Category: 112-63-0

Dorko, Eva; Kotai, Bianka; Foldes, Tamas; Gyomore, Adam; Papai, Imre; Soos, Tibor published the artcile< Correlating electronic and catalytic properties of frustrated Lewis pairs for imine hydrogenation>, Application In Synthesis of 112-63-0, the main research area is borane acidity frustrated Lewis pair catalysis imine hydrogenation.

Gradually substituting meta- and para-hydrogen atoms to fluorines or chlorines, a series of seventeen triarylboranes with a general BX2Y structure was generated for frustrated Lewis pair hydrogenation of imines and comprehensively characterized using combined exptl. and theor. methods.

Journal of Organometallic Chemistry published new progress about Boranes Role: CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PROC (Process), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nitsche, Tobias; Steinkoenig, Jan; De Bruycker, Kevin; Bloesser, Fabian R.; Blanksby, Stephen J.; Blinco, James P.; Barner-Kowollik, Christopher published the artcile< Mapping the Compaction of Discrete Polymer Chains by Size Exclusion Chromatography Coupled to High-Resolution Mass Spectrometry>, SDS of cas: 112-63-0, the main research area is polystyrene tetrazole fumarate exclusion chromatog mass spectrometry.

We introduce a powerful approach based on the combination of size exclusion chromatog. with high-resolution mass spectrometry to selectively follow the compaction of discrete polymer chains that have uniform elemental composition Single-chain nanoparticles (SCNP) have attracted considerable interest for a wide range of applications associated with their adjustable morphol. However, the precise characterization of morphol. changes during the compaction is still challenging using existing anal. techniques. We employ a polystyrene backbone functionalized with tetrazole and fumarate moieties to utilize the nitrile imine-mediated tetrazole-ene cycloaddition for compaction. As every compaction step is associated with an elimination of one nitrogen mol., it can be monitored via high-resolution electrospray ionization mass spectrometry. The combination with size exclusion chromatog. enables the direct correlation of changes in mass with changes in morphol. associated with the compaction. By establishing a calibration between the retention time and the hydrodynamic radius, ion chromatograms of discrete chains can be directly applied to determine the reduction in hydrodynamic radius associated with each crosslinking event. Therefore, accessing the compaction of discrete polymer chains becomes possible for the first time.

Macromolecules (Washington, DC, United States) published new progress about Hydrodynamic radius. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dezanet, Lorenza N. C.; Miailhes, Patrick; Lascoux-Combe, Caroline; Chas, Julie; Maylin, Sarah; Gabassi, Audrey; Rougier, Hayette; Delaugerre, Constance; Lacombe, Karine; Boyd, Anders published the artcile< Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is human liver fibrosis tenofovir HIV hepatitis B; group-based trajectory models; hepatic fibrosis; hepatitis B virus; human immunodeficiency virus.

Data on liver fibrosis evolution and its involvement in liver-related morbidity are scarce in individuals with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infection during treatment. We identified profiles of liver fibrosis evolution in coinfected patients undergoing tenofovir (TDF). We included 169 HIV-HBV-coinfected patients on TDF-based antiretroviral therapy. Virol. and clin. data were obtained at TDF-initiation and every 6-12 mo. From data on non-invasive liver fibrosis assessments collected yearly (FibroTest), we established clusters of individuals with similar liver fibrosis evolution using group-based trajectory models. Four profiles of liver fibrosis evolution were established from a median follow-up of 7.6 years (IQR = 3.1-13.1): low fibrosis with no progression (29.6%, profile A), low fibrosis with progression (22.5%, profile B), moderate fibrosis with high fluctuation (39.6%, profile C), and cirrhosis with no regression (8.3%, profile D). When compared to profile A, baseline HBeAg-pos. status was associated with profiles B (P = .007) and C (P = .004), older age with profiles C (P < .001) and D (P = .001), exposure to second-generation protease inhibitors with profile C (P = .004), and CD4+ <500/mm3 at the last visit with profiles C (P = .02) and D (P = .002). Incident liver-related events occurred in profiles other than A (B, n = 1/38; C, n = 6/67; D, n = 3/14) and all five cases of hepatocellular carcinoma occurred in profiles C (n = 2) and D (n = 3). TDF-treated HIV-HBV coinfected individuals do not seem to benefit from comparable levels of liver fibrosis regression as in HBV mono-infection. Liver-related morbidity occurs mainly in those with fluctuating or consistently high fibrosis levels. Liver International published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ogoshi, Yosuke; Matsui, Takuya; Mitani, Ikuo; Yokota, Masahiro; Terashita, Masakazu; Motoda, Dai; Ueyama, Kazuhito; Hotta, Takahiro; Ito, Takashi; Hase, Yasunori; Fukui, Kenji; Deai, Katsuya; Yoshiuchi, Hiromi; Ito, Soichiro; Abe, Hiroyuki published the artcile< Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia>, Application In Synthesis of 112-63-0, the main research area is JTZ951 HIF prolyl hydroxylase inhibitor kidney anemia.

Inhibition of hypoxia inducible factor prolyl hydroxylase (PHD) represents a promising strategy for the discovery of a next generation treatment for renal anemia. We identified several 5,6-fused ring systems as novel scaffolds of the PHD inhibitor on the basis of pharmacophore anal. In particular, triazolopyridine derivatives showed potent PHD2 inhibitory activities. Examination of the predominance of the triazolopyridines in potency by electrostatic calculations suggested favorable π-π stacking interactions with Tyr310. Lead optimization to improve the efficacy of erythropoietin release in cells and in vivo by improving cell permeability led to the discovery of JTZ-951 (compound 14), with a 5-phenethyl substituent on the triazolopyridine group, which increased Hb levels with daily oral dosing in rats. Compound 14 was rapidly absorbed after oral administration and disappeared shortly thereafter, which could be advantageous in terms of safety. Compound 14 was selected as a clin. candidate.

ACS Medicinal Chemistry Letters published new progress about Hemoglobins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Elajaili, Hanan; Hernandez-Lagunas, Laura; Harris, Peter; Sparagna, Genevieve C.; Jonscher, Raleigh; Ohlstrom, Denis; Sucharov, Carmen C.; Bowler, Russell P.; Suliman, Hagir; Fritz, Kristofer S.; Roede, James R.; Nozik, Eva S. published the artcile< Extracellular superoxide dismutase (EC-SOD) R213G variant reduces mitochondrial ROS and preserves mitochondrial function in bleomycin-induced lung injury>, Application of C19H34O2, the main research area is SOD2 polymorphism ROS glutathione mitochondrial respiration lung injury.

Extracellular superoxide dismutase (EC-SOD) is highly expressed in the lung and vasculature. A common human single nucleotide polymorphism (SNP) in the matrix binding region of EC-SOD leads to a single amino acid substitution, R213G, and alters EC-SOD tissue binding affinity. The change in tissue binding affinity redistributes EC-SOD from tissue to extracellular fluids. Mice (R213G mice) expressing a knock-in of this EC-SOD SNP exhibit elevated plasma and reduced lung EC-SOD content and activity and are protected against bleomycin-induced lung injury and inflammation. It is unknown how the redistribution of EC-SOD alters site-specific redox-regulated mols. relevant for protection. In this study, we tested the hypothesis that the change in the local EC-SOD content would influence not only the extracellular redox microenvironment where EC-SOD is localized but also protect the intracellular redox status of the lung. Mice were treated with bleomycin and harvested 7 days post-treatment. Superoxide levels, measured by ESR (EPR), were lower in plasma and Bronchoalveolar lavage fluid (BALF) cells in R213G mice compared to wild-type (WT) mice, while lung cellular superoxide levels in R213G mice were not elevated post-bleomycin compared to WT mice despite low lung EC-SOD levels. Lung glutathione redox potential (EhGSSG), determined by HPLC and fluorescence, was more oxidized in WT compared to R213G mice. In R213G mice, lung mitochondrial oxidative stress was reduced shown by mitochondrial superoxide level measured by EPR in lung and the resistance to bleomycin-induced cardiolipin oxidation Bleomycin treatment suppressed mitochondrial respiration in WT mice. Mitochondrial function was impaired at baseline in R213G mice but did not exhibit further suppression in respiration post-bleomycin. Collectively, the results indicate that R213G variant preserves intracellular redox state and protects mitochondrial function in the setting of bleomycin-induced inflammation.

Advances in Redox Research published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (SOD1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Ruiying; Zheng, Ying; Han, Tao; Lan, Jie; He, Laixi; Shi, Jianyou published the artcile< Angiogenic Actions of Paeoniflorin on Endothelial Progenitor Cells and in Ischemic Stroke Rat Model>, Related Products of 112-63-0, the main research area is paeoniflorin neuroprotectant VEGF endothelial cell angiogenesis ischemic stroke; Angiogenesis; Biological Features; Endothelial Progenitor Cells; Ischemic Stroke; Paeoniflorin; Vascular Regeneration.

Ischemic stroke is one of the major diseases with high morbidity, mortality, and disability rate all over the world. Chinese herb-derived active components would provide valuable candidate compounds for ischemic stroke therapy. Paeoniflorin (PF) is an active ingredient from Paeoniae Radix which possesses neurovascular effect after ischemia. However, so far, few studies are reported on the efficacy and mechanism of PF from angiogenesis aspects. Results from our in vitro studies showed that the ability for proliferation, migration, and tube formation in bone marrow-derived endothelial progenitor cells (BM-EPCs) was promoted by coculturing with PF (100μM). Furthermore, to investigate the angiogenic effects of PF in vivo, we constructed an ischemic stroke model in rats and found that PF could reduce cerebral infarction, alleviate pathol. injury, and increase the secretion of pro-angiogenic factors and cerebral vascular d. after intraperitonially administration of 40 mg · kg-1 · day-1 for 14 days. Up-regulating the expression of VEGF/VEGF-R2 might be the mechanism of PF’s angiogenic action. In conclusion, the present study provides evidence that PF is an active monomer of Traditional Chinese Medicine which shows angiogenic actions on endothelial progenitor cells and in ischemic stroke rat model.

American Journal of Chinese Medicine published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Yizhe; Zhang, Shujie; Luo, Xin; Zhao, Han; Xiang, Xiaoxing published the artcile< Paeoniflorin mitigates PBC-induced liver fibrosis by repressing NLRP3 formation.>, Application In Synthesis of 112-63-0, the main research area is .

PURPOSE: To delve into the influence of paeoniflorin (PA) on abating primary biliary cholangitis (PBC)-induced liver fibrosis and its causative role. METHODS: Our team allocated the mice to control group, PA group, PBC group and PBC+PA group. We recorded the weight change of mice in each group. We used Masson staining for determining liver fibrosis, immunofluorescence staining for measuring tumor necrosis factor-α (TNF-α) expression, quantitative real-time polymerase chain reaction (qRT-PCR) for assaying related gene expression, as well as Western blot for testing related protein expression. RESULTS: The weight of PBC model mice declined. Twenty-four weeks after modeling, the positive rate of anti-mitochondrial antibody-M2 (AMA-M2) in PBC mice reached 100%. Alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), hydroxyproline (HYP), laminin (LN), procollagen type III (PC III), and malondialdehyde (MDA) contents saliently waxed (p<0.01). Meanwhile, superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) activity patently waned (p<0.01). Liver fibrosis levels were flagrantly higher (p<0.01), and TNF-α, NOD-like receptor protein 3 (NLRP3), caspase-1, interleukin-18 (IL-18), and interleukin-1β (IL-1β) protein or gene expression were manifestly up-regulated (p<0.01). PA could restore the weight of PBC mice, strikingly restrain the positive expression of AMA-M2, and down-regulate serum ALP, ALT, AST, HYP, LN, PC III, MDA in PBC mice (p<0.01). PA could also significantly up-regulate SOD and GSH-px levels (p<0.01), down-regulate IL-1β, IL-18, caspase-1, NLRP3, and TNF-α protein or gene expression in PBC mice (p<0.01) and inhibit liver fibrosis levels (p<0.01). CONCLUSIONS: PA can reduce PBC-induced liver fibrosis in mice and may function by curbing the formation of NLRP3. Acta cirurgica brasileira published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zuo, Xiang; Cheng, Cang; Zhang, Yanghui published the artcile< Palladium-catalyzed cross-coupling of 2-iodobiphenyls with ortho-chloroacetophenones through dual C-H arylation for the construction of tribenzo[a,c,f]cyclooctanones>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tribenzocyclooctanone preparation; iodobiphenyl ortho chloroacetophenone cross coupling reaction palladium arylation.

The palladium-catalyzed cross-coupling reaction of 2-iodobiphenyls with ortho-chloroacetophenones has been developed. The reaction involves C-H activation of 2-iodobiphenyls and yields eight-membered carbocycles by forming two C-C bonds. The protocol provides a straightforward method for the construction of tribenzo[a,c,f]cyclooctanones with simple substrates and allows easy access to its various derivatives

Organic Chemistry Frontiers published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent) (ortho-chloro-). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Feng; Zeng, Xing-Ping; Wang, Chao; Zhao, Xiao-Li; Zhou, Jian published the artcile< Organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position>, Quality Control of 112-63-0, the main research area is thiooxindole alkoxyoxindole organocatalytic stereoselective amination butylazodicarboxylate.

The authors report the first organocatalytic asym. synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position. Importantly, 3-thiooxindoles and 3-alkoxyoxindoles are demonstrated to be reactive nucleophiles for the development of catalytic asym. reactions for the first time.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amination catalysts (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peng, Lichong; Zhang, Xiuling; Sun, Yaxin; Li, Congju published the artcile< Electrospun ZIF-derived cavity porous carbon nanofibers as a freestanding cathode for lithium-oxygen batteries with ultralow overpotential>, Computed Properties of 112-63-0, the main research area is electrospun ZIF derived carbon nanofiber cathode lithium oxygen battery.

Construction of an efficient electrocatalyst for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) with low overpotential and cycling stability for lithium-oxygen batteries still remains a puzzling challenge. Herein, we propose a scalable approach to integrate ZIF derivatives into cavity porous carbon nanofibers (CPCNFs) via an electrospinning technique and thermal treatment (Zn/CoNC@CPCNFs). The ultralong interconnected nanofiber matrix is beneficial, and the developed Zn/CoNC@CPCNFs catalyst with excellent flexibility can be utilized as a free-standing electrode based on an air-cathode. Moreover, this confinement strategy ensures the dispersion of Co-based species and abundant porosity structure, which contributes to the transport and adsorption of oxygen and exposes more Co-N coordination catalytic centers, as a result of a drastically ultralow voltage gap. Consequently, a cell based on a Zn/CoNC@CPCNF electrode presents remarkably decreased charge-discharge polarization (0.36 V), a high initial discharge capacity with an ultra-low overpotential of 0.59 V, and long-term cyclability with a cut-off capacity of 0.2 mA h cm-2 at 0.02 mA cm-2. We hope that our protocol will offer instruction for the design and application of oxygen electrocatalysts for energy conversion and storage.

Nanoscale published new progress about Agglomeration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics