Category: 112-63-0

Hu, Shaojian; Zhu, Jianhua; Wu, Bencheng; Ma, Rui; Li, Xiaohui published the artcile< Green synthesis of ester base oil with high viscosity - Part II: Reaction kinetics study>, Electric Literature of 112-63-0, the main research area is ester base oil high viscosity green synthesis reaction kinetics.

As an eco-friendly lubricant base oil, ester base oil is receiving increasing attention. However, studies on synthetic reaction kinetics of high viscosity complex ester have been rarely reported. In this work, based on the principle of equal reactivity of all functional groups and simplified kinetics models, synthetic reaction kinetics for high viscosity complex ester was investigated in two steps. As for the esterification of trimethylolpropane with glutaric acid, the activation energies of the first and second stage were 55.3 and 73.5 kJ/mol, resp. As for the esterification of the first step products with 2-ethylhexanoic acid, the activation energies of the first and second stage were 60.6 and 98.2 kJ/mol, resp. As for the esterification of the first step products with n-heptanoic acid, its activation energy was 68.9 kJ/mol. A mutation phenomenon on reaction order from zero to second order was discovered, which could be explained by the strong adsorption of organic acid on catalyst surface. The conversion rate of carboxyl of synthetic reaction for mixed acid ester was estimated by simulation, and average relative error was less than 3.0%. The synthetic process of high viscosity complex ester was considered to consist of a series of parallel-consecutive reactions with addition-elimination mechanism.

Chemical Engineering Research and Design published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lukovits, Istvan; Linert, Wolfgang published the artcile< A Topological Account of Chirality>, Category: esters-buliding-blocks, the main research area is mol topol chirality.

Graph invariants may differentiate structural isomers but are inappropriate to account for stereoisomerism and to distinguish between chiral structures. This work is an attempt to address this problem. A chiral function F satisfying condition F(D) = -F(L), where D and L denote enantiomers of the same structure, was applied in combination with Randic index 1χv. The resulting index χc was used to explain the variance in thin-layer chromatog. retention indexes.1.

Journal of Chemical Information and Computer Sciences published new progress about Amino acids Role: PRP (Properties) (topol. index). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bellucci, Maria Cristina; Sacchetti, Alessandro; Volonterio, Alessandro published the artcile< Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides>, Category: esters-buliding-blocks, the main research area is orotyl aminophenylalanine preparation combinatorial multicomponent reaction regioselective cyclization; dihydroorotic acid amide preparation combinatorial multicomponent reaction regioselective cyclization; carbodiimide; combinatorial chemistry; dihydroorotic acid; domino process; multicomponent reactions.

A process featuring a sequential multicomponent reaction followed by a regioselective postcyclization strategy was implemented for the facile synthesis of N,N’-disubstituted dihydroorotic acid amides under mild conditions. We obtained, for the first time, a library of 29 derivatives, encompassing 19 Nα-substituted-N4-dihydroorotyl-4-aminophenylalanine derivatives, a key residue of gonadotropin-releasing hormone antagonist Degarelix. The corresponding products were prepared from easily accessible starting materials in good to excellent yields with broad substrate scope.

ACS Combinatorial Science published new progress about Combinatorial chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fang, Fang; Wen, Wei-Bo; Xie, Xue-Hua; Yang, Ling; Zhang, Xu; Zhao, Jie published the artcile< The Mechanism of Jian-Gan-Xiao-Zhi Decoction in Insulin Resistant Adipocytes and Its Component Analysis>, Quality Control of 112-63-0, the main research area is Jian Gan hepatoprotectant adipocyte non alc fatty liver disease.

Jian-Gan-Xiao-Zhi decoction (JGXZ) is a traditional Chinese medicine formula to treat patients with non-alc. fatty liver disease (NAFLD). The study aimed to analyze the mechanism of JGXZ in adipocytes and detect the main components of the drug in rat serum. 3T3-L1 preadipocytes were used to establish an insulin resistant (IR) adipocyte model. Lipid accumulation in adipocytes was detected by oil red O staining. After JGXZ treatment, glucose consumption, total cholesterol (TC), and triglyceride (TG) were analyzed using the corresponding kits. ROS levels were measured by flow cytometry. In addition, Western blot was used to assess LKB1/AMPK and JNK/IRS/PI3k/AKT expressions. The main components of JGXZ in rat serum samples were detected by LC-MS/MS using a Phenomenex Luna C18 column, a mobile phase of methanol and 0.1% formic acid solution, and ESI detection. JGXZ significantly decreased glucose levels and adipogenesis, accompanied by decreased IR (P < 0.01). Besides, JGXZ markedly affected ROS, LKB1/AMPK, and JNK/IRS/PI3k/AKT levels (P < 0.01). R1, Rg1, paeoniflorin, Rb1, astragaloside IV, and tanshinone could be significantly quantified. JGXZ decreased glucose and lipid synthesis, possibly via the ROS/AMPK/JNK pathway. R1, Rg1, paeoniflorin, Rb1, astragaloside IV, and tanshinone in JGXZ could play major roles in treating NAFLD, which could assist in the study of the mechanism of JGXZ in treating NAFLD. Natural Product Communications published new progress about Adipocyte. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kato, Kazuaki; Mizusawa, Tomoki; Ohara, Akihiro; Ito, Kohzo published the artcile< Direct enhancement of intercomponent interactions in polyrotaxane and its pronounced effects on glass state properties>, HPLC of Formula: 112-63-0, the main research area is enhancement intercomponent interaction polyrotaxane glass state polybutadiene cyclodextrin.

Strong interactions between the host cyclodextrin and the threading guest polymer were introduced by selective modifications to the polymer of a polybutadiene-based polyrotaxane. The changes in the intercomponent interactions influenced the mobility of the threading polymer that was confined in the glassy host framework, resulting in different mech. properties.

Chemical Communications (Cambridge, United Kingdom) published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guan, Yun; Pan, Mingyuan; Yang, Jun; Lu, Qiuxia; Han, Liangfu; Liu, Ying; Li, Jing; Zhu, Huaguang; Gong, Xiu; Mei, Guanghai; Liu, Xiaoxia; Pan, Li; Dai, Jiazhong; Wang, Yang; Wang, Enmin; Wang, Xin published the artcile< A phase II open label, single arm study of hypofractionated stereotactic radiotherapy with chemoradiotherapy using intensity-modulated radiotherapy for newly diagnosed glioblastoma after surgery: the HSCK-010 trial protocol>, HPLC of Formula: 112-63-0, the main research area is Adjuvant chemoradiotherapy; Hypofractionated stereotactic radiotherapy; Newly diagnosed glioblastoma.

Abstract: Background: The most frequently diagnosed primary brain tumor is glioblastoma (GBM). Nearly all patients experience tumor recurrence and up to 90% of which is local recurrence. Thus, increasing the therapeutic ratio of radiotherapy using hypofractionated stereotactic radiotherapy (HSRT) can reduce treatment time and may increase tumor control and improve survival. To evaluate the efficacy and toxicity of the combination of HSRT and intensity-modulated radiotherapy (IMRT) with temozolomide after surgery in GBM patients and provide evidence for further randomized controlled trials. Methods/design: HSCK-010 is an open-label, single-arm phase II trial (NCT04547621) which includes newly diagnosed GBM patients who underwent gross total resection. Patients will receive the combination of 30 Gy/5fx HSRT, and 20 Gy/10fx IMRT adjuvant therapy with concurrent temozolomide and adjuvant chemotherapy. The primary endpoint is overall survival (OS). Secondary outcomes include progression-free survival (PFS) rate, objective-response rate (ORR), quality of life (Qol) before and after the treatment, cognitive function before and after the treatment, and rate of treatment-related adverse events (AE). The combination of HSRT and IMRT with temozolomide can benefit the patients after surgery with good survival, acceptable toxicity, and reduced treatment time. Trial registration: NCT04547621. Registered on 14 Sept. 2020.

BMC Cancer published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Qin; Law, Andy; Crowder, Michael W.; Geysen, H. Mario published the artcile< Homo-cysteinyl peptide inhibitors of the L1 metallo-β-lactamase, and SAR as determined by combinatorial library synthesis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is homocysteinyl peptide inhibitor metallo beta lactamase QSAR combinatorial library.

Homo-cysteinyl peptides were found to be more active than cysteinyl peptides toward L1 metallo-β-lactamase as reversible competitive inhibitors. A combinatorial library of more than 90 homo-cysteinyl peptides was synthesized and screened for their inhibitory activity toward the L1 enzyme. A systematic structure-activity relationship anal. has revealed the preferred interaction groups for L1 conserved binding sites of β-lactam substrates. The most active compound 95b, had a Ki of 2.1 nM.

Bioorganic & Medicinal Chemistry Letters published new progress about Combinatorial library. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Robins, Morris J.; Miranda, Karl; Rajwanshi, Vivek K.; Peterson, Matt A.; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Balzarini, Jan published the artcile< Synthesis and Biological Evaluation of 6-(Alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one Base and Nucleoside Derivatives>, Synthetic Route of 112-63-0, the main research area is cytotoxicity cyclization desilylation cross coupling ammonolysis nucleoside bicyclic furopyrimidinone; alkynyl furopyrimidinone bicyclic nucleoside kinase antiviral synthesis human cytomegalovirus.

Derivatives of the 2′-deoxynucleoside of furo[2,3-d]pyrimidin-2(3H)-one with long-chain alkyl (or 4-alkylphenyl) substituents at C6 exhibit remarkable anti-VZV (varicella-zoster virus) potency and selectivity, and analogous 2′,3′-dideoxynucleoside derivatives show anti-HCMV (human cytomegalovirus) activity. We now report a synthetic approach that enables the preparation of long-chain 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-ones, e.g. I, in which the rod-like acetylene spacer replaces the 4-substituted-Ph ring at C6 via desilylation, Cu-catalyzed 5-endo-Dig cyclization, cross-coupling, and ammonolysis reactions. Analogs with Me, β-D-ribofuranosyl, β-D-arabinofuranosyl, and 2-deoxy-β-D-erythro-pentofuranosyl substituents at N3 have been prepared Long-chain derivatives at C6 in the 2′-deoxynucleoside series showed virus-encoded nucleoside kinase-sensitive anti-VZV activity. Surprisingly, 3-methyl-6-(octyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one (prepared as a neg. anti-VZV test control) exhibited anti-HCMV activity, which supports the possibility of development of non-nucleoside anti-HCMV agents originating from uncomplicated derivatives of such bicyclic ring systems.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koppenhoefer, Bernhard; Allmendinger, Hans published the artcile< Derivatization reactions for enantiomer resolution of hydroxy acids by gas chromatography: a comparison of methods>, Application of C19H34O2, the main research area is derivatization hydroxy acid gas chromatog; enantiomer resolution gas chromatog derivatization; esterification enantiomer resolution gas chromatog.

Mandelic acid was converted to several derivatives that are resolved into enantiomers by gas chromatog. on the chiral stationary phase Chirasil-Val. Only the easily performed esterification by an alc. such as 3-pentanol, catalyzed by dry HCl, is satisfactory in terms of racemization, side-reactions, and chromatog. properties.

Fresenius’ Zeitschrift fuer Analytische Chemie published new progress about Alcohols Role: USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meng, Lingqiao; Shi, Xingzhao; Zhang, Ruilong; Yan, Long; Liang, Zhaopeng; Nie, Yijing; Zhou, Zhiping; Hao, Tongfan published the artcile< Preparation and properties study of waterborne polyurethane synthesized by mixing polyester diols and isocyanates>, Formula: C19H34O2, the main research area is polyester diol isocyanate polymerization; waterborne polyurethane preparation.

In view of environmental protection requirements, it is an inevitable trend for waterborne coatings to replace traditional coatings. Waterborne polyurethane (WPU), a kind of typical resin used in coatings, has become a research hot topic of waterborne coatings because of its advantages, such as non-polluting, safe and reliable, excellent properties, good compatibility, and easy modification. In this article, solvent-free WPU is prepared by mixing 4,4′-dicyclohexylmethane diisocyanate/isophorone diisocyanate (HMDI/IPDI) and polycarbonate diol/ Polycaprolactone diol (PCDL/PCL). Through the comparison of the properties of the polymer, the best amount of raw materials was determined Specifically, R = 1.35 (R is NCO/OH ratio), the content of dimethylolpropionic acid (DMPA) is 5.5%, the content of trimethylol propane (TMP) is 2.5%, the mole ratio of HMDI/IPDI is 2:1, the mole ratio of PCDL/PCL is 2:1, and the preeminent WPU shows the excellent thermal stability, the contact angle of 118.04°, the hardness is H. The chem. structures and rough surface morphologies of the WPU films were characterized by FT-IR, TG, AFM, and SEM, resp. Therefore, considering the film properties, and the low cost, simple, and green process, this research will offer the possibility of application of this free-solvent WPU in industrial production and large-scale application.

Journal of Applied Polymer Science published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics