Category: 112-63-0

Vannoni, Lorenzo; Pizzimenti, Silvia; Caroti, Giulia; La Nasa, Jacopo; Duce, Celia; Bonaduce, Ilaria published the artcile< Disclosing the chemistry of oil curing by mass spectrometry using methyl linoleate as a model binder>, Quality Control of 112-63-0, the main research area is mass spectrometry methyl linoleate model binder oil curing.

The structure of the polymeric fraction in an oil painting is believed to be strongly connected to the stability of the paint layers over time, but its mol. characterization is extremely difficult given the complex composition of a vegetable oil-based polymer. In this study we report the implementation of a methodol. approach for the systematic mass spectrometric investigation of the mol. features of the products of oxidative degradation and crosslinking of oil paint layers upon curing. The approach is based on the use of Me linoleate as a simplified model of an oil paint binder. Gas-chromatog. coupled with mass spectrometry, solid phase microextraction gas chromatog. mass spectrometry, flow injection electrospray mass spectrometry and evolved gas anal. mass spectrometry, are used to analyze the evolution of compounds produced over seven months of natural ageing, from the volatile products to the macromol. and cross-linked fractions. The aim is to improve our fundamental mol. understanding of the curing process of oil paints, and to investigate the balance between oxidative degradation and crosslinking when specific binder-pigment combinations are in place. Model paint layers were prepared using lead white and ultramarine blue as pigments. These two pigments are known to produce paint layers with different stability over time. The use of Me linoleate as model oil binder greatly simplifies the mass spectral features of the lipid paint fraction, enabling the detection of products of oxidation and crosslinking with a new high level of mol. detail. Data clearly show that crucial differences between paints containing the two pigments establish with time, which are mostly related to the cross-linked fraction.

Microchemical Journal published new progress about Chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Correia, Jose Tiago M.; Acconcia, Lais V.; Coelho, Fernando published the artcile< Studies on Pumiliotoxin A Alkaloids: An Approach to Preparing the Indolizidinic Core by Intramolecular Diastereoselective N-Heterocyclic Carbene Catalyzed Benzoin Reaction>, Quality Control of 112-63-0, the main research area is pumiliotoxin A indolizidinic core preparation intramol diastereoselective benzoin; diastereoselective heterocyclic carbene catalyst benzoin reaction.

In this article, we describe the development of a convergent organocatalytic strategy to prepare the indolizidinic core I of the pumiliotoxin A alkaloid family. The key step of the proposed strategy is based on a diastereoselective N-heterocyclic carbene catalyzed benzoin reaction, in which the Breslow intermediate generated from an enal moiety in dicarbonyl compound II (umpolung a1 to d1 – acyl anion equivalent) attacks a ketone moiety intramolecularly to provide the indolizidinone core in good yield with good selectivity.

European Journal of Organic Chemistry published new progress about Benzoin condensation reaction (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Simsek, Rahime; Linden, Anthony; Safak, Cihat published the artcile< (±)-9-(2-Bromophenyl)-7,7-dimethyl-1,3,4,5,6,7,8,9-octahydrofuro[3,4-b]quinoline-1,8-dione>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is mol structure bromophenyl methyl furoquinolinedione.

The title compound, C19H18BrNO3, has potential Ca modulatory properties. Crystallog. data are given. The 1,4-dihydropyridine ring has a very shallow boat conformation and is one of the most planar examples of this moiety. The 2-bromophenyl substituent is in the axial synperiplanar orientation. The quinoline ring has a half-chair conformation, with the unusual arrangement of the out-of-plane atom being on the opposite side of the ring plane to the bromophenyl substituent. The mols. are linked into chains by intermol. H bonds.

Acta Crystallographica, Section C: Crystal Structure Communications published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lahner, Harald; Mathew, Annie; Klocker, Anna Lisa; Unger, Nicole; Theysohn, Jens; Rekowski, Jan; Joeckel, Karl-Heinz; Theurer, Sarah; Schmid, Kurt Werner; Herrmann, Ken; Fuehrer, Dagmar published the artcile< Streptozocin/5-fluorouracil chemotherapy of pancreatic neuroendocrine tumours in the era of targeted therapy>, Related Products of 112-63-0, the main research area is pancreatic neuroendocrine tumor streptozocin fluorouracil chemotherapy; 5-fluorouracil; Objective response; Pancreatic neuroendocrine tumor; Streptozocin; Survival.

The role of streptozocin-based chemotherapy (STZ CTx) in advanced, well-differentiated pancreatic neuroendocrine tumors (PanNET) and the best sequence of treatments in advanced PanNET are unclear. We examined the outcomes after STZ CTx in patients who had been selected according to the current therapeutic guidelines. Data from 50 PanNET patients consecutively treated with STZ CTx between 2010 and 2018 were analyzed. The endpoints of the study were the objective-response rate (ORR), progression-free survival (PFS), and overall survival (OS). STZ CTx was the first-line treatment in 54% of patients. The PanNET grades were as follows: 6% G1, 88% G2, and 6% well-differentiated G3. The ORR was 38%. Stable disease was the best response in 38% of patients and 24% showed progressive disease. Treatment was discontinued because of toxicity in one patient. Median PFS and OS were 12 (95% confidence interval (CI), 8.5-15.5) and 38 mo (95% CI, 20.4-55.6), resp. In the Kaplan-Meier anal., the median OS was 89 mo (95% CI, 34.9-143.1) for STZ CTx as first-line therapy compared with 22 mo (95% CI, 19.3-24.7; p = 0.001, log-rank test) for subsequent lines. Bone metastases neg. impacted survival (HR, 2.71, p = 0.009, univariate anal., HR, 2.64, p = 0.015, multivariate anal., and Cox regression). In patients selected according to current guidelines, PFS, and OS after STZ CTx were lower than previously reported, whereas ORR was unchanged. First-line treatment was pos. associated with OS and the presence of bone metastases was neg. associated with OS. Pre-treatment with targeted or peptide-receptor radionuclide therapy did not alter ORR, PFS, or OS.

Endocrine published new progress about Anemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kondo, Hiroki; Uno, Shingo; Moriuchi, Fumio; Sunamoto, Junzo; Ogushi, Susumu; Tsuru, Daisuke published the artcile< Synthesis and enzymatic carboxylation of a biotin-containing peptide representing the coenzyme binding site of E. coli acetyl-CoA carboxylase>, Electric Literature of 112-63-0, the main research area is acetyl CoA carboxylase biotin binding site; peptide biotin acetyl CoA carboxylase.

A biotin-containing pentapeptide, Boc-Glu-Ala-Met-Bct-Met (I) (where Boc = tert-butoxycarbonyl and Bct = N’-biotinyl-L-lysine), that corresponds to the coenzyme-binding site of Escherichia coli acetyl-CoA carboxylase (II) was prepared I, as well as free biotin, served as substrate for the carboxylation reaction catalyzed by the biotin carboxylase subunit dimer of E. coli II. The Km and Vmax values for I were 18 mM and 2.8 μM min-1, resp. The corresponding values for biotin were 214 mM and 28 μM min-1. Thus, the overall reactivity (Vmax/Km) of I exceeded that of biotin by 20%.

Bulletin of the Chemical Society of Japan published new progress about Escherichia coli. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhaoqiang; Kang, Chengjun; Peh, Shing Bo; Shi, Dongchen; Yang, Fengxia; Liu, Qixing; Zhao, Dan published the artcile< Efficient Adsorption of Acetylene over CO2 in Bioinspired Covalent Organic Frameworks>, Formula: C19H34O2, the main research area is adsorption acetylene CO2 bioinspired covalent organic framework.

Rational design of covalent organic frameworks (COFs) to broaden their diversity is highly desirable but challenging due to the limited, expensive, and complex building blocks, especially compared with other easily available porous materials. In this work, we fabricated two novel bioinspired COFs, namely, NUS-71 and NUS-72, using reticular chem. with ellagic acid and triboronic acid-based building blocks. Both COFs with AB stacking mode exhibit high acetylene (C2H2) adsorption capacity and excellent separation performance for C2H2/CO2 mixtures, which is significant but rarely explored using COFs. The impressive affinities for C2H2 appear to be related to the sandwich structure formed by C2H2 and the host framework via multiple host-guest interactions. This work not only represents a new avenue for the construction of low-cost COFs but also expands the variety of the COF family using natural biochems. as building blocks for broad application.

Journal of the American Chemical Society published new progress about Adsorbents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Dan; Dai, Yitong; Chen, Xuejiao; Zhang, Xuena; Yue, Danwei; Wang, Jingying; Guo, Yongsheng published the artcile< Stability and catalytic activity of hyperbranched polyglycerol stabilized gold nanofluids>, Quality Control of 112-63-0, the main research area is polyglycerol stabilized gold nanofluid stability catalytic activity.

A gold nanofluid with good suspension stability was prepared using hyperbranched polyglycerol (HPG) as a stabilizer because of the functional hydroxyl groups at the end of every branch in its structure. The effects of reaction-medium pH and temperature on the preparation of the HPG-gold nanofluids were discussed. The influences of pH on the stability of HPG-gold nanofluids after preparation were investigated. The HPG-gold nanofluid was employed as catalyst for the reduction of 4-nitrophenol. The results showed that HPG-Au nanofluid stabilized at high pH range (pH = 10). The nanofluid exhibited high activity in the catalytic hydrogenation of 4-nitrophenol. The HPG-gold nanofluid was promising for applications of quasi-homogeneous catalysis.

Journal of Molecular Liquids published new progress about Catalysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Kyungae; Campbell, Jennifer; Swoboda, Jonathan G.; Cuny, Gregory D.; Walker, Suzanne published the artcile< Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antibacterial Staphylococcus wall teichoate biosynthesis inhibitor preparation structure activity.

A small mol. (1835F03) that inhibits Staphylococcus aureus wall teichoic acid biosynthesis, a proposed antibiotic target, has been discovered. Rapid, parallel, solution-phase synthesis was employed to generate a focused library of analogs, providing detailed information about structure-activity relationships and leading to the identification of targocil, a potent antibiotic.

Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ruan, Yonglan; Ling, Jinying; Ye, Fan; Cheng, Nuo; Wu, Fei; Tang, Zongxiang; Cheng, Xiaolan; Liu, Hongquan published the artcile< Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway>, Product Details of C19H34O2, the main research area is paeoniflorin SUCNR TRPV HIF NLRP CFA inflammatory pain signaling; Inflammatory pain; NLPR3; Paeoniflorin; SUCNR1; Succinate; TRPV1.

Treatment of chronic inflammatory pain remains a major goal in the clinic. It is thus of prime importance to characterize inherent pathophysiol. pathways to design new therapeutic strategies and analgesics for pain management. Paeoniflorin (PF), a monoterpenoid glycoside from Paeonia lactiflora Pallas plants, possesses promising anti-nociceptive property. However, therapeutic effect and underlying mechanism of action of PF on inflammatory pain have not yet been fully elucidated. In this study, we aim to investigate the analgesic effect further and clarify its mechanism of action of PF on complete freund’s adjuvant (CFA)-evoked inflammatory pain. Twenty-four male mice were divided into 3 groups: sham, CFA, and CFA + PF groups (n = 8/group). Mice were treated with normal saline or PF (30 mg/kg) for 11 days. Footpad swelling (n = 8/group), mech. (n = 8/group) and thermal hypersensitivity (n = 8/group) were measured to evaluate the analgesic effect of PF on CFA-injected mice. At the end of the animal experiment, blood and L4-L6 dorsal root ganglion neurons were collected to assess the therapeutic effect of PF on CFA-induced inflammatory pain. Next, hematoxylin and eosin, quant. realtime PCR, ELISA, capsaicin and di-Me succinate induced pain test (n = 8/group), motor coordination test (n = 8/group), tail flicking test (n = 8/group), pyruvate and succinate dehydrogenase assay (n = 6/group), immunohistochem. staining, were performed to clarify the action mechanism of PF on CFA-evoked inflammatory pain. Besides, the effect of PF on TRPV1 was evaluated by whole-cell patch clamp recording on primary neurons (n = 7). Finally, mol. docking further performed to evaluate the binding ability of PF to TRPV1. PF significantly relieved inflammatory pain (P < 0.001) and paw edema (P < 0.001) on a complete Freund adjuvant (CFA)-induced peripheral inflammatory pain model. Furthermore, PF inhibited neutrophil infiltration (P < 0.01), IL-1β increase (P< 0.01), and pain-related peptide substance P release (P < 0.001). Intriguingly, CFA-induced succinate aggregation was notably reversed by PF via modulating pyruvate and SDH activity (P < 0.01). In addition, PF dampened the high expression of subsequent succinate receptor SUCNR1 (P < 0.01), HIF-1α(P < 0.05), as well as the activation of NLRP3 inflammasome (P < 0.05) and TRPV1 (P < 0.05). More importantly, both capsaicin and di-Me succinate supplementation obviously counteracted the pain-relieving effect of PF and TRPV1 (P < 0.01 or P < 0.001). Our findings suggest that PF can significantly relieve CFA-induced paw swelling, as well as mech. and thermal hyperalgesia. PF alleviated inflammatory pain partly through inhibiting the activation of TRPV1 and succinate/SUCNR1-HIF-1α/NLRP3 pathway. Furthermore, we found that PF exerted its analgesic effect without affecting motor coordination and pain-related cold ion-channels. In summary, this study may provide valuable evidence for the potential application of PF as therapeutic strategy for inflammatory pain treatment. International Immunopharmacology published new progress about Analgesia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peng, Yiyuan; Liu, Hanliang; Tang, Min; Cai, Lisheng; Pike, Victor published the artcile< Highly efficient N-monomethylation of primary aryl amines>, Related Products of 112-63-0, the main research area is monomethylation primary aryl amine.

A highly efficient method for specific synthesis of N-monomethylarylamines is presented. Anilines were treated with acetic anhydride and triethylamine in dry CH2Cl2 to give the corresponding acetamides. The subsequent N-monomethylation of acetyl aryl amines with Me iodide and NaH in THF introduced Me group. Acid hydrolysis of the N-Me acetanilides in ethylene glycol generated the corresponding N-methyl-N-aryl amines in high yields. This method was also used to synthesize (E)-2-bromo-5-(4-methylaminostyryl)pyridine that may be useful as an amyloid imaging agent for Alzheimer’s disease.

Chinese Journal of Chemistry published new progress about Acetylation (protection of amines before methylation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics