Category: 112-63-0

Ciesluk, Mateusz; Piktel, Ewelina; Wnorowska, Urszula; Sklodowski, Karol; Kochanowicz, Jan; Kulakowska, Alina; Bucki, Robert; Pogoda, Katarzyna published the artcile< Substrate viscosity impairs temozolomide-mediated inhibition of glioblastoma cells′ growth>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Drug effectiveness; Glioblastoma; Polyacrylamide hydrogels; Rheology; Temozolomide; Viscoelasticity.

The mech. state of the extracellular environment of the brain cells considerably affects their phenotype during the development of central nervous system (CNS) pathologies, and when the cells respond to drugs. The reports on the evaluation of the viscoelastic properties of different brain tumors have shown that both tissue stiffness and viscosity can be altered during cancer development. Although a compelling number of reports established the role of substrate stiffness on the proliferation, motility, and drug sensitivity of brain cancer cells, there is a lack of parallel data in terms of alterations in substrate viscosity. Based on viscoelasticity measurements of rat brain samples using strain rheometry, polyacrylamide (PAA) hydrogels mimicking elastic and viscous parameters of the tissues were prepared Optical microscopy and flow cytometry were employed to assess the differences in glioblastoma cells morphol., proliferation, and cytotoxicity of anticancer drug temozolomide (TMZ) due to increased substrate viscosity. Our results indicate that changes in substrate viscosity affect the proliferation of untreated glioma cells to a lesser extent, but have a significant impact on the apoptosis-associated depolarization of mitochondria and level of DNA fragmentation. This suggests that viscosity sensing and stiffness sensing machinery can activate different signaling pathways in glioma cells. Collected data indicate that viscosity should be considered an important parameter in in vitro polymer-based cell culture systems used for drug screening.

Biochimica et Biophysica Acta, Molecular Basis of Disease published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xiao; Cai, Liang; Chen, Tao; Qiao, Jingyi; Zhang, Xiaosong published the artcile< Vapor-liquid equilibrium measurements and assessments of Low-GWP absorption working pairs (R32+DMETEG, R152a+DMETEG, and R161+DMETEG) for absorption refrigeration systems>, Reference of 112-63-0, the main research area is R32 R152a R161 DMETEG vapor liquid equilibrium absorption refrigeration.

This research aims to develop novel binary working pairs using low-GWP refrigerants (R32, R152a, or R161) and one chem. absorbent (DMETEG) for absorption refrigeration systems. The solubility data were determined from 293.15 to 343.15 K using a static method and were correlated with the five-parameter non-random two-liquid (NRTL) activity coefficient model with an average relative absolute error of <2.4%. All three binary mixtures exhibited neg. deviations from Raoult's law. DMETEG was further assessed with other organic solvents that were previously measured to verify its highest affinity with HFCs. Based on the obtained VLE data, the thermodn. performances in both the single-stage absorption refrigeration system (ARS) and the absorption-compression hybrid refrigeration system (ACHRS) were assessed. R161 yielded the highest cooling COP of 0.519-0.555 when the generation temperature was above 135°C, followed by the R152a at 0.231-0.518 when below 135°C. Different from the trends of COP variations, R152a had the highest ECOP of 0.091-0.158 when the generation temperature was below 135°C while R161 showed the highest ECOP of 0.116-0.137 over 135°C. ACHRS can effectively enhance the cooling performances of ARS via compression and its compression ratios got optimized. Overall, the R161 + DMETEG showed the best potential as the working pair. Energy (Oxford, United Kingdom) published new progress about Absorptive refrigeration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Planas, Oriol; Wang, Feng; Leutzsch, Markus; Cornella, Josep published the artcile< Fluorination of arylboronic esters enabled by bismuth redox catalysis>, Product Details of C19H34O2, the main research area is bismuth triarylbismuth oxidative addition reductive elimination fluorination catalyst; organoboron compound arylboronic acid fluorination substitution triarylbismuth complex catalyst; crystal structure triarylbismuth sulfinimide complex difluoride.

Triarylbismuth complexes undergo oxidative addition to yield difluorobismuth(V) derivatives, which, upon the reductive elimination provide a valuable route for catalytic fluorination of organoboron compounds Bismuth catalysis has traditionally relied on the Lewis acidic properties of the element in a fixed oxidation state. In this paper, we report a series of bismuth complexes that can undergo oxidative addition, reductive elimination, and transmetalation in a manner akin to transition metals. Rational ligand optimization featuring a sulfoximine moiety produced an active catalyst for the fluorination of aryl boronic esters through a bismuth (III)/bismuth (V) redox cycle. Crystallog. characterization of the different bismuth species involved, together with a mechanistic investigation of the carbon-fluorine bond-forming event, identified the crucial features that were combined to implement the full catalytic cycle.

Science (Washington, DC, United States) published new progress about Aryl fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nagatomo, Akito; Kaneko, Yoshiro published the artcile< Sol-gel preparation of amphiphilic silsesquioxane containing ether-chain and ammonium groups capable of forming reverse micelles>, COA of Formula: C19H34O2, the main research area is soluble gel preparation amphiphilic silsequioxane reverse micelle hydrophilic dye.

In this study, we prepared an amphiphilic silsesquioxane (Am-SO) capable of forming reverse micelles. The synthesis was performed by the sol-gel reaction of a mixture of triethoxysilane containing an ether-chain and 3-aminopropyltrimethoxysilane in aqueous hydrochloric acid. The gel permeation chromatog. measurement of Am-SO in chloroform eluent (<1.0 w/v%) showed a correlation between the excluded volumes (mol. weights of the peak tops; Mp's) and concentrations, i.e., higher Mp's at higher concentrations On the contrary, the Mp's of Am-SQ in chloroform were constant at concentrations above 1.0 w/v%. These results indicated that Am-SQ could form reverse micelles at a relatively high concentration in chloroform. Furthermore, dynamic fight scattering measurements of the Am-SO chloroform solutions having various concentrations were performed. The average particle size (diameter) of the 0.5 w/v% Am-SQ solution was assessed to be 0.86 ± 0.13 nm, whereas those in the solutions above 1.0 w/v% concentration were 8-11 nm, indicating that Am-SQ afforded stable reverse micelles at concentrations above 1.0 w/v%. In addition, the reverse micelles of Am-SQ in chloroform could incorporate ionic hydrophilic dyes, such as tetraphenylporphine tetrasulfonic acid and 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt, as confirmed both visually and by UV-Vis spectroscopy. Journal of Nanoscience and Nanotechnology published new progress about Amphiphiles. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Josa-Cullere, Laia; Madden, Katrina S.; Cogswell, Thomas J.; Jackson, Thomas R.; Carter, Tom S.; Zhang, Douzi; Trevitt, Graham; Davies, Stephen G.; Vyas, Paresh; Wynne, Graham M.; Milne, Thomas A.; Russell, Angela J. published the artcile< A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo>, Quality Control of 112-63-0, the main research area is imidazopyridine antitumor acute myeloid leukemia cell differentiation human.

Induction of differentiation is a promising therapeutic strategy against acute myeloid leukemia. However, current differentiation therapies are effective only to specific patient populations. To identify novel differentiation agents with wider efficacy, authors developed a phenotypic high-throughput screen with a range of genetically diverse cell lines. From the resulting hits, one chem. scaffold was optimized in terms of activity and physicochem. properties to yield OXS007417 I, a proof-of-concept tool compound, which was also able to decrease tumor volume in a murine in vivo xenograft model.

Journal of Medicinal Chemistry published new progress about Acute myeloid leukemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xin, Qingping; Zhao, Meixue; Guo, Jianping; Huang, Dandan; Zeng, Yinan; Zhao, Yuhang; Zhang, Teng; Zhang, Lei; Wang, Shaofei; Zhang, Yuzhong published the artcile< Light-responsive metal-organic framework sheets constructed smart membranes with tunable transport channels for efficient gas separation>, Application of C19H34O2, the main research area is light metal organic framework sheet membrane gas separation.

Exploring a new type of smart membrane with tunable separation performance is a promising area of research. In this study, new light-responsive metal-organic framework [Co(azpy)] sheets were prepared by a facile microwave method for the first time, and were then incorporated into a polymer matrix to fabricate smart mixed matrix membranes (MMMs) applied for flue gas desulfurization and decarburization. The smart MMMs exhibited significantly elevated SO2(CO2)/N2 selectivity by 184(166)% in comparison with an unfilled polymer membrane. The light-responsive characteristic of the smart MMMs was investigated, and the permeability and selectivity of the Co(azpy) sheets-loaded smart MMMs were able to respond to external light stimuli. In particular, the selectivity of the smart MMM at the Co(azpy) content of 20% for the SO2/N2 system could be switched between 341 and 211 in situ irradiated with Vis and UV light, while the SO2 permeability switched between 58 Barrer and 36 Barrer, resp. This switching influence was mainly ascribed to the increased SO2 adsorption capacity in the visible light condition, as verified by adsorption test. The CO2 permeability and CO2/N2 selectivity of MMMs in the humidified state could achieve 248 Barrer and 103.2, surpassing the Robeson′s upper bound reported in 2019.

RSC Advances published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Kui; Wang, Meng-Meng; Dou, Hong-Xi; Xing, Si-Yang; Zhu, Bo-Lin; Cui, Jian-Hua published the artcile< Comparative Study on the Supramolecular Assemblies Formed by Calixpyridinium and Two Alginates with Different Viscosities>, Related Products of 112-63-0, the main research area is alginate calixpyridinium viscosity aggregation.

In this work, a comparative study on the supramol. assemblies formed by calixpyridinium and two alginates with different viscosities was performed. We found that sodium alginate (SA) with medium viscosity (SA-M) had a better capability to induce aggregation of calixpyridinium in comparison with SA with low viscosity (SA-L) because of the stronger electrostatic interactions between calixpyridinium and SA-M. Therefore, the morphol. of calixpyridinium-SA-M supramol. aggregates was a compact spherical structure, while that of calixpyridinium-SA-L supramol. aggregates was an incompact lamellar structure. As a result, adding much more amount of 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt to calixpyridinium-SA-M solution was required to achieve the balance of the competitive binding, and in comparison with calixpyridinium-SA-L supramol. aggregates, calixpyridinium-SA-M supramol. aggregates were more sensitive to alkali. However, for the same reason, in comparison with calixpyridinium-SA-M supramol. aggregates, calixpyridinium-SA-L supramol. aggregates were much more stable in water not only at room temperature but also at a higher temperature, and even in salt solution Therefore, in comparison with calixpyridinium-SA-L supramol. aggregates, calixpyridinium-SA-M supramol. aggregates exhibited a completely opposite response to acid because of the generation of salt. Because SA is an important biomaterial with excellent biocompatibility, it is anticipated that this comparative study is extremely important in constructing functional supramol. biomaterials.

ACS Omega published new progress about Acidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Huiting; Li, Jiuyan; Liu, Di; Huang, Tingting; Li, Deli published the artcile< Effects of Electron Affinity and Steric Hindrance of the Trifluoromethyl Group on the π-Bridge in Designing Blue Thermally Activated Delayed Fluorescence Emitters>, Application of C19H34O2, the main research area is OLED TADF electron affinity steric hindrance; electron affinity steric hindrance trifluoromethyl pi Bridge; triazine acceptor carbazole tertbutylcarbazole donor; TADF; blue emission; electron affinity; fluorescence; steric hindrance.

To explore the correlation of the acceptor electron affinity and the mol. conformation to the thermally activated delayed fluorescence (TADF) feature, a series of D-π-A mols. were designed and synthesized with triazine (Trz) as the acceptor (A) and carbazole (Cz) or tert-butylcarbazole (BuCz) as the donor (D). On the phenylene bridge between D and A, Me or trifluoromethyl was incorporated close either to D or to A to tune the mol. conformation and the electron-withdrawing ability of acceptor. Both the twist angles and the singlet and triplet energy difference (ΔEST) were observed strongly dependent on the type and position of the substituent on the π-bridge. Only those mols. with trifluoromethyl locating close to the D side, namely TrzCz-CF3 and TrzBuCz-CF3, exhibit TADF feature, verifying that both sufficient electron affinity of the A unit and large dihedral angle between D and the π-bridge are necessary to ensure the occurrence of TADF. The blue organic light-emitting diodes OLED fabricated with TrzCz-CF3 and TrzBuCz-CF3 achieved external quantum efficiencies of 9.40% and 14.22% with CIE coordinates of (0.19, 0.23) and (0.18, 0.29) resp. This study provides practical design strategy for blue TADF materials particularly when planar and less crowded group is used as donor.

Chemistry – A European Journal published new progress about Blue-emitting electroluminescent devices. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Shaojian; Zhu, Jianhua; Wu, Bencheng; Ma, Rui; Li, Xiaohui published the artcile< Green synthesis of ester base oil with high viscosity - Part II: Reaction kinetics study>, Electric Literature of 112-63-0, the main research area is ester base oil high viscosity green synthesis reaction kinetics.

As an eco-friendly lubricant base oil, ester base oil is receiving increasing attention. However, studies on synthetic reaction kinetics of high viscosity complex ester have been rarely reported. In this work, based on the principle of equal reactivity of all functional groups and simplified kinetics models, synthetic reaction kinetics for high viscosity complex ester was investigated in two steps. As for the esterification of trimethylolpropane with glutaric acid, the activation energies of the first and second stage were 55.3 and 73.5 kJ/mol, resp. As for the esterification of the first step products with 2-ethylhexanoic acid, the activation energies of the first and second stage were 60.6 and 98.2 kJ/mol, resp. As for the esterification of the first step products with n-heptanoic acid, its activation energy was 68.9 kJ/mol. A mutation phenomenon on reaction order from zero to second order was discovered, which could be explained by the strong adsorption of organic acid on catalyst surface. The conversion rate of carboxyl of synthetic reaction for mixed acid ester was estimated by simulation, and average relative error was less than 3.0%. The synthetic process of high viscosity complex ester was considered to consist of a series of parallel-consecutive reactions with addition-elimination mechanism.

Chemical Engineering Research and Design published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lukovits, Istvan; Linert, Wolfgang published the artcile< A Topological Account of Chirality>, Category: esters-buliding-blocks, the main research area is mol topol chirality.

Graph invariants may differentiate structural isomers but are inappropriate to account for stereoisomerism and to distinguish between chiral structures. This work is an attempt to address this problem. A chiral function F satisfying condition F(D) = -F(L), where D and L denote enantiomers of the same structure, was applied in combination with Randic index 1χv. The resulting index χc was used to explain the variance in thin-layer chromatog. retention indexes.1.

Journal of Chemical Information and Computer Sciences published new progress about Amino acids Role: PRP (Properties) (topol. index). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics