Category: 112-63-0

Akiel, Maaged A.; Alshehri, Ohoud Y.; Aljihani, Shokran A.; Almuaysib, Amani; Bader, Ammar; Al-Asmari, Ahmed I.; Alamri, Hassan S.; Alrfaei, Bahauddeen M.; Halwani, Majed A. published the artcile< Viridiflorol induces anti-neoplastic effects on breast, lung, and brain cancer cells through apoptosis>, Application of C19H34O2, the main research area is brain cancer cells anti neoplastic effect breast lung apoptosis; Anticancer; Apoptosis; Natural product; Viridiflorol, Cytotoxicity, Drug discovery.

All active natural mols. are not fully exploited as therapeutic agents, causing delays in the advancement of anticancer drug discovery. Viridiflorol is a natural volatile element that may work as anti-cancer compound We tested the anticancer properties of viridiflorol at different concentrations ranging from 0.03 to 300μM in vitro on three cancer cells including breast (MCF-7), lung (A549) and brain (Daoy). The cancer cells responses were documented after treatment using MTT and Annexin V assays. Viridiflorol showed cytotoxic effects against all tested cell lines, reducing cell viability in a concentration-dependent manner with variable IC50 values. Daoy and A549 cell lines were more sensitive to viridiflorol when compared with temozolomide and doxorubicin, resp. Viridiflorol demonstrated the highest anticancer activity against the Daoy cells with an estimated IC50 of 0.1μM followed by MCF-7 at 10μM, and A549 at 30μM. In addition, upon exposure to concentrations ranging from 30μM to 300μM of viridiflorol, early and late apoptotic cell death was induced in a concentration dependent manner in Daoy (55.8-72.1), MCF-7 (36.2-72.7) and A459 (35-98.9) cell lines, resp. In conclusion, viridiflorol demonstrates cytotoxic and apoptotic ability in three different cancer cell lines (brain, breast and lung).

Saudi Journal of Biological Sciences published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Taylor, D. Martin; Morgan, Hywel; D’Silva, Claudius published the artcile< Behavior of avidin and avidin/bisbiotin polymers at the air-water interface>, COA of Formula: C19H34O2, the main research area is avidin biotin derivative polymer interface; bisbiotin avidin polymer interface.

The surface behavior of avidin and two polymers, formed by affinity polymerization from two-different stoichiometric mixtures of avidin and the bifunctional ligand bisbiotin, has been investigated at the air/water interface. Strong hysteresis in the pressure-area isotherms is attributed to mech. distortion of the mols. When subjected to step change in pressure, the monolayer area relaxes to a new equilibrium value following first-order dynamics, the time constant being of the order of minutes for a pressure change of 5 mN m-1. Equilibrium isotherms for the fully relaxed monolayers are linear over most of the pressure range, with both compression and expansion isotherms exactly coincident. Monolayers of the avidin/bisbiotin polymer were deposited onto electron microscope grids by the Langmuir-Blodgett technique and imaged in a transmission electron microscope. The area per repeat unit was estimated to be ∼30 nm2 in good agreement with previous estimates, but much smaller than the area per mol. obtained by extrapolating the pressure-area isotherm to zero pressure. Finally it is shown that spreading solvents containing a high percentage of chloroform cause avidin to denature at the air/water interface, this manifesting itself as a large mol. area at low surface pressure. However, it appears that denaturation may be reversed almost completely when the monolayer is compressed. The investigation suggests that it may be feasible to fabricate mol. electronic networks based on affinity polymerization

Journal of Colloid and Interface Science published new progress about Avidins Role: BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nagy, Audric; Collard, Laurent; Indukuri, Kiran; Leyssens, Tom; Riant, Olivier published the artcile< Enantio-, Regio- and Chemoselective Copper-Catalyzed 1,2-Hydroborylation of Acylsilanes>, Computed Properties of 112-63-0, the main research area is hydroboration reduction ketone acylsilane preparation hydroxyalkylsilane enantiomer copper catalyst; copper diphosphine complex catalyst asym hydroboration acylsilane preparation hydroxyalkylsilane; chiral alc preparation hydroxyalkylsilane asym reduction ketone acylsilane pinacolboronate; acylsilane; asymmetric synthesis; copper; hydroborylation; hydroxysilanes.

Enantioselective synthesis of synthetically significant (α-hydroxyallyl)silanes, (α-hydroxybenzyl)silanes, and (α-hydroxyalkyl)silanes is reported. The present copper-catalyzed 1,2-selective hydroborylation of acylsilanes affords the aforementioned products in high yields and with high enantiomeric excesses. This robust and scalable additive-free catalytic system relies on the use of low copper(II) acetate and diphosphine ligand loadings at room temperature in the presence of a com. available and bench-stable hydride source.

Chemistry – A European Journal published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation) (silylated). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Boyington, Allyson J.; Riu, Martin-Louis Y.; Jui, Nathan T. published the artcile< Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates>, Product Details of C19H34O2, the main research area is alkylpyridine preparation; halopyridine olefin regioselective hydroarylation iridium catalyst.

The intermol. alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive anti-Markovnikov selectivity. This system is mild, tolerant of many functional groups, and effective for the preparation of a wide range of complex alkylpyridines.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiao, Wenhui; Zhu, Shan; Shao, Jingrong; Zhang, Xiaoliang; Xu, Yanglu; Zhang, Yixuan; Wang, Ran; Zhong, Yuxu; Kong, Dexin published the artcile< ZSTK474 sensitizes glioblastoma to temozolomide by blocking homologous recombination repair>, Synthetic Route of 112-63-0, the main research area is .

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Temozolomide (TMZ) is used as the standard chemotherapeutic agent for GBM but with limited success, and treatment failure is mainly due to tumor resistance. One of the leading causes of TMZ resistance is the upregulation of the DNA repair mechanism. Therefore, targeting the DNA damage response (DDR) is proposed to be an effective strategy to sensitize tumor cells to TMZ. In the present study, we demonstrated that the combined use of the PI3K inhibitor ZSTK474 and TMZ showed synergetic anticancer effects on human GBM cells in vitro and in vivo. The combination treatment led to significantly increased cell apoptosis and DNA double strand breaks (DSBs). In addition, a mechanistic study indicated that TMZ enhanced the homologous recombination (HR) repair efficiency in GBM cells, while ZSTK474 impaired HR repair by blocking the phosphorylation of ATM and the expression of BRCA1/2 and Rad51, thereby sensitizing GBM cells to TMZ. Moreover, TMZ activated the PI3K signaling pathway through upregulation of the PI3K catalytic subunits p110α and p110β and the phosphorylation of Akt. Meanwhile, ZSTK474 blocked the activity of the PI3K/Akt pathway. Taken together, our findings suggested that the combination of ZSTK474 and TMZ might be a potential therapeutic option for GBM.

BioMed Research International published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; Palaniappan, Murugesan; Faver, John C.; Riehle, Kevin; Matzuk, Martin M.; Simmons, Nicholas published the artcile< Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis>, SDS of cas: 112-63-0, the main research area is palladium catalyzed hydroxycarbonylation heteroaryl halide DNA encoded library synthesis.

A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets.

Bioconjugate Chemistry published new progress about Carbonylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haynes, Cally J. E.; Berry, Stuart N.; Garric, Joachim; Herniman, Julie; Hiscock, Jennifer R.; Kirby, Isabelle L.; Light, Mark E.; Perkes, Gregory; Gale, Philip A. published the artcile< Small neutral molecular carriers for selective carboxylate transport>, Application In Synthesis of 112-63-0, the main research area is crystal structure neutral carrier carboxylate transport.

A series of neutral thiourea receptors were found to mediate the antiport of chloride with a range of biol. relevant carboxylate anions across phospholipid bilayers. Simple structural modification of the carriers resulted in a change in the lactate/pyruvate transport selectivity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Bilayer biological membrane (unilamellar vesicles). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Xiaoai; Chen, Haiqiang; Xiao, Jie; Liu, Jingyi; Tang, Niang; Zhou, Aimei published the artcile< Variations of volatile flavour compounds in finger citron (Citrus medica L. var. sarcodactylis) pickling process revealed by E-nose, HS-SPME-GC-MS and HS-GC-IMS>, Application of C19H34O2, the main research area is Citrus volatile flavor pickling E nose; E-nose; Finger citron; HS-GC-IMS; HS-SPME-GC-MS; Pickling process; Volatile flavour.

In this study, the variations of volatile flavor components in the pickling process of finger citron were investigated by electronic nose (E-nose), headspace solid phase microextraction-gas chromatog.-mass spectrometry (HS-SPME-GC-MS) and headspace-gas chromatog.-ion mobility spectrometry (HS-GC-IMS). Linalool, limonene, (E)-3,7-dimethyl-1,3,6-octatriene, myrcene, 3-carene, β-pinene, α-pinene, terpinolene, 1-methyl-4-(1-methylethyl)-1,4-cyclohexadiene, α-terpinene, (S)-β-bisabolene, 1-isopropyl-2-methylbenzene and 1-methyl-4-(1-methylethenyl)-benzene were the stable substances at relatively high contents in finger citron at different pickling process. Salting and drying steps in the pickling process exerted greatest influence on the volatile components of finger citron. Salting promoted the generation of aldehydes, esters and acids, but led to the disappearance of alcs., while drying promoted the generation of alcs., phenols, aldehydes and acids at the expense of reduction in terpenoids. Our study revealed that the characteristic volatile compounds of finger citron pickled products was mainly formed by the biol. reactions in the salting stage and thermal chem. transformations in the drying stage. This study also validated the suitability of E-nose combined with HS-SPME-GC-MS and HS-GC-IMS in tracking the changes of volatile components in finger citron during the pickling process.

Food Research International published new progress about Citron. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Jian; Xu, Ningbo; Liu, Boyang; Wang, Chenyang; He, Zhenyan; Lenahan, Cameron; Tang, Wenhui; Zeng, Huijun; Guo, Hongbo published the artcile< lncRNA XLOC013218 promotes cell proliferation and TMZ resistance by targeting the PIK3R2-mediated PI3K/AKT pathway in glioma>, Related Products of 112-63-0, the main research area is Sp1; chemoresistance; glioma; lncRNA XLOC; temozolomide.

The discovery of long noncoding RNAs (lncRNAs) has improved the understanding of development and progression in various cancer subtypes. However, the role of lncRNAs in temozolomide (TMZ) resistance in glioblastoma multiforme (GBM) remains largely undefined. In this present study, the differential expression of lncRNAs was identified between U87 and U87 TMZ-resistant (TR) cells. lncRNA XLOC013218 (XLOC) was drastically upregulated in TR cells and was associated with poor prognosis in glioma. Overexpression of XLOC markedly increased TMZ resistance, promoted proliferation, and inhibited apoptosis in vitro and in vivo. In addition, RNA-seq anal. and gain-of-function or loss-of-function studies revealed that PIK3R2 was the potential target of XLOC. Mechanistically, XLOC recruited specificity protein 1 (Sp1) transcription factor and promoted the binding of Sp1 to the promoters of PIK3R2, which elevated the expression of PIK3R2 in both mRNA and protein levels. Finally, PIK3R2-mediated activation of the PI3K/AKT signaling pathway promoted TMZ resistance and cell proliferation, but inhibited cell apoptosis. In conclusion, these data highlight the vital role of the XLOC/Sp1/PIK3R2/PI3K/AKT axis in GBM TMZ resistance.

Cancer Science published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glen, Pauline E.; O’Neill, James A. T.; Lee, Ai-Lan published the artcile< Synthesis of a C1-symmetric Box macrocycle and studies towards active-template synthesis of mechanically planar chiral rotaxanes>, Synthetic Route of 112-63-0, the main research area is box macrocycle active template synthesis mech planar chiral rotaxane.

A C1-sym. Box macrocycle has been synthesized for the first time. The Box macrocycle along with other C1 and C2-sym. Box ligands were evaluated and compared as ligands in the Cadiot-Chodkiewicz, oxidative Heck and CuAAC “”click”” reactions as part of our studies towards achieving active-metal template synthesis of mech. planar chiral rotaxanes. This study constitutes the first report of Cadiot-Chodkiewicz and CuAAC “”click”” reactions using Box ligands, as well as the first dedicated study of oxidative Heck reactions using Box ligands.

Tetrahedron published new progress about Alkadiynes Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics