Category: 112-63-0

Cheng, Jie; Liu, Ying; Yan, Jinxin; Zhao, Lina; Zhou, Yinglin; Shen, Xuyang; Chen, Yunan; Chen, Yining; Meng, Xianbin; Zhang, Xinxiang; Jiang, Peng published the artcile< Fumarate suppresses B-cell activation and function through direct inactivation of LYN>, Computed Properties of 112-63-0, the main research area is B cell activation LYN fumarate TCA cycle.

Activated B cells increase central carbon metabolism to fulfill their bioenergetic demands, yet the mechanistic basis for this, as well as metabolic regulation in B cells, remains largely unknown. Here, we demonstrate that B-cell activation reprograms the tricarboxylic acid cycle and boosts the expression of fumarate hydratase (FH), leading to decreased cellular fumarate abundance. Fumarate accumulation by FH inhibition or dimethyl-fumarate treatment suppresses B-cell activation, proliferation and antibody production Mechanistically, fumarate is a covalent inhibitor of tyrosine kinase LYN, a key component of the BCR signaling pathway. Fumarate can directly succinate LYN at C381 and abrogate LYN activity, resulting in a block to B-cell activation and function in vitro and in vivo. Therefore, our findings uncover a previously unappreciated metabolic regulation of B cells, and reveal LYN is a natural sensor of fumarate, connecting cellular metabolism to B-cell antigen receptor signaling.

Nature Chemical Biology published new progress about Animal gene, lyn Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Cheng; He, Hui; Li, Qunyang; Liang, Xutong published the artcile< Synthesis and characterization of flame-retardant polyurethane based on new chain extenders>, Quality Control of 112-63-0, the main research area is waterborne polyurethane flame retardancy adhesive property.

A series of novel flame-retardant waterborne polyurethanes (FWPU) were synthesized with tris(hydroxymethyl)phosphine (THPO) obtained from the reaction of tetrakis(hydroxymethyl)phosphonium sulfate and bis(2-hydroxyethyl)terephthalate from the alcoholysis of waste poly(ethylene terephthalate) as flame-retardant chain extenders. Influences of THPO on flame retardancy and bonding properties of FWPU were investigated using limiting oxygen index (LOI) measurement, vertical burning test, cone calorimeter test (CCT), thermogravimetric anal. and shear tensile test. The results of LOI, vertical burning test and CCT indicated that flame retardancy of FWPU was improved with the introduction of THPO. The peak of heat release rate of FWPU with 1.5 wt% THPO was 401 kW m-2. After hard segment flame-retardant modification, the initial bonding strength of FWPU adhesive increased by 150%, and the final bonding strength decreased slightly. A new way is provided for the design of novel reactive FWPU which maintained better flame retardancy and adhesive properties after hard segment flame-retardant modification.

Polymer International published new progress about Adhesives. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chang, Tao; Jing, Huanwang; Jin, Lili; Qiu, Wenyuan published the artcile< Quaternary onium tribromide catalyzed cyclic carbonate synthesis from carbon dioxide and epoxides>, HPLC of Formula: 112-63-0, the main research area is quaternary onium tribromide salen cobalt phenyltrimethylammonium tribromide coupling catalyst; cyclic carbonate preparation epoxide carbon dioxide coupling mild condition.

Efficient organic catalysts of quaternary onium tribromide and metal-containing catalysts of SalenCoX/PTAT [phenyltrimethylammonium tribromide] were prepared and used to catalyze the coupling reaction of carbon dioxide and epoxides, to obtain cyclic carbonates including chiral propylene carbonate under extremely mild conditions.

Journal of Molecular Catalysis A: Chemical published new progress about Coupling reaction catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wood, David K.; Weingeist, David M.; Bhatia, Sangeeta N.; Engelward, Bevin P. published the artcile< Single cell trapping and DNA damage analysis using microwell arrays>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is single cell trapping DNA damage microwell array.

With a direct link to cancer, aging, and heritable diseases as well as a critical role in cancer treatment, the importance of DNA damage is well-established. The intense interest in DNA damage in applications ranging from epidemiol. to drug development drives an urgent need for robust, high throughput, and inexpensive tools for objective, quant. DNA damage anal. We have developed a simple method for high throughput DNA damage measurements that provides information on multiple lesions and pathways. Our method utilizes single cells captured by gravity into a microwell array with DNA damage revealed morphol. by gel electrophoresis. Spatial encoding enables simultaneous assays of multiple exptl. conditions performed in parallel with fully automated anal. This method also enables novel functionalities, including multiplexed labeling for parallel single cell assays, as well as DNA damage measurement in cell aggregates. We have also developed 24- and 96-well versions, which are applicable to high throughput screening. Using this platform, we have quantified DNA repair capacities of individuals with different genetic backgrounds, and compared the efficacy of potential cancer chemotherapeutics as inhibitors of a critical DNA repair enzyme, human AP endonuclease. This platform enables high throughput assessment of multiple DNA repair pathways and subpathways in parallel, thus enabling new strategies for drug discovery, genotoxicity testing, and environmental health.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Computer program (comet anal. pipeline). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Futagawa, Tohru; Nishiyama, Norio; Tai, Akira; Okuyama, Tadashi; Sugimura, Takashi published the artcile< Preparation of gem-dimethylcyclopropane-fused compounds through sigmatropic rearrangements. On/off-switching of the tautomerization of 3,4-homotropylidene by steric hindrance>, Related Products of 112-63-0, the main research area is gem dimethylcyclopropane fused sigmatropic rearrangement switching tautomerization homotropylidene; steric hindrance valence tautomerization.

Cyclopropanation of 4,8,8-trimethylcycloheptatriene having an ether function at the 3-position by unsubstituted carbenoid addition resulted in a complex mixture mainly due to quick valence tautomerization of the produced 3,4-homotropylidene analog during the reaction. Dihalocarbene addition to the same substrate proceeded exclusively at the 3,4-position to give an adduct, where the tautomerization process was interrupted by steric hindrance caused by the halogen substituents. Removal of the halogen atoms by reduction promotes the tautomerization to give a gem-dimethylcyclopropane-fused product. Stereospecificity of the tautomerization was also demonstrated by obtaining the product in an optically pure state.

Tetrahedron published new progress about AM1 (molecular orbital method). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mullah, Nasreen N.; Sopchik, Alan E.; Bentrude, Wesley G. published the artcile< Effect on chair-chair equilibrium of 3-substituted-1,3,2-oxazaphosphorinanes of replacement of Me2N substituent on phosphorus by isoPr2N>, Application of C19H34O2, the main research area is substituent effect conformation dioxaphosphorinane; NMR substituent effect conformation dioxaphosphorinane.

The chair-chair conformational equilibrium (A (I) ⇌ B (II)) (R = Ph, Me, isoPr; R1 = H, Me) of 1,3,2-dioxaphosphorinanes featuring three-coordinated P substituted with an isoPr2N group (1-6) were studied by 1H NMR spectroscopy. Compared to the analogous series with an Me2N group on P, 1-6 populate the chair conformation B with R2N equatorial to a greater extent. This is interpreted to mean that conformer A is more destabilized by a greater steric size of isoPr2N than is conformer B. Thus, the repulsive interactions between equatorial Me2N and the substituent on N3, believed to be responsible for depopulation of B that result in an unexpectedly high population of A with Me2N on P, is overcome by destabilization of A by the axial isoPr2N. The apparent size effect of substituents on N3 in destabilization of B follows the order Ph > isoPr > Me, as observed earlier for the series with Me2N group on P.

Heteroatom Chemistry published new progress about Conformation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Temburnikar, Kartik W.; Ross, Christina R.; Wilson, Gerald M.; Balzarini, Jan; Cawrse, Brian M.; Seley-Radtke, Katherine L. published the artcile< Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is halogenated pyrrolo pyrimidine derivative preparation antitumor cancer; Apoptosis; Cell cycle arrest; Cytostatic; Heterocyclic chemistry; Thieno[3,2-d]pyrimidine.

In vitro evaluation of the halogenated pyrrolo[3,2-d]pyrimidines identified antiproliferative activities in compounds 1 and 2 against four different cancer cell lines. Upon screening of a series of pyrrolo[3,2-d]pyrimidines, the 2,4-Cl compound 1 was found to exhibit antiproliferative activity at low micromolar concentrations Introduction of iodine at C7 resulted in significant enhancement of potency by reducing the IC50 into sub-micromolar levels, thereby suggesting the importance of a halogen at C7. This finding was further supported by an increased antiproliferative effect for 4 as compared to 3. Cell-cycle and apoptosis studies conducted on the two potent compounds 1 and 2 showed differences in their cytotoxic mechanisms in triple neg. breast cancer MDA-MB-231 cells, wherein compound 1 induced cells to accumulate at the G2/M stage with little evidence of apoptotic death. In contrast, compound 2 robustly induced apoptosis with concomitant G2/M cell cycle arrest in this cell model.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crich, David; Fortt, Simon M. published the artcile< Studies on 6,7-unsaturated carbonyl radical cyclizations>, Category: esters-buliding-blocks, the main research area is selenol ester radical cyclization regiochem; ring closure radical unsaturated silenol ester; carbonyl radical unsaturated ring closure; cyclohexanone; cycloheptanone; alkyloxy selenol ester radical cyclization.

6,7-Unsaturated carbonyl radicals, generated by the action of Bu3SnH on the corresponding selenol esters, cyclize to give either cyclohexanones or cycloheptanones, depending on the nature and position of the substituents in the hydrocarbon chain. Thus, cyclization of PhSeCOCH2CHRCH2CHR1CH:CH2 (I, R = H, R1 = OEt) with Bu3SnH gave 27% cycloheptanone II, while I (R = OSiPh2CMe3, R1 = H) gave 57% cyclohexanone III and 17% cycloheptanone II. In all cases, uncyclized aldehydes were isolated as byproducts. Allyloxy selenol esters cyclized similarly to give oxacyclohexanones and oxacyclaheptanones.

Tetrahedron Letters published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pazy, Yael; Kulik, Tikva; Bayer, Edward A.; Wilchek, Meir; Livnah, Oded published the artcile< Ligand exchange between proteins: exchange of biotin and biotin derivatives between avidin and streptavidin>, HPLC of Formula: 112-63-0, the main research area is ligand exchange protein biotin derivative avidin streptavidin.

We have studied the structural elements that affect ligand exchange between the two high affinity biotin-binding proteins, egg white avidin and its bacterial analog, streptavidin. For this purpose, we have developed a simple assay based on the antipodal behavior of the two proteins toward hydrolysis of biotinyl p-nitrophenyl ester (BNP). The assay provided the exptl. basis for these studies. It was found that biotin migrates unidirectionally from streptavidin to avidin. Conversely, the biotin derivative, BNP, is transferred in the opposite direction, from avidin to streptavidin. A previous crystallog. study provided insight into a plausible explanation for these results. These data revealed that the non-hydrolyzable BNP analog, biotinyl p-nitroanilide, was almost completely sheltered in streptavidin as opposed to avidin in which the disordered conformation of a critical loop resulted in the loss of several hydrogen bonds and concomitant exposure of the analog to the solvent. In order to determine the minimal modification of the biotin mol. required to cause the disordered loop conformation, the structures of avidin and streptavidin were determined with norbiotin, homobiotin, and a common long-chain biotin derivative, biotinyl ε-aminocaproic acid. Six new crystal structures of the avidin and streptavidin complexes with the latter biotin analogs and derivatives were thus elucidated. It was found that extending the biotin side chain by a single CH2 group (i.e. homobiotin) is sufficient to result in this remarkable conformational change in the loop of avidin. These results bear significant biotechnol. importance, suggesting that complexes containing biotinylated probes with streptavidin would be more stable than those with avidin. These findings should be heeded when developing new drugs based on lead compounds because it is difficult to predict the structural and conformational consequences on the resultant protein-ligand interactions.

Journal of Biological Chemistry published new progress about Avidins Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Na; Yang, Hong; Liu, Ke; Zhou, Liwei; Huang, Yuting; Cao, Danyan; Li, Yanlian; Sun, Yaoliang; Yu, Aisong; Du, Zhiyan; Yu, Feng; Zhang, Ying; Wang, Bingyang; Geng, Meiyu; Li, Jian; Xiong, Bing; Xu, Shilin; Huang, Xun; Liu, Tongchao published the artcile< Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors>, Formula: C19H34O2, the main research area is imidazole preparation SAR antitumor activity inhibitor.

A series of NSD2-PWWP1 inhibitors I (R = 4-cyanophenyl, 4-cyanonaphthalen-1-yl, 8-cyanoquinolin-5-yl, etc.; R1 = H, OMe, F, Cl, CF3; R2 = H, Me, OMe; R3 = aminomethyl, CHO, 4-aminopiperidin-1-yl, etc.), and further structure-based optimization resulted in a potent inhibitor compound I (R = 4-cyanonaphthalen-1-yl; R1 = R2 = Me; R3 = 4-aminopiperidin-1-yl) (II), that has high selectivity toward the NSD2-PWWP1 domain were reported. The detailed biol. evaluation revealed that compound II can bind to NSD2-PWWP1 and then affect the expression of genes regulated by NSD2. The current discovery will provide a useful chem. probe to the future research in understanding the specific regulation mode of NSD2 by PWWP1 recognition and pave the way to develop potential drugs targeting NSD2 protein.

Journal of Medicinal Chemistry published new progress about Amines Role: PAC (Pharmacological Activity), PKT (Pharmacokinetics), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics