Category: 112-63-0

Barton, John W.; Buhaenko, Michael; Moyle, Brian; Ratcliffe, Norman M. published the artcile< A promising material for nonlinear optics: observation of second harmonic generation from [N-(4-carboxypentyl)-N-methylamino]-4'-nitrostilbene-coated substrates>, Quality Control of 112-63-0, the main research area is nonlinear optic material; carboxypentylmethylaminonitrostilbene Langmuir Blodgett glass coating; second harmonic glass coating carboxypentylmethylaminonitrostilbene.

Glass coated with p-O2NC6H4CH:CHC6H4[NMe(CH2)4CO2H]-p (prepared in 4 steps from p-O2NC6H4Me) by the Langmuir-Blodgett technique gave a noncentrosym. material exhibiting 2nd harmonic generation, 1.06 to 0.53 μm.

Journal of the Chemical Society, Chemical Communications published new progress about Second-harmonic generation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Singh Syali, Mohanjeet; Mishra, Kuldeep; Kanchan, D. K.; Kumar, Deepak published the artcile< Studies on a novel Na+ superionic conducting polymer gel cocktail electrolyte membrane immobilizing molecular liquid mixture of carbonates, tetraglyme and ionic liquid>, Quality Control of 112-63-0, the main research area is superionic conducting polymer gel carbonates tetraglyme ionic liquid.

Novel Na+ superionic conducting polymer gel cocktail electrolyte membranes immobilizing mol. liquid mixture of carbonates, tetraglyme and ionic liquid have been prepared by solution cast method. The optimized free standing electrolyte membrane offers ionic conductivity of 3.3 x 10-3 S cm-1 and sodium-ion transport number of 0.31 at ambient temperature The detailed ion-dynamics have been investigated with the help of frequency dependent dielec. and modulus studies. The possible interaction of these mol. liquids with sodium tetrafluoroborate salt and poly(vinylidiene fluoride-hexafluoropropylene) polymer host is investigated by FTIR studies. The DSC study confirms that the electrolyte system maintains the gel phase up to ∼ 120°C. The linear sweep voltammetry reveal the working voltage range offered by the electrolyte system to be 3.46 V. The Elec. double layer capacitor (EDLC) cell with optimized electrolyte membrane and electrodes of activated carbon demonstrate the specific discharge capacity of ∼ 60F g-1 and drops negligibly with cycle number The reported Na+ superionic conducting cocktail electrolyte system can be utilized as an electrolyte while fabricating electrochem. devices especially the EDLCs.

Journal of Molecular Liquids published new progress about Activated carbon fibers Role: PEP (Physical, Engineering or Chemical Process), PROC (Process). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gruber, Stefan; Ametamey, Simon M.; Schibli, Roger published the artcile< Unexpected reactivity of cyclic perfluorinated iodanes with electrophiles>, Related Products of 112-63-0, the main research area is perfluorinated compound preparation reactivity.

The cyclic perfluorinated iodanes react with electrophiles (E+ = Br, Cl, F, I) to afford perfluorinated E-RF compounds This reactivity is unexpected since cyclic perfluorinated iodanes are considered as electrophilic reagents that normally react with nucleophiles (e.g. Nu- = SR, OR) to afford Nu-RF products. The utility of this new transformation is demonstrated for a [18F]CF3CF2-containing compound which was prepared from [18F]XeF2 obtained from cyclotron produced [18F]fluoride.

Chemical Communications (Cambridge, United Kingdom) published new progress about Electrophiles. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Meng-Meng; Yin, Deng-Ke; Rui, Xue-Lin; Shao, Fu-Ping; Li, Jia-Cheng; Xu, Li; Yang, Ye published the artcile< Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is colorectal cancer colitis Wnt signaling pathway; AOM-DSS; CAC; Gut microbiota; Pai-Nong-San; Wnt signaling pathway.

Pai-Nong-San (PNS), a prescription of traditional Chinese medicine, has been used for years to treat abscessation-induced diseases including colitis and colorectal cancer. This study was aimed to investigate the preventive effects and possible protective mechanism of PNS on a colitis-associated colorectal cancer (CAC) mouse model induced by azoxymethane (AOM)/dextran sodium sulfate (DSS). The macroscopic and histopathol. examinations of colon injury and DAI score were observed The inflammatory indicators of intestinal immunity were determined by immunohistochem. and immunofluorescence. The high throughput 16S rRNA sequence of gut microbiota in the feces of mice was performed. Western blot was used to investigate the protein expression of the Wnt signaling pathway in colon tissues. PNS improved colon injury, as manifested by the alleviation of hematochezia, decreased DAI score, increased colon length, and reversal of pathol. changes. PNS treatment protected against AOM/DSS-induced colon inflammation by regulating the expression of CD4+ and CD8+ T cells, inhibiting the production of HIF-α, IL-6, and TNF-α, and promoting the expression of IL-4 and IFN-γ in colon tissues. Meanwhile, PNS improved the components of gut microbiota, as measured by the adjusted levels of Firmicutes, Bacteroidetes, Proteobacteria, and Lactobacillus. PNS down-regulated the protein expression of p-GSK-3β, β-catenin, and c-Myc, while up-regulating the GSK-3β and p-β-catenin in colon tissues of CAC mice. In conclusion, our results suggested that PNS exhibits protective effect on AOM/DSS-induced colon injury and alleviates the development of CAC through suppressing inflammation, improving gut microbiota, and inhibiting the Wnt signaling pathway.

Chinese Journal of Natural Medicines (Amsterdam, Netherlands) published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Yang; Liu, Yi; Dai, Ya-Zhong; Yang, Chi-Yuan; Un, Hio-Ieng; Liu, Si-Wei; Shi, Ke; Wang, Jie-Yu; Pei, Jian published the artcile< 5,5'-Diazaisoindigo: an Electron-Deficient Building Block for Donor-Acceptor Conjugated Polymers>, Computed Properties of 112-63-0, the main research area is isoindigo derivative donor acceptor conjugated polymer; conjugated polymers; diazaisoindigo; donor-acceptor systems; electron-deficient compounds.

A novel electron-deficient building block, 5,5′-diazaisoindigo (5DNIID), was synthesized through a facile method in good yield. As a derivative of isoindigo, 5DNIID shows an ultra-low LUMO level of -3.92 eV after incorporation of two electron-deficient nitrogen atoms into the para-position of the amine groups in the isoindigo π skeleton. Modified polymerization conditions were applied to efficiently afford the donor-acceptor (D-A) conjugated polymer 5DNIID-2T, which exhibited a p-type charge transport property.

Chemistry – An Asian Journal published new progress about Annealing. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

El Ouar, Mohamed; Knouzi, Nousedine; Hamelin, Jack published the artcile< Reaction of Ethyl 7-Aminoindole-2-carboxylate with β-Diketone and β-Oxo Ester Compounds>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is pyrroloquinoline preparation; aminoindolecarboxylate reaction diketone oxo ester; indolecarboxylate amino reaction diketone oxo ester.

Reaction of Et 7-aminoindole-2-carboxylate has been investigated: 1H-pyrrolo[3,2-h]quinoline and 6-hydroxy-1H-pyrrolo[3,2-h]quinoline derivatives are obtained with β-diketones and β-oxo esters, resp.

Journal of Chemical Research, Synopses published new progress about Diketones, 1,3-diketones Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Levin, Yevgenia; Hamza, Khalil; Abu-Reziq, Raed; Blum, Jochanan published the artcile< Sol-gel entrapped pyridinium hydrobromide perbromide as a recyclable bromination agent: its application to a one-pot bromination and dehydrobromination process>, Electric Literature of 112-63-0, the main research area is bromination solgel entrapped pyridinium hydrobromide perbromide.

Silica sol-gel encaged pyridinium hydrobromide perbromide can be used for clean, odorless bromination of a variety of substrates, including alkenes, ketones, and arenes. The used heterogenized bromination reagent can be recharged with bromine and recycled. In the presence of sol-gel entrapped 1,5,7-triazabicyclo[4.4.0]dec-5-ene, dibromides are dehydrobrominated to give vinyl monobromides and/or alkynes. Encapsulation of the pyridinium derivative and the guanidine base within sep. sol-gel matrixes enables the use of both opposing reagents in one-pot reactions without their mutual destroying each other.

European Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Del Pozo, Vanessa; Robles, Andrew J.; Fontaine, Shaun D.; Liu, Qianqian; Michalek, Joel E.; Houghton, Peter J.; Kurmasheva, Raushan T. published the artcile< PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is PEGylated talazoparib temozolomide Ewing sarcoma; Molecular medicine; Oncology; Pharmacology.

Current therapy is ineffective for relapsed and metastatic Ewing sarcoma (EwS) owing to development of drug resistance. Macromol. prodrugs potentially lead to lower drug exposure in normal tissues and reduced toxicity. We evaluated the efficacy of PEGylated talazoparib (PEG∼TLZ), a PARP1 inhibitor, alone or in combination with the DNA-alkylating agent temozolomide (TMZ) in EwS and other pediatric tumors using conventional testing or single-mouse trial (SMT). A single dose of PEG∼TLZ (10 μmol/kg on day 0) combined with 5 daily doses of TMZ (40 mg/kg starting on day 3/4) produced minimal toxicity, and the combination achieved maintained complete response in EwS and glioblastoma models. The SMT trial with the 3-day interval between PEG∼TLZ and TMZ resulted in objective responses in EwS and other xenografts. Thus, PEG∼TLZ + TMZ demonstrated a broad range of activity in pediatric solid tumor models. Furthermore, the therapeutic window of PEG∼TLZ + TMZ was enhanced compared with the free-TLZ combination.

iScience published new progress about Alkylating agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Subramanian, K.; Somachandran, R. S. published the artcile< Synthesis of castor oil based pristine and silver nanoparticle embedded polyurethanes and their characterization by thermal and antibacterial activity analysis for biomedical applications>, Formula: C19H34O2, the main research area is Bacillus castor oil silver nanoparticle polyurethane antibacterial thermal stability.

Ecofriendly and sustainable pristine and silver nanoparticle embedded polyurethanes (PUs)/polyureas were synthesized by using the renewable castor oil as the main component, 1,6-hexane diol, poly(propylene glycol) and poly(propylene glycol)-bis-2-amino Pr ether as chain extenders, trimethylolpropane/or glycerol as cross linkers and toluene diisocyanate and dibutyltindilaurate as curator and catalyst, resp. The prepared PUs were characterized for their thermal degradation by simultaneous TGA/DTA, structural features by FT-IR and antibacterial activity against Bacillus subtilis and E. coli. The onset degradation temperature (265-269°C) of the PUs was much lower than the onset weight loss temperature of castor oil. In air, the thermal degradation was exothermic at temperatures beyond 300°C. Unlike the pristine PUs, AgNPs embedded PUs displayed antibacterial activity and comparatively lower degradation temperature due to the catalytic effect of silver nanoparticles (AgNPs). These PUs may be used for various biomedical applications such as antibacterial foam, antibacterial scaffold, body implant, food packaging, wound dressing, etc.

Asian Journal of Chemistry published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lan, X-Y; Li, D; Li, S; Zhong, L-Z; Zhao, H; Xi, Y-L; Sun, Z-W published the artcile< Impact of angiogenic inhibition in the treatment of newly diagnosed and recurrent glioblastoma: a meta-analysis based on randomized controlled trials.>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

OBJECTIVE: Glioblastoma (GBM) is the most common and aggressive primary malignant tumor of the central nervous system in adults with high recurrence and mortality rates. Although radiotherapy and temozolomide have become the standard therapeutic regimen for GBM as adjuvant chemoradiotherapy after surgical resection, clinical outcomes remain suboptimal. In recent years, targeted antiangiogenic therapy has attracted considerable attention, but its therapeutic efficacy and safety are still controversial. MATERIALS AND METHODS: Randomized controlled trials (RCTs) of chemoradiotherapy with or without bevacizumab for the treatment of glioblastoma were collected by searching on the Pubmed, Embase, Cochrane, Ovid, Scopus, Web of Science, and Google Scholar databases from the date of database establishment to February 2022. Meta-analysis was performed using RevMan 5.3 software after two investigators independently screened the literature, extracted data, and assessed the risk bias of included studies. RESULTS: A total of 7 RCTs were included. The meta-analysis showed that bevacizumab in combination with chemoradiotherapy was superior to chemoradiotherapy alone in terms of progression-free survival (PFS), with a statistically significant difference. Interestingly, bevacizumab in combination with chemoradiotherapy improved PFS more significantly in recurrent glioblastoma than in newly diagnosed glioblastoma. However, for overall survival (OS), the combination of bevacizumab with chemoradiotherapy was similar to chemoradiotherapy alone, which was not significantly different. With regard to safety, the incidence of most adverse events was higher in the combination of bevacizumab and chemoradiotherapy than in chemoradiotherapy alone, especially in terms of hematologic adverse events. CONCLUSIONS: Current evidence suggests that angiogenesis inhibitor-containing chemoradiotherapy regimens are preferentially recommended for patients with recurrent glioblastoma to prolong their progression-free survival, provided that safety is acceptable, but this does not confer a significant benefit on overall patient survival.

European review for medical and pharmacological sciences published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics