Category: 112-63-0

Kim, Seok-Chan; Choi, Kwan-Min; Cheong, Chan-Seong published the artcile< Synthesis of amlodipine using aza Diels-Alder reaction>, COA of Formula: C19H34O2, the main research area is amlodipine synthesis Diels Alder alkene butynoate regioselective.

Amlodipine I was prepared via aza Diels Alder reaction of alkene II with Me butynoate.

Bulletin of the Korean Chemical Society published new progress about Diels-Alder reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Bo; Li, Yongliang; Tomkiewicz-Raulet, Celine; Dao, Pascal; Lietha, Daniel; Yen-Pon, Expedite; Du, Zhiyun; Coumoul, Xavier; Garbay, Christiane; Etheve-Quelquejeu, Melanie; Chen, Huixiong published the artcile< Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma>, Related Products of 112-63-0, the main research area is malignant glioblastoma FAK cell migration cell cycle autophosphorylation.

Human malignant glioblastoma (GBM) is a highly invasive and lethal brain tumor. Targeting of integrin downstream signaling mediators in GBM such as focal adhesion kinase (FAK) seems reasonable and recently demonstrated promising results in early clin. studies. Herein, we report the structure-guided development of a series of covalent inhibitors of FAK. These new compounds displayed highly potent inhibitory potency against FAK enzymic activity with IC50 values in the nanomolar range. Several inhibitors retarded tumor cell growth as assessed by a cell viability assay in multiple human glioblastoma cell lines. They also significantly reduced the rate of U-87 cell migration and delayed the cell cycle progression by stopping cells in the G2/M phase. Furthermore, these inhibitors showed a potent decrease of autophosphorylation of FAK in glioblastoma cells and its downstream effectors Akt and Erk as well as nuclear factor-κB. These data demonstrated that these inhibitors may have the potential to offer a promising new targeted therapy for human glioblastomas.

Journal of Medicinal Chemistry published new progress about Cell cycle checkpoint (cell cycle arrest, at G2/M phase). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Qin; Yin, Zheng-Lan; Ouyang, Ban-Lai; Peng, Yi-Yuan published the artcile< Pyridinium tribromide catalyzed condensation of indoles and aldehydes to form bisindolylalkanes>, Category: esters-buliding-blocks, the main research area is indole carbonyl aldehyde ketone condensation pyridinium bromide catalyst; alkane bisindolyl preparation.

An efficient synthetic method for bis(indol-3-yl)alkane derivatives was developed. In the presence of 5 mol% of pyridinium tribromide, the condensation of indoles and aldehydes proceeded smoothly under mild conditions, giving rise to the corresponding bis(indol-3-yl)alkanes in good to excellent yields.

Chinese Chemical Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zaleskaya-Hernik, Marta; Dobrzycki, Lukasz; Karbarz, Marcin; Romanski, Jan published the artcile< Fluorescence Recognition of Anions Using a Heteroditopic Receptor: Homogenous and Two-Phase Sensing>, Product Details of C19H34O2, the main research area is crown ether squaramide ion pair receptor fluorescent sensor; anthracene; crown ethers; fluorescent sensors; ion pair receptors; squaramides; sulfate extraction.

In contrast to monotopic receptor 3, the anthracene functionalized squaramide dual-host receptor 1 is capable of selectively extracting sulfate salts, as was evidenced unambiguously by DOSY, mass spectrometry, fluorescent and ion chromatog. measurements. The receptors were investigated in terms of anion and ion pair binding using the UV-vis and 1H NMR titrations method in acetonitrile. The reference anion receptor 3, lacking a crown ether unit, was found to lose the enhancement in anion binding induced by the presence of cations. Besides the ability to bind anions in an enhanced manner exhibited by ion pair receptors 2 and 4, changing the 1-aminoanthracene substituent resulted in their exhibiting a lower anion affinity than receptor 1. By using receptor 1 and adjusting the water content in organic phase it was possible to selectively detect sulfates both by “”turn-off”” and “”turn-on”” fluorescence, and to do so homogenously and under interfacial conditions. Such properties of receptor 1 have allowed the development of a new type of sensor capable of recognizing and extracting potassium sulfate from the aqueous medium across a phase boundary, resulting in an appropriate fluorescent response in the organic solution

International Journal of Molecular Sciences published new progress about Aqueous solutions. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Berger, Dan M.; Torres, Nancy; Dutia, Minu; Powell, Dennis; Ciszewski, Greg; Gopalsamy, Ariamala; Levin, Jeremy I.; Kim, Kyung-Hee; Xu, Weixin; Wilhelm, James; Hu, YongBo; Collins, Karen; Feldberg, Larry; Kim, Steven; Frommer, Eileen; Wojciechowicz, Donald; Mallon, Robert published the artcile< Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors>, SDS of cas: 112-63-0, the main research area is pyrazolopyrimidine preparation BRaf kinase inhibitor.

As part of our research effort to discover B-Raf kinase inhibitors, we prepared a series of C-3 substituted N-(3-(pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamides. X-ray crystallog. studies revealed that one of the more potent inhibitors bound to B-Raf kinase without forming a hinge-binding hydrogen bond. With basic amine residues appended to C-3 aryl residues, cellular activity and solubility were enhanced over previously described compounds of this class.

Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship (B-Raf kinase-inhibiting). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ali, Mohammed Hashmat; Stricklin, Susan published the artcile< Oxidation of sulfides with pyridinium tribromide in the presence of hydrated silica gel>, COA of Formula: C19H34O2, the main research area is sulfide oxidation pyridinium bromide; sulfoxide preparation.

A variety of sulfides were oxidized to sulfoxides utilizing pyridinium tribromide in the presence of hydrated silica gel in a non-aqueous media. A combination of pyridinium tribromide and hydrated silica gel releases mol. bromine slowly in the reaction, affecting the oxidation Hydrated silica gel also promotes decomposition of the bromosulfonium intermediate to the product. This procedure employs non-aqueous media for the first time in such a reaction.

Synthetic Communications published new progress about Oxidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lokhov, R. E. published the artcile< Kinetics of N-oxidation of compounds of the quinoline series and isomeric benzoquinolines by perbenzoic acid in chloroform and aqueous dioxane>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is oxidation quinoline benzoquinoline peroxybenzoic acid.

Rate constants and activation parameters were determined for the title reactions; a bimol. mechanism was indicated. Annelation of pyridine lowered its oxidation rate. The rate constant for oxidation of 4-amino-2,3-benzoquinoline was nearly an order of magnitude higher in CHCl3 than in aqueous dioxane. Correlations with nucleophilicity parameters and half-wave potentials for the reduction of the azine cations were discussed. The electron d. at N had a small effect; π conjugation between the substituent and the reaction center was an important factor.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about Nucleophilicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alekseyev, Roman S.; Amirova, Sabina R.; Terenin, Vladimir I. published the artcile< Synthesis of 5-chloro-7-azaindoles by Fischer reaction>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is azaindole preparation; hydrazinopyridine polyphosphoric acid Fischer cyclization.

A simple and effective method on the basis of Fischer reaction in polyphosphoric acid is proposed for the synthesis of previously unknown heterocyclic structures that contain the 5-chloro-1H-pyrrolo[2,3-b]pyridine system. This method can be used for the synthesis of 3-substituted and 2,3-disubstituted 5-chloro-7-azaindoles, e.g., I, with alkyl and aryl substituents.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Carbonyl compounds (organic) Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Yanyan; Yin, Shaojie; Chen, Xiaolan; Shi, Feifei; Wang, Jing; Yang, Haifeng published the artcile< The inhibitory effect of paeoniflorin on reactive oxygen species alleviates the activation of NF-κB and MAPK signalling pathways in macrophages.>, SDS of cas: 112-63-0, the main research area is MAPK; NF-κB; ROS; inflammation; macrophages; paeoniflorin.

Paeoniflorin (PF) has been proven to possess a protective effect in some inflammatory diseases, but the underlying mechanism remains unclear. Macrophages play central roles in inflammatory responses and LPS-stimulated RAW264.7 macrophage is an ideal model for studying the anti-inflammatory effects and mechanisms of drugs. Thus, it was used to explore the anti-inflammatory mechanism of PF in this study. The results showed that PF markedly attenuated the activation of NF-κB, extracellular signal-regulated kinase (ERK1/2) and p38 mitogen activated protein kinase (p38) signalling pathways induced by LPS exposure. In addition, PF pretreatment dose-dependently suppressed the production of cytokines and the expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Concomitantly, PF pretreatment dramatically inhibited the accumulation of intracellular reactive oxygen species (ROS) without affecting the phagocytosis of macrophages. Furthermore, it has proved the scavenging effect of PF on ROS was involved in the anti-inflammatory process. This study provides a novel aspect to the understanding of the anti-inflammatory mechanism of PF.

Microbiology (Reading, England) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Bo; Yan, Lin; Pan, Yuanhang; Lee, Richmond; Liu, Hongjun; Han, Zhiqiang; Huang, Kuo-Wei; Tan, Choon-Hong; Jiang, Zhiyong published the artcile< Lewis base catalyzed enantioselective allylic hydroxylation of Morita-Baylis-Hillman carbonates with water>, Electric Literature of 112-63-0, the main research area is alc enantioselective synthesis; Morita Baylis Hillman carbonate allylic hydroxylation Lewis base catalyst.

A Lewis base catalyzed allylic hydroxylation of Morita-Baylis-Hillman (MBH) carbonates has been developed. Various chiral MBH alcs. can be synthesized in high yields (up to 99%) and excellent enantioselectivities (up to 94% ee). This is the first report using water as a nucleophile in asym. organocatalysis. The nucleophilic role of water has been verified using 18O-labeling experiments

Journal of Organic Chemistry published new progress about Allylic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics