Category: 112-63-0

DerSarkissian, Maral; Bhak, Rachel H.; Oglesby, Alan; Priest, Julie; Gao, Emily; Macheca, Monica; Sharperson, Camara; Duh, Mei Sheng published the artcile< Retrospective analysis of comorbidities and treatment burden among patients with HIV infection in a US Medicaid population>, Formula: C19H34O2, the main research area is HIV infection cardiovascular disease hypertension asthma comorbidity antiretroviral therapy; Antiretroviral therapy; HIV burden; comorbidity; concomitant medication; pill burden.

Comorbidities and comedications are important factors influencing optimal therapy because people are living longer with HIV infection. This study describes the long-term comorbidity profile and treatment burden among people with HIV-1 infection. This retrospective study included Medicaid claims data from patients with ≥1 antiretroviral (ARV) claim between 2016 and 2017 (most recent claim defined the index date), ≥1 HIV diagnosis within 1 yr before index, age ≥18 years at first HIV diagnosis and <65 years at index, ≥12 mo of continuous eligibility before index, and no history of HIV-2 infection. Comorbidities, concomitant medication use, and pill burden were assessed in the 4 years before index. Analyses were stratified by patient age and treatment experience. Among 3456 patients, the mean (standard deviation [SD]) age was 47.1 (10.4) years; the majority were black (55%) and men (63%). In general, the prevalence of comorbidities increased from the fourth year to the first year before index and included cardiovascular disease (28-40%), hypertension (24-37%), hyperlipidemia (12-17%), and asthma/chronic obstructive pulmonary disease (13-19%). Concomitant medication use corresponding to these comorbidities slightly increased over time. In the year before index, mean (SD) daily pill burden was 2.1 (1.4) for ARVs and 5.9 (5.9) for non-ARVs. Older age and prior treatment experience were associated with higher rates of comorbidities and greater pill burden. In people with HIV infection, comorbidities and concomitant medication use increased with age, supporting considerations for streamlined ARV regimens highlighted in treatment guidelines. Current Medical Research and Opinion published new progress about Aging, animal. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Branco, Luis C.; Serbanovic, Ana; Nunes da Ponte, Manuel; Afonso, Carlos A. M. published the artcile< Clean osmium-catalyzed asymmetric dihydroxylation of olefins in ionic liquids and supercritical CO2 product recovery>, Application In Synthesis of 112-63-0, the main research area is asym dihydroxylation olefin ionic liquid osmium catalyst.

The combination of ionic liquids (ILs) as solvents in the asym. Sharpless dihydroxylation (AD) with the use of scCO2 in the separation process allows a simple, efficient, clean and robust system for the reuse of the AD catalytic system, which also does not need the use of organic solvents either for the reaction or for the separation of products and allows the isolation of the diol, in high yield and enantiomeric excess and basically without contamination with osmium. The AD reaction was performed with the substrates 1-hexene and styrene, using the catalytic system consisting of (DHQD)2PHAL (1.0 mol% ) and K2OsO2(OH)4 (0.5 mol% ) and the co-oxidants K3Fe(CN)6 and N-methylmorpholine oxide (NMO). Under these conditions, a range of ILs based on the methylimidazolium (mim), dimethylimidazolium (bdmim) and tetraalkyldimethylguanidinium (dmg) cations were screened.

Chemical Communications (Cambridge, United Kingdom) published new progress about Dihydroxylation catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Bin; Meng, Xiang; Ma, Yanfang; Li, Huizhen; Liu, Yuqi; Shi, Nannan; Chen, Yaolong; Wang, Yanping; Lu, Cheng published the artcile< Clinical safety of total glucosides of paeony adjuvant therapy for rheumatoid arthritis treatment: a systematic review and meta-analysis>, Electric Literature of 112-63-0, the main research area is meta analysis methotrexate antiinflammatory rheumatoid arthritis; Adjuvant therapy; Clinical safety; Meta-analysis; Rheumatoid arthritis; Systematic review; Total glucosides of paeony.

Total glucosides of paeony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pallas, has been increasingly used as the adjunctive therapy for rheumatoid arthritis (RA) patients. Though TGP could mitigate the unanticipated adverse effects during the conventional treatment of RA, high-quality evidence-based meta-anal. data on this subject are still insufficient. The objective of this study is to evaluate the clin. safety of TGP adjuvant therapy in the RA treatment. PubMed, EMBASE, Web of Science, China Network Knowledge Infrastructure (CNKI), SinoMed and WanFang Data were retrieved for randomized controlled trials (RCTs) and cohort study about TGP adjuvant therapy in patients with RA up to 28 Jan. 2021. Literatures with eligibility criteria and information were screened and extracted by two researchers independently. The RevMan5.3 software was used for data anal. with effect estimates as risk ratio (RR) with 95% confidence interval (CI). A total of 39 studies involving 3680 RA participants were included. There were 8 comparisons: TGP plus methotrexate (MTX) therapy vs. MTX therapy, TGP plus leflunomide (LEF) therapy vs. LEF therapy, TGP plus MTX and LEF therapy vs. MTX plus LEF therapy, TGP plus tripterygium glycosides (TG) therapy vs. TG therapy, TGP plus meloxicam (MLX) therapy vs. MLX therapy and TGP plus sulfasalazine (SSZ) therapy vs. SSZ therapy, TGP plus iguratimod (IGU) therapy vs. IGU therapy, TGP plus prednisone acetate tablets (PAT) therapy vs. PAT therapy. The meta-anal. results showed that the occurrence of hepatic adverse effect (RR = 0.31, 95% CI = 0.23-0.41, P < 0.00001) and leukopenia (RR = 0.41, 95% CI = 0.26-0.66, P = 0.0002) in TGP adjuvant therapy was significant decreased compared with non-TGP therapy. However, only TGP plus LEF therapy (RR = 0.22, 95% CI = 0.08-0.60, P = 0.003) and TGP plus MTX and LEF therapy (RR = 0.31, 95% CI = 0.22-0.42, P < 0.00001) had statistical difference in the subgroups of hepatic adverse effect. In leukopenia, TGP plus MTX and LEF therapy (RR = 0.47, 95% CI = 0.25-0.87, P = 0.02) had statistical difference. This meta-anal. indicated that TGP adjuvant therapy might alleviate the incidence of hepatic adverse effect and leukopenia for the RA treatment compared to non-TGP therapy. The clin. safety of TGP adjuvant therapy warrant further investigation in exptl. studies. BMC Complementary Medicine and Therapies published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shuai, Shu-Yuan; Liu, Shan-Shan; Liu, Xiao-Jin; Zhang, Guo-Song; Zheng, Qin; Yue, Peng-Fei; Yang, Ming; Hu, Peng-Yi published the artcile< Essential oil of Ligusticum chuanxiong Hort. Regulated P-gp protein and tight junction protein to change pharmacokinetic parameters of temozolomide in blood, brain and tumor.>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Essential oil of Ligusticum chuanxiong Hort.; Glioma; P-gp; Pharmacokinetics; Temozolomide; Tight junction.

ETHNOPHARMACOLOGICAL RELEVANCE: The existence of the blood-brain barrier/blood tumor barrier (BBB/BTB) severely restricts the effectiveness of anti-tumor drugs, thus glioma is still an incurable disease with a high fatality rate. Chuanxiong (Ligusticum chuanxiong Hort., Umbelliferae) was used as a messenger drug to increase the distribution of drugs in brain tissue, and its application in Chinese herbal formula for treating glioma was also the highest. AIM OF THE STUDY: Our previous researches showed that essential oil (EO) of chuanxiong could promote temozolomide (TMZ) entry into glioma cells in vitro and enhance TMZ-induced anticancer efficiency in vivo, and therefore, the aim of this study was to investigate whether EO could increase the concentration accumulation of TMZ in brain or tumor of C6 glioma rats and the related mechanisms. MATERIALS AND METHODS: The pharmacokinetics were conducted in C6 glioma rats by administering either TMZ alone or combined with EO through oral routes. TMZ concentration in blood, brain and tumor was detected using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) and then pharmacokinetic parameters were calculated. The changed expressions of P-gp protein, tight junction occludin, claudin-5 and zonula occludens-1 (ZO-1) in brain of glioma rats were studied by Western blot to clarify the mechanism. Finally, the chemical composition of EO was analyzed by gas chromatography-massspectrometry (GC-MS). RESULTS: The results showed that EO significantly affected the pharmacokinetic parameters such as Tmax, Cmax and CL (p < 0.01), but did not significantly change the AUC(0→∞) of TMZ in blood (p > 0.05). However, EO markedly improved the AUC(0→∞)of TMZ in brain and tumor (p < 0.01). The calculate drug targeting index was greater than 1, indicating that EO could promote the distribution of TMZ to the brain and tumor. Western blot analysis showed that EO significantly inhibited the expression of P-gp, tight junction protein claudin-5, occludin and ZO-1. And meanwhile, the expressions of P-gp, claudin-5 and occludin also markedly down-regulated in EO-TMZ co-administration treatment. GC-MS analysis of the TIC component of EO was (E)-Ligustilide (36.93%), Terpinolene (7.245%), gamma-terpinene (7.225%) etc. CONCLUSION: EO could promote the distribution of TMZ in the brain and tumor of C6 glioma rats, which may attribute to down-regulate the expression of P-gp, claudin-5 and occludin. Journal of ethnopharmacology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bruvers, Z.; Zuika, I. published the artcile< SCF MO calculations of quinoline and its derivatives. 3. Energy of protonation and basic properties>, Computed Properties of 112-63-0, the main research area is protonation quinoline substituent effect MO; electron configuration quinoline derivative; bond energy protonated quinoline derivative.

The protonation energy (E), N charge, N-H bond energy, and pKNH+ were calculated for quinoline and its NH2, MeO, MeS, and other derivatives by the CNDO/2 method. In quinolines substituted at the 3-, 4-, 5-, 6-, and 7-positions, E and pKNH+ were determined mainly by the interaction of the substituent with the heterocyclic system. 2-Substituted quinolines exhibited steric effects, and 8-substituted quinolines showed H-bonding effects.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about Basicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Karunakaran, K.; Elango, K. P. published the artcile< Kinetics and mechanism of oxidation of (arylthio)acetic acids by pyridinium hydrobromide perbromide>, Synthetic Route of 112-63-0, the main research area is kinetics pyridinium hydrobromide perbromide arylthioacetic acid; oxidation pyridinium hydrobromide perbromide arylthioacetic acid; mechanism pyridinium hydrobromide perbromide arylthioacetic acid.

Oxidation of several monosubstituted (phenylthio)acetic acids (PTAA) by pyridinium hydrobromide perbromide (PHPB) was studied in aqueous acetic acid. The reaction is first order with respect to PHPB. Michaelis-Menten type kinetics are observed with respect to (arylthio)acetic acid. The effect of solvent composition indicates that the transition state is more polar than the reactants. The formation constants of the intermediate substrate-PHPB complexes and the rates of their decomposition were determined at different temperatures The rates of oxidation of para and meta-substituted (phenylthio)acetic acids were correlated with Hammett’s substituent constants The p value is -1:60 at 35°C. The rates of oxidation of ortho substituted compounds are correlated with Charton’s triparametric equation. A mechanism involving the decomposition of the intermediate complex in the slow rate-determining step affording a sulfonium ion which hydrolyses in a subsequent fast step to the sulfoxide is proposed.

Journal of Physical Organic Chemistry published new progress about Formation constant. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beltzig, Lea; Christmann, Markus; Kaina, Bernd published the artcile< Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics>, Application In Synthesis of 112-63-0, the main research area is apoptosis; artesunate; cell death; cellular senescence; chloroquine; curcumin; fisetin; glioma; senolytics; temozolomide.

A first-line therapeutic for high-grade glioma, notably glioblastoma (GBM), is the DNA methylating drug temozolomide (TMZ). Previously, we showed that TMZ induces not only apoptosis and autophagy, but also cellular senescence (CSEN). We presented the hypothesis that GBM cells may escape from CSEN, giving rise to recurrent tumors. Furthermore, the inflammatory phenotype associated with CSEN may attenuate chemotherapy and drive tumor progression. Therefore, treatments that specifically target senescent cells, i.e., senolytic drugs, may lead to a better outcome of GBM therapy by preventing recurrences and tumor inflammation. Here, we tested Bcl-2 targeting drugs including ABT-737, ABT-263 (navitoclax), several natural substances such as artesunate, fisetin and curcumin as well as lomustine (CCNU) and ionizing radiation (IR) for their senolytic capacity in GBM cells. Addnl., several proteins involved in the DNA damage response (DDR), ATM, ATR, Chk1/2, p53, p21, NF-kB, Rad51, PARP, IAPs and autophagy, a pathway involved in CSEN induction, were tested for their impact in maintaining CSEN. Treatment of GBM cells with a low dose of TMZ for 8-10 days resulted in >80% CSEN, confirming CSEN to be the major trait induced by TMZ. To identify senolytics, we treated the senescent population with the compounds of interest and found that ABT-737, navitoclax, chloroquine, ATMi, ATRi, BV-6, PX-866 and the natural compounds fisetin and artesunate exhibit senolytic activity, inducing death in senescent cells more efficiently than in proliferating cells. Curcumin showed the opposite effect. No specific effect on CSEN cells was observed by inhibition of Chk1/Chk2, p21, NF-kB, Rad51 and PARP. We conclude that these factors neither play a critical role in maintaining TMZ-induced CSEN nor can their inhibitors be considered as senolytics. Since IR and CCNU did not exhibit senolytic activity, radio- and chemotherapy with alkylating drugs is not designed to eliminate TMZ-induced senescent cancer cells.

Cells published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kolekar, Yuvraj A.; Bhanage, Bhalchandra M. published the artcile< Pd-Catalyzed Oxidative Aminocarbonylation of Arylboronic Acids with Unreactive Tertiary Amines via C-N Bond Activation>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is amine tertiary arylboronic acid palladium catalyst aminocarbonylation bond activation; tertiary amide preparation.

An efficient synthesis of tertiary amides from aryl boronic acids and inert tertiary amines through the oxidative carbonylation via C(sp3)-N bond activation is presented. This protocol significantly restricts the homocoupling biarylketone product. It involves the use of a homogeneous PdCl2/CuI catalyst and a heterogeneous Pd/C based catalyst, which promotes C(sp3)-N bond activation of tertiary amines with aryl boronic acids. This process represents a ligand-free, base-free, and recyclable catalyst along with an ideal oxidant like mol. oxygen.

Journal of Organic Chemistry published new progress about Amides, tertiary Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hatami, Behnam; Ebrahimi, Aliasghar; Ehrampoush, Mohammad Hassan; Salmani, Mohammad Hossein; Dalvand, Arash; Pirmoradi, Neda; Angelidaki, Irini; Fotidis, Ioannis A.; Mokhtari, Mehdi published the artcile< Recovery of intermittent cycle extended aeration system sludge through conversion into biodiesel by in-situ transesterification>, COA of Formula: C19H34O2, the main research area is fatty acid methyl ester sludge transesterification biodiesel synthesis.

The feasibility of using intermittent cycle extended aeration system (ICEAS) sludge as a lipid feedstock for biodiesel production was investigated. The main effects of in situ transesterification parameters, reaction temperature (30-70°C), reaction time (4-24 h), catalyst concentration (1-5% volume/volume), and proportion of methanol to dry sludge (5-25 mL/g) at five-levels as well as their simultaneous interactions were evaluated to develop an empirical model. Optimized conditions were obtained at 60°C, 4.65% (volume/volume) H2SO4, 17.84 h reaction time, and 5:1 methanol to dry sludge proportion (ml/g), leading to a maximum of 18.58% (weight/weight) biodiesel yield with 94.23% fatty acid Me ester content. This result was higher in comparison with yields derived from conventional activated sludge, membrane bioreactor and anaerobic-anoxic-oxic processes. The ICEAS technol. advantages are owned to its different configurations leading to production of one blended sludge, shorter hydraulic retention time and higher COD to nitrogen ratios. The predominance of fatty acid Me esters such as palmitic, oleic, palmitoleic, stearic, linoleic and myristic acid Me ester, in the obtained biodiesel, indicated suitability of ICEAS sludge as feedstock for biodiesel production

Renewable Energy published new progress about Aeration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Xiao-Jing; Abdiaj, Irini; Sambiagio, Carlo; Li, Chenfei; Zysman-Colman, Eli; Alcazar, Jesus; Noel, Timothy published the artcile< Visible-Light-Promoted Iron-Catalyzed C(sp2)-C(sp3) Kumada Cross-Coupling in Flow>, Product Details of C19H34O2, the main research area is Kumada cross coupling aryl chloride Grignard reagent iron catalyst; visible light Kumada cross coupling iron catalyst mechanism flow; Kumada coupling; cross-coupling; flow chemistry; iron catalysis; photocatalysis.

A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada-Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes’ residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application. The mechanism was studied using radical clock experiments, kinetic measurements, DFT and other techniques.

Angewandte Chemie, International Edition published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics