Category: 112-63-0

Krchnak, V.; Arnold, Z. published the artcile< Novel pyrimidine derivatives, reactions, and ultraviolet spectra>, Product Details of C19H34O2, the main research area is pyrimidine methyleneamino hydrolysis; hydrolysis methyleneaminopyrimidine; UV pyrimidine.

The conditions were studied for selective hydrolysis of I (R1 = NH2, NMe2, OH, OAc, OMe, SH, SMe, H, F, Cl, Br, SOME2, SO2Me, CN) and the products characterized by uv spectra. Hydrolysis of I in boiling 0.02M H2SO4 or 0.2M AcOH gave the corresponding II, while treating I with 0.2M H2SO4 at 110° or with boiling 5% K2CO3 solution yielded the appropriate III. In strongly alk. media I (R1 = CN) gave III (R1 = CONH2) and III (R1 = CO2H). Special conditions were required for the hydrolysis of I (R1 = F) (IV) which gave in 3M KHF2 at 75° II (R1 = F) and at 120° afforded III (R1 = F), while heating IV in 5% K2CO3 solution yielded III (R1 = NMe2).

Collection of Czechoslovak Chemical Communications published new progress about Hydrolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hammer, Theodore J.; Pugh, Coleen; Soucek, Mark D. published the artcile< Ultraviolet-Curable Cycloaliphatic Polyesters Containing Spiroacetal Moieties for Application as Powder Coatings>, Category: esters-buliding-blocks, the main research area is UV curable cycloaliphatic polyester spiroacetal powder coating.

Thermosetting cycloaliphatic powder coatings that exhibit good weatherability, corrosion resistance, and mech. properties have been desired for some time. Unfortunately, most cycloaliphatic resins have glass transition temperatures (Tgs) that are too low for powder coating applications. In this study, a series of UV-curable, cycloaliphatic polyesters was synthesized from 3,9-bis(1,1-dimethyl-2-hydroxyethyl)-2,4,8,10-tetraoxaspiro[5.5]undecane (spiroglycol), 1,4-cyclohexanedimethanol, and 1,4-cyclohexanedicarboxylic acid. The oligomers were characterized by 1H NMR spectroscopy, Fourier-transform IR spectroscopy, gel-permeation chromatog., and differential scanning calorimetry. The Tg value, the tensile strength, and the modulus of the crosslinked polyesters systematically increased with the spiroglycol (SPG) loading level. Dynamic mech. anal. experiments highlighted structure-property relationships and showed evidence of secondary relaxations at around -44°C. These β-relaxations were attributed to conformational transitions of the cycloaliphatic rings. The oligomers that contained 30 and 45 mol % SPG had Tgs that were suitable for powder coating applications. As such, they were formulated into UV-curable powder coatings. Coated test panels were evaluated in a salt spray chamber (ASTM B117) and a QUV weatherometer. The impact resistance, adhesion, and pencil hardness properties of the coatings were also evaluated. When compared to conventional (aromatic-based) controls, the cycloaliphatic powder coatings exhibited comparable weatherability, corrosion resistance, and Tgs along with superior impact resistance, substrate adhesion, and resistance to yellowing. These findings suggest that the cycloaliphatic powder coatings would be good alternatives to aromatic-based systems that are used in exterior durable clear coat applications.

ACS Applied Polymer Materials published new progress about Adhesion, physical. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shiau, Stephanie; Yin, Michael T.; Strehlau, Renate; Shen, Jing; Abrams, Elaine J.; Coovadia, Ashraf; Kuhn, Louise; Arpadi, Stephen M. published the artcile< Bone turnover markers in children living with HIV remaining on ritonavir-boosted lopinavir or switching to efavirenz>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is lopinavir efavirenz ritonavir children living human immuno virus; Bone; Bone turnover markers; Osteocalcin; Protease inhibitors.

We previously found lower bone mass but similar bone turnover in pre-pubertal children living with HIV (CLWH) on a ritonavir-boosted lopinavir (LPV/r)-based vs. efavirenz-based antiretroviral therapy regimen 2 years after switch. Here, we evaluate if bone turnover differed between the groups close to the time of switch. Samples from 108 children remaining on LPV/r and 104 children switched to efavirenz were available for anal. 8 wk post-randomization. Bone turnover markers, including C-telopeptide of type 1 collagen (CTx), procollagen type-I N-terminal propeptide (P1NP), and osteocalcin were measured. Markers of immune activation were also measured, including IL-6, TNF-alpha, soluble CD14 and high-sensitivity C-reactive protein (CRP). Eight weeks post-randomization, we did not detect differences in CTx (1.42 vs. 1.44 ng/mL, p = 0.85) or P1NP concentrations (622 vs. 513 ng/mL, p = 0.68) between treatment groups. At 8 wk, the treatment groups also had similar levels of IL-6, TNF-alpha, soluble CD14 and high-sensitivity CRP. Osteocalcin (ng/mL) was higher in the LPV/r than efavirenz group both at 8 wk (88.6 vs. 67.3, p = 0.001) and 2 years (67.6 vs. 49.8, p = 0.001). Overall, we failed to detect difference in bone turnover by P1NP and CTx in virol.-suppressed CLWH on different regimens at a time point close to the switch. We did observe higher levels of total osteocalcin in children remaining on LPV/r compared to children switched to efavirenz. Future studies should focus on uncovering the mechanism and determining whether perturbation in undercarboxylated osteocalcin could explain some of the bone side effects noted with protease inhibitors.

Bone (New York, NY, United States) published new progress about Animal gene, IL-6 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kuang, Silan; Hua, Haiming; Lai, Pengbin; Li, Jialin; Deng, Xiaodie; Yang, Yang; Zhao, Jinbao published the artcile< Anion-containing solvation structure reconfiguration enables wide-temperature electrolyte for high-energy-density lithium-metal batteries>, Application of C19H34O2, the main research area is solvation structure reconfiguration wide temperature electrolyte; lithium ion secondary battery electrolyte; high voltage; liPO2F2; localized high-concentration electrolyte; solvation structure; wide temperature.

The demand for high-energy-d. lithium batteries (LBs) that work under a wide temperature range (-40 to 60°C) has been increasing recently. However, the conventional lithium hexafluorophosphate (LiPF6)-based ester electrolyte with a solvent-based solvation structure has limited the practical application of LBs under extreme temperature conditions. In this work, a novel localized high-concentration electrolyte (LHCE) system is designed to achieve the anion-containing solvation structure with less free solvent mols. using lithium difluorophosphate (LiPO2F2) as a lithium salt, which enables wide-temperature electrolyte for LBs. The optimized solvation structure contributes to the cathode-electrolyte interface (CEI) with abundant LiF and P-O components on the surface of the LiNi0.5Co0.2Mn0.3O2 (NCM523) cathode, effectively inhibiting the decomposition of electrolyte and the dissolution of transition-metal ions (TMIs). Moreover, the weakened Li+-dipole interaction is also beneficial to the desolvation process. Therefore, the 4.3 V Li||NCM523 cell using the modified electrolyte maintains a high capacity retention of 81.0% after 200 cycles under 60°C. Meanwhile, a considerable capacity of 70.9 mAh g-1 (42.0% of that at room temperature) can be released at an extremely low temperature of -60°C. This modified electrolyte dramatically enhances the electrochem. stability of NCM523 cells by regulating the solvation structure, providing guidelines for designing a multifunctional electrolyte that works under a wide temperature range.

ACS Applied Materials & Interfaces published new progress about Battery cathodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Xiaodong; Yuan, Lujie; Gai, Yongkang; Liu, Qingyao; Yin, Lianglan; Jiang, Yaqun; Wang, Yichun; Zhang, Yongxue; Lan, Xiaoli published the artcile< Targeted radiotherapy of pigmented melanoma with 131I-5-IPN>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is pigmented melanoma radiotherapy IPN; Melanin; Melanoma; Picolinamide; Targeted radionuclide therapy.

Purpose: There has been no satisfactory treatment for advanced melanoma until now. Targeted radionuclide therapy (TRNT) may be a promising option for this heretofore lethal disease. Our goal in this study was to synthesize 131I-N-(2-(diethylamino)ethyl)-5-(iodo-131I)picolinamide (131I-5-IPN) and evaluate its therapeutic ability and toxicity as a radioiodinated melanin-targeting therapeutic agent. Methods: The trimethylstannyl precursor was synthesized and labeled with 131I to obtain 131I-5-IPN. The pharmacokinetics of 131I-5-IPN was evaluated through SPECT imaging, and its biodistribution was assessed in B16F10 tumor models and in A375 human-to-mouse xenografts. For TRNT, B16F10 melanoma-bearing mice were randomly allocated to receive one of five treatments (n = 10 per group): group A (the control group) received 0.1 mL saline; group B was treated with an equimolar dose of unlabeled precursor; group C received 18.5 MBq of [131I]NaI; group D and E received one or two dose of 18.5 MBq 131I-5-IPN, resp. TRNT efficacy was evaluated through tumor volume measurement and biol. study. The toxic effects of 131I-5-IPN on vital organs were assessed with laboratory tests and histopathol. examination The radiation absorbed dose to vital organs was estimated based on biodistribution data. Results:131I-5-IPN was successfully prepared with a good radiochem. yield (55% ± 5%, n = 5), and it exhibited a high uptake ratio in melanin-pos. B16F10 cells which indicating high specificity. SPECT imaging and biodistribution of 131I-5-IPN showed lasting high tumor uptake in pigmented B16F10 models for 72 h. TRNT with 131I-5-IPN led to a significant anti-tumor effect and Groups D and E displayed an extended median survival compared to groups A, B, and C. The highest absorbed dose to a vital organ was 0.25 mSv/MBq to the liver; no obvious injury to the liver or kidneys was observed during treatment. 131I-5-IPN treatment was associated with reduction of expression of proliferating cell nuclear antigen (PCNA) and Ki67 and cell cycle blockage in G2/M phase in tumor tissues. Decreased vascular endothelial growth factor and CD31 expression, implying reduced tumor growth, was noted after TRNT. Conclusion: We successfully synthesized 131I-5-IPN, which presents long-time retention in melanotic melanoma. TRNT with 131I-5-IPN has the potential to be a safe and effective strategy for management of pigmented melanoma.

Journal of Experimental & Clinical Cancer Research published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Globisch, Daniel; Lowery, Colin A.; McCague, Karen C.; Janda, Kim D. published the artcile< Uncharacterized 4,5-Dihydroxy-2,3-Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species>, Product Details of C19H34O2, the main research area is dihydroxypentanedione DPD NMR spectroscopy signaling bacteria.

The combination of NMR spectroscopy and 4,5-dihydroxy-2,3-pentanedione (DPD) homolog anal. reveals that DPD, a bacterial signaling compound in the autoinducer-2 (AI-2) class, exists as a much more complex structural array of mols. than previously appreciated. This finding suggests the existence of a larger bacterial chem. signaling language than previously thought.

Angewandte Chemie, International Edition published new progress about Molecular structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Agai, Bela; Proszenyak, Agnes; Tarkanyi, Gabor; Vida, Laszlo; Faigl, Ferenc published the artcile< Convenient, benign and scalable synthesis of 2- and 4-substituted benzylpiperidines>, Quality Control of 112-63-0, the main research area is benzylpiperidine preparation carbinol ketone deoxygenation pyridine hydrogenation temperature acidity.

A short, scalable and environmentally benign synthesis of 2- and 4-substituted benzylpiperidines, e.g. I, has been developed. The method is based on the temperature-programmed consecutive deoxygenation and heteroaromatic ring saturation of aryl(pyridin-2-yl)- and aryl(pyridin-4-yl)methanols and aryl(pyridin-4-yl)methanones in the presence of Pd/C catalyst. The crucial roles of the temperature, the acidity and the substrate structure in the change of selectivity have been demonstrated by isolation of several substituted aryl(piperidine)methanols. The carbinols and ketones were prepared from com. available pyridinecarbaldehydes or 4-cyanopyridine and substituted bromobenzenes via organometallic intermediates.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Deussen, Heinz-Josef; Boutton, Carlo; Thorup, Niels; Geisler, Tommy; Hendrickx, Eric; Bechgaard, Klaus; Persoons, Andre; Bjornholm, Thomas published the artcile< New chiral bis(dipolar) 6,6'-disubstituted binaphthol derivatives for second-order nonlinear optics>, Electric Literature of 112-63-0, the main research area is chiral binaphthol naphthodioxepin derivative nonlinear optic; dioxepin dinaphtho chiral derivative nonlinear optic; crystal structure chiral binaphthol derivative; mol structure chiral binaphthol derivative; dipole moment chiral binaphthol derivative; second harmonic generation chiral binaphthol derivative; hyperpolarizability chiral binaphthol derivative; SHG chiral binaphthol derivative; NLO chiral binaphthol derivative; atropisomer chiral binaphthol derivative NLO.

Several chiral mols. with C2 symmetry derived from two geometries of the binaphthol (BN) system substituted with different acceptors have been synthesized in order to study the possibility of producing noncentrosym. crystals formed from these chiral structures. All the mols. possess two equal donor-acceptor (D – A) systems linked together to give a bis(dipolar) V-shaped system. The dihedral angle θ between the two connected D – A systems has been controlled by chem. methods; this leads to distinct changes in the optical spectra of the connected D – A chromophores, primarily changes caused by effective conjugation of the D – A system imposed by conformation constraints. The crystal structure of chiral (S)-2,2′-diethoxy-1,1′-binaphthyl-6,6′-dicarbaldehyde has been elucidated and indicates that the dipoles in the naphthyl moiety within the overall noncentrosym. crystal can cancel out exactly despite the noncentrosymmetry. The crystal structure of racemic 9,14-dicyanodinaphtho[2,1-d:1′,2′-f][1,3]-dioxepin [(±)-I, A = CN] was found to be centrosym. The new compounds were investigated for second-harmonic generation (including BN derivatives reported earlier) by the Kurtz – Perry powder test to evaluate the second-order nonlinear optical (NLO) properties of polycrystalline samples. Although chirality ensures noncentrosym. crystals, only modest (≈ 2-methyl-4-nitroaniline) or no nonlinearities were observed in the powder test. For a representative selection of the mols., the first mol. hyperpolarizabilities βz were shown to be very high [up to 888 × 10-30 esu for II with A = (E)-CH:CH(p-PhCHC(CN)2)] by elec. field induced second harmonic generation (EFISHG) measurements. Synthetic routes are reported for optically pure 6,6′-disubstituted-2,2′-diethoxy-1,1′-binaphthyls [II; A = CN, SO2CH3, (E)-CH:CHSO2CH3, (E)-CH:CH(p-PhCN), (E)-CH:CH(p-PhSO2CH3), (E)-CH:CH(p-PhCH:C(CN)2), (E)-CH:CHCH:C(CN)2] and optically pure 9,14-disubstituted-dinaphtho[2,1-d:1′,2′-f][1,3]dioxepins [I; A = CN (only racemic), SO2CH3, (E)-CH:CH(p-PhCN), (E)-CH:CH(p-PhSO2CH3), (E)-CH:CH(p-PhNO2), (E)-CH:CH(p-PhCH:C(CN)2), (E)-CH:CHCH:C(CN)2].

Chemistry – A European Journal published new progress about Acetals, cyclic Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crittall, Matthew R.; Fairhurst, Nathan W. G.; Carbery, David R. published the artcile< Point-to-helical chirality transfer for a scalable and resolution-free synthesis of a helicenoidal DMAP organocatalyst>, Quality Control of 112-63-0, the main research area is helicenoidal DMAP organocatalyst stereoselective preparation rhodium catalyzed triyne cycloisomerization; point helical chirality transfer cycloisomerization resolution free.

The synthesis of a second-generation [6]-helicenoidal DMAP organocatalyst I is reported. The synthesis is reliant upon a highly diastereoselective Rh-catalyzed [2+2+2] triyne cycloisomerization, using an existing stereocenter to control the sense of forming helicity. Taken together, a scalable (>1 g), resolution-free entry to a helical DMAP with the capacity for subsequent functionalization, has been achieved.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cycloisomerization (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Jianfeng; Jin, Zhichao; Chi, Yonggui Robin published the artcile< Organocatalytic Enantioselective γ-Aminoalkylation of Unsaturated Ester: Access to Pipecolic Acid Derivatives>, Product Details of C19H34O2, the main research area is pipecolic acid substituted preparation; unsaturated ester enantioselective aminoalkylation hydrazone heterocyclic carbene organocatalyst.

The direct γ-carbon functionalization of α,β-unsaturated esters via N-heterocyclic carbene (NHC) catalysis is disclosed. This catalytically generated nucleophilic γ-carbon undergoes highly enantioselective additions to hydrazones. The resulting δ-lactam products can be readily transformed to optically enriched pipecolic acid derivatives

Organic Letters published new progress about Aminoalkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics