Category: 112-63-0

Abram, Michal; Rapacz, Anna; Mogilski, Szczepan; Latacz, Gniewomir; Lubelska, Annamaria; Kaminski, Rafal M.; Kaminski, Krzysztof published the artcile< Multitargeted Compounds Derived from (2,5-Dioxopyrrolidin-1-yl)(phenyl)-Acetamides as Candidates for Effective Anticonvulsant and Antinociceptive Agents>, Product Details of C19H34O2, the main research area is epilepsy neuropathic pain anticonvulsant antinociceptive multitargeted drugs hybrid compound; Hybrid compounds; anticonvulsant activity; antinociceptive activity; epilepsy; multitargeted drugs; neuropathic pain.

We developed a focused set of original hybrid pyrrolidine-2,5-dione derivatives with potent anticonvulsant and antinociceptive properties. These hybrid compounds demonstrated broad-spectrum protective activity in a range of mouse models, such as the maximal electroshock (MES) test, the pentylenetetrazole-induced seizures (scPTZ), and the 6 Hz (32 mA) seizures. Compound 22(I) showed the most potent anticonvulsant activity (ED50 MES = 23.7 mg/kg, ED50 6 Hz (32 mA) = 22.4 mg/kg, ED50scPTZ = 59.4 mg/kg). In addition, 22 revealed potent efficacy in the formalin-induced tonic pain. These in vivo activities of 22 are likely mediated by several targets and may result from the inhibition of central sodium/calcium currents and transient receptor potential vanilloid 1 (TRPV1) receptor antagonism. Finally, the lead compound 22 revealed drug-like absorption, distribution, metabolism, excretion, toxicity (ADME-Tox) properties in the in vitro assays, making it a potential candidate for further development in epilepsy and neuropathic pain indications.

ACS Chemical Neuroscience published new progress about Analgesics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qu, Jinglin; Yan, Zijuan; Wang, Xuchao; Deng, Jun; Liu, Feipeng; Rong, Zi-Qiang published the artcile< Nickel-catalyzed cross-coupling of epoxides with aryltriflates: rapid and regioselective construction of aryl ketones>, Related Products of 112-63-0, the main research area is aryl ketone regioselective preparation; aryltriflate epoxide nickel catalyst cross coupling.

Herein, a facile synthetic method for the construction of ketones RCH2C(O)Ar [R = Ph, 2-MeC6H4, Bn, etc.; Ar = Ph, 4-FC6H4, 4-C(O)Me, etc.] via Ni-catalyzed cross coupling of epoxides with aryltriflates was presented. A range of easily accessible epoxides could be highly regioselectively converted to the corresponding aryl ketones with good yields in a redox neutral fashion.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl triflates Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Knyazev, V. N.; Drozdov, V. A. published the artcile< Use of new titrants for conducting redox reactions in nonaqueous media>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is titrant redox nonaqueous potentiometry; borohydride titrant nonaqueous potentiometry; aminoethylhydroquinone titrant nonaqueous potentiometry; hydroquinone aminoethyl titrant nonaqueous potentiometry; chlorooxochromium titrant nonaqueous potentiometry; chromyl chloride titrant nonaqueous potentiometry; chlorooxochromate potassium titrant nonaqueous potentiometry; pyridine bromide perbromide redox titrant; selenium titration nonaqueous potentiometric.

NaBH4, 2,5-bis(diethylaminomethyl)hydroquinone, CrO2Cl2, CrO2(OK)Cl, and C5H5N.HBr3 were examined as titrants in nonaqueous media for Ag and UO22+ nitrates, Ti(IV), Hg(II), and Sn(II,IV) chlorides, H2SeO3, I, o- and p-benzoquinones, hydroquinone, resorcinol, pyrocatechol, alcs., aldehydes, etc. The titrations at 20±0.2.degree. were performed by using a potentiometer with different electrode pairs. With NaBH4 and a calomel – Pt electrode pair, individual compounds can be determined and Ag+ and Hg2+ salts can be differentially titrated in pyridine medium. The titrations with Mannich base were carried out in EtOH or MeOH; calomel – Pt and Pt- Sb electrode pairs were suitable for the titrations The reactions with Ag, Cu(II), and Hg(II) salts were quant. The Ag(I), Cu(II), and Hg(II) salts were reduced to Ag0, Cu(I), Hg(I). The mixtures of Ag+ + Hg2+ and Ag+ + Cu2+ can be titrated quant. PhOH, cresols, xylenols, guaiacol, hydroxybenzoic acids, styrene, aryl-α-tetralol, cyclohexene, diphenylpropane, 4-hydroxydiphenyl, and a number of other di- and trihydric phenols as well as their derivatives reacted quant. with C5H5N.HBr3 in an alk. medium (NaOAc), whereas α,β-nonsatd. acids did not.

Izvestiya Timiryazevskoi Sel’skokhozyaistvennoi Akademii published new progress about Reducing agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ayadi, Awatef; Szukalski, Adam; El-Ghayoury, Abdelkrim; Haupa, Karolina; Zouari, Nabil; Mysliwiec, Jaroslaw; Kajzar, Francois; Kulyk, Bohdan; Sahraoui, Bouchta published the artcile< TTF based donor-pi-acceptor dyads synthesized for NLO applications>, Reference of 112-63-0, the main research area is TTF donor pi acceptor dyad synthesized NLO.

Two new TTF-pi-acceptor dyads that contain p-nitrophenyl group as acceptor and bis-(styryl)benzene system as an efficient π-conjugated bridge were synthesized by multistep synthetic procedure and their electrochem. behavior was studied by cyclic voltammetry (CV). The occurrence of an intramol. charge transfer (ICT) in these mols. was evidenced by UV-Visible electronic absorption spectroscopy and these studies were completed by DFT calculations in both gas phase and in solution The nonlinear optical parameters obtained via SHG and THG measurements are described and indicate that these materials are valuable candidates for the construction of optoelectronic and photonic devices. The Optical Kerr Effect measurements indicate that these materials exhibit a great potential in the field of optical switchers construction, where the material’s photoresponse time is a crucial parameter.

Dyes and Pigments published new progress about Charge transfer interaction (intramol.). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cronin, Sarah A.; Connon, Stephen J. published the artcile< The kinetic resolution of oxazinones by alcoholysis: Access to orthogonally protected β-amino acids>, SDS of cas: 112-63-0, the main research area is amino acid beta enantioselective synthesis amide coupling; oxazinone catalytic alcoholytic kinetic resolution cinchona alkaloid catalyst.

The catalytic, alcoholytic kinetic resolution of oxazinones is reported. A novel, stereochem. dense cinchona alkaloid-based catalyst can facilitate the highly enantiodiscriminatory (S up to 101) ring-opening of oxazinones equipped with electrophilic aryl units to generate orthogonally protected β-amino acids for the first time.

Organic & Biomolecular Chemistry published new progress about Alcoholysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tesileanu, C Mircea S; Gorlia, Thierry; Golfinopoulos, Vassilis; French, Pim J; van den Bent, Martin J published the artcile< MGMT promoter methylation determined by the MGMT-STP27 algorithm is not predictive for outcome to temozolomide in IDH-mutant anaplastic astrocytomas.>, Computed Properties of 112-63-0, the main research area is .

There is no abstract available for this document.

Neuro-oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bhar, Abdenbi; Aune, Jean Pierre; Benali-Cherif, Nourredine; Benmenni, Leila; Giorgi, Michel published the artcile< Three polychloromononitrobenzenes: C6H3Cl2NO2, C6H2Cl3NO2 and C6HCl4NO2>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is mol structure chloromononitrobenzene derivative.

3,5-Dichloronitrobenzene (I), 3,4,5-trichloronitrobenzene (II) and 2,3,5,6-tetrachloronitrobenzene (III) are frequently used as intermediates in the manufacture of dyes as well as phyto-sanitary and drug products. In both compounds (I) and (II), the NO2 plane and the benzene ring plane are coplanar, but in (III) these planes have a mean dihedral angle of 88°. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section C: Crystal Structure Communications published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Mengxue; Li, Xia; Holmes, Nathaniel Graham; Li, Ruying; Wang, Jiajun; Yin, Geping; Zuo, Pengjian; Sun, Xueliang published the artcile< Flame-Retardant and Polysulfide-Suppressed Ether-Based Electrolytes for High-Temperature Li-S Batteries>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is flame retardant ether electrolytes lithium sulfur battery; Li−S batteries; ether-based electrolyte; high temperature; inert diluter; nonflammable.

Lithium-sulfur (Li-S) batteries are drawing huge attention as attractive chem. power sources. However, traditional ether-based solvents (DME/DOL) suffer from safety issues at high temperatures and serious parasitic reactions occur between the Li metal anodes and soluble lithium polysulfides (LiPSs). Herein, we propose a polysulfide-suppressed and flame-retardant electrolyte operated at high temperatures by introducing an inert diluent 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl (TTE) into the high-concentration electrolyte (HCE). Li dendrites are also efficiently suppressed by the formed LiF-rich protective layer. Furthermore, the shuttle effect is mitigated by the decreased solubility of LiPSs. At 60°C, Li-S batteries using this nonflammable ether-based electrolyte exhibit a high capacity of 666 mAh g-1 over 100 cycles at a current rate of 0.2C, showing the greatly improved high-temperature performance compared to batteries with traditional ether-based electrolytes. The improved electrochem. performance across a range of temperatures and the enhanced safety suggest that the electrolyte has a great practical prospect for safe Li-S batteries.

ACS Applied Materials & Interfaces published new progress about Batteries. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Wenbin; Zhao, Feiyang published the artcile< Prediction of critical properties of biodiesel fuels from FAMEs compositions using intelligent genetic algorithm-based back propagation neural network>, SDS of cas: 112-63-0, the main research area is biodiesel fatty acid methyl ester back propagation neural network.

In this study, an intelligent genetic algorithm (GA)-based back propagation neural network (BPNN) model was proposed to predict the properties of biodiesel fuels according to FAMEs compositions The hybrid BPNN-GA model has five inputs (Me palmitate, Me stearate, Me oleate, Me linoleate and Me linolenate) corresponding to the FAMEs compositions and outputs with estimated fuel properties, with the GA assisting on training to find out local min. deviation and updated weighting configurations. It was found that the intelligent learning-training method proposed hybrid BPNN-GA model enabled to map the non-linear relationships between the FAMEs compositions and key properties of biodiesel fuels with fairly good agreement. The predicted value of fuel properties agrees with measured ones with R-square up to 96%, along with lower value (less than 10%) over Root Mean Square Error (RMSE) and Mean Absolute Percentage Error (MAPE) than those of other empirical correlations. In addition, a sensitivity anal. was conducted to in-depth investigate the FAMEs compositions on key properties. It was concluded that saturated FAMEs have pos. impacts on CN, KV and the CFPP, while IV is typically dependent on unsaturated FAMEs. Therefore, it is attainable to formulate new types of alternative fuels based on the required properties on diesel engine applications.

Energy Sources, Part A: Recovery, Utilization, and Environmental Effects published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Achalkumar, Ammathnadu S.; Veerabhadraswamy, B. N.; Hiremath, Uma S.; Rao, Doddamane S. Shankar; Prasad, Subbarao Krishna; Yelamaggad, Channabasaveshwar V. published the artcile< Photoluminescent discotic liquid crystals derived from tris(N-salicylideneaniline) and stilbene conjugates: Structure-property correlations>, Related Products of 112-63-0, the main research area is salicylideneaniline stilbene conjugate preparation photoluminescent discotic liquid crystal.

Luminescent discotic liquid crystals based on tris(N-salicylideneaniline)s [TSANs] bearing trans-stilbene fluorophores have been synthesized. Their mesomorphic and photophys. properties were studied. These TSANs existing in the form of C3h and Cs geometrical isomers of the keto-enamine tautomer self-assemble to form the columnar phase and exhibit fluorescence both in solution and mesophase states. These columnar mesophases also exhibit frozen (glassy) columnar phase, which ensures preserved fluorescence intensity, defect free alignment and simultaneous restriction on the motion of ionic impurities. These features make them promising candidates for the use in organic light emitting diodes, particularly as emissive layers. This study also led to an understanding about the dependence of their mesomorphism (mesophase type, stability and thermal range) and photophys. features on the number and pattern of their peripheral substitution, in comparison to the analogous columnar liquid crystalline TSANs reported earlier.

Dyes and Pigments published new progress about Cyclic voltammetry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics