Category: 112-63-0

Ohanessian, Jacqueline; Caron, Michel published the artcile< A spectrophotometric study of the carbohydrate binding site of peanut lectin>, Application In Synthesis of 112-63-0, the main research area is peanut lectin carbohydrate binding; structure activity carbohydrate binding lectin.

The difference spectra spectrophotometric method (spectra recorded between 260 and 300 nm, determined at 10°) was used to determine the binding constants for specific binding of sugars (16 mono-and oligosaccharides) to peanut lectin. For C(6), an extracyclic chain is needed for lectin interaction, and orientation of the -OH group on C(6) is essential; substitution of the hydroxymethyl group decreases the strength of the association A free axial -OH on C(4) is needed for binding. A C(2) equatorial hydroxyl group is not essential for interaction, but the axial position of this group decreases the binding. Methylation of C(1) favors association; there seems to be a slight preference for the α-anomer configuration. For the glycosidic bonds, compounds with the β(1→4) linkage bind more strongly to the lectin than those with the α(1→6) linkage. Overall, these results show that the sequence C(4)-O(4), C(5), C(6)-O(6) of the galactopyranosyl ring is involved in the interactions in the carbohydrate binding site of peanut lectin as postulated previously (Lotan, R., et al, 1975), and that for di- and oligosaccharides, it appears that the configuration of C(1), the nature of the osidic bond and of the 2nd residue may influence the strength of the association

Lectins: Biology, Biochemistry, Clinical Biochemistry published new progress about Agglutinins and Lectins Role: BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abdel Karim, M.; Sima, A.; Mekki, Mai published the artcile< Chemical constituents and antimicrobial activity of sudanese lagenaria siceraria standley (Cucurbitaceae) Oil>, Application In Synthesis of 112-63-0, the main research area is Cucurbitaceae oil sudanese lagenaria siceraria standley antimicrobial activity.

In this study, the constituents and antimicrobial activity of Lagenaria siceraria oil. have been investigated. Lagenaria sicerariaStandley is a common fruit vegetable in the family Cucurbitaceae. The fruit has many uses in ethnomedicine. Fruit is used as diuretic, immunosuppressant, cardio-protective and cardio-tonic. Lagenaria siceraria possesses antioxidant, hypolipidemic and hepatoprotective properties. GC- MS anal. of Lagenaria siceraria oil revealed the presence of three major constituents: linoleic acid Et ester (57.96%); 9,12-octadecenoic acid Me ester (19.56%) and hexdecanoic acid (10.15%%). The oil was screened for antimicrobial activity against five standard human pathogens by using the paper disk diffusion method. The oil showed moderate activity against Pseudomonas aeruginosa.

Pharmaceutical and Chemical Journal published new progress about Acetoxymethyl esters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dai, Weimin; Wu, An; Li, Yunping; Yu, Guofeng; Yan, Xinjiang published the artcile< XPA Enhances Temozolomide Resistance of Glioblastoma Cells by Promoting Nucleotide Excision Repair.>, Application In Synthesis of 112-63-0, the main research area is XPA; glioblastoma; nucleotide excision repair; temozolomide.

Glioblastoma is the most frequent, as well as aggressive kind of high-grade malignant glioma. Chemoresistance is posing a significant clinical barrier to the efficacy of temozolomide-based glioblastoma treatment. By suppressing xeroderma pigmentosum group A (XPA), a pivotal DNA damage recognition protein implicated in nucleotide excision repair (NER), we devised a novel method to enhance glioblastoma therapy and alleviate temozolomide resistance. On the basis of preliminary assessment, we found that XPA dramatically increased in glioblastoma compared with normal cells and contributed to temozolomide resistance. By constructing XPA stably knockdown cells, we illustrate that XPA protects glioma cells from temozolomide-triggered reproductive cell death, apoptosis, as well as DNA repair. Besides, XPA silencing remarkably enhances temozolomide efficacy in vivo. This study revealed a crucial function of XPA-dependent NER in the resistance of glioma cells to temozolomide.

Cell transplantation published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ito, Kenji; Chuang, Jeffrey; Alvarez-Lorenzo, Carmen; Watanabe, Tsuyoshi; Ando, Nozomi; Grosberg, Alexander Yu. published the artcile< Multiple-contact adsorption of target molecules by heteropolymer gels>, Electric Literature of 112-63-0, the main research area is thermal sensitive isopropylacrylamide copolymer gel adsorption.

We examined adsorption of target mols. through a multiple-contact interaction in a thermo-sensitive heteropolymer gel which can undergo a volume transition at 34 °C in water. Multi-valent anionic target mols. were adsorbed electrostatically by monovalent cationic adsorbing sites in the gel. The overall affinity (SK) between the gel and the target mol. was calculated from the initial slope of the Langmuir adsorption isotherm: [Tads] = KS[Tsol]/(1 + K[Tsol]), where S, K, [Tsol] and [Tads] represent the number of adsorption sites per unit volume of the gel, the effective binding constant, the equilibrium target concentration in the external solution, and the target concentration adsorbed in the gel, resp. The affinity for the collapsed gel at 60° was studied in terms of the concentrations of three factors: the adsorber, the coexistent salt, and the cross-linker. We found that the relationship between the affinity and these factors can be summarized by an equation first suggested by T. Tanaka.

Macromolecular Symposia published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khan, Anowar H.; Cook, Jeffery K.; Wortmann, Wayne J. III; Kersker, Nathan D.; Rao, Asha; Pojman, John A.; Melvin, Adam T. published the artcile< Synthesis and characterization of thiol-acrylate hydrogels using a base-catalyzed Michael addition for 3D cell culture applications>, Reference of 112-63-0, the main research area is thiol acrylate hydrogel Michael addition 3D cell culture.

There is significant interest in developing new approaches for culturing mammalian cells in a three-dimensional (3D) environment due to the fact that it better recapitulates the in vivo environment. The goal of this work was to develop thiol-acrylate, biodegradable hydrogels that possess highly tunable properties to support in vitro 3D culture. Six different hydrogel formulations were synthesized using two readily available monomers, a trithiol (ETTMP 1300 [ethoxylated trimethylolpropane tri(3-mercaptopropionate) 1300]) and a diacrylate (PEGDA 700 [polyethylene glycol diacrylate 700]), polymerized by a base-catalyzed Michael addition reaction. The resultant hydrogels were homogeneous, hydrophilic, and biodegradable. Different mech. properties such as gelation time, storage modulus (or the elasticity G’), swelling ratio, and rate of degradation were tuned by varying the weight percentage of polymer, the molar ratio of thiol-to-acrylate groups, and the pH of the solution Cytocompatibility was assessed using two model breast cancer cell lines by both 2D and 3D cell culturing approaches. The hydrogel formulations with a thiol-to-acrylate molar ratio of 1.05 were found to be optimal for both 2D and 3D cultures with MDA-MB-231 cellular aggregates found to be viable after 17 days of 3D continuous culture. Finally, MCF7 cells were observed to form 3D spheroids up to 600μm in diameter as proof of principle for the thiol-acrylate hydrogel to function as a scaffold for in vitro 3D cell culture. A comparison of the different mech. properties of the six hydrogel formulations coupled with in vitro cell culture results and findings from previously published hydrogels conclude that the thiol-acrylate hydrogels have significant potential as a scaffold for 3D cell culture.

Journal of Biomedical Materials Research, Part B: Applied Biomaterials published new progress about Animal tissue culture. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nishikawa, Toshio; Urabe, Daisuke; Yoshida, Kazumasa; Iwabuchi, Tomoko; Asai, Masanori; Isobe, Minoru published the artcile< Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analogue of Puffer Fish Toxin>, SDS of cas: 112-63-0, the main research area is asym synthesis deoxytetrodotoxin analog Puffer fish toxin synthon.

8,11-Dideoxytetrodotoxin, an unnatural tetrodotoxin analog, was synthesized in a highly stereoselective manner from a common intermediate in our synthetic studies on tetrodotoxin. The synthesis features neighboring group participation of trichloroacetamide for stereoselective hydroxylation, protection of ortho ester, and guanidine installation with Boc-protected isothiourea.

Organic Letters published new progress about Hydroxylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jang, Keun Sam; Shin, Dong Seok; Srisook, Ekaruth; Song, Ho-Chun; Chi, Dae Yoon published the artcile< Versatile functionalization of electron rich-fused heterocyclic arenes via electrophilic aromatic addition reaction and their applications>, SDS of cas: 112-63-0, the main research area is methoxyquinaldine regioselective bromomethoxylation; bromo alkoxyquinaldine preparation; dibromo dimethoxydihydroquinaldine amine regioselective nucleophilic substitution reaction; amino bromo methoxyyquinaldine preparation.

Divergent functionalized 8-methoxyquinaldines were synthesized via regioselective debromination, 1,3-bromine shift process, aromatization with treatment of a strong base, nucleophilic substitution reaction at the C7 position using amines and cyanide as a nucleophile in the absence of a metal source and a catalyst from an unusual electrophilic aromatic addition (AdEAr) reaction products. In addition, quinaldine-7,8-dione was prepared by presence of CAN (ceric ammonium nitrate) in AcOH and H2O for 10 min at room temperature from N-(alkylamino)-8-methoxyquinalidines. During the AdEAr reaction, new stereoselective dearomatized addition products were generated via discriminative reaction routes depending on the methoxy and bromine occupancy position. The AdEAr reaction not only allowed for the functionalization of electron rich-fused heterocyclic arenes, but also provided a new synthetic route to an alternative mechanism for electrophilic aromatic substitution reactions.

Tetrahedron published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kikalishvili, T. J.; Kereselidze, J. A. published the artcile< Trimeric mechanism of proton transfer in imidazole>, Formula: C19H34O2, the main research area is imidazole derivative proton transfer trimeric mechanism AM1 MO.

The energy, electronic, and structural characteristics of the tautomeric transformation of imidazole were calculated by the quantum-chem. semiempirical AM1 method. It was concluded on the basis of the calculated data that proton transfer in the tautomeric transformation 1H-imidazole ⇄ 3H-imidazole can take place by a trimeric mechanism.

Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about Potential energy surface (proton transfer). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bollini, Mariela; Domaoal, Robert A.; Thakur, Vinay V.; Gallardo-Macias, Ricardo; Spasov, Krasimir A.; Anderson, Karen S.; Jorgensen, William L. published the artcile< Computationally-Guided Optimization of a Docking Hit to Yield Catechol Diethers as Potent Anti-HIV Agents>, Quality Control of 112-63-0, the main research area is catechol ether anti HIV reverse transcriptase inhibitor computational optimization.

A 5-μM docking hit has been optimized to an extraordinarily potent (55 pM) non-nucleoside inhibitor of HIV reverse transcriptase. Use of free energy perturbation (FEP) calculations to predict relative free energies of binding aided the optimizations by identifying optimal substitution patterns for Ph rings and a linker. The most potent resultant catechol diethers feature terminal uracil and cyanovinylphenyl groups. A halogen bond with Pro95 likely contributes to the extreme potency of compound 42 (I). In addition, several examples are provided illustrating failures of attempted grafting of a substructure from a very active compound onto a seemingly related scaffold to improve its activity.

Journal of Medicinal Chemistry published new progress about AIDS (disease). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nogales-Delgado, Sergio; Encinar Martin, Jose Maria; Sanchez Ocana, Mercedes published the artcile< Use of mild reaction conditions to improve quality parameters and sustainability during biolubricant production>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is safflower oil biolubricant production oxidative stability biodegradability sustainability viscosity.

The use of alternative sources to produce less pollutant biofuels and biomaterials, replacing petroleum-derived products, is becoming an important issue for international organizations, governments, and society. Thus, biodiesel and biolubricant production has been increasingly researched, offering promising results. These products present some advantages such as sustainability or biodegradability, among others. However, some of their quality parameters can be altered during storage, mainly due to their low oxidative stability. Consequently, auto-oxidation processes can take place, increasing viscosity or acid number, which can compromise their marketability. To avoid these inconveniences, some alternatives have been presented, such as the use of antioxidants, vegetable oil selection or the promotion of mild chem. conditions during production The aim of this work was to assess the use of vacuum during biolubricant production from high-oleic safflower oil through double transesterification with methanol and 2-ethyl-2-(hydroxymethyl)-1,3-propanediol to obtain mild chem. conditions. Under these circumstances (working pressure at 210 mmHg) and compared to previous studies, temperature and catalyst addition could be reduced from 140 to 100°C and from 0.5 to 0.3%, resp., increasing the reaction yield from 92.9 to 94.69% and improving the quality of the biolubricant, with 30% increase in viscosity index.

Biomass and Bioenergy published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics