Category: 112-63-0

Ma, Jianze; Huang, You; Chen, Ruyu published the artcile< N-Heterocyclic carbene-catalyzed (NHC) three-component domino reactions: highly stereoselective synthesis of functionalized acyclic ε-ketoesters>, Category: esters-buliding-blocks, the main research area is aryl ketoester diastereoselective synthesis; unsaturated aryl aldehyde chalcone propargyl alc three component reaction; heterocyclic carbene catalyst.

A novel NHC-catalyzed three-component domino strategy to access high functionalized cis-ε-ketoesters with excellent yields (up to 98%) and high stereoselectivities (up to 20:1) is documented. The title domino reactions are atom economical and work on a broad range of substrates. The relative stereochem. could be explained by a cascade crossed-benzoin/oxy-Cope rearrangement/esterification process. The thus-obtained products are of potential synthetic value in the drug research and combinatorial chem.

Organic & Biomolecular Chemistry published new progress about Chalcones Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yu-Xiang; Wu, Chien-Wei; Kuo, Ting-Yang; Chang, Yu-Lung; Jen, Ming-Hsing; Chen, I-Wen Peter published the artcile< Large-Scale Production of Large-Size Atomically Thin Semiconducting Molybdenum Dichalcogenide Sheets in Water and Its Application for Supercapacitor>, Computed Properties of 112-63-0, the main research area is molybdenum dichalcogenide semiconducting sheet water supercapacitor.

To progress from laboratory research to com. applications, it is necessary to develop an effective method to prepare large quantities and high-quality of the large-size atomically thin molybdenum dichalcogenides (MoS2). Aqueous-phase processes provide a viable method for producing thin MoS2 sheets using organolithium-assisted exfoliation; unfortunately, this method is hindered by changing pristine semiconducting 2H phase to distorted metallic 1T phase. Recovery of the intrinsic 2H phase typically involves heating of the 1T MoS2 sheets on solid substrates at high temperature This has restricted and hindered the utilization of 2H phase MoS2 sheets suspensions. Here, we demonstrate that the synergistic effect of the rigid planar structure and charged nature of organic salt such as imidazole (ImH) can be successfully used to produce atomically thin 2H-MoS2 sheets suspension in water. Moreover, lateral size and area of the exfoliated sheet can be up to 50 μm and 1000 μm2, resp. According to the XPS measurements, nearly 100% of the 2H-MoS2 sheets was successfully prepared A composite paper supercapacitor using the exfoliated 2H-MoS2 and carbon nanotubes delivered a superior volumetric capacitance of ∼410 F/cm3. Therefore, the organic salts-assisted liquid-phase exfoliation has great potential for large-scale production of 2H-MoS2 suspensions for supercapacitor application.

Scientific Reports published new progress about Carbon nanotubes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Yansong; Jin, Yujuan; Wang, Bo; Tian, Huafeng; Weng, Yunxuan; Sun, Kangdi; Men, Shuang published the artcile< Preparation and characterization of compatibilized and toughened polylactic acid/cellulose acetate films by long-chain hyperbranched polymers>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is compatibilized toughened polylactide cellulose acetate hyperbranched polymer.

A type of long-chain hyperbranched polymers (LCHBPs) was prepared by grafting hydroxyl-terminated flexible long chain onto hyperbranched polymers (HBPs). The structure of LCHBPs was confirmed by Fourier transform IR (FT-IR) and NMR (1H-NMR) anal. It was then used as the modifier for toughening and compatibilizing the polylactic acid (PLA)/cellulose acetate (CA) blends. Upon the addition of LCHBPs, the compatibility between PLA and CA was improved, the dispersion of CA particles in PLA matrix was more uniform, and the brittle-ductile tear transition of the PLA/CA blends was occurred. The crystallization of PLA was promoted by the addition of LCHBPs. By adding LCHBPs, glass transition temperature and cold crystallization temperature were reduced, the crystallizability was enhanced, and the crystallization temperature range was expanded. The thermal decomposition temperature of the PLA/CA was found increased with the addition of LCHBPs. When the content of LCHBPs was 1 phr, the elongation at break and the tear strength of the PLA/CA blends were increased by 484% and 38.24%, resp. Meanwhile, the thermal stability and hydrophilic properties of the blend films were improved by adding LCHBPs.

Journal of Applied Polymer Science published new progress about Crystallization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chernov, Alexandr N.; Tsapieva, Anna; Alaverdian, Diana A.; Filatenkova, Tatiana A.; Galimova, Elvira S.; Suvorova, Mariia; Shamova, Olga V.; Suvorov, Alexander N. published the artcile< In Vitro Evaluation of the Cytotoxic Effect of Streptococcus pyogenes Strains, Protegrin PG-1, Cathelicidin LL-37, Nerve Growth Factor and Chemotherapy on the C6 Glioma Cell Line>, Application In Synthesis of 112-63-0, the main research area is anticancer PG1 LL37 NGF chemotherapy cytotoxicity Streptococcus glioma; LL-37; MTT assay; NGF; PG-1; Streptococcus pyogenes; cathelicidin family peptides; chemotherapy; cytotoxicity; glioma C6; human normal fibroblasts; real-time xCELLigence system; trypan blue assay.

Brain cancer treatment, where glioblastoma represents up to 50% of all CNS malignancies, is one of the most challenging calls for neurooncologists. The major driver of this study was a search for new approaches for the treatment of glioblastoma. We tested live S. pyogenes, cathelicidin family peptides and NGF, assessing the oncolytic activity of these compounds as monotherapy or in combination with chemotherapeutics. For cytotoxicity evaluation, we used the MTT assay, trypan blue assay and the xCELLigence system. To evaluate the safety of the studied therapeutic approaches, we performed experiments on normal human fibroblasts. Streptococci and peptides demonstrated high antitumor efficiency against glioma C6 cells in all assays applied, surpassing the effect of chemotherapeutics (doxorubicin, carboplatin, cisplatin, etoposide). A real-time cytotoxicity anal. showed that the cell viability index dropped to 21% 2-5 h after S. pyogenes strain exposure. It was shown that LL-37, PG-1 and NGF also exhibited strong antitumor effects on C6 glioma cells when applied at less than 10-4 M. Synergistic effects for combinations of PG-1 with carboplatin and LL-37 with etoposide were shown. Combinations of S. pyogenes strain #7 with NGF or LL-37 demonstrated a cytotoxic effect (56.7% and 57.3%, accordingly) on C6 glioma cells after 3 h of exposure.

Molecules published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Saini, Nipun; Virdee, Manjot S.; Helfrich, Kaylee K.; Kwan, Sze Ting Cecilia; Mooney, Sandra M.; Smith, Susan M. published the artcile< Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders>, Reference of 112-63-0, the main research area is FASD maternal hepatic glucose amino acid metabolome analysis; amino acids; fetal weight; gluconeogenesis; glucose; hepatic metabolism; maternal–fetal metabolism; pregnancy; prenatal alcohol exposure; untargeted metabolomics.

Prenatal alc. exposure (PAE) causes fetal growth restrictions. A major driver of fetal growth deficits is maternal metabolic disruption; this is under-investigated following PAE. Untargeted metabolomics on the dam and fetus exposed to alc. (ALC) revealed that the hepatic metabolome of ALC and control (CON) dams were distinct, whereas that of ALC and CON fetuses were similar. Alc. reduced maternal hepatic glucose content and enriched essential amino acid (AA) catabolites, N-acetylated AA products, urea content, and free fatty acids. These alterations suggest an attempt to minimize the glucose gap by increasing gluconeogenesis using AA and glycerol. In contrast, ALC fetuses had unchanged glucose and AA levels, suggesting an adequate draw of maternal nutrients, despite intensified stress on ALC dams. Maternal metabolites including glycolytic intermediates, AA catabolites, urea, and one-carbon-related metabolites correlated with fetal liver and brain weights, whereas lipid metabolites correlated with fetal body weight, indicating they may be drivers of fetal weight outcomes. Together, these data suggest that ALC alters maternal hepatic metabolic activity to limit glucose availability, thereby switching to alternate energy sources to meet the high-energy demands of pregnancy. Their correlation with fetal phenotypic outcomes indicates the influence of maternal metabolism on fetal growth and development.

Nutrients published new progress about Alcohols Role: ADV (Adverse Effect, Including Toxicity), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hsu, Day-Shin; Liang, Suz-Ping published the artcile< NHC-Mediated Synthesis of Tricyclic Spirocarbocycles via an Intramolecular Stetter Reaction of Cyclic Enal-Enones>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tricyclic spirocarbocycle preparation; cyclic enal enone intramol Stetter reaction nitrogen heterocyclic carbene.

A general and efficient method for the synthesis of tricyclic spirocarbocycles is described. Various cyclic enal-enones were reacted with an N-heterocyclic carbene and an intramol. Stetter reaction proceeded smoothly to give various tricyclic spiro-1,4-diketones in 31-72% yields. The ring size of the spiro compounds can be easily controlled using different cyclic enals and enones, or by altering the length of the carbon tether.

Journal of Organic Chemistry published new progress about Diketones Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tian, Haiping; Zhai, Wanchen; Sun, Ke; Zhu, Yunwen; Zhou, Hongli; Wan, Peng published the artcile< Chemical composition and potential bioactivities of essential oil from Quercus mongolica bark>, SDS of cas: 112-63-0, the main research area is Quercus bark essential oil pentadecanoic acid antioxidant anticoagulant.

The chem. composition and potential bioactivities of essential oil from Quercus mongolica bark (EOQMB) were researched for value-added utilization processing byproduct. The results of gas chromatog.-mass spectrometry (GC-MS) anal. showed that 30 components accounting for 98.42% were identified in EOQMB, with pentadecanoic acid the most abundant compound accounting for 34.90%, which was further confirmed by the Fourier transform IR observation. EOQMB exerts antioxidant activities, and the IC50 values for scavenging DPPH radical, ABTS radical, and hydroxyl radical were 8.48, 0.77, and 3.54 mg/mL, resp. The effects of EOQMB on prolonging activated partial thromboplastin time and thrombin time and on decreasing fibrinogen are similar to those of heparin, and the promising anticoagulant activities of EOQMB could be largely contributed by pentadecanoic acid. Herein, the present study uncovered that the waste Q. mongolica bark can serve as a new potential material in pharmaceutical products.

Arabian Journal of Chemistry published new progress about Anticoagulants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Liu; Lu, Pingan; Qu, Song published the artcile< Commentary: Kinesin Family Member C1 Increases Resistance of Glioblastoma to Temozolomide Through Promoting DNA Damage Repair.>, Application of C19H34O2, the main research area is DNA-PK; KIFC1; chemoresistance; neoplasms; normal tissue toxicity.

There is no abstract available for this document.

Cell transplantation published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Carol Sze Ki; Kirpluks, Mikelis; Priya, Anshu; Kaur, Guneet published the artcile< Conversion of food waste-derived lipid to bio-based polyurethane foam>, Formula: C19H34O2, the main research area is polyurethane foam lipid food waste.

Food waste contains complex nutrients such as carbohydrates, fats, proteins which could be broken down into simpler substrates such as sugars (e.g., glucose), lipids and proteins (e.g., free amino nitrogen). These components can be used for conversion into useful bio-based products such as chems., materials and fuels. This research aimed at the development of bio-based polyurethane (PU) materials using food waste-derived lipids. Since the quality of lipid plays an important role in polyol synthesis, optimal extraction procedures were developed to select the most appropriate method for polyol synthesis. From obtained lipids, two polyol synthesis methods were used, lipid transamidation with diethanolamine (DEOA or DEA) and lipid epoxidation and subsequent epoxy ring opening with trimethylolpropane. Bio-polyol obtained in transamidation reaction was used to obtain rigid PU foams with three different isocyanate indexes of 130; 150 and 200 while bio-polyol form epoxy ring opening was used to obtain rigid PU foams with an isocyanate index of 150. The initial formulations were suitable to produce good quality rigid PU foam samples at a laboratory scale. The resultant rigid PU foams are promising for further studies and development of thermal insulation materials.

Case Studies in Chemical and Environmental Engineering published new progress about Enzymic hydrolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guemues, Selcuk; Tuerker, Lemi published the artcile< Substituent effect on the aromaticity of 1,3-azole systems>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is oxazole imidazole thiazole substituent effect aromaticity.

The effects of substituent type and position on the aromaticity of certain derivatives of oxazole, imidazole and thiazole have been theor. investigated by using d. functional theory at the levels of B3LYP/6-31G(d,p) and B3LYP/6-31++G(d,p) methods. The second heteroatom substitution decreased aromaticity of furan, pyrrole and thiophene. The decreased aromaticity was gained back to some extent by the substitution of strong electron withdrawing groups or atoms (NO2 and F). Nucleus-independent chem. shift (NICS) data have been considered to determine the aromaticity of the systems. The most effective substitution to enhance the aromaticity has been calculated to be at position 4. The variation of the bond lengths of the main skeleton supported the findings through NICS calculations The frontier MO energies have also been reported to draw a general correlation between these energies and the aromaticity of the system.

Heterocyclic Communications published new progress about Aromaticity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics