Category: 112-63-0

Nevesely, Tomas; Molloy, John J.; McLaughlin, Calum; Bruess, Linda; Daniliuc, Constantin G.; Gilmour, Ryan published the artcile< Leveraging the n→π* Interaction in Alkene Isomerization by Selective Energy Transfer Catalysis>, Product Details of C19H34O2, the main research area is alkene isomerization energy transfer catalysis crystal structure light DFT; alkenes; bioinspired reactions; catalysis; isomerization; stereochemistry.

Examples of geometric alkene isomerization in nature are often limited to the net exergonic direction (ΔG°<0), with the antipodal net endergonic processes (ΔG°>0) comparatively under-represented. Inspired by the expansiveness of the maleate to fumarate (Z→E) isomerization in biochem., we investigated the inverse E→Z variant to validate nO→πC=O* interactions as a driving force for contra-thermodn. isomerization. A general protocol involving selective energy transfer catalysis with inexpensive thioxanthone as a sensitizer (λmax=402 nm) is disclosed. While in the enzymic process nO→πC=O* interactions commonly manifest themselves in the substrate, these same interactions are shown to underpin directionality in the antipodal reaction by shortening the product alkene chromophore. The process was validated with diverse fumarate derivatives (>30 examples, up to Z:E>99:1), including the first examples of tetrasubstituted alkenes, and the involvement of nO→πC=O* interactions was confirmed by X-ray crystallog.

Angewandte Chemie, International Edition published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Lei; Li, Sun; Chauhan, Pankaj; Hack, Daniel; Philipps, Arne R.; Puttreddy, Rakesh; Rissanen, Kari; Raabe, Gerhard; Enders, Dieter published the artcile< Asymmetric, Three-Component, One-Pot Synthesis of Spiropyrazolones and 2,5-Chromenediones from Aldol Condensation/NHC-Catalyzed Annulation Reactions>, HPLC of Formula: 112-63-0, the main research area is pyrazolone enal NHC chiral aldol condensation annulation catalyst; spiropyrazolone stereoselective preparation; diketone cyclic enal NHC chiral aldol condensation annulation catalyst; chromenedione stereoselective preparation; N-heterocyclic carbene; asymmetric synthesis; chromenedione; multicomponent reaction; spiropyrazolone.

A novel one-pot, three-component diastereo- and enantioselective synthesis of spiropyrazolones has been developed involving the aldol condensation of an enal to generate α,β-unsaturated pyrazolones, which react with a second equivalent of enal through an N-heterocyclic carbene (NHC)-catalyzed [3+2] annulation. The desired spirocyclopentane pyrazolones I (R = Ph, 4-MeOC6H4, 2-MeOC6H4, 4-ClC6H4, 4-BrC6H4, 2-furanyl, 3-thienyl, etc.; R1 = t-Bu, Et, 4-MeOC6H4, 2-naphthyl; R2 = Ph, 4-MeOC6H4, 4-BrC6H4, Bn, t-Bu, etc.) are obtained in moderate to good yields and good to excellent stereoselectivities. Alternatively, starting from cyclic 1,3-diketones, 2,5-chromenediones II (R = Ph, 4-MeOC6H4, 4-MeC6H4, 4-ClC6H4, 2-MeOC6H4, etc.; R1= R2= Me, H; R1= H, R2= Ph) are available through [2+4] annulation.

Chemistry – A European Journal published new progress about Aldol condensation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pirrung, Michael C.; Liu, Yufa; Deng, Liu; Halstead, Diana K.; Li, Zhitao; May, John F.; Wedel, Michael; Austin, Darrell A.; Webster, Nicholas J. G. published the artcile< Methyl Scanning: Total Synthesis of Demethylasterriquinone B1 and Derivatives for Identification of Sites of Interaction with and Isolation of Its Receptor(s)>, Quality Control of 112-63-0, the main research area is demethylasterriquinone B1 derivative preparation; methyl scanning demethylasterriquinone B1 derivative insulin receptor binding.

The principle of Me scanning is proposed for determination of the sites of interaction between biol. active small mols. and their macromol. target(s). It involves the systematic preparation of a family of methylated derivatives of a compound and their biol. testing. As a functional assay, the method can identify the regions of a mol. that are important (and unimportant) for biol. activity against even unknown targets, and thus provides an excellent complement to structural biol. Me scanning was applied to demethylasterriquinone B1, a small-mol. mimetic of insulin. A new, optimal total synthesis of this natural product was developed that enables the family of Me scan derivatives to be concisely prepared for evaluation in a cellular assay. The results of this experiment were used to design a biotin-demethylasterriquinone conjugate for use as an affinity reagent. This compound was prepared in tens of milligram quantities in a four-step synthesis.

Journal of the American Chemical Society published new progress about Insulin receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schatz, Devon J.; Kwon, Yonghoon; Scully, Thomas W.; West, F. G. published the artcile< Interrupting the Nazarov Cyclization with Bromine>, COA of Formula: C19H34O2, the main research area is divinyl ketone derivative tandem Nazarov cyclization pyridinium bromide perbromide; brominated cyclopentanone preparation.

The generation of dibrominated cyclopentanones via an interrupted Nazarov cyclization is reported. The installation of two Br atoms occurs at the α and α’ positions of the cyclopentanyl scaffold via successive nucleophilic and electrophilic bromination of the 2-oxidocyclopentenyl cation and its resulting enolate. Notably, the reaction proceeds with good diastereoselectivity, favoring the sym. product.

Journal of Organic Chemistry published new progress about Bromination, electrophilic. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hong, Seung-Mo; Hwang, Seok-Ho published the artcile< Synthesis and Characterization of Multifunctional Secondary Thiol Hardeners Using 3-Mercaptobutanoic Acid and Their Thiol-Epoxy Curing Behavior>, HPLC of Formula: 112-63-0, the main research area is multifunctional secondary thiol hardener mercaptobutanoate epoxy curing.

3-Mercaptobutanoic acid (3-MBA) was synthesized by the less odorous Michael addition pathway using an isothiouronium salt intermediate. Using the synthesized 3-MBA, multifunctional secondary thiol (sec-thiol) compounds were obtained and applied to thiol-epoxy curing systems as hardeners. As the functionality of the sec-thiol hardeners increased, the purity of the product obtained after distillation decreased. The equivalent epoxy mixtures with multifunctional sec-thiol hardeners were evaluated based on their impact on the curing behavior in thiol-epoxy click reactions by differential scanning calorimetry. The thermal features of sec-thiol-epoxy click reactions in the presence of a base catalyst were assessed according to the functionality of the sec-thiol hardeners. Our results showed that sec-thiol hardeners with less reactivity to the epoxy group provide long-term storage stability for the formulated epoxy resin, promising for industrial applications.

ACS Omega published new progress about Crosslinking. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jockusch, Steffen; Tao, Chuanjuan; Li, Xiaoxu; Anderson, Thomas K.; Chien, Minchen; Kumar, Shiv; Russo, James J.; Kirchdoerfer, Robert N.; Ju, Jingyue published the artcile< A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19>, Synthetic Route of 112-63-0, the main research area is antiviral drug RNA polymerase nucleotide analog COVID19 SARS; COVID-19; Exonuclease; Nucleotide analogues; RNA-Dependent RNA polymerase; SARS-CoV-2.

SARS-CoV-2, a member of the coronavirus family, is responsible for the current COVID-19 worldwide pandemic. We previously demonstrated that five nucleotide analogs inhibit the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), including the active triphosphate forms of Sofosbuvir, Alovudine, Zidovudine, Tenofovir alafenamide and Emtricitabine. We report here the evaluation of a library of nucleoside triphosphate analogs with a variety of structural and chem. features as inhibitors of the RdRps of SARS-CoV and SARS-CoV-2. These features include modifications on the sugar (2′ or 3′ modifications, carbocyclic, acyclic, or dideoxynucleotides) or on the base. The goal is to identify nucleotide analogs that not only terminate RNA synthesis catalyzed by these coronavirus RdRps, but also have the potential to resist the viruses′ exonuclease activity. We examined these nucleotide analogs for their ability to be incorporated by the RdRps in the polymerase reaction and to prevent further incorporation. While all 11 mols. tested displayed incorporation, 6 exhibited immediate termination of the polymerase reaction (triphosphates of Carbovir, Ganciclovir, Stavudine and Entecavir; 3′-OMe-UTP and Biotin-16-dUTP), 2 showed delayed termination (Cidofovir diphosphate and 2′-OMe-UTP), and 3 did not terminate the polymerase reaction (2′-F-dUTP, 2′-NH2-dUTP and Desthiobiotin-16-UTP). The coronaviruses possess an exonuclease that apparently requires a 2′-OH at the 3′-terminus of the growing RNA strand for proofreading. In this study, all nucleoside triphosphate analogs evaluated form Watson-Crick-like base pairs. The nucleotide analogs demonstrating termination either lack a 2′-OH, have a blocked 2′-OH, or show delayed termination. Thus, these nucleotide analogs are of interest for further investigation to evaluate whether they can evade the viral exonuclease activity. Prodrugs of five of these nucleotide analogs (Cidofovir, Abacavir, Valganciclovir/Ganciclovir, Stavudine and Entecavir) are FDA-approved medications for treatment of other viral infections, and their safety profiles are well established. After demonstrating potency in inhibiting viral replication in cell culture, candidate mols. can be rapidly evaluated as potential therapies for COVID-19.

Antiviral Research published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cervellieri, Salvatore; Lippolis, Vincenzo; Mancini, Erminia; Pascale, Michelangelo; Logrieco, Antonio Francesco; De Girolamo, Annalisa published the artcile< Mass spectrometry-based electronic nose to authenticate 100% Italian durum wheat pasta and characterization of volatile compounds>, SDS of cas: 112-63-0, the main research area is electronic nose durum wheat pasta volatile compound mass spectrometry; Authentication; Chemometrics; Durum wheat pasta; Geographical origin; MS-based electronic nose; Volatile organic compounds.

Headspace solid-phase microextraction (HS-SPME) coupled with mass spectrometry-based electronic nose (MS-eNose), in combination with multivariate statistical anal. was used as untargeted method for the rapid authentication of 100% Italian durum wheat pasta. Among the tested classification models, i.e. PCA-LDA, PLS-DA and SVMc, SVMc provided the highest accuracy results in both calibration (90%) and validation (92%) processes. Potential markers discriminating pasta samples were identified by HS-SPME/GC-MS anal. Specifically, the content of a pattern of 8 out of 59 volatile organic compounds (VOCs) was significantly different between samples of 100% Italian durum wheat pasta and pasta produced with durum wheat of different origins, most of which were related to different lipidic oxidation in the two classes of pasta. The proposed MS-eNose method is a rapid and reliable tool to be used for authenticating Italian pasta useful to promote its typicity and preserving consumers from fraudulent practices.

Food Chemistry published new progress about Durum wheat. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Bit; Sun, Wei; Lee, Hyungjun; Basavarajappa, Halesha; Sulaiman, Rania S.; Sishtla, Kamakshi; Fei, Xiang; Corson, Timothy W.; Seo, Seung-Yong published the artcile< Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids>, Category: esters-buliding-blocks, the main research area is photoaffinity probe antiangiogenic homoisoflavonoid; Antiangiogenic agents; Homoisoflavonoids; Human retinal microvascular endothelial cells; Photoaffinity probes; Wet age-related macular degeneration.

A naturally occurring homoisoflavonoid cremastranone (1) inhibited angiogenesis in vitro and in vivo. The authors developed an analog SH-11037 (2) which is more potent than cremastranone in human retinal microvascular endothelial cells (HRECs) and blocks neovascularization in animal models. Despite their efficacy, the mechanism of these compounds is not yet fully known. In building on a strong foundation of SAR and creating a novel chem. tool for target identification of homoisoflavonoid-binding proteins, various types of photoaffinity probes were designed and synthesized in which benzophenone and biotin were attached to homoisoflavanonoids using PEG linkers on either the C-3′ or C-7 position. Notably, the photoaffinity probes linking on the phenol group of the C-3′ position retain excellent activity of inhibiting retinal endothelial cell proliferation with up to 72 nM of GI50.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiangiogenic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Konyukhova, T. M.; Abramenko, P. I.; Kurkina, L. G. published the artcile< Indolomonomethinecyanines, their spectral and polarographic properties>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is indolocyanine monomethine spectra polarog; substituent effect polarog reduction potential.

Twelve indolomonomethinecyanies (I; R = H, Ph; R1 = H, Me; R2 = H, CO2H, CO2Et; R3 = H, Cl, NO2, CO2H) were prepared by condensation of 1-methyl-3-formylindoles with indoles unsubstituted in the 3 position in MeNO2 in the presence of HBr. For R = H, R3 has little effect on the position of the absorption maximum; introduction of R = Ph causes a hypsochromic shift due to steric hindrance. All the I exhibit a low polarog. reduction potential, which is lower for R = Ph than for R = H.

Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D. I. Mendeleeva published new progress about Cyanine dyes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nardeli, Jessica V.; Fugivara, Cecilio S.; Taryba, Maryna; Montemor, M. F.; Benedetti, Assis V. published the artcile< Self-healing ability based on hydrogen bonds in organic coatings for corrosion protection of AA1200>, Formula: C19H34O2, the main research area is aluminum alloy corrosion resistant coating polyurethane microstructure.

Biobased polyurethane coatings derived from vegetable oils, with 2 different compositions, were prepared and applied on the AA1200 aluminum alloy to confer corrosion protection. The influence of the ratio between the polyester (flexible segment) and the prepolymer (rigid segment) was investigated. IR spectroscopy studies evidenced the difference between the areas of the bands (-NH) and optical and SEM evidenced the morphol. features of the coating surface before and after immersion in aggressive medium. The barrier properties and anti-corrosion performance of the coatings were evaluated by electrochem. impedance spectroscopy and the results revealed an increase of impedance over the immersion time. Localized corrosion studies confirmed the self-healing effect in coatings formulated with the highest content of polyester.

Corrosion Science published new progress about Anticorrosive coating materials. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics