Category: 112-63-0

Li, Bao Qiong; Li, Xin Kang; Lin, Yuan; Li, Ze Ying; Zhang, Xiang-Zhi; Feng, Na; Ma, Ai-Jun; Chen, Chao Yang; Tan, Lin Fan published the artcile< Development and validation of ultra-high performance supercritical fluid chromatography method for quantitative determination of six compounds in Guizhi Fuling capsule and tablet samples>, SDS of cas: 112-63-0, the main research area is Guizhi fuling formula; multiple compounds; ultra-high performance supercritical fluid chromatography.

A fast and simple ultra-high performance supercritical fluid chromatog. method has been developed for the determination of six analytes, namely (paeonol, coumarin, cinnamic alc., cinnamic acid, paeoniflorin, and amygdalin) in Guizhi Fuling capsule and tablet samples. The influence of the key chromatog. parameters for the separation purposes was evaluated. The optimal column was Trefoil CEL1 column. The optimal mobile phase was a gradient mixture of carbon dioxide and methanol at flow rate of 1.0 mL/min. The back pressure of the system was set to 1.38 x 107 Pa and the temperature to 45°C. The six compounds were separated within 11 min by the proposed ultra-high performance supercritical fluid chromatog. method with satisfactory resolution Method validation confirmed that the procedure is accurate with the recovery rates from 87.04 to 104.30%, intraday precision values less than 4.81% and interday precision less than 5.22%, and linear with R2 higher than 0.9967. Therefore, this work provides a simple and novel method for the simultaneous anal. of six compounds in Guizhi Fuling capsule and tablet samples.

Journal of Separation Science published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Beibei; Kong, Tao; Xu, Wenzhi; Su, Ruigong; Gao, Yunhua; Cheng, Guosheng published the artcile< Surface Functionalization of Zinc Oxide by Carboxyalkylphosphonic Acid Self-Assembled Monolayers>, Reference of 112-63-0, the main research area is carboxyalkylphosphonic acid self assembled monolayer zinc oxide antibody biosensor.

Two carboxyalkylphosphonic acids (HOOC(CH2)nP(O)(OH)2, n = 2 for 3-PPA and n = 9 for 10-PDA) were deposited onto 1-dimensional zinc oxide (ZnO) nanowires and bare ZnO wafers to form stable self-assembled monolayers (SAMs). The samples were systematically characterized using wettability, at. force microscopy (AFM), FTIR spectroscopy (FTIR), and XPS. 3-PPA was bound to the ZnO surfaces mainly through the CO2H headgroup, and 10-PDA formed self-assembled monolayers on the nanoscaled ZnO surface through the PO3H2 headgroups. To verify the potential use of the functionalized surfaces in the construction of biosensors or bioelectronics, IgG protein immobilization through SAM bridging was demonstrated. This work expands the application of phosphonic acid-based surface functionalization on sensing and optoelectronic devices.

Langmuir published new progress about Binding energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beg, Sarwar; Panda, Sagar S.; Singh, Kamalinder K. published the artcile< Chemometrics-assisted development of a validated LC method for simultaneous estimation of temozolomide and γ-linolenic acid: Greenness assessment and application to lipidic nanoparticles>, Reference of 112-63-0, the main research area is Box-Behnken design; Chemometrics; Forced degradation; Green method; Lipid nanoparticles; Liquid chromatography; Simultaneous estimation; Stability indicating; Temozolamide; γ-Linolenic acid.

The described work entails the development of a simple, sensitive, green, and robust high-performance liquid chromatog. (HPLC) method for simultaneous estimation of temozolomide (TMZ) and γ-linolenic acid (GLA). The chemometric factor screening study helped identify the critical method parameters optimized using Box-Behnken design for improved understanding and enhancing the method performance. Chromatog. separation was performed on a Kinetex C18 column (150 x 4.6 mm, 5 μm particle size) using methanol: water (pH adjusted to 3.5 using 0.5% volume/volume O-phosphoric acid) as the mobile phase at 0.5 mL/min flow rate and diode array detection between 210 and 360 nm. The linearity of the method was observed for concentrations of TMZ and GLA ranging between 1 and 100 μg.mL-1 (R2 = 0.999, p < 0.05). Accuracy evaluation showed good percent recovery within 97.9-100%, while intra- and inter-day precision showed RSD values within 0.37%-1.01%. The limit of detection and quantification for TMZ was found to be 0.75 and 1.0 μg.mL-1, resp., while the values 0.55 and 1.0 μg.mL-1, resp., were observed for GLA. System suitability (96.9-102.8%), its limits, and robustness evaluation indicated good percent recovery within, while RSD values were found to be within the acceptable limit of less than 2%. The method was specific for its ability to detect the analytes and their degradation products during forced degradation studies, which also indicated that TMZ was highly prone to alk. conditions while GLA showed mild degradation in all the studied conditions. The estimation of both the analytes from lipid nanoparticles formulation showed good values for total drug content (82.6-85.3%), entrapment efficiency (95.4 to 98.7%), and drug loading (25.2 to 38.4%). Overall, the results indicated that the developed method was reliable for its accuracy, precision, sensitivity, and specificity for simultaneous estimation of the analytes. The method was found to be stability-indicating in nature and suitable for simultaneous estimation of TMZ and GLA from the developed nanoparticles formulation. Further, employing a greenness assessment approach established the method greenness. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Yong; Jiang, Minbao; Wang, Tao; Xiong, Yunkui; Li, Jun; Guo, Huijiao; Lei, Aiwen published the artcile< Synergy of anodic oxidation and cathodic reduction leads to electrochemical deoxygenative C2 arylation of quinoline N-oxides>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is anodic oxidation cathodic reduction electrochem deoxygenative arylation quinoline oxide.

The 1st example of electrochem. deoxygenative C2 arylation of quinoline N-oxides using sulfonyl hydrazines was demonstrated. By employing both anodic oxidation and cathodic reduction, a variety of 2-arylquinolines were synthesized under metal catalyst-, exogenous-oxidant-, and exogenous-reductant-free conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about Arylation (electrochem.). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

McKenzie, Lallie C.; Huffman, Lauren M.; Hutchison, James E. published the artcile< The evolution of a green chemistry laboratory experiment greener brominations of stilbene>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is green chem education laboratory experiment bromination reagent stilbene.

The use of green metrics to compare three bromination laboratory procedures demonstrates the effectiveness of an incremental greening process for chem. curricula. Ongoing assessment and introduction of improved methods into the organic teaching laboratory leads to innovative experiments that improve safety and effectively teach green principles and applications as well as traditional chem. concepts and laboratory skills. As a result of this process, bromination of alkenes can now be introduced to students through the use of a safe, effective, modern procedure.

Journal of Chemical Education published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polishchuk, Pavel G.; Muratov, Eugene N.; Artemenko, Anatoly G.; Kolumbin, Oleg G.; Muratov, Nail N.; Kuz’min, Victor E. published the artcile< Application of Random Forest Approach to QSAR Prediction of Aquatic Toxicity>, Reference of 112-63-0, the main research area is QSAR random forest aquatic toxicity Tetrahymena modeling lipophilicity polarizability.

This work is devoted to the application of the random forest approach to QSAR anal. of aquatic toxicity of chem. compounds tested on Tetrahymena pyriformis. The simplex representation of the mol. structure approach implemented in HiT QSAR Software was used for descriptors generation on a two-dimensional level. Adequate models based on simplex descriptors and the RF statistical approach were obtained on a modeling set of 644 compounds Model predictivity was validated on two external test sets of 339 and 110 compounds The high impact of lipophilicity and polarizability of investigated compounds on toxicity was determined It was shown that RF models were tolerant for insertion of irrelevant descriptors as well as for randomization of some part of toxicity values that were representing a “”noise””. The fast procedure of optimization of the number of trees in the random forest has been proposed. The discussed RF model had comparable or better statistical characteristics than the corresponding PLS or KNN models.

Journal of Chemical Information and Modeling published new progress about Amines Role: ADV (Adverse Effect, Including Toxicity), PRP (Properties), BIOL (Biological Study) (amyl-). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Minhas, Harsimran K.; Riley, William; Stuart, Alison M.; Urbonaite, Martyna published the artcile< Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol>, COA of Formula: C19H34O2, the main research area is dicarbonyl compound hypervalent fluoroiodane fluorination; fluoro dicarbonyl compound preparation; alkenyl carboxylic acid hypervalent fluoroiodane regioselective fluorocyclization; fluorolactone preparation.

Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent was used in HFIP to monofluorinate 1,3-carbonyl compounds and to fluorocyclize unsaturated carboxylic acids in excellent yields under mild reaction conditions.

Organic & Biomolecular Chemistry published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Naves, Yves Rene; Conia, Jean Marie published the artcile< On a putative synthesis of piperitenone>, Reference of 112-63-0, the main research area is .

The compound C10H14O, prepared by Bergmann and Bracha (CA 54, 22703c) by condensation of mesityl oxide (2-methyl-2-penten-4-one) (I) and Me vinyl ketone (II) in the presence of Na tert-pentoxide, which was claimed to be 2-isopropylidene-5-methyl-5-cyclohexen-2-one (III), was shown to be isoxylitone (3-methyl-4-isopropylidene-5-isopropyl-2-cyclohexen-1-one) (IV), formed by the condensation of 2 mols. of I. The infrared spectra of III and IV and of their resp. dinitrophenylhydrazones were given. IV was unchanged by heating with HCO2H and not susceptible to catalytic dehydrogenation with Pd.

Bulletin de la Societe Chimique de France published new progress about IR spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Jinhui; Yousuf, Mohammed Adnan; Yang, Wenmin; Zhu, Qiuying; Shen, Zhiyong; Lan, Guanghua; Chen, Yi; Chen, Huanhuan; Fan, Wensheng; Xing, Hui; Shao, Yiming; Ruan, Yuhua; Li, Liming published the artcile< Mortality and attrition rates within the first year of antiretroviral therapy initiation among people living with HIV in Guangxi, China: an observational cohort study>, Formula: C19H34O2, the main research area is stavudine azidothymidine tenofovir antiretroviral agent human immunodeficiency virus infection.

To assess the mortality and attrition rates within the first year of antiretroviral therapy (ART) initiation among people living with human immunodeficiency virus (PLHIV) in rural Guangxi, China. The core treatment indicators and data were collected with standard and essential procedures as per the Free ART Manual guidelines across all the rural health care centers of Guangxi. Participants. 58,115 PLHIV who were under ART were included in the study. The data collected included sociodemog. characteristics that consist of age, sex, marital status, route of HIV transmission, CD4 cell count before ART, initial ART regimen, level of ART site, and year of ART initiation. Primary and Secondary Outcome Measures. Mortality and attrition rate following ART initiation. The average mortality rate was 5.94 deaths, and 17.52 attritions per 100 person-years within the first year of ART initiation among PLHIV. The mortality rate was higher among i.v. drug users (Adjusted Hazard Ratio (AHR) 1.27, 95% Confidence Interval (CI) 1.14-1.43), prefecture as a level of ART site (AHR 1.14, 95% CI 1.02-1.28), and county as the level of ART site (AHR 2.12, 95% CI 1.90-2.37). Attrition was higher among i.v. drug users (AHR 1.87, 95% CI 1.75-2.00), the first-line ART containing AZT (AHR 1.09, 95% CI 1.03-1.16), and first-line ART containing LVP/r (AHR 1.34, 95% CI 1.23-1.46). The mortality and attrition rates were both at the highest level in the first year of post-ART; continued improvement in the quality of HIV treatment and care is needed.

BioMed Research International published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tian, Heng-Zhi; Tang, Qing-Gang; Lin, Guo-Qiang; Sun, Xing-Wen published the artcile< Asymmetric synthesis of chiral 1,2-oxazinane and hexahydropyridazine spirocyclic scaffolds by organocatalytic [4 + 2] cycloaddition>, SDS of cas: 112-63-0, the main research area is indolinone alkoxycarbonylmethylene diastereoselective enantioselective cycloaddition unsaturated ester hydrazide; oxazinane spiro oxindole asym synthesis; pyridazinone spiro oxindole asym synthesis.

A novel approach to synthesize chiral 1,2-oxazinane spirocyclic scaffolds I (X = O; Y = H2; R1 = H, 5-MeO, 6-Br, 7-F, etc.; R2 = Me, Et, t-Bu, PhCH2; R3 = Boc, Cbz; R4 = Et; R5 = Ac, Boc, PhCO) by organocatalytic [4 + 2] cycloaddition reaction between methyleneindolinones II and γ-aminooxy-α,β-unsaturated esters EtO2CCH:CHCH2ONHR5 has been developed. Furthermore, a hydrazide 1,4-synthon PhCH2NHNHC(O)CH:CHCO2R4 (R4 = Me, Et, n-Bu) was designed and synthesized to construct the corresponding chiral hexahydropyridazine spirocyclic scaffolds I (X = NH; Y = O; R3 = Boc; R5 = PhCH2) via [4 + 2] cycloaddition reaction with methyleneindolinones II. Both reactions gave the corresponding products in good to excellent yields, excellent diastereoselectivity and good enantioselectivity.

RSC Advances published new progress about [4+2] Cycloaddition reaction (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics