Category: 112-63-0

Santschi, Nico; Ross, Cody; Benson, Pitts; Jelier, J.; Verel, Rene published the artcile< Determining the predominant tautomeric structure of iodine-based group-transfer reagents by 17O NMR spectroscopy>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is crystal mol structure benziodoxole fluoromethylation cyclic thioperoxide tautomeric iodine; DFT NMR iodine tautomeric thioperoxide tautomeric fluoromethylation cyclic benziodoxole; 17O NMR spectroscopy; electrophilic; hypervalent iodine; trifluoromethylation; trifluoromethylthiolation.

Cyclic benziodoxole systems have become a premier scaffold for the design of electrophilic transfer reagents. A particularly intriguing aspect is the fundamental I(I)-I(III) tautomerism about the hypervalent bond, which has led in certain cases to a surprising re-evaluation of the classic hypervalent structure. Thus, through a combination of 17O NMR spectroscopy at natural abundance with DFT calculations, we establish a convenient method to provide solution-phase structural insights for this class of ubiquitous reagents. In particular, we confirm that Shen′s revised, electrophilic SCF3-transfer reagent also adopts an “”acyclic”” thioperoxide tautomeric form in solution After calibration, the approach described herein likely provides a more general and direct method to distinguish between cyclic and acyclic structural features based on a single exptl. 17O NMR spectrum and a computationally-derived isotropic shift value. Furthermore, we apply this structural elucidation technique to predict the constitution of an electrophilic iodine-based cyano-transfer reagent as an NC-I-O motif and study the acid-mediated activation of Togni′s trifluoromethylation reagent.

Beilstein Journal of Organic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Orbegozo, Thomas; de Vries, Johannes G.; Kroutil, Wolfgang published the artcile< Biooxidation of Primary Alcohols to Aldehydes through Hydrogen Transfer Employing Janibacter terrae>, COA of Formula: C19H34O2, the main research area is Janibacter oxidation primary alc.

Chemoselective oxidations still represent a challenge for chemists. Lyophilized cells of Janibacter terrae were employed for the chemoselective oxidation of primary alcs. to the corresponding aldehydes by hydrogen transfer with the use of acetaldehyde as the hydrogen acceptor. Secondary alc. moieties were transformed at a much slower rate. The substrate spectrum encompasses substituted benzyl alcs., whereby substrates with a substituent in the meta position were well tolerated, whereas only very small substituents were tolerated in the ortho position. Furthermore, n-alkanols and allylic alcs. were transformed with good conversions. The biocatalyst was compatible with DMSO as a water miscible organic solvent up to 30 % volume/volume

European Journal of Organic Chemistry published new progress about Aldehydes Role: BPN (Biosynthetic Preparation), BIOL (Biological Study), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bazie, Wilfried Wenceslas; Some, Diane Yirgnur; Traore, Isidore Tiandiogo; Sanon, Anselme; Konate, Issouf; Tassembedo, Souleymane; Taofiki, Ajani Ousmane; Kania, Dramane; Ouedraogo, Abdoulaye; Vuylsteke, Bea; Gilbert, Caroline; Meda, Nicolas; Ouedraogo, Abdoul Salam; Nagot, Nicolas published the artcile< Immunovirological discordance among female sex workers who start antiretroviral therapy in Burkina Faso>, Electric Literature of 112-63-0, the main research area is human sex worker antiretroviral therapy immunovirol discordance; Antiretroviral therapy; Burkina Faso; Female sex workers; HIV-1; Immunovirological discordance.

In people living with HIV/AIDS (PLWHA), initiation of antiretroviral therapy (ART) leads to sustained effective suppression of viral replication and increasing CD4 + T cell count. However, a fraction of ART-treated patients still fail to reach adequate CD4 + T cell number despite a suppressed viral load (VL), and this phenomenon is defined as immunovirol. discordance (IVD). In Africa, several studies have reported immunovirol. outcomes of antiretroviral therapy, but little is known about IVD occurrence in Female sex workers (FSW). This study aimed to assess the prevalence of IVD and associated factors among a cohort of HIV infected FSW in Burkina Faso. We conducted a cohort study from Dec. 2003 to Oct. 2016. Immunovirol. discordance was defined as CD4 + T cell gain < 100 cells/μL despite a suppressed VL (VL < 1000 copies/mL) 12 mo after ART initiation. The CD4 + T cells were counted using BD FACSCount System and point of care Pima CD4 + Analyzer. HIV-1 RNA was quantified by real-time polymerase-chain-reaction assay with the use of the ABI 7000 system. We conducted a logistic regression to identify factors associated with discordant responses. Among the 123 HIV-1 infected FSW having at least 12 mo follow-up on ART, 105 (85.4%) achieved HIV-1 RNA suppression. Among the latter 25 gained less than 100 CD4 + T cells within 12 mo follow-up. The IVD rate was 23.8% (95%CI 16.04%-33.11%). After adjustment for age, WHO clin. stage and ART regimen including nucleoside/nucleotide reverse transcriptase inhibitors, only baseline CD4 + T cell count between 200 to 350 cells/μL (adjusted OR: 4.15; 95%CI 1.13-15.22) and 350 to 500 cells/μL (adjusted OR: 17.50; 95%CI 2.68-114.31) remain significantly associated with IVD occurrence. Immunovirol. discordance response was common in FSW with proportions close to those observed in the general population. A diagnosis and personalized follow-up of patients who do not achieve full immune reconstitution would make it possible to avoid complications in terms of morbidity and mortality. BMC Infectious Diseases published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Damanskiene, Eligija; Balnyte, Ingrida; Valanciute, Angelija; Alonso, Marta Maria; Preiksaitis, Aidanas; Stakisaitis, Donatas published the artcile< The Different Temozolomide Effects on Tumorigenesis Mechanisms of Pediatric Glioblastoma PBT24 and SF8628 Cell Tumor in CAM Model and on Cells In Vitro>, Related Products of 112-63-0, the main research area is pediatric glioblastoma tumorigenesis temozolomide; CAM; EZH2; KCC2; NKCC1; PCNA; pediatric glioblastoma; temozolomide.

It is necessary to elucidate the individual effects of temozolomide (TMZ) on carcinogenesis and tumor resistance to chemotherapy mechanisms. The study aimed to investigate the TMZ 50 and 100μM dose effect difference between PBT24 and SF8628 cell line high-grade pediatric glioblastoma (phGBM) xenografts in a chicken chorioallantoic membrane (CAM) model, on PCNA and EZH2 immunohistochem. expression in the tumor and on the expression of NKCC1, KCC2, E- and N-cadherin genes in TMZ-treated and control cell groups in vitro. TMZ at a 100μg dose reduced the incidence of PBT24 xenograft invasion into the CAM, CAM thickening and the number of blood vessels in the CAM (p < 0.05), but did not affect the SF8628 tumor in the CAM model. The TMZ impact on PBT24 and SF8628 tumor PCNA expression was similarly significantly effective but did not alter EZH2 expression in the studied tumors. The TMZ at 50μM caused significantly increased RNA expression of the NKCC1 gene in both studied cell types compared with controls (p < 0.05). The expression of the KCC2 gene was increased in PBT24 TMZ-treated cells (p < 0.05), and no TMZ effect was found in SF8628-treated cells. The study supports the suggestion that individual sensitivity to TMZ should be assessed when starting treatment. International Journal of Molecular Sciences published new progress about Blood vessel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pomel, V.; Rovera, J. C.; Godard, A.; Marsais, F.; Queguiner, G. published the artcile< Synthesis of new pyridine intermediates as precursors for the elaboration of streptonigrin analogs by the metalation-cross-coupling strategy>, Quality Control of 112-63-0, the main research area is aminopyridinecarboxylic acid precursor streptonigrin analog preparation; pyridinecarboxylic acid amino preparation.

3-Amino-6-pyridinecarboxylic acid derivatives, precursor for the pyridine C ring of streptonigrin analogs, were prepared from readily available 2-amino-6-chloro-3-nitropyridine.

Journal of Heterocyclic Chemistry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Taylor, D. M.; Morgan, H.; D’Silva, C. published the artcile< Characterization of chemisorbed monolayers by surface potential measurements>, Synthetic Route of 112-63-0, the main research area is chemisorption aminopropylsilane biotin avidin gold.

Chemisorption was used to immobilize uniform, low-defect d. monolayers of (3-aminopropyl)silane and of d-biotin on evaporated gold substrates. The quality of the monolayers was confirmed by surface potential measurements and by copper decoration. Avidin was immobilized to these monolayers by (i) crosslinking to the (3-aminopropyl)silane with glutaraldehyde and (ii) binding directly to the biotin ligand. The changes in surface potential observed during each immobilization step are shown to be related directly to the mol. structure of each chemisorbed layer. Significantly, when the avidin is immobilized on the biotin monolayer the tetrameric protein is oriented with one pair of biotin binding sites on the upper surface of the protein monolayer. This allows the bifunctional ligand, 1,12-bis(biotinamide)dodecane to be bound to the protein giving the possibility of attaching further protein layers to form mol. organizates suitable for mol. electronic and mol. sensing applications.

Journal of Physics D: Applied Physics published new progress about Avidins Role: PRP (Properties). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Moser, Russell J.; Brown, Ellis Vincent published the artcile< Mass spectra of some 5- and 6-substituted 2-pyridinecarboxylic acids. Nature of fragmentation step for loss of carbon dioxide>, Application of C19H34O2, the main research area is pyridine carboxylic acid mass spectra.

The fragmentation patterns were obtained by electron-impact on 6-acetamido-, 6-amino-, 6-bromo-, 6-chloro-, 6-methoxy-, 6-methyl-, 6-nitro-, 5-carboxy-, 5-iodo-, 5-methoxy- and 5-nitro-2-pyridinecarboxylic acids, as well as 2- and 3-pyridinecarboxylic acids. Most of these acids lost CO2 [M – 44] as their first major fragmentation. This is in direct contrast to the substituted benzoic acids which show loss of OH [M – 17] or CO2H [M – 45] in their first major fragmentation. The ring N may determine which pathway predominates.

Organic Mass Spectrometry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lizarzaburu, Mike; Turcotte, Simon; Du, Xiaohui; Duquette, Jason; Fu, Angela; Houze, Jonathan; Li, Leping; Liu, Jinqian; Murakoshi, Michiko; Oda, Kozo; Okuyama, Ryo; Nara, Futoshi; Reagan, Jeff; Yu, Ming; Medina, Julio C. published the artcile< Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus>, Electric Literature of 112-63-0, the main research area is alkylphenylalaninamide pyridinylphenylamine oxobipyridinylamine preparation GPR142 agonist; structure alkylphenylalaninamide pyridinylphenylamine oxobipyridinylamine GPR142 agonism exposure; cytochrome P 450 inhibition alkylphenylalaninamide pyridinylphenylamine oxobipyridinylamine.

N-alkylphenylalaninamides of pyridinylphenyl- and oxobipyridinylamines such as I were prepared as GPR142 agonists for potential use as antidiabetic agents for type 2 diabetes and tested for their agonism of GPR142 in vitro and in human plasma and their inhibition of cytochrome P 450 enzymes such as isoforms 3A4 and 2D6. Optimization of the original lead compound gave agonists 90 times more potent against human GPR142. Inhibition of cytochrome P 450 isoforms 3A4 and 2D6 was reduced by increasing the polarity of the biarylamine moiety. The pharmacokinetics of I and a thiazolylmethyl phenylalaninamide of an aminopyridinylbenzoate were determined in rats.

Bioorganic & Medicinal Chemistry Letters published new progress about G protein-coupled receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (GPR 142). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi published the artcile< Palladium-Catalyzed Annulation of o-Iodobiphenyls with o-Bromobenzyl Alcohols: Synthesis of Functionalized Triphenylenes via C-C and C-H Bond Cleavages>, Application of C19H34O2, the main research area is palladium phosphine catalyzed annulation iodobiphenyl bromobenzyl alc triphenylene; decarbonylative cross coupling intramol cyclization triphenylene synthesis.

Treatment of o-iodobiphenyls with o-bromobenzyl alcs. in the presence of cesium carbonate under palladium catalysis affords a series of highly substituted triphenylenes [e.g., o-iodobiphenyl + 2-(2-bromophenyl)-2-propanol in presence of PdCl2(NCPh)2/P[3,5-(CF3)2C6H3]3 and Cs2CO3 afforded triphenylene in 81% yield].. The reaction involves two C-C bond formations and C-C and C-H bond cleavages. A combination of palladium and an electron-deficient phosphine ligand proves to be effective for both decarbonylative cross-coupling and intramol. cyclization.

Organic Letters published new progress about Aralkyl alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Yan; Wu, Weibo; Li, Hu; Zhao, Wenfeng; Yang, Song published the artcile< Sustainable and rapid production of biofuel γ-valerolactone from biomass-derived levulinate enabled by a fluoride-ionic liquid>, Related Products of 112-63-0, the main research area is biofuel valerolactone biomass derived levulinate fluoride ionic liquid.

γ-Valerolactone (GVL) is a versatile biomass-derived mol. for both value-added chems. and biofuels, which is typically prepared from levulinates over metal particles or oxides in the presence of hydrogen, formic acid or alc. Herein, we reported a rapid and mild approach for cascade hydrogenation-cyclization of Et levulinate (EL) to GVL in the presence of readily available ionic liquid tetrabutylammonium fluoride ([TBA]F) and polymethylhydrosiloxane (PMHS) as catalyst and hydrogen source, resp. After reacting at room temperature for 30 min, a high GVL yield of 85% with TOF value of 52 h-1 could be obtained over 3 mol% [TBA]F. In addition to optimizing reaction parameters, the catalytic mechanism was also elucidated for the one-pot sequential transformation of EL to GVL.

Energy Sources, Part A: Recovery, Utilization, and Environmental Effects published new progress about Biofuels. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics