Category: 112-63-0

Hoshi, Masayuki; Hayatsu, Takaki; Okimoto, Mitsuhiro; Kodama, Satoshi published the artcile< Transfer of alk-1-enyl group from boron to tin: a highly stereoselective synthesis of (E)-alk-1-enyltributylstannanes>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is stannane alkenyl preparation halodestannylation stereoselective; borane dicyclohexyl alkenyl preparation stannylation stereoselective; alkene terminal iodo bromo preparation.

Treatment of (E)-alk-1-enyldicyclohexylboranes with tributyltin methoxide in the presence of galvinoxyl (1 mol.%) at room temperature results in transfer of the alk-1-enyl group from boron to tin to give (E)-alk-1-enyltributylstannanes in a highly stereoselective fashion. Subsequent halodestannylation of (E)-alk-1-enyltributylstannanes is allowed to proceed in a one-pot manner to produce the corresponding (E)-1-iodoalk-1-enes and (E)-1-bromoalk-1-enes in good to high yields, resp.

Synlett published new progress about Boranes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (alkenylboranes). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Tian-Ze; Xie, Jin; Jiang, Yu; Sha, Feng; Wu, Xin-Yan published the artcile< Enantioselective Vinylogous Michael/Cyclization Cascade Reaction of Acyclic β,γ-Unsaturated Amides with Isatylidene Malononitriles: Asymmetric Construction of Spirocyclic Oxindoles>, Application of C19H34O2, the main research area is enantioselective vinylogous Michael reaction cyclization cascade reaction; spirocyclic oxindole preparation unsaturated amide isatylidene malononitrile cascade reaction.

The first direct and enantioselective vinylogous Michael/cyclization cascade reaction between acyclic β,γ-unsaturated amides and isatylidene malononitriles has been developed. Optically active spirocyclic oxindoles have been obtained in good-to-excellent yields (84-96%) and enantioselectivity (79-97% ee) in the presence of 2 mol% (DHQD)2PYR [2,5-diphenyl-4,6-bis(9-O-dihydroquinyl)pyrimidine].

Advanced Synthesis & Catalysis published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sander, Kerstin; Gendron, Thibault; Yiannaki, Elena; Cybulska, Klaudia; Kalber, Tammy L.; Lythgoe, Mark F.; Arstad, Erik published the artcile< Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18>, HPLC of Formula: 112-63-0, the main research area is pharmacokinetics sulfonium salt small mol fluorine 18 immunolabeling bioimaging.

Positron emission tomog. (PET) is unique in that it allows quantification of biochem. processes in vivo, but difficulties with preparing suitably labeled radiotracers limit its scientific and diagnostic applications. Aromatic [18F]fluorination of drug-like small mols. is particularly challenging as their functional group compositions often impair the labeling efficiency. Herein, we report a new strategy for incorporation of 18F into highly functionalized aromatic compounds using sulfonium salts as leaving groups. The method is compatible with pharmacol. relevant functional groups, including aliphatic amines and basic heterocycles. Activated substrates react with [18F]fluoride at room temperature, and with heating the reaction proceeds in the presence of hydrogen bond donors. Furthermore, the use of electron rich spectator ligands allows efficient and regioselective [18F]fluorination of non-activated aromatic moieties. The method provides a broadly applicable route for 18F labeling of biol. active small mols., and offers immediate practical benefits for drug discovery and imaging with PET.

Scientific Reports published new progress about Biological uptake. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jozwiak, Malgorzata; Burakowski, Andrzej; Tyczynska, Magdalena; Komudzinska, Marlena published the artcile< Compression of selected glymes in N,N-dimethylformamide + water. The hydration numbers and hydrophobic hydration process of glymes>, Reference of 112-63-0, the main research area is glyme DMF water hydrophobic hydration number compression process.

This paper presents the speed of sound in selected glymes (monoglyme, diglyme, triglyme and tetraglyme) in N,N-dimethylformamide + water mixed solvent at four temperatures: 293.15 K, 298.15 K, 303.15 K and 308.15 K. The data obtained were used to calculate the values of isentropic compressibility (κS) of glymes solutions and apparent molar isentropic compression (KS,Φ,m), as well as the limiting partial molar isentropic compression (K0S,m) of glymes in the mixed solvent (DMF + W). Changes in the obtained values of the physicochem. parameters, as functions of temperature or mole fraction of water in the mixed solvent, were analyzed in terms of the mol. interactions and structural differentiation of the investigated systems. The hydrophobic hydration process of the studied glymes is visible in the high water content area of the mixed solvent. The hydration number of glymes in water at four temperatures was calculated and analyzed.

Journal of Molecular Liquids published new progress about Compression. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Olsen, Thale Kristin; Dyberg, Cecilia; Embaie, Bethel Tesfai; Alchahin, Adele; Milosevic, Jelena; Ding, Jane; Otte, Jörg; Tümmler, Conny; Hed Myrberg, Ida; Westerhout, Ellen M; Koster, Jan; Versteeg, Rogier; Ding, Han-Fei; Kogner, Per; Johnsen, John Inge; Sykes, David B; Baryawno, Ninib published the artcile< DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma.>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Cancer; Oncology; Therapeutics.

Despite intensive therapy, children with high-risk neuroblastoma are at risk of treatment failure. We applied a multiomic system approach to evaluate metabolic vulnerabilities in human neuroblastoma. We combined metabolomics, CRISPR screening, and transcriptomic data across more than 700 solid tumor cell lines and identified dihydroorotate dehydrogenase (DHODH), a critical enzyme in pyrimidine synthesis, as a potential treatment target. Of note, DHODH inhibition is currently under clinical investigation in patients with hematologic malignancies. In neuroblastoma, DHODH expression was identified as an independent risk factor for aggressive disease, and high DHODH levels correlated to worse overall and event-free survival. A subset of tumors with the highest DHODH expression was associated with a dismal prognosis, with a 5-year survival of less than 10%. In xenograft and transgenic neuroblastoma mouse models treated with the DHODH inhibitor brequinar, tumor growth was dramatically reduced, and survival was extended. Furthermore, brequinar treatment was shown to reduce the expression of MYC targets in 3 neuroblastoma models in vivo. A combination of brequinar and temozolomide was curative in the majority of transgenic TH-MYCN neuroblastoma mice, indicating a highly active clinical combination therapy. Overall, DHODH inhibition combined with temozolomide has therapeutic potential in neuroblastoma, and we propose this combination for clinical testing.

JCI insight published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Makarouni, Dimitra; Kordulis, Christos; Dourtoglou, Vassilis published the artcile< Solvent-Driven Selectivity on the One-Step Catalytic Synthesis of Manoyl Oxide Based on a Novel and Sustainable ""Zeolite Catalyst-Solvent"" System>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is manoyl oxide preparation zeolite glyme catalyst cyclodehydration sclareol.

Presented is the application of a novel “”zeolite catalyst-solvent”” system for the sustainable one-step synthesis of the terpenoid manoyl oxide I, the potential precursor of forskolin and Ambrox. Manoyl oxide high-yield and large-scale production over a zeolite catalyst has been infeasible so far, while the proposed system results in 90% yields at 135°C and atm. pressure. A substrate-controlled methodol. is used to achieve selectivity. Solvent-driven catalysis was demonstrated, as the activation energy barrier decreases in the presence of appropriate solvents, being 62.7 and 93.46 kJmol-1 for a glyme-type solvent and dodecane, resp. Finally, catalyst acidity was found to be a key parameter for the process.

Catalysis Letters published new progress about Acidity (catalyst). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yanlin; Yu, Zhen; Wang, Binbo; Xu, Xiwei; Feng, Hongzhi; Li, Pengyun; Zhu, Jin; Ma, Songqi published the artcile< High-performance epoxy covalent adaptable networks enabled by alicyclic anhydride monoesters>, Quality Control of 112-63-0, the main research area is covalent adaptable epoxy network alicyclic anhydride monoester curing.

Transesterification-based covalent adaptable networks (CANs) exhibit malleability and reprocessability, yet are highly dependent on the addition of a large amount of catalysts to accelerate transesterification reactions. A strategy of dynamic transfer auto-catalysis has been proposed by pending dynamically transferable anhydride monoesters at the network, which will greatly enhance the auto-catalytic efficiency. Here two trifunctional acids from alicyclic five-membered cyclic anhydride and six-membered cyclic anhydride, were synthesized and cured with bisphenol A epoxy monomer, resp. The reprocessability, degradability and mech. properties of the obtained epoxy CANs can be readily tuned by changing the structure of the trifunctional acid. The conformational transition of the non-planar ring accelerated network rearrangement and the large steric hindrance slowed down the degradation rate and the rigid feature endowed high thermal and mech. properties of the epoxy CANs. In addition, the kinetically slow formation of six-membered cyclic anhydride than that of five-membered cyclic anhydride, led to the lower dynamic transfer auto-catalytic efficiency of its monoester. However, its good solubility in water gave it a fast degradation rate.

European Polymer Journal published new progress about Activation energy (of stof relaxation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Konishi, Teruko; Ishii, Tadashi published the artcile< The origin and functions of arabinofuranosyl residues in plant cell walls>, HPLC of Formula: 112-63-0, the main research area is review arabinofuranosyl residue plant cell wall.

A review. L-Arabinofuranosyl (Araf) residues are a quantifiably important constituent of plant cell walls. The results of earlier studies have led to the hypothesis that UDP-L-arabinopyranose (UDP-Arap) is the sugar donor and that the conversion to Araf occurs during the glycosyl transfer reaction. However, this mechanism is unlikely because UDP-L-arabinofuranose (UDP-Araf) has been shown to be the sugar donor in the conversion of Araf-containing oligosaccharides in plant extracts We speculated that UDP-Arap reacts with a mutase to form UDP-Araf and identified and partially characterized a rice UDP-L-arabinopyranose mutase (UAM) that catalyzes the interconversion of UDP-Arap and UDP-Araf. To investigate the effects of depleting Araf residues on cell wall structure and on rice growth and development, we used RNAi to suppress UAM expression in rice plants. Several transgenic plants had reduced proportions of Araf in their cell walls together with a decrease in the extent of substitution of the xylan backbone and a reduction of between 25% and 80% in ferulic acid and p-coumaric acid content. Transgenic plants with over 25% reduction in Araf residues were dwarfed and infertile. These results suggested that Araf residues are required for normal plant growth, development, and reproduction

Trends in Glycoscience and Glycotechnology published new progress about Cell wall. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

De Giorgio, Francesca; Gaboardi, Mattia; Gigli, Lara; Brutti, Sergio; Arbizzani, Catia published the artcile< Deciphering the Interplay between Binders and Electrolytes on the Performance of Li4Ti5O12 Electrodes for Li-Ion Batteries>, Computed Properties of 112-63-0, the main research area is binder electrolyte lithium titanium oxide electrode battery.

Lithium titanium oxide (Li4Ti5O12, LTO) is an attractive neg. electrode for the development of safe-next-generation-lithium-ion batteries (LIBs). LTO can find specific applications complementary to existing alternatives for LIBs thanks to its good rate capability at high C-rates, fast lithium intercalation, and high cycling stability. Furthermore, LIBs featuring LTO electrodes are inherently safer owing to the LTO’s operating potential of 1.55 V vs. Li+/Li where the commonly used organic-based electrolytes are thermodynamically stable. Herein, we report the combined use of water-soluble sodium alginate (SA) binder and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI)-tetraglyme (1m-T) electrolyte and we demonstrate the improvement of the electrochem. performance of LTO-based electrodes with respect to those operating in conventional electrolyte 1M LiPF6-ethylene carbonate: di-Me carbonate (LP30). We also tackle the anal. of the impact of combining the binder/electrolyte on the long-term cycling performance of LTO electrodes featuring SA or conventional polyvinylidene fluoride (PVdF) as binders. Therefore, to assess the impact of the combination of binder/electrolyte on performance, we performed post-mortem characterization by ex situ synchrotron diffraction experiments of LTO electrodes after cycling in LP30 and 1m-T electrolytes.

Energies (Basel, Switzerland) published new progress about Binders. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Farmer, Luc J.; Ledeboer, Mark W.; Hoock, Thomas; Arnost, Michael J.; Bethiel, Randy S.; Bennani, Youssef L.; Black, James J.; Brummel, Christopher L.; Chakilam, Ananthsrinivas; Dorsch, Warren A.; Fan, Bin; Cochran, John E.; Halas, Summer; Harrington, Edmund M.; Hogan, James K.; Howe, David; Huang, Hui; Jacobs, Dylan H.; Laitinen, Leena M.; Liao, Shengkai; Mahajan, Sudipta; Marone, Valerie; Martinez-Botella, Gabriel; McCarthy, Pamela; Messersmith, David; Namchuk, Mark; Oh, Luke; Penney, Marina S.; Pierce, Albert C.; Raybuck, Scott A.; Rugg, Arthur; Salituro, Francesco G.; Saxena, Kumkum; Shannon, Dean; Shlyakter, Dina; Swenson, Lora; Tian, Shi-Kai; Town, Christopher; Wang, Jian; Wang, Tiansheng; Wannamaker, M. Woods; Winquist, Raymond J.; Zuccola, Harmon J. published the artcile< Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases>, Related Products of 112-63-0, the main research area is VX509 decernotinib Janus kinase inhibitor autoimmune disease.

While several therapeutic options exist, the need for more effective, safe, and convenient treatment for a variety of autoimmune diseases persists. Targeting the Janus tyrosine kinases (JAKs), which play essential roles in cell signaling responses and can contribute to aberrant immune function associated with disease, has emerged as a novel and attractive approach for the development of new autoimmune disease therapies. We screened our compound library against JAK3, a key signaling kinase in immune cells, and identified multiple scaffolds showing good inhibitory activity for this kinase. A particular scaffold of interest, the 1H-pyrrolo[2,3-b]pyridine series (7-azaindoles), was selected for further optimization in part on the basis of binding affinity (Ki) as well as on the basis of cellular potency. Optimization of this chem. series led to the identification of VX-509 (decernotinib), a novel, potent, and selective JAK3 inhibitor, which demonstrates good efficacy in vivo in the rat host vs. graft model (HvG). On the basis of these findings, it appears that VX-509 offers potential for the treatment of a variety of autoimmune diseases.

Journal of Medicinal Chemistry published new progress about Autoimmune disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics