Category: 112-63-0

Jagadeesh, Rajenahally V.; Stemmler, Tobias; Surkus, Annette-Enrica; Junge, Henrik; Junge, Kathrin; Beller, Matthias published the artcile< Hydrogenation using iron oxide-based nanocatalysts for the synthesis of amines>, HPLC of Formula: 112-63-0, the main research area is aryl amine preparation chemoselective; nitro arene iron oxide nanocatalyst hydrogenation; secondary aryl amine preparation; aromatic amine aldehyde iron oxide nanocatalyst reductive amination; iron oxide nitrogen doped graphene layer nanocatalyst preparation.

In this protocol, the preparation of nanoscale iron oxide-based materials and their use in the catalysis of different hydrogenation reactions was described. Pyrolysis of a Fe(OAc)2-phenanthroline complex on carbon at 800 °C under argon atm. results in the formation of nanoscale Fe2O3 particles surrounded by nitrogen-doped graphene layers. By applying these catalysts, the hydrogenation of structurally diverse and functionalized nitroarenes to anilines proceeds with excellent selectivity. Furthermore, it was shown that one-pot reductive amination of carbonyl compounds with nitroarenes was also possible in the presence of these iron oxide catalysts. Herein, the synthesis of more than 40 amines, which are important feedstocks and key intermediates for pharmaceuticals, agrochems. and polymers was also reported. The detailed preparation of the catalysts and the procedures for the hydrogenation processes were presented. The overall time required for the catalyst preparation and for the hydrogenation reactions are 35 h and 20-35 h, resp.

Nature Protocols published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kabilan, S.; Girija, R. published the artcile< Kinetics and mechanism of the oxidation of ortho-substituted benzyl alcohols by pyridinium dichromate>, Category: esters-buliding-blocks, the main research area is oxidation benzyl alc ortho substituted pyridinium dichromate kinetics mechanism; LFER oxidation benzyl alc ortho substituted pyridinium dichromate.

The kinetics and mechanism of the oxidation of benzyl alc. and some ortho-substituted benzyl alcs. by pyridinium dichromate (PDC) in the presence of trichloroacetic acid (TCA) in 100% acetonitrile medium have been studied. The product of oxidation has been identified as the corresponding benzaldehyde. The stoichiometry of the reaction is found to be 1.5:1. The reaction is first order each in substrate and oxidant concentrations The mechanism of oxidation varies with the nature of the chromium (VI) species and the solvent used.

Oxidation Communications published new progress about Activation enthalpy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

DesMarteau, Darryl D.; Petrov, Viacheslav A.; Montanari, Vittorio; Pregnolato, Massimo; Resnati, Giuseppe published the artcile< Mild and Selective Oxygenation of Sulfides to Sulfoxides and Sulfones by Perfluoro-cis-2,3-dialkyloxaziridines>, Related Products of 112-63-0, the main research area is sulfide oxidation perfluorodialkyloxaziridine; oxaziridine perfluorodialkyl oxidation sulfide; sulfone aliphatic aromatic; sulfoxide preparation oxidation.

Sulfides are oxidized to sulfoxides by stoichiometric amounts of perfluoro-cis-2,3-dialkyloxaziridines I (Rf1, Rf2 = n-C4F9, n-C3F7 or n-C6F13, n-C5F11). The reactions proceed at -40° with nearly complete selectivity and very good yields. Sulfoxides are also oxidized easily by I under mild conditions to corresponding sulfones. The oxidation of some bioactive sulfides (promazine, albendazole, biotin, and others) is also reported.

Journal of Organic Chemistry published new progress about Chemoselectivity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

DiMauro, Erin F.; Newcomb, John; Nunes, Joseph J.; Bemis, Jean E.; Boucher, Christina; Chai, Lilly; Chaffee, Stuart C.; Deak, Holly L.; Epstein, Linda F.; Faust, Ted; Gallant, Paul; Gore, Anu; Gu, Yan; Henkle, Brad; Hsieh, Faye; Huang, Xin; Kim, Joseph L.; Lee, Josie H.; Martin, Matthew W.; McGowan, David C.; Metz, Daniela; Mohn, Deanna; Morgenstern, Kurt A.; Oliveira-dos-Santos, Antonio; Patel, Vinod F.; Powers, David; Rose, Paul E.; Schneider, Stephen; Tomlinson, Susan A.; Tudor, Yan-Yan; Turci, Susan M.; Welcher, Andrew A.; Zhao, Huilin; Zhu, Li; Zhu, Xiaotian published the artcile< Structure-Guided Design of Aminopyrimidine Amides as Potent, Selective Inhibitors of Lymphocyte Specific Kinase: Synthesis, Structure-Activity Relationships, and Inhibition of in Vivo T Cell Activation>, Product Details of C19H34O2, the main research area is aminopyrimidine amide preparation selective inhibitor lymphocyte specific kinase; T cell activation proliferation inhibitor aminopyrimidine amide; crystal structure lymphocyte specific kinase cocrystal aminopyrimidine amide; mol structure lymphocyte specific kinase cocrystal aminopyrimidine amide.

The lymphocyte-specific kinase (Lck), a member of the Src family of cytoplasmic tyrosine kinases, is expressed in T cells and natural killer (NK) cells. Genetic evidence, including knockout mice and human mutations, demonstrates that Lck kinase activity is critical for normal T cell development, activation, and signaling. Selective inhibition of Lck is expected to offer a new therapy for the treatment of T-cell-mediated autoimmune and inflammatory disease. With the aid of x-ray structure-based anal., aminopyrimidine amides were designed from aminoquinazolines, which had previously been demonstrated to exhibit potent inhibition of Lck and T cell proliferation. The authors describe the synthesis and structure-activity relations of novel aminopyrimidine amides possessing improved cellular potency and selectivity profiles relative to their aminoquinazoline predecessors. Orally bioavailable compound 2-methyl-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5-pyrimidinyl]-5-[[[3-(trifluoromethyl)phenyl]carbonyl]amino]benzamide inhibited the anti-CD3-induced production of interleukin-2 (IL-2) in mice in a dose-dependent manner (ED50 = 9.4 mg/kg). The crystal and mol. structures of cocrystals of Lck kinase with 4-methyl-N3-[2-[4-(4-methylpiperazin-1-yl)phenylamino]pyrimidin-5-yl]-N1-[3-(trifluoromethyl)phenyl]isophthalamide and 2-methyl-N-[4-methyl-3-[[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5-pyrimidinyl]amino]carbonyl]phenyl]-3-(trifluoromethyl)benzamide were determined by x-ray crystallog.

Journal of Medicinal Chemistry published new progress about Amides Role: PAC (Pharmacological Activity), PKT (Pharmacokinetics), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Yuzhen; Scafaro, Andrew P.; Asao, Shinichi; Furbank, Robert T.; Agostino, Antony; Day, David A.; von Caemmerer, Susanne; Danila, Florence R.; Rug, Melanie; Webb, Daryl; Lee, Jiwon; Atkin, Owen K. published the artcile< Dark respiration rates are not determined by differences in mitochondrial capacity, abundance and ultrastructure in C4 leaves>, Synthetic Route of 112-63-0, the main research area is C4 photosynthesis leaf bundle sheath mitochondria light respiration; C4 photosynthetic pathway; C4 plants; bundle sheath; mitochondria; mitochondrial ultrastructure; respiration.

Our understanding of the regulation of respiration in C4 plants, where mitochondria play different roles in the different types of C4 photosynthetic pathway, remains limited. We examined how leaf dark respiration rates (Rdark), in the presence and absence of added malate, vary in monocots representing the three classical biochem. types of C4 photosynthesis (NADP-ME, NAD-ME and PCK) using intact leaves and extracted bundle sheath strands. In particular, we explored to what extent rates of Rdark are associated with mitochondrial number, volume and ultrastructure. Based on examination of a single species per C4 type, we found that the respiratory response of NAD-ME and PCK type bundle sheath strands to added malate was associated with differences in mitochondrial number, volume, and/or ultrastructure, while NADP-ME type bundle sheath strands did not respond to malate addition In general, mitochondrial traits reflected the contributions mitochondria make to photosynthesis in the three C4 types. However, despite the obvious differences in mitochondrial traits, no clear correlation was observed between these traits and Rdark. We suggest that Rdark is primarily driven by cellular maintenance demands and not mitochondrial composition per se, in a manner that is somewhat independent of mitochondrial organic acid cycling in the light.

Plant, Cell & Environment published new progress about Leaf. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fearon, Daren; Westwood, Isaac M.; van Montfort, Rob L. M.; Bayliss, Richard; Jones, Keith; Bavetsias, Vassilios published the artcile< Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition>, Formula: C19H34O2, the main research area is aminopyridinone fragment compound library screening MPS1 Aurora kinase inhibitor; 3-Aminopyridin-2-one; Aurora kinase; Fragment compound library; MPS1 kinase.

Screening a 3-aminopyridin-2-one based fragment library against a 26-kinase panel representative of the human kinome identified 3-amino-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2(1H)-one (2) and 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one (3) as ligand efficient inhibitors of the mitotic kinase Monopolar Spindle 1 (MPS1) and the Aurora kinase family. These kinases are well recognized as attractive targets for therapeutic intervention for treating cancer. Elucidation of the binding mode of these fragments and their analogs has been carried out by x-ray crystallog. Structural studies have identified key interactions with a conserved lysine residue and have highlighted potential regions of MPS1 which could be targeted to improve activity and selectivity.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luo, Shanshan; Lin, Paul P.; Nieh, Liang-Yu; Liao, Guan-Bo; Tang, Po-Wen; Chen, Chi; Liao, James C. published the artcile< A cell-free self-replenishing CO2-fixing system>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is carbon dioxide fixing system.

Biol. CO2 fixation is so far the most effective means for CO2 reduction at scale and accounts for most of the CO2 fixed on Earth. Through this process, carbon is fixed in cellular components and biomass during organismal growth. To uncouple CO2 fixation from growth and cellular regulation, cell-free CO2 fixation systems represent an alternative approach since the rate can be independently manipulated. Here we designed an oxygen-insensitive, self-replenishing CO2 fixation system with opto-sensing. The system comprises a synthetic reductive glyoxylate and pyruvate synthesis (rGPS) cycle and the malyl-CoA-glycerate (MCG) pathway to produce acetyl-CoA (CoA), pyruvate and malate from CO2, which are also intermediates in the cycle. We solved various problems associated with the in vitro system, and implemented opto-sensing modules to control the regeneration of cofactors. We accomplished sustained operation for 6 h with a CO2-fixing rate comparable to or greater than typical CO2 fixation rates of photosynthetic or lithoautotrophic organisms. [graphic not available: see fulltext].

Nature Catalysis published new progress about Biomass. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koring, Laura; Sitte, Nikolai A.; Bursch, Markus; Grimme, Stefan; Paradies, Jan published the artcile< Hydrogenation of Secondary Amides using Phosphane Oxide and Frustrated Lewis Pair Catalysis>, Quality Control of 112-63-0, the main research area is secondary amine preparation; amide hydrogenation phosphine oxide catalyst frustrated Lewis pair; carboxylic amide; frustrated Lewis pair; hydrogen; hydrogenation; phosphane oxide.

The metal-free catalytic hydrogenation of secondary amides for synthesis of amines RCH2NHR1 [R = i-Pr, Ph, 4-BrC6H4, etc.; R1 = Me, Et, Ph, etc.] was developed. The reduction was realized by two new catalytic reactions. First, the amide was converted into the imidoyl chloride by triphosgene (CO(OCCl3)2) using novel phosphorus(V) catalysts. Second, the in situ generated imidoyl chlorides were hydrogenated in high yields by an FLP-catalyst. Mechanistic and quantum mech. calculations supported an autoinduced catalytic cycle for the hydrogenation with chloride acting as unusual Lewis base for FLP-mediated H2-activation.

Chemistry – A European Journal published new progress about Amides, secondary Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Todoriki, Sota; Hosoda, Yui; Yamamoto, Tae; Watanabe, Mayu; Sekimoto, Akiyo; Sato, Hiroshi; Mori, Takefumi; Miyazaki, Mariko; Takahashi, Nobuyuki; Sato, Emiko published the artcile< Methylglyoxal Induces Inflammation, Metabolic Modulation and Oxidative Stress in Myoblast Cells>, HPLC of Formula: 112-63-0, the main research area is metabolome methylglyoxal Murf1 ATP Nqo1 PPARA inflammation oxidative stress; chronic kidney disease; metabolic alteration; methylglyoxal; myoblast cell; sarcopenia.

Uremic sarcopenia is a serious clin. problem associated with phys. disability and increased morbidity and mortality. Methylglyoxal (MG) is a highly reactive, dicarbonyl uremic toxin that accumulates in the circulatory system in patients with chronic kidney disease (CKD) and is related to the pathol. of uremic sarcopenia. The pathophysiol. of uremic sarcopenia is multifactorial; however, the details remain unknown. We investigated the mechanisms of MG-induced muscle atrophy using mouse myoblast C2C12 cells, focusing on intracellular metabolism and mitochondrial injury. We found that one of the causative pathol. mechanisms of uremic sarcopenia is metabolic flow change to fatty acid synthesis with MG-induced ATP shortage in myoblasts. Evaluation of cell viability revealed that MG showed toxic effects only in myoblast cells, but not in myotube cells. Expression of mRNA or protein anal. revealed that MG induces muscle atrophy, inflammation, fibrosis, and oxidative stress in myoblast cells. Target metabolomics revealed that MG induces metabolic alterations, such as a reduction in tricarboxylic acid cycle metabolites. In addition, MG induces mitochondrial morphol. abnormalities in myoblasts. These changes resulted in the reduction of ATP derived from the mitochondria of myoblast cells. Our results indicate that MG is a pathogenic factor in sarcopenia in CKD.

Toxins published new progress about Atrogin 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Qiang; Wu, Jing; Huang, Jiawen; Hu, Rong; You, Haiyan; Liu, Lingyu; Wang, Dongtao; Wei, Lianbo published the artcile< Paeoniflorin ameliorates skeletal muscle atrophy in chronic kidney disease via AMPK/SIRT1/PGC-1α-mediated oxidative stress and mitochondrial dysfunction>, Computed Properties of 112-63-0, the main research area is chronic kidney disease skeletal muscle atrophy AMPK SIRT1 PGC1A; oxidative stress mitochondrial dysfunction paeoniflorin; AMPK/SIRT1/PGC-1α; chronic kidney disease; mitochondrial dysfunction; oxidative stress; paeoniflorin; skeletal muscle atrophy.

Skeletal muscle atrophy is a common and serious complication of chronic kidney disease (CKD). Oxidative stress and mitochondrial dysfunction are involved in the pathogenesis of muscle atrophy. The aim of this study was to explore the effects and mechanisms of paeoniflorin on CKD skeletal muscle atrophy. We demonstrated that paeoniflorin significantly improved renal function, calcium/phosphorus disorders, nutrition index and skeletal muscle atrophy in the 5/6 nephrectomized model rats. Paeoniflorin ameliorated the expression of proteins associated with muscle atrophy and muscle differentiation, including muscle atrophy F-box (MAFbx/atrogin-1), muscle RING finger 1 (MuRF1), MyoD and myogenin (MyoG). In addition, paeoniflorin modulated redox homeostasis by increasing antioxidant activity and suppressing excessive accumulation of reactive oxygen species (ROS). Paeoniflorin alleviated mitochondrial dysfunction by increasing the activities of electron transport chain complexes and mitochondrial membrane potential. Furthermore, paeoniflorin also regulates mitochondrial dynamics. Importantly, paeoniflorin upregulated the expression of silent information regulator 1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), and phosphorylation of AMP-activated protein kinase (AMPK). Similar results were observed in C2C12 myoblasts treated with TNF-α and paeoniflorin. Notably, these beneficial effects of paeoniflorin on muscle atrophy were abolished by inhibiting AMPK and SIRT1 and knocking down PGC-1α. Taken together, this study showed for the first time that paeoniflorin has great therapeutic potential for CKD skeletal muscle atrophy through AMPK/SIRT1/PGC-1α-mediated oxidative stress and mitochondrial dysfunction.

Frontiers in Pharmacology published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics