Category: 112-63-0

Yang, Wanchun; Yuan, Qiuyun; Zhang, Shuxin; Zuo, Mingrong; Li, Tengfei; Li, Junhong; Zhou, Xingwang; Li, Mao; Feng, Wentao; Xia, Xiaoqiang; Chen, Mina; Liu, Yanhui published the artcile< Elevated GIGYF2 expression suppresses tumor migration and enhances sensitivity to temozolomide in malignant glioma>, Formula: C19H34O2, the main research area is GIGYF2 tumor migration temozolomide malignant glioma.

Glioma is a common type of malignant and aggressive tumor in the brain. Despite progress on mechanistic studies, current understanding of the initiation and progression of glioma remains incomplete. GIGYF2 is a critical regulator in neural development and degeneration, however, its contribution in glioma is not yet elucidated. In this study, using an integrative approach spanning bioinformatic anal. and functional approaches, we explored the potential contribution of GIGYF2 in glioma. Bioinformatic data from public database and our cohort showed that GIGYF2 expression was closely associated with low glioma malignancy and better patient survival. Elevation of GIGYF2 expression impaired cell migration and enhanced temozolomide sensitivity of human glioma cells. We further establish its mol. mechanism by demonstrating that GIGYF2 inhibits MMP-9 mediated cell migration pathway and pro-survival AKT/Bax/Caspase-3 signaling. Our work identifies the suppressive role of GIGYF2 in gliomas, and clarifies the relationship between GIGYF2 expression and glioma malignancy, which may provide a potential target for future interventions.

Cancer Gene Therapy published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (GIGYF2). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nury, T.; Yammine, A.; Ghzaiel, I.; Sassi, K.; Zarrouk, A.; Brahmi, F.; Samadi, M.; Rup-Jacques, S.; Vervandier-Fasseur, D.; Pais de Barros, J. P.; Bergas, V.; Ghosh, S.; Majeed, M.; Pande, A.; Atanasov, A.; Hammami, S.; Hammami, M.; Mackrill, J.; Nasser, B.; Andreoletti, P.; Cherkaoui-Malki, M.; Vejux, A.; Lizard, G. published the artcile< Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases>, Reference of 112-63-0, the main research area is review oxiapoptophagy nutrient synthetic mol 7beta hydroxycholesterol ketocholesterol; 7-Ketocholesterol; 7β-Hydroxycholesterol; Age-related diseases; Endoplasmic reticulum; Lysosome; Mitochondria; Nutrients; Oxiapoptophagy; Oxysterol; Peroxisome.

A review. Age-related diseases for which there are no effective treatments include cardiovascular diseases; neurodegenerative diseases such as Alzheimer′s disease; eye disorders such as cataract and age-related macular degeneration; and, more recently, Severe Acute Respiratory Syndrome (SARS-CoV-2). These diseases are associated with plasma and/or tissue increases in cholesterol derivatives mainly formed by auto-oxidation: 7-ketocholesterol, also known as 7-oxo-cholesterol, and 7β-hydroxycholesterol. The formation of these oxysterols can be considered as a consequence of mitochondrial and peroxisomal dysfunction, leading to increased in oxidative stress, which is accentuated with age. 7-ketocholesterol and 7β-hydroxycholesterol cause a specific form of cytotoxic activity defined as oxiapoptophagy, including oxidative stress and induction of death by apoptosis associated with autophagic criteria. Oxiaptophagy is associated with organelle dysfunction and in particular with mitochondrial and peroxisomal alterations involved in the induction of cell death and in the rupture of redox balance. As the criteria characterizing 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity are often simultaneously observed in major age-related diseases (cardiovascular diseases, age-related macular degeneration, Alzheimer′s disease) the involvement of these oxysterols in the pathophysiol. of the latter seems increasingly likely. It is therefore important to better understand the signalling pathways associated with the toxicity of 7-ketocholesterol and 7β-hydroxycholesterol in order to identify pharmacol. targets, nutrients and synthetic mols. attenuating or inhibiting the cytotoxic activities of these oxysterols. Numerous natural cytoprotective compounds have been identified: vitamins, fatty acids, polyphenols, terpenes, vegetal pigments, antioxidants, mixtures of compounds (oils, plant extracts) and bacterial enzymes. However, few synthetic mols. are able to prevent 7-ketocholesterol- and/or 7β-hydroxycholesterol-induced cytotoxicity: di-Me fumarate, monomethyl fumarate, the tyrosine kinase inhibitor AG126, memantine, simvastatine, Trolox, dimethylsufoxide, mangafodipir and mitochondrial permeability transition pore (MPTP) inhibitors. The effectiveness of these compounds, several of which are already in use in humans, makes it possible to consider using them for the treatment of certain age-related diseases associated with increased plasma and/or tissue levels of 7-ketocholesterol and/or 7β-hydroxycholesterol.

Ageing Research Reviews published new progress about Alzheimer disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xiao-San; Chen, Tang-Ji; Xu, Zhi-Peng; Long, Juan; He, Miao-Ying; Zhan, He-Hui; Zhuang, Hai-Cai; Wang, Qi-Lin; Liu, Li; Yang, Xue-Mei; Tang, Jin-Shan published the artcile< Synthesis and biological evaluation of 3β-O-neoglycosides of caudatin and its analogues as potential anticancer agents>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is neoglycoside caudatin analogs preparation anticancer structure activity relationship; 3β-O-neoglycosides; Anticancer activity; Caudatin; Glycosylated modification.

In order to study the structure-activity relationship (SAR) of C21-steroidal glycosides toward human cancer cell lines and explore more potential anticancer agents, a series of 3β-O-neoglycosides of caudatin and its analogs were synthesized. The results revealed that most of peracetylated 3β-O-monoglycosides demonstrated moderate to significant antiproliferative activities against four human cancer cell lines (MCF-7, HCT-116, HeLa, and HepG2). Among them, 3β-O-(2,3,4-tri-O-acetyl-β-L-glucopyranosyl)-caudatin exhibited the highest antiproliferative activity aganist HepG2 cells with an IC50 value of 3.11 μM. Mech. studies showed that compound3β-O-(2,3,4-tri-O-acetyl-β-L-glucopyranosyl)-caudatin induced both apoptosis and cell cycle arrest at S phase in a dose dependent manner. Overall, these present findings suggested that glycosylation is a promising scaffold to improve anticancer activity for naturally occurring C21-steroidal aglycons, and compound3β-O-(2,3,4-tri-O-acetyl-β-L-glucopyranosyl)-caudatin represents a potential anticancer agent deserved further investigation.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jin, Bo; Wang, Tong; Chen, Jia-yi; Liu, Xiao-qing; Zhang, Yi-xin; Zhang, Xiu-ying; Sheng, Zun-lai; Yang, Hong-Liang published the artcile< Synthesis and biological evaluation of 3-(pyridine-3-yl)-2-oxazolidinone derivatives as antibacterial agents>, SDS of cas: 112-63-0, the main research area is pyridinyl oxazolidinone preparation mol docking antibiofilm antibacterial activity; 3-(pyridine-3-yl)-2-oxazolidinone; antibacterial activity; biofilm formation inhibitory activity; drug resistance development; molecular docking.

In this research, a series of 3-(pyridine-3-yl)-2-oxazolidinone derivatives I [R = (pyridin-3-yl)carbonyl, Me, N-cyclohexylcarbamoyl, etc.], II (X = F, H) was designed, synthesized, and evaluated for in vitro antibacterial activity, which included bacteriostatic, morphol., kinetic studies, and mol. docking. The results demonstrated that compounds II [R = cyclohexanecarbonyl, (2E)-3-(furan-2-yl)prop-2-enoyl (III), (2E)-3-(pyridin-3-yl)prop-2-enoyl, N-(4-chlorophenyl)carbamoyl; X = F] exhibited strong antibacterial activity similar to that of linezolid toward five Gram-pos. bacteria. After observing the effect of the drug on the morphol. and growth dynamics of the bacteria, the possible modes of action were predicted by mol. docking. Furthermore, the antibiofilm activity and the potential drug resistance assay were proceeded. These compounds exhibited universal antibiofilm activity and compound III showed significant concentration-dependent inhibition of biofilm formation. Compound III also showed a stable effect on S. pneumoniae (ATCC 49619) with less drug resistance growth for 15 days, which is much longer than that of linezolid. Overall, these results can be used to guide further exploration of novel antimicrobial agents.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kaur-Bhambra, Jasmeet; Wardak, Daniel L. R.; Prosser, James I.; Gubry-Rangin, Cecile published the artcile< Revisiting plant biological nitrification inhibition efficiency using multiple archaeal and bacterial ammonia-oxidizing cultures>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is ammonia plant biol nitrification inhibition multiple archaea oxidizing culture.

Nitrification is a major process within the nitrogen (N) cycle leading to global losses of N, including fertilizer N, from natural and agricultural systems and producing significant nitrous oxide emissions. One strategy for the mitigation of these losses involves nitrification inhibition by plant-derived biol. nitrification inhibitors (BNIs). Cultivation-based studies of BNIs, including screening for new compounds, have predominantly investigated inhibition of a single ammonia-oxidising bacterium (AOB), Nitrosomonas europaea, even though ammonia oxidation in soil is usually dominated by ammonia-oxidising archaea (AOA), especially in acidic soils, and AOB Nitrosospira sp., rather than Nitrosomonas, in fertilised soils. This study aimed to assess the sensitivity of ammonia oxidation by a range of AOA and AOB pure cultures to BNIs produced by plant roots (Me 3-(4-hydroxyphenyl) propionate, sakuranetin and 1,9-decanediol) and shoots (linoleic acid, linolenic acid and Me linoleate). AOA were generally more sensitive to BNIs than AOB, and sensitivity was greater to BNIs produced by shoots than those produced by roots. Sensitivity also varied within AOA and AOB cultures and between different BNIs. In general, N. europaea was not a good indicator of BNI inhibition, and findings therefore highlight the limitations of use of a single bioassay strain and suggest the use of a broader range of strains that are more representative of natural soil communities.

Biology and Fertility of Soils published new progress about Acid soils. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Naidu, K. Reddi Mohan; Dadapeer, E.; Reddy, C. Bhupendra; Rao, A. Janardhan; Reddy, C. Suresh; Raju, C. Naga published the artcile< Polyethylene glycol-promoted dialkyl, aryl/heteroaryl phosphonates>, Synthetic Route of 112-63-0, the main research area is phosphite halide Michaelis Arbuzov rearrangement polyethylene glycol; phosphonate preparation.

A new, straightforward polyethylene glycol-promoted method for Michaelis-Arbuzov rearrangement was described.

Synthetic Communications published new progress about Haloalkanes Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl, heteroaryl). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Persano, Francesca; Gigli, Giuseppe; Leporatti, Stefano published the artcile< Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas>, Electric Literature of 112-63-0, the main research area is review natural compound temozolomide anticancer agent prognosis glioma; brain tumors; curcumin; epigallocatechin gallate; glioblastoma; glioma tumors; natural compounds; resveratrol.

A review. In humans, glioblastoma is the most prevalent primary malignant brain tumor. Usually, glioblastoma has specific characteristics, such as aggressive cell proliferation and rapid invasion of surrounding brain tissue, leading to a poor patient prognosis. The current therapy-which provides a multidisciplinary approach with surgery followed by radiotherapy and chemotherapy with temozolomide-is not very efficient since it faces clin. challenges such as tumor heterogeneity, invasiveness, and chemoresistance. In this respect, natural substances in the diet, integral components in the lifestyle medicine approach, can be seen as potential chemotherapeutics. There are several epidemiol. studies that have shown the chemopreventive role of natural dietary compounds in cancer progression and development. These heterogeneous compounds can produce anti-glioblastoma effects through upregulation of apoptosis and autophagy; allowing the promotion of cell cycle arrest; interfering with tumor metabolism; and permitting proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis inhibition. Although these beneficial effects are promising, the efficacy of natural compounds in glioblastoma is limited due to their bioavailability and blood-brain barrier permeability. Thereby, further clin. trials are necessary to confirm the in vitro and in vivo anticancer properties of natural compounds In this article, we overview the role of several natural substances in the treatment of glioblastoma by considering the challenges to be overcome and future prospects.

International Journal of Molecular Sciences published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Goudela, Sophia; Karatza, Panayiota; Koukaki, Marina; Frillingos, Stathis; Diallinas, George published the artcile< Comparative substrate recognition by bacterial and fungal purine transporters of the NAT/NCS2 family>, Category: esters-buliding-blocks, the main research area is substrate recognition bacteria fungus purine transporter protein; nucleobase ascorbate transporter protein substrate.

We compared the interactions of purines and purine analogs with representative fungal and bacterial members of the widespread Nucleobase-Ascorbate Transporter (NAT) family. These are: UapA, a well-studied xanthine-uric acid transporter of A. nidulans, Xut1, a novel transporter from C. albicans, described for the first time in this work, and YgfO, a recently characterized xanthine transporter from E. coli. Using transport inhibition experiments with 64 different purines and purine-related analogs, we describe a kinetic approach to build models on how NAT proteins interact with their substrates. UapA, Xut1 and YgfO appear to bind several substrates via interactions with both the pyrimidine and imidazol rings. Fungal homologues interact with the pyrimidine ring of xanthine and xanthine analogs via H-bonds, principally with N1-H and =O6, and to a lower extent with =O2. The E. coli homolog interacts principally with N3-H and =O2, and less strongly with N1-H and =O6. The basic interaction with the imidazol ring appears to be via a H-bond with N9. Interestingly, while all three homologues recognize xanthines with similar high affinities, interaction with uric acid or/and oxypurinol is transporter-specific. UapA recognizes uric acid with high affinity, principally via three H-bonds with =O2, =O6 and =O8. Xut1 has a 13-fold reduced affinity for uric acid, based on a different set of interactions involving =O8, and probably H atoms from positions N1, N3, N7 or N9. YgfO does not recognize uric acid at all. Both Xut1 and UapA recognize oxypurinol, but use different interactions reflected in a nearly 26-fold difference in their affinities for this drug, while YgfO interacts with this analog very inefficiently.

Molecular Membrane Biology published new progress about Bacteria. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vedachalam, Seenuvasan; Zeng, Jing; Gorityala, Bala Kishan; Antonio, Meraldo; Liu, Xue-Wei published the artcile< N-Heterocyclic Carbene-Catalyzed Intramolecular Aldehyde-Nitrile Cross Coupling: An Easy Access to 3-Aminochromones>, Computed Properties of 112-63-0, the main research area is crystal mol structure amino methoxy chromenone; amino chromone preparation; heterocyclic carbene catalyzed intramol aldehyde nitrile cross coupling.

An immense effort has been made to develop an efficient strategy for the carbon-carbon bond formation between aldehyde and nitrile intramolecularly using an N-heterocyclic carbene catalyst to derive 3-aminochromone derivatives in good to excellent yields (80-95%).

Organic Letters published new progress about C-C bond formation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sadeghpour, H.; Jalilian, A. R.; Shafiee, A.; Akhlaghi, M.; Miri, R.; Mirzaei, M. published the artcile< Radiosynthesis of dimethyl-2-[18F]-(fluoromethyl)-6-methyl-4-(2-nitrophenyl)-1,4- dihydropyridine-3,5-dicarboxylate for L-type calcium channel imaging>, Computed Properties of 112-63-0, the main research area is fluorine 19 dimethylfluoromethylmethylnitrophenyl dihydropyridine dicarboxylate radiosynthesis calcium channel imaging.

Di-Me 2-(fluoromethyl)-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate 4a, a fluorinated nifedipine analog, has been shown to elicit significant calcium channel blocker activity using a guinea pig ileal longitudinal smooth muscle model. In order to perform biol. studies for detection of L-type calcium channel distribution, we decided to prepare the [18F]-labeled compound The latter compound was prepared in no-carrier-added (n.c.a.) form from di-Me 2-(bromomethyl)-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate 2 in one step at 80°C in Kryptofix[222]/K[18F]F and acetonitrile as a solvent in 15 min. Column chromatog. afforded the radiochem. pure compound in 20 min. Radiochem. purity of the 18F-nifedipine was determined by RTLC and HPLC (> 98%) and specific activity of 21-48 GBq/μmol (EOB).

Radiochimica Acta published new progress about Calcium channel blockers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics