Category: 112-63-0

Lee, Joyce H.; Mosher, Eric P.; Lee, Young-Sam; Bumpus, Namandje N.; Berger, James M. published the artcile< Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is topoisomerase chemotherapeutic inhibition TCA cycle metabolite; DNA topology; ICRF-187; TCA cycle; cancer; chemotherapy; dexrazoxane; etoposide; metabolism; topoisomerase.

Topoisomerase II (topo II) is essential for disentangling newly replicated chromosomes. DNA unlinking involves the phys. passage of one duplex through another and depends on the transient formation of double-stranded DNA breaks, a step exploited by frontline chemotherapeutics to kill cancer cells. Although anti-topo II drugs are efficacious, they also elicit cytotoxic side effects in normal cells; insights into how topo II is regulated in different cellular contexts is essential to improve their targeted use. Using chem. fractionation and mass spectrometry, we have discovered that topo II is subject to metabolic control through the TCA cycle. We show that TCA metabolites stimulate topo II activity in vitro and that levels of TCA flux modulate cellular sensitivity to anti-topo II drugs in vivo. Our work reveals an unanticipated connection between the control of DNA topol. and cellular metabolism, a finding with ramifications for the clin. use of anti-topo II therapies.

Cell Chemical Biology published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Qing-Juan; Lv, Wen-Liang; Li, Juan-Mei; Zhang, Ting-Ting; Zhou, Wen-Hui; Zhang, Qiang; Wang, Jiu-Chong; Wang, Qing-Nan; Yao, Zi-Ang; Qiang, Rui; Chen, Si-Tong; Zhao, Xin; Liu, Shuang; Cao, Zheng-Min; Xu, Lei; Li, Gao-Hui; Chen, Jing; Wang, Li published the artcile< YinQiSanHuang Jiedu decoction for the treatment of hepatitis B-related compensated liver cirrhosis: study protocol for a multi-center randomized controlled trial>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is YinQiSanHuang Jiedu decoction hepatitis B liver cirrhosis treatment.

Hepatitis B-related compensated liver cirrhosis is related to a higher risk of hepatocellular carcinoma, and antiviral therapy is the preferred method. As the pathol. mechanisms of liver fibrosis are complex, drugs developed for a single target are difficult to be effective in clin. practice, so there are no chem. drugs or biol. drugs with clear efficacy available for clin. application at present. Traditional Chinese medicine is a kind of medical science that has been gradually formed during thousands of years and continuously enriched by the people of all ethnic groups in China. Traditional Chinese medicine shows curative effects in the treatment of liver diseases, especially in the field of liver fibrosis prevention and treatment. This study aims to test the integrative medicine (Chinese medicine plus antiviral therapy) effective on lowing hepatocellular carcinoma risk among patients with hepatitis-related compensated liver cirrhosis. This is a multi-center randomized controlled trial, and a total of 5 hospitals and 802 patients will be involved in. All the subjects are randomly allocated to the YinQiSanHuang Jiedu decoction (YQSHD) group (n = 401) or the placebo group (n = 401). The YQSHD group receives YQSHD granule with entecavir (ETV), and the placebo group receives YQSHD placebo with ETV. The treatment period will last for 52 wk, and the follow-up period for 52 ± 2 wk. The primary outcome measure is the annual incidence of HCC. Outcomes will be assessed at baseline and after treatment. The objective of this trial is ′′the integrative of YQSHD with ETV reduce the annual incidence of HCC to 1%′′. The protocol has been approved by the Medical Ethics Committee of Guang′anmen Hospital, China (Number2019-006-KY), and the other centers in the trial will not begin recruiting until the local ethical approval has been obtained. Trial final results will be disseminated via publication.

Trials published new progress about Amino acids Role: NPO (Natural Product Occurrence), PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), OCCU (Occurrence), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zou, Changfei; Yang, Li; Luo, Kaili; Liu, Lei; Tao, Xiyuan; Yi, Lingguang; Liu, Xianhu; Zhang, Xiaoyan; Wang, Xianyou published the artcile< In Situ Formed Protective Layer: Toward a More Stable Interface between the Lithium Metal Anode and Li6PS5Cl Solid Electrolyte>, Application of C19H34O2, the main research area is lithium metal battery anode solid electrolyte interface ionic liquid.

Due to the advantages of high safety and high energy d., solid-state lithium batteries (SSLBs) are promising competitors for next-generation batteries. Unfortunately, the growth of Li dendrites and irreversible capacity loss caused by the Li metal anode/solid electrolyte interfacial incompatibility remain challenges. Herein, an in situ formed artificial protective layer between the lithium metal anode and solid electrolyte Li6PS5Cl (LPSC) is introduced. A stable solid electrolyte interface (SEI) is in situ formed in the Li/Li6PS5Cl interface via the electrochem. reduction of the liquid electrolyte LiTFSI/tetraethylene glycol di-Me ether (Li(G4)TFSI), which is beneficial for the improvement of the stability of interfacial chem. and homogeneous lithium deposition behavior. The assembled Li/Li(G4)TFSI-assisted Li6PS5Cl/Li sym. cells enable stable cycles for 850 and 400 h at a c.d. of 0.1 and 0.2 mA/cm2, resp. Moreover, the LiNi0.6Co0.1Mn0.3O2(NCM613)/Li(G4)TFSI-assisted Li6PS5Cl/Li SSLBs can achieve prominent cycling stability at room temperature This work provides a new insight into the interfacial modification to design SSLBs with high energy d.

ACS Applied Energy Materials published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pang, Xianwu; Tang, Kailing; He, Qin; Huang, Jinghua; Fang, Ningye; Zhou, Xinjuan; Zhu, Qiuying; Wu, Xiuling; Shen, Zhiyong; Liang, Shujia published the artcile< HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China>, Synthetic Route of 112-63-0, the main research area is HIV drug resistance and HIV1 transmission diagnosis Southwest China; Antiretroviral resistance; Antiretroviral therapy; HIV drug resistance; Human immunodeficiency virus 1; Primary antiretroviral resistance; Transmitted drug resistance.

The widespread use of antiretroviral therapy (ART) has resulted in the development of transmitted drug resistance (TDR), which reduces ART efficacy. We explored TDR prevalence and its associated risk factors in newly diagnosed individuals in Guangxi. We enrolled 1324 participants who were newly diagnosed with HIV-1 and had not received ART at voluntary counselling and testing centers (VCT) in Guangxi, China, who had not received ART. Phylogenetic relationship, transmission cluster, and genotypic drug resistance analyses were performed using HIV-1 pol sequences. We analyzed the association of demog. and virol. factors with TDR. In total, 1151 sequences were sequenced successfully, of which 83 (7.21%) showed evidence of TDR. Multivariate logistic regression anal. revealed that there was significant difference between the prevalence of TDR and unmarried status (adjusted odds ratio (aOR) = 2.41, 95% CI: 1.23-4.71), and CRF08_BC subtype (aOR = 2.03, 95% CI: 1.13-3.64). Most cases of TDR were related to resistance to non-nucleoside reverse transcriptase inhibitors (4.87%) and V179E was the most common mutation detected. We identified a total of 119 HIV transmission clusters (n = 585, 50.8%), of which 18 (15.1%) clusters showed evidence of TDR (36, 41.86%). Three clusters were identified that included drug-resistant individuals having a transmission relationship with each other. The following parameters were associated with TDR transmission risk: Unmarried status, educational level of junior high school or below, and CRF08_BC subtype may be a risk of the transmission of TDR. Our findings indicated that moderate TDR prevalence and highlighted the importance of continuous TDR monitoring and designing of strategies for TDR mitigation.

BMC Infectious Diseases published new progress about Antiviral agent resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beccalli, Egle M.; Bernasconi, Alice; Borsini, Elena; Broggini, Gianluigi; Rigamonti, Micol; Zecchi, Gaetano published the artcile< Tunable Pd-Catalyzed Cyclization of Indole-2-carboxylic Acid Allenamides: Carboamination vs Microwave-Assisted Hydroamination>, Application of C19H34O2, the main research area is vinyl imidazoindole preparation; indolecarboxylic acid allenamide preparation carboamination hydroamination palladium catalyst.

A variety of 3-vinyl-substituted imidazo[1,5-a]indole derivatives were synthesized by intramol. Pd-catalyzed cyclization of the title allenamides through either a domino carbopalladation/exo-cyclization process or a novel hydroamination reaction that proceeds smoothly under microwave irradiation Both observed pathways involve a π-allyl-palladium(II) complex arising from insertion of the allene group into a palladium(II) species, the latter being formed in situ by the intervention of an aryl iodide or of the N-H group. In both cases, the role of nucleophile is covered by the indole nitrogen.

Journal of Organic Chemistry published new progress about Allenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (allenamides). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Yong; Liu, Zhiyan; Hou, Enhua; Ma, Nannan; Fan, Jiangping; Jin, Cheng-Yun; Yang, Ruige published the artcile< Non-food bioactive natural forest products as insecticide candidates: Preparation, biological evaluation and molecular docking studies of novel N-(1,3-thiazol-2- yl)carboxamides fused (+)-nootkatone from Chamaecyparis nootkatensis [D. Don] Spach>, SDS of cas: 112-63-0, the main research area is Chamaecyparis nootkatensis mol docking study nootkatone.

(+)-Nootkatone, a non-food bioactive natural bicyclic sesquiterpene ketone, is isolated from Chamaecyparis nootkatensis [D. Don] Spach as a renewable forest resource. In continuation of our effort to develop synthetic natural derived insecticides from non-food bioactive products, a small library of thirty N-(1,3- thiazol-2-yl)carboxamides fused (+)-nootkatone was prepared by mol. hybridization and characterized by 1H/13C NMR, HR-MS, and IR spectroscopy. Their insecticidal activities against Mythimna separata Walker and Plutella xylostella Linnaeus were evaluated. Compounds B6, B7, B9, B19-21 and B24 showed better insecticidal activity against M. separata than the botanical insecticide azadirachtin, and their LC50 values ranged from 0.55-0.68 mg/mL. Particularly, compound B9 exhibited 1.87-fold more pronounced insecticidal activity against M. separata than azadirachtin. The insecticidal activity of B21 against P. xylostella was 1.37-fold of that of azadirachtin. Through acetylcholinesterase (AChE) inhibitory activity and mol. docking studies, AChE may be the insecticidal target of B9 against M. separata. In addition, three pronounced compounds B9, B21 and B24 exhibited low hemolytic and cytotoxic activities on normal mammalian cells. These findings will give insights into the further development of (+)-nootkatone derivatives as potentially synthetic natural derived insecticides for pest management.

Industrial Crops and Products published new progress about Cupressus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Yuan; Lu, Jiliang; Zhao, Yuchen; Liao, Weilin; Xing, Enhui; Hu, Xiangguo; Ouyang, Ying; Luo, Yibin; Shu, Xingtian published the artcile< The research of palmitoyl hyperbranched polyglycerol synergized catalytic cracking reaction of hydrocarbons>, Application In Synthesis of 112-63-0, the main research area is palmitoyl hyperbranched polyglycerol catalysis hydrocarbon cracking olefin.

The polymer material palmitoyl hyperbranched polyglycerol (PHPG) was synthesized and studied as carbenium initiator in catalytic cracking reaction for the 1st time. The introduction of PHPG could significantly promote the conversions and light olefins yields in naphtha and model compounds tests (e.g., conversion and yield of light olefins from octane increased by 10.31 and 4.73 percentage points). Control experiments of thermal cracking and anal. of catalytic cracking products selectivities were supportive for the proposal that PHPG functionalized carbenium mechanism by enhancing the carbenium formation step. A 1st-order power law model was established based on the reaction rate derivation of octane and Et-cyclohexane catalytic cracking. Kinetics study revealed the reduction in activation energy (e.g., for octane by 4.2%), and therefore illustrated the alternative reaction path created by the introduced PHPG.

Fuel published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mo, F.; Meletti, S.; Belcastro, V.; Quadri, S.; Napolitano, M.; Bello, L.; Dainese, F.; Scarpelli, M.; Florindo, I.; Mascia, A.; Pauletto, G.; Bruno, F.; Pellerino, A.; Giovannini, G.; Polosa, M.; Sessa, M.; Conti Nibali, M.; Di Gennaro, G.; Gigli, G. L.; Pisanello, A.; Cavallieri, F.; Ruda, R. published the artcile< Lacosamide in monotherapy in BTRE (brain tumor-related epilepsy): results from an Italian multicenter retrospective study>, Formula: C19H34O2, the main research area is lacosamide brain tumor epilepsy monotherapy population; Epilepsy; Lacosamide; Primary brain tumor; Seizure freedom; Side effects.

Lacosamide (LCM) is a third-generation anti-seizure medication (ASM) approved for focal onset epilepsy in patients aged ≥ 4.378 Previous studies have reported an efficacy of LCM as add-on treatment in brain tumor-related epilepsy (BTRE). To date, there are no studies in the literature focusing on lacosamide used in monotherapy to treat BTRE. In our retrospective study we investigated efficacy and tolerability of LCM in monotherapy in a multicenter national cohort of primary brain tumor patients. We collected from 12 Italian Centers 132 patients with primary brain tumors who were treated with LCM in monotherapy. For each patient we evaluated seizure freedom at 3 and 6 mo (primary endpoints), side effects and drop-out rate (secondary endpoints). Overall, LCM led to seizure freedom in 64.4% of patients at 3 mo and 55% at 6 mo. Patients who used two or more ASMs before LCM had a worse seizure control than patients in monotherapy with LCM as first choice. In 14 patients, we observed seizure control despite tumor progression on magnetic resonance (MRI). Multivariate anal. showed that gross-total resection at diagnosis was significantly associated with higher seizure freedom rate at 6 mo. Side effects were mainly mild (grade 1-2 according to CTCAE classification) and drop-out rate was low (1.5%). Main side effects were dizziness and somnolence. This is the first study showing a good efficacy and tolerability of LCM when used in monotherapy in BTRE. Further prospective studies are needed to confirm these preliminary data, investigating also quality of life and neurocognitive functions.

Journal of Neuro-Oncology published new progress about Anticonvulsants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peddagopu, Nishant; Sanzaro, Salvatore; Rossi, Patrizia; Paoli, Paola; Malandrino, Graziella published the artcile< A One-Pot Synthesis of ""K(hfa) glyme"" Adducts: Effect of the Polyether Length on the Ion Coordination Sphere>, Synthetic Route of 112-63-0, the main research area is potassium diketonate polyether polymeric complex preparation crystal structure; thermal stability potassium diketonate polyether polymeric complex.

Potassium complexes are starting to gather more and more interest from academia and industry because of their intriguing application possibilities. Novel adducts of potassium hexafluoroacetylacetonato [K(hfa)] with polyethers (monoglyme, diglyme, triglyme, and tetraglyme) were synthesized through a single step reaction and characterized through FTIR spectroscopy as well as 1H and 13C NMR spectroscopy. Single crystal x-ray diffraction studies enabled the identification of fascinating K coordination polymeric networks.

European Journal of Inorganic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glinsky-Olivier, Nicolas; Yang, Shengwen; Retailleau, Pascal; Gandon, Vincent; Guinchard, Xavier published the artcile< Enantioselective Gold-Catalyzed Pictet-Spengler Reaction>, SDS of cas: 112-63-0, the main research area is tetrahydro carboline enantioselective preparation gold catalyst; tryptamine arylaldehyde Pictet Spengler reaction.

Cationic chiral Au(I) complexes catalyze asym. Pictet-Spengler reactions between tryptamines and arylaldehydes. The resulting tetrahydro-β-carbolines I (R1 = H, 5-Me, 5-OMe; R2 = Allyl, Bn, CH2Mes, etc.; R3 = Ph, 4-Et-C6H4, 2-CN-C6H4, 3ClC6H4, etc.)are obtained with wide functional group tolerance in high yield and with high enantioselectivities (up to 95%). Aldehydes bearing polar or protic functions are well tolerated. The reaction features a hitherto unknown C2-auration of the indole as the key step, supported by d. functional theory calculations

Organic Letters published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics