Zn(0) acts as a reductant and that Zn(II) generates arylzinc species that might play a role in the C(sp2)-S carboxylation of arylsulfonium salts. Overall, the reductive Ni-catalyzed C(sp2)-S carboxylation reaction proceeds under mild conditions in a non-amide solvent, displays a wide substrate scope, and can be applied to the formal para C-H carboxylation of arenes. In the part of experimental materials, we found many familiar compounds, such as 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Reference of 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Reference of 3-(Methoxycarbonyl)benzoic acid

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics