Category: 112-63-0

Zhao, Qian; Feng, Li-Ying; Huang, Wei; He, Xiang-Hong; Peng, Cheng; Han, Bo published the artcile< An NHC-Catalyzed Cross-Benzoin-Esterification Sequential Reaction for the Synthesis of Trifluoromethyl-Substituted α,β-Unsaturated Esters>, SDS of cas: 112-63-0, the main research area is ester unsaturated trifluoromethylated preparation NHC organocatalytic multicomponent reaction; benzaldehyde ethoxytrifluoroethanol bromocinnamaldehyde cross benzoin esterification sequential reaction.

Efficient preparation of synthetically important CF3-containing α,β-unsaturated esters is described using an NHC-catalyzed multicomponent reaction. This approach combines sequential NHC-mediated HOMO and LUMO activation to produce a C-C bond and C-O bond in a one-pot operation.

Synlett published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lo, Kong Mun; Ng, Seik Weng published the artcile< Dipyridinium tribromidochloridobis(4-chlorophenyl)stannate(IV)>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is crystal structure stannate chlorophenyl bromo chloro complex dipyridinium salt; mol structure stannate chlorophenyl bromo chloro complex dipyridinium salt; hydrogen bond stannate chlorophenyl bromo chloro complex dipyridinium salt.

The tin atom in the substituted ammonium stannate(IV), (C5H6N)2[SnBr3(C6H4Cl)2Cl], lies on a center of symmetry in a distorted octahedral coordination geometry. Each independent halogen site is occupied by bromine and chlorine anions in an approx. 3:1 ratio. The pyridinium cation forms a hydrogen bond to only one of the halogen atoms. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amin, Iyman; Prashant Saxena published the artcile< Glioblastoma a Malignant Form of Tumor: a Review on Its Cellular Target, Route, and Its Treatment>, Computed Properties of 112-63-0, the main research area is review bevacizumab temozolomide anticancer agent glioblastoma.

A review. The pathophysiol. of glioblastoma is so complex; it affects a number of different cellular processes. The FDA has approved a number of treatments, including temozolomide and bevacizumab, yet the survival rate remains the same at 1 yr or less. As a result of the failure of different chemotherapies and target pharmacol. therapies, we must concentrate on the use of less toxic agents, such as natural compounds, which may have a greater prognostic value. This quick overview covers the following topics: Glioblastoma has a variety of various routes associated with it, including mol. and patrimonial indications. Treatments for glioblastoma are available. Certain natural compounds may have the ability to minimize toxicity while also improving prognostic value. Glioblastoma multiforme is a grade 4 glioma brain tumor that develops from glial cells in the brain. The grade of a brain tumor indicates how probable it is to grow and spread. Grade 4 tumors are the most dangerous and aggressive. Despite the FDAs approval of temozolomide with bevacizumab and several other drugs, the 1-yr survival rate remains constant We must focus on the use of less toxic agents, such as natural compounds, that may have a greater prognostic value and less toxicity, due to the failure of various chemotherapies, surgeries, radiation, and target pharmaceutical therapies.

Current Tissue Microenvironment Reports published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Tianzeng; Chen, Tieqiao; Han, Li-Biao published the artcile< Oxidative Dephosphorylation of Benzylic Phosphonates with Dioxygen Generating Symmetrical trans-Stilbenes>, Application In Synthesis of 112-63-0, the main research area is benzylic phosphonate oxidative dephosphorylation; stilbene stereoselective preparation.

Under a dioxygen atm., benzylphosphonates and related phosphoryl compounds can readily produce the corresponding trans-stilbenes in high yields with high selectivity upon treatment with bases. Various functional groups were tolerable under the reaction conditions.

Journal of Organic Chemistry published new progress about Dephosphorylation (oxidative). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stefancich, Giorgio; Artico, Marino; Massa, Silvio; Vomero, Salvatore published the artcile< Research on nitrogen heterocyclic compounds. XII. Synthesis of 5H-pyrrolo[1,2-b][2]benzazepine derivatives>, Electric Literature of 112-63-0, the main research area is pyrrolobenzazepine; carboxymethylbenzylpyrrole preparation cyclization; chloromethylbenzylpyrrolecarboxaldehyde cyclization.

Several routes to the unknown 5H-pyrrolo[1,2-b][2]benzazepine ring system have been explored. 1-(2-Cyanobenzyl)pyrrole was useful as starting material for 1-(2-carboxymethylbenzyl)pyrrole and 1-(2-chloromethylbenzyl)-2-pyrrolecarboxaldehyde. Polyphosphoric acid-catalyzed intramol. cyclization of the former substance and treatment of the latter compound with KCN led to 11-oxo-10,11-dihydo-5H-pyrrolo[1,2-b][2]benzazepine and to 10-cyano-5H-pyrrolo[1,2-b][2]benzazepine, resp., which were converted to the parent nucleus 5H-pyrrolo[1,2-b][2]benzazepine and its 10,11-dihydro- and 1,2,3,10,11,11a-hexahydro derivatives

Journal of Heterocyclic Chemistry published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ai, Zhengdong; Ma, Chong; Wan, Ruiming; Yin, Jingyi; Li, Guiming; Li, Yan; Chen, Li published the artcile< Anticancer Activity and Molecular Mechanism of Momordica cochinchinensis Seed Extract in Chronic Myeloid Leukemia Cells>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Momordica chronic myeloid leukemia seed signal transduction anticancer.

Targeting Bcr-Abl is the key to the treatment of chronic myeloid leukemia. Despite great progress in the treatment of patients with chronic CML, advanced CML patients are still unable to obtain effective and safe drugs. Momordica cochinchinensis seed is the dried ripe seed of Momordica cochinchinensis, which is a kind of fruit and consumed for dietary as well as medicinal uses. This study aimed to investigate the anticancer activity of Momordica cochinchinensis seed extract (MCSE) in CML cells. CML cells (KBM5 and KBM5-T315I) were treated with MCSE and analyzed for growth, apoptosis, and signal transduction. Nude mouse xenograft model was used to evaluate the antitumor activity of MCSE In Vivo. MCSE significantly reduced the cell viability of CML cells, triggered G0/G1 phase arrest in KBM5 cells and S phase arrest in KBM5-T315I cells. Concurrently, MCSE caused the activation of caspase-3, -8, -9, PARP and the degradation of Mcl-1, ultimately triggering endogenous and exogenous cell apoptosis. Meanwhile, MCSE downregulated Bcr-Abl levels and its downstream signaling pathways. Addnl., MCSE inhibited the growth of CML cells in nude mouse xenografts. Taken together, this study demonstrated the anticancer mechanism of MCSE, namely blocking Bcr-Abl and downregulating Mcl-1, and finally induced apoptosis of CML cells.

Nutrition and Cancer published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

published the artcile< Dual Temozolomide and ICI Treatment Is Efficacious and Safe in MSS mCRC.>, Related Products of 112-63-0, the main research area is .

Patients with MSS and MGMT-depleted mCRC exhibited clinical benefit post-temozolomide and ICI treatment.

Cancer discovery published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ohkuma, Takeshi; Kurono, Nobuhito; Sakaguchi, Yusuke; Yamauchi, Kohei; Yurino, Taiga published the artcile< Enantioselective Cyanosilylation of Alkynyl Ketones Catalyzed by Combined Systems Consisting of Chiral Ruthenium(II) Complex and Lithium Phenoxide>, SDS of cas: 112-63-0, the main research area is ketone alkynyl cyanotrimethylsilane ruthenium complex lithium cyanosilylation catalyst; alkynyl tertiary cyanohydrin silyl ether stereoselective preparation.

Asym. cyanosilylation of alkynyl ketones with the catalyst systems consisting of amino acid/2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP)/ruthenium(II) complex and lithium phenoxide (Ru·Li cat.) was studied. The reaction was conducted in tert-Bu Me ether (TBME) at -78 °C with a substrate-to-catalyst molar ratio (S/C) as high as 2000. A series of simple and functionalized ketones was converted into the alkynyl tertiary cyanohydrin derivatives in up to 99% ee. Appropriate selection of an amino-acid ligand of the catalyst according to the substrate structure was crucially important to achieve high enantioselectivity and a wide scope of substrates. Transformation of the chiral cyanohydrin product into a functionalized lactone was also examined

Advanced Synthesis & Catalysis published new progress about Alkoxysilanes Role: SPN (Synthetic Preparation), PREP (Preparation) (alkynyl tertiary cyanohydrin). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Delahaye, Maarten; Tanini, Flaminia; Holloway, Joshua O.; Winne, Johan M.; Du Prez, Filip E. published the artcile< Double neighbouring group participation for ultrafast exchange in phthalate monoester networks>, Electric Literature of 112-63-0, the main research area is phthalate monoester network ultrafast exchange thermal mech rheol property.

Phthalate monoesters (PMEs) were recently introduced as a simple dynamic covalent bond for implementation in covalent adaptable networks (CANs), which undergo rapid transesterifications in the absence of catalysts, due to the neighboring group participation (NGP) of a carboxylic acid moiety. In this work, it is shown that the PME transesterification can be very significantly accelerated by the presence of another neighboring group on the reactive alc. moieties. The kinetic effects are demonstrated using a short model study of PMEs with different substituents at the β-carbon position, showing a remarkable acceleration for alcs. containing tertiary amines on the β-carbon. Following the model study, materials were synthesized by a (partial) replacement of the conventionally used diol with a β-amino-diol, leading to the formation of networks with an increased Tg and Young’s-modulus, which is rationalized as a result of the formation of an ionic network (COO- and NHR3+). Stress relaxation experiments show a decrease in relaxation times by a factor of 500, compared to similar networks derived from non-amine-substituted hydroxyl monomers. This ultrafast relaxation, enabled by a double NGP, resulted in CANs that show potential to be processed through extrusion while maintaining their overall network connectivity.

Polymer Chemistry published new progress about Creep. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gillanders, Ross N.; Glackin, James M. E.; Babic, Zdenka; Mustra, Mario; Simic, Mitar; Kezic, Nikola; Turnbull, Graham A.; Filipi, Janja published the artcile< Biomonitoring for wide area surveying in landmine detection using honeybees and optical sensing>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is amitraz honeybee pheromone REST sampling luminescence quenching environmental modeling; Apis mellifera carnica; Environmental modelling; Honeybee; Luminescence quenching; Nitroaromatic; REST sampling.

Humanitarian demining is a worldwide effort and the range of climates and environments prevent any one detection method being suitable for all sites, so more tools are required for safe and efficient explosives sensing. Landmines emit a chem. flux over time, and honeybees can collect the trace residues of explosives (as particles or as vapor) on their body hairs. This capability was exploited using a passive method allowing the honeybees to freely forage in a mined area, where trace explosives present in the environment stuck to the honeybee body, which were subsequently transferred onto an adsorbent material for anal. by a fluorescent polymer sensor. Potential false pos. sources were investigated, namely common bee pheromones, the anti-varroa pesticide Amitraz, and the environment around a clean apiary, and no significant response was found to any from the sensor. The mined site gave a substantial response in the optical sensor films, with quenching efficiencies of up to 38%. A model was adapted to estimate the mass of explosives returned to the colony, which may be useful for estimating the number of mines in a given area.

Chemosphere published new progress about Apis mellifera carnica. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics