Category: 112-63-0

Baldwin, John J.; Christy, Marcia E.; Denny, George H.; Habecker, Charles N.; Freedman, Mark B.; Lyle, Paulette A.; Ponticello, Gerald S.; Varga, Sandor L.; Gross, Dennis M.; Sweet, Charles S. published the artcile< 尾1-Selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. II>, SDS of cas: 112-63-0, the main research area is imidazole aminohydroxypropoxyphenyl; aminohydroxypropoxyphenylimidazole preparation adrenoceptor antagonist.

An attempt to develop a highly cardioselective 尾-adrenoceptor antagonist devoid of intrinsic sympathetic activity (ISA) focused on exploring structure-activity relationships around imidazole (S)-I (R = 2-thienyl, X = bond). Strategies to reduce or eliminate ISA centered on structural changes that could influence activation of the receptor by the drug itself or by a metabolite. The approaches involved eliminating the acidic imidazole N-H proton, incorporating substituents ortho to the 尾-adrenergic blocking side chain, increasing steric bulk around the N-H moiety, decreasing lipophilicity, introducing intramol. hydrogen bonding involving the imidazole N-H, and displacing the imidazole ring from an activating position by the incorporation of a spacer element. The compounds were investigated in vitro for 尾-adrenoceptor antagonism and in vivo for ISA. From these studies, the most successful variation involved the insertion of a spacer between the imidazole and aryl rings. (S)-I.HCl (R = MeCO, X = CH2) was highly cardioselective (dose ratio 尾2/尾1 > 9333) and devoid of ISA.

Journal of Medicinal Chemistry published new progress about 尾1-Adrenoceptor antagonists. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aboelazayem, Omar; Gadalla, Mamdouh; Saha, Basudeb published the artcile< Comprehensive Optimization of Biodiesel Production Conditions via Supercritical Methanolysis of Waste Cooking Oil>, Related Products of 112-63-0, the main research area is waste cooking oil biodiesel production optimization methanolysis.

Biodiesel has been established as a promising alternative fuel to petroleum diesel. This study offers a promising energy conversion platform to valorise high acidity waste cooking oil (WCO) into biodiesel in a single-step reaction via supercritical methanol. Carbon dioxide (CO2) has been used as a co-solvent in the reaction with a catalytic effect to enhance the production of biodiesel. This work provides an in-depth assessment of the yield of four fatty acids Me esters (FAME) from their correspondent triglycerides and fatty acids. The effects of four independent process variables, i.e., methanol to oil (M:O) molar ratio, temperature, pressure, and time, have been investigated using Response Surface Methodol. (RSM). Four quadratic models have been developed between process variables and the yield of FAMEs. The statistical validation of the predicted models has been performed using anal. of variance (ANOVA). Numerical optimization has been employed to predict the optimal conditions for biodiesel production The predicted optimal conditions are at 25:1 M:O molar ratio, 254.7掳C, 110 bar within 17 min resulting in 99.2%, 99.3%, 99.13%, and 99.05% of methyl-oleate, methyl-palmitate, methyl-linoleate, and methyl-stearate yields, resp. The predicted optimum conditions have been validated exptl.

Energies (Basel, Switzerland) published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bojanowski, Jan; Albrecht, Anna published the artcile< Doubly Decarboxylative Synthesis of 4-(Pyridylmethyl)chroman-2-ones and 2-(Pyridylmethyl)chroman-4-ones under Mild Reaction Conditions.>, Category: esters-buliding-blocks, the main research area is pyridylmethyl chromanone preparation; carboxy chromanone pyridyl acetic acid decarboxylative Michael addition; Michael addition; chromone-3-carboxylic acid; coumarin-3-carboxylic acid; decarboxylation.

The doubly decarboxylative Michael-type addition of pyridylacetic acid to chromone-3-carboxylic acids or coumarin-3-carboxylic acids were developed. This protocol was realized under Bronsted base catalysis, providing biol. interesting 4-(pyridylmethyl)chroman-2-ones and 2-(pyridylmethyl)chroman-4-ones in good or very good yields. The decarboxylative reaction pathway was confirmed by mechanistic studies. Moreover, an attempts to develop enantioselective variant of the cascade was described.

Molecules published new progress about C-H bond activation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gul, M.; Zulkifli, N. W. M.; Masjuki, H. H.; Kalam, M. A.; Mujtaba, M. A.; Harith, M. H.; Syahir, A. Z.; Ahmed, Waqar; Bari Farooq, Abdul published the artcile< Effect of TMP-based-cottonseed oil-biolubricant blends on tribological behavior of cylinder liner-piston ring combinations>, Quality Control of 112-63-0, the main research area is TMP cottonseed oil biolubricant blend tribol behavior automotive engine.

Cottonseed oil-based biolubricant was synthesized by the TMP-based transesterification process. 10-50% by volume blends of TMP-based cotton-biolubricant and SAE-40 were prepared and tested on the high-frequency-reciprocating-rig with engine cylinder-liner and piston-ring combination to investigate their tribol. While tribol. characteristics were also evaluated by four-ball tribo-testers at high constant load of 785 N. 10% addition of cotton-biolubricant showed the lowest friction and wear as compared to SAE-40 but>10% volume of cotton biolubricant in blend increased the wear and friction considerably as tested by both HFRR and four-ball. Hence, 10% addition of TMP-cotton-biolubricant can be utilized as an energy-saving lubricant additive to partially reduce the dependency on petroleum-based lubricant for automotive engine application.

Fuel published new progress about Crankcase oil. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fuerstner, Alois; Bonnekessel, Melanie; Blank, Jarred T.; Radkowski, Karin; Seidel, Guenter; Lacombe, Fabrice; Gabor, Barbara; Mynott, Richard published the artcile< Total synthesis of myxovirescin A1>, Synthetic Route of 112-63-0, the main research area is myxovirescin A1 total synthesis regioselective Negishi Suzuki coupling; stereoselective hydrogenation oxyallylation total synthesis myxovirescin A1; ring closing metathesis total synthesis myxovirescin A1; hydrosilylation trans total synthesis myxovirescin A1.

A convergent total synthesis of the antibiotic macrolide myxovirescin A1 (I) is described that is largely based on reagent- and catalyst-controlled transformations. This includes a highly regioselective Negishi reaction of dibromo-alkene (E)-BrCH:CBrCH2OMe with an alkynyl-zinc reagent, and a palladium catalyzed alkyl-Suzuki coupling of the resulting enyne derivative (E)-MeC顚咰CH:CBrCH2OMe (II) with the 9-BBN-adduct derived from alkene III. The latter was obtained via an asym. hydrogenation of the chlorinated 尾-ketoester EtO2CCH2COCH2Cl and an anti-selective oxyallylation of the functionalized aldehyde (S)-OHCCH2CH(CH2N3)OCH2OMe as the key steps. The preparation of a bis-borylated allyl-donor used in the oxyallylation step, however, required careful optimization and led to important insights into the nature of the classical hydroborating agent “”di(isopinocampheyl)borane (Ipc2BH)””. It was unambiguously shown by X-ray crystallog. that in the solid state this compound is dimeric, but it is prone to undergo an essentially quant. mono-deborylation when dissolved in CH2Cl2 or benzene; its composition in ethereal solvents is even more complex as evident from 11B NMR data. The product derived from II and III was elaborated into the enyne-yne derivative IV, which served as the substrate for an exquisitely selective ring closing alkyne metathesis reaction (RCAM) catalyzed by a molybdenum tris-amido complex activated in situ with CH2Cl2. The resulting cyclic enyne was subjected to a ruthenium catalyzed trans-hydrosilylation/proto-desilylation tandem. Although [Cp*Ru(MeCN)3]PF6 had previously been recommended as catalyst of choice for trans-hydrosilylation reactions of internal alkynes, this complex failed to afford the desired product, whereas its sterically less hindered congener [CpRu(MeCN)3]PF6 permitted the reaction to be performed in appreciable yield, but at the expense of a lower stereoselectivity. AgF-mediated proto-desilylation of the isomeric silanes followed by cleavage of the remaining acetal protecting groups afforded myxovirescin A1 and its hitherto unknown 14Z-isomer.

Chemistry – A European Journal published new progress about Allylation (oxyallylation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tripathi, Prashasti; Puranik, Vineeta; Purwar, Shalini published the artcile< Comparison of branded and non-branded food samples widely consumed in north India with reference to Trans fatty acid content>, Application of C19H34O2, the main research area is trans fatty acid content branded nonbranded food sample.

Trans fatty acids (TFA) are the geometrical isomers of monounsaturated and polyunsaturated fatty acids that affect the function-al and physicochem. properties of these fatty acids, which in turn affect their metabolism in humans. Since the database available for trans fatty acids in food from India is scarce, the research report generates data about trans fatty acid content in selected foods popular in north India. In this report, various food samples like cookies, chocolates, biscuits, pizza, fries, indigenous snacks like samosa, pakora and indigenous sweets like jalebi, gulab jamun, and laddoo were analyzed for the Trans Fatty Acid (TFA) content by gas chromatog. A large variation was found in trans fatty acid content among these food samples. The results also showed that only 4.5% of the samples were found to contain TFA less than 0.5% while approx. 8% of samples having more than 5% TFA (1 branded and 6 non-branded samples). Also, a large variation was found in the trans fatty acid content of branded and non-branded food samples with the mean value of TFA in branded and non-branded food groups as 1.781 and 6.125 resp. and the t-value of 0.852 between the two groups. When regulations are emphasizing on labeling the TFA content on the product, there are arrays of unlabeled products which are not governed under any regulations. Hence there is a need for strong food regulations to bring levels of trans fats in processed foods to negligible levels.

Journal of Applied and Natural Science published new progress about Bakery cakes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xiaowei; Jin, Feng; Jiang, Shiyu; Cao, Jun; Meng, Yanchun; Xu, Yu; ChunmengWang; Chen, Yong; Yang, Huijuan; Kong, Yunyi; Liu, Xin; Luo, Zhiguo published the artcile< Rh-endostatin combined with chemotherapy in patients with advanced or recurrent mucosal melanoma: retrospective analysis of real-world data>, Category: esters-buliding-blocks, the main research area is recombinant human endostatin recurrent mucosal melanoma chemotherapy; Lymphocyte-to-monocyte ratio; Mucosal melanoma; Recombinant human endostatin (Rh-endostatin); Survival.

Mucosal melanoma is rare and has distinct clin. and genetic features. Even with advances in targeted and immune therapies, the survival of patients with advanced or recurrent mucosal melanomas remains poor. The standard treatment remains controversial and we conducted this real-world study aimed to explore continuous i.v. recombinant human endostatin (Rh-endostatin) infusion plus chemotherapy in this population in the first-line setting. Overall, 43 patients with advanced or recurrent mucosal melanoma treated at Fudan University Shanghai Cancer Center between Apr. 2017 and August 2020 were retrospectively included. Patients received dacarbazine plus cisplatin or temozolomide plus cisplatin per the investigators’ preference. Rh-endostatin (105 mg/m2) was administered with continuous infusion for 168 h (Civ 168 h). Of the 43 patients, 72.1% had metastatic disease, and the most common primary site was the gastrointestinal tract (51.2%). The most commonly observed mutations were NRAS (23.1%), BRAF (7.7%) and CKIT mutations (5.1%). An objective response was observed in 12 (30.0%) of the 40 evaluable patients, and disease control was achieved in 31 (77.5%) patients. With a median follow-up of 17.6 mo, the median progression-free survival (PFS) and overall survival (OS) were 4.9 and 15.3 mo, resp. Addnl., high lymphocyte-to-monocyte ratio (LMR) (p = 0.023, HR 0.29, 95% CI: 0.10-0.84) and BRAF/KIT/RAS mutation (p = 0.028, HR 0.24, 95% CI: 0.07-0.86) were independently correlated with prolonged OS. Toxicity was manageable overall. Continuous Rh-endostatin infusion plus chemotherapy was effective and safe for the treatment of advanced or recurrent mucosal melanoma. High LMR was correlated with favorable PFS and OS in this patient population.

Investigational New Drugs published new progress about Anemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Takemura, Naho; Sumida, Yuto; Ohmiya, Hirohisa published the artcile< Organic Photoredox-Catalyzed Silyl Radical Generation from Silylboronate>, Related Products of 112-63-0, the main research area is silyl radical generation method silylboronate light driven; three component reaction silyl radical acylimidazole alkene photocatalysis; acylsilane derivative radical preparation heterocyclic carbene photocatalysis.

A visible-light-driven silyl radical generation method from silylboronates was developed. The activation of silylboronates with a catalytic amount of mild base promoted the single-electron oxidation process to form silyl radicals. Facile single electron transfer for the borate form readily occurred without H atom transfer for hydrosilane in the presence of various photoredox catalysts. Combining this protocol with radical-mediated N-heterocyclic carbene catalysis enabled the acylsilylation of alkenes via a radical relay process with silyl radical generation. Also, the recent advanced methods for the synthesis of silylboronates significantly improved the utility of this silyl radical generation alkenes acylimidazole.

ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sandbhor, Puja; Goda, Jayant. S.; Mohanty, Bhabani; Chaudhari, Pradip; Dutt, Shilpee; Banerjee, Rinti published the artcile< Bio-polymeric transferrin-targeted temozolomide nanoparticles in gel for synergistic post-surgical GBM therapy>, Application In Synthesis of 112-63-0, the main research area is biopolymeric transferrin temozolomide nanoparticle gel synergistic glioblastoma.

Spatiotemporal targeting of anti-glioma drugs remains a pressing issue in glioblastoma (GBM) treatment. We challenge this issue by developing a minimally invasive in situ implantable hydrogel implant comprising transferrin-targeted temozolomide-miltefosine nanovesicles in the surgically resected GBM cavity (tumor bed). Injection of the “”nanovesicle in hydrogel system”” in orthotopic GBM-bearing mice improved drug penetration into the peri-cavitary region (鈭?.5 mm in depth) with the potential to act as a bridge therapy in the immediate postoperative period, before the initiation of adjuvant radiotherapy. The controlled and sustained release of temozolomide over a month in the surgical cavity eradicated the microscopic GBM cells present within the tumor bed, thereby augmenting the efficacy of adjuvant therapy. The drug (temozolomide and miltefosine) combination was tolerable and efficiently inhibited tumor growth, causing significant prolongation of the survival of tumor-bearing mice compared to that with the free drug. Direct implantation at the target site in the brain resulted in spatiotemporal anti-glioma activity with minimal extracranial and systemic distribution. Nanovesicle in flexible hydrogel systems can be used as potential platforms for the post-surgical management of GBM before initiating adjuvant radiation therapy.

Nanoscale published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jimenez-Morales, Jose Marcos; Hernandez-Cuenca, Yanet Elisa; Reyes-Abrahantes, Ander; Ruiz-Garcia, Henry; Barajas-Olmos, Francisco; Garcia-Ortiz, Humberto; Orozco, Lorena; Quinones-Hinojosa, Alfredo; Reyes-Gonzalez, Jesus; Abrahantes-Perez, Maria del Carmen published the artcile< MicroRNA delivery systems in glioma therapy and perspectives: A systematic review>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is review glioma microRNA delivery systems antitumor lipid nanoparticles; Drug delivery system; Glioma; MicroRNAs; Molecular targeted therapy; Translational medicine.

A review. Gliomas are the deadliest of all primary brain tumors, and they constitute a serious global health problem. MicroRNAs (miRNAs) are gene expression regulators associated with glioma pathogenesis. Thus, miRNAs represent potential therapeutic agents for treating gliomas. However, miRNAs have not been established as part of the regular clin. armamentarium. This systemic review evaluates current mol. and pre-clin. studies with the aim of defining the most appealing supramol. platform for administering therapeutic miRNA to patients with gliomas. An integrated anal. suggested that cationic lipid nanoparticles, functionalized with octa-arginine peptides, represent a potentially specific, practical, non-invasive intervention for treating gliomas. This supramol. platform allows loading both hydrophilic (miRNA) and hydrophobic (anti-tumor drugs, like temozolomide) mols. This systemic review is the first to describe miRNA delivery systems targeted to gliomas that integrate several types of mols. as active ingredients. Further exptl. validation is warranted to confirm the practical value of miRNA delivery systems.

Journal of Controlled Release published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics