Category: 112-63-0

Wang, Peng-Cheng; Wang, Sheng-Xin; Yan, Xiang-Li; He, Ying-Ying; Wang, Min-Chun; Zheng, Hao-Zhen; Shi, Xu-Guang; Tan, Yong-Heng; Wang, Li-Sheng published the artcile< Combination of paeoniflorin and calycosin-7-glucoside alleviates ischaemic stroke injury via the PI3K/AKT signalling pathway>, Electric Literature of 112-63-0, the main research area is HT22 cells; Ischaemia/reperfusion injury; OGD/R injury; neuroprotective effects; synergistic enhancement; synergistic interaction.

ContextPaeoniflorin (PF) and calycosin-7-glucoside (CG, Paeonia lactiflora Pall. extract) have demonstrated protective effects in ischemic stroke. ObjectiveTo investigate the synergistic effects of PF + CG on ischemia/reperfusion injury in vivo and in vitro. Materials and methodsMale Sprague-Dawley rats were subjected to the middle cerebral artery occlusion/reperfusion (MCAO/R). After MCAO/R for 24 h, rats were randomly subdivided into 5 groups: sham, model (MCAO/R), study treatment (PF + CG, 40 + 20 mg/kg), LY294002 (20 mg/kg), and study treatment + LY294002. Males were given via intragastric administration; the duration of the in vivo experiment was 8 days. Neurol. deficits, cerebral infarction, brain edoema, and protein levels were assessed in vivo. Hippocampal neurons (HT22) were refreshed with glucose-free DMEM and placed in an anaerobic chamber for 8 h. Subsequently, HT22 cells were reoxygenated in a 37 °C incubator with 5% CO2 for 6 h. SOD, MDA, ROS, LDH and protein levels were measured in vitro. ResultsPF + CG significantly reduced neurobehavioral outcomes (21%), cerebral infarct volume (44%), brain edoema (1.6%) compared with the MCAO/R group. Moreover, PF + CG increased p-PI3K/PI3K (4.69%, 7.4%), p-AKT/AKT (6.25%, 60.6%) and Bcl-2/BAX (33%, 49%) expression in vivo and in vitro, and reduced GSK-3β (10.5%, 9.6%) expression. In vitro, PF + CG suppressed apoptosis in HT22 cells and decreased ROS and MDA levels (20%, 50%, resp.). ConclusionsPF + CG showed a synergistic protective effect against ischemic brain injury, potentially being a future treatment for ischemic stroke.

Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aimi, Takahiro; Meguro, Tomohiro; Kobayashi, Akihiro; Hosoya, Takamitsu; Yoshida, Suguru published the artcile< Nucleophilic transformations of azido-containing carbonyl compounds via protection of the azido group>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is azido alc preparation; carbonyl compound azido nucleophile nucleophilic transformation.

Nucleophilic transformations of azido-containing carbonyl compounds, e.g., 4-(4-azidophenyl)benzaldehyde are discussed. The phosphazide formation from azides and di(tert-butyl)(4-(dimethylamino)phenyl)phosphine (Amphos) enabled transformations of carbonyl groups with nucleophiles such as lithium aluminum hydride and organometallic reagents RMgX (R = Et, Ph, 2-thienyl, etc.; X = Cl, Br). The good stability of the phosphazide moiety allowed to perform consecutive transformations of a diazide like 3-azido-5-(azidomethyl)benzaldehyde through triazole I formation and the Grignard reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Karabanova, L. V.; Honcharova, L. A.; Shtompel, V. I. published the artcile< Structure and Properties of the POSS-Containing Nanocomposites Based on Polyurethane Matrix>, Category: esters-buliding-blocks, the main research area is polyurethane polyhedral oligomeric silsesquioxane nanocomposite structure property.

Nanocomposites based on Polyurethane (PU) matrix and 1,2-propanediolisobutyl-POSS (POSS) nanoparticles were prepared and investigated. POSS nanoparticles were incorporated into PU matrix in the process of PU synthesis. The structure peculiarities, the dynamic mech. and thermal properties, the morphol. of the nanocomposites have been investigated. Overall, it was found that POSS nanoparticles are capable to be incorporated into PU polymer chain by a chem. reaction between hydroxyl groups of POSS and diisocyanate groups of PU. The incorporation of the POSS nanoparticles into PU matrix leads to the formation of a more ordered structure, the POSS acts as a nanostructuring agent in the system. The introduction of the POSS nanoparticles into PU matrix significantly affects the thermal properties of the nanocomposites: the increasing in thermal stability was found. Investigation by WAXS/SAXS methods has shown that nanofiller POSS slightly affects the amorphous structure of PU. However, to a greater extent, the nanofiller POSS affects the microphase structure of PU. By dynamic mech. anal., it was detected that the storage moduli of PU/POSS nanocomposites exceeds the storage modulus of PU. But Mn/Mo changes non-monotonically with POSS content. The storage modulus of the nanocomposites increases in 1, 5 times compared to the native PU for the nanocomposites contained from 1 to 5 weight% of POSS. From the morphol. investigation, it is obvious that POSS introduced into PU matrix acts as nanostructuring agent. As a result, the nanocomposites with more ordered structure are formed thus leading to materials with improved thermal stability.

Springer Proceedings in Physics published new progress about Complex modulus, tan δ. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Fangdi; Grenert, James P; Tan, Lisa; Van Ziffle, Jessica; Joseph, Nancy M; Mulvey, Claire K; Bergsland, Emily published the artcile< Checkpoint Inhibitor Immunotherapy to Treat Temozolomide-Associated Hypermutation in Advanced Atypical Carcinoid Tumor of the Lung.>, Computed Properties of 112-63-0, the main research area is .

There is no abstract available for this document.

JCO precision oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Jie; Han, Lin; Yang, Feng; Zhao, Mingliang; Zhou, Hong; Hu, Linwang published the artcile< SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy>, Reference of 112-63-0, the main research area is Bcl-2; Glioblastoma; SOCS5; autophagy; resistance; temozolomide.

Temozolomide (TMZ) is the primary chemotherapeutic drug for treating glioblastoma (GBM); however, the final clin. outcome is considerably limited by the poor response and resistance to TMZ. Although autophagy is thought to be associated with chemotherapy resistance and cancer cell survival, the precise mol. mechanisms underlying this process remain elusive. The suppressor of cytokine signaling (SOCS) family is widely distributed in vivo and exerts a range of effects on tumors; however, the expression pattern and role of SOCS in GBM remains unknown. In this study, we determined that high SOCS5 expression level was associated with poor prognosis and TMZ resistance in GBM. TMZ induced an increase in SOCS5 expression level and upregulated autophagy during the acquisition of drug resistance. The observed increase in the extent of autophagy was mediated by SOCS5. Mechanistically, SOCS5 enhances the transcription of Bcl-2. Knockdown of SOCS5 inhibited TMZ chemoresistance in GBM cells through the inhibition of Bcl-2 recruited autophagy; upregulation of Bcl-2 blocked this effect. In summary, our findings revealed the involvement and underlying mechanism of SOCS5 in TMZ resistance. SOCS5 plays a critical role in GBM chemoresistance and may serve as a novel prognostic marker and therapeutic target for chemotherapeutically treating drug-resistant GBM.

Bioengineered published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Walker, James A.; Vickerman, Kevin L.; Humke, Jenna N.; Stanley, Levi M. published the artcile< Ni-Catalyzed alkene carboacylation via amide C-N bond activation>, Reference of 112-63-0, the main research area is allylbenzamide carboacylation nickel; indanone preparation; nickel carboacylation catalyst.

A Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid pinacol esters is reported. The reaction is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceeds via alkene insertion into a Ni(II)-acyl bond. The exo-selective carboacylation reaction generates 2-benzyl-2,3-dihydro-1H-inden-1-ones in moderate to high yields from a variety of arylboronic acid pinacol esters and substituted o-allylbenzamides. These results show that amides are practical substrates for alkene carboacylation via amide C-N bond activation, and this approach bypasses challenges associated with alkene carboacylation triggered by C-C bond activation.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schulz, Julia A.; Rodgers, Louis T.; Kryscio, Richard J.; Hartz, Anika M. S.; Bauer, Bjorn published the artcile< Characterization and comparison of human glioblastoma models>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is ABC transporters; Glioblastoma; Invasiveness; U251-RedFLuc; U87-luc2.

Abstract: Glioblastoma (GBM) is one of the deadliest cancers. Treatment options are limited, and median patient survival is only several months. Translation of new therapies is hindered by a lack of GBM models that fully recapitulate disease heterogeneity. Here, we characterize two human GBM models (U87-luc2, U251-RedFLuc). In vitro, both cell lines express similar levels of luciferase and show comparable sensitivity to temozolomide and lapatinib exposure. In vivo, however, the two GBM models recapitulate different aspects of the disease. U87-luc2 cells quickly grow into large, well-demarcated tumors; U251-RedFLuc cells form small, highly invasive tumors. Using a new method to assess GBM invasiveness based on detecting tumor-specific anti-luciferase staining in brain slices, we found that U251-RedFLuc cells are more invasive than U87-luc2 cells. Lastly, we determined expression levels of ABC transporters in both models. Our findings indicate that U87-luc2 and U251-RedFLuc GBM models recapitulate different aspects of GBM heterogeneity that need to be considered in preclin. research.

BMC Cancer published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pan, Zhaoqun; Huang, Bingsheng; Zhu, Liqiang; Zeng, Kelin published the artcile< Synthesis of a boron-containing adhesion promoter for improving the adhesion of addition-cure silicone rubber to PPA>, Reference of 112-63-0, the main research area is polyphthalamide silicone rubber adhesion promoter optical property.

In this study, a boron-containing adhesion promoter PhBSiO with a high refractive index and MeBSiO with a low refractive index were synthesized by a non-hydrolytic sol-gel reaction. The chem. structures of the synthesized adhesion promoters were firstly characterized by IR spectroscopy (FT-IR) and gel permeation chromatog. (GPC). Then, the effects of adhesion promoters on the bonding properties of the cured silicone rubber were analyzed and the compatibility of the adhesion promoters to the silicon rubber was further studied through light transmittance detection. The boron-containing silicone adhesion promoters significantly enhanced the bonding strength of the cured silicone rubber to poly-phthalamide (PPA). When the addition amounts of PhBSiO and MeBSiO was 3.0 phr, the shear strength between silicone rubber and PPA resp. reached 0.761 MPa and 0.809 MPa, which were 145% and 161% higher than that of silicone rubber without adhesion promoter. In addition, the adhesion mechanism of the boron-containing adhesion promoter was investigated. The microscopic morphol. of the fractured surface of the cured silicone rubber further demonstrated that boron atoms in the adhesion promoters significantly improved the adhesion strength between silicone rubber and PPA.

Journal of Adhesion Science and Technology published new progress about Adhesion promoters. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Chao; Gu, Haiwei; Jin, Yan; Wurm, Daniel; Freidhof, Brian; Lu, Yingying; Chen, Qin M. published the artcile< Metabolomics of oxidative stress: Nrf2 independent depletion of NAD or increases of sugar alcohols>, SDS of cas: 112-63-0, the main research area is Nrf2 NAD sugar alc oxidative stress metabolomic; Cardiomyocytes; NAD; Nrf2 knockout; Pentose phosphate pathway; Sugar alcohols.

Nrf2 encodes a transcription factor best known for regulating the expression of antioxidant and detoxification genes. Recent evidence suggested that Nrf2 mediates metabolic reprogramming in cancer cells. However, the role of Nrf2 in the biochem. metabolism of cardiac cells has not been studied. Using LC-MS/MS-based metabolomics, we addressed whether knocking out the Nrf2 gene in AC16 human cardiomyocytes affects metabolic reprogramming by oxidative stress. Profiling the basal level metabolites showed an elevated pentose phosphate pathway and increased levels of sugar alcs., sorbitol, L-arabitol, xylitol and xylonic acid, in Nrf2 KO cells. With sublethal levels of oxidative stress, depletion of NAD, an increase of GDP and elevation of sugar alcs., sorbitol and dulcitol, were detected in parent wild type (WT) cells. Knocking out Nrf2 did not affect these changes. Biochem. assays confirmed depletion of NAD in WT and Nrf2 KO cells due to H2O2 treatment. These data support that although Nrf2 deficiency caused baseline activation of the pentose phosphate pathway and sugar alc. synthesis, a brief exposure to none-LDs of H2O2 caused NAD depletion in an Nrf2 independent manner. Loss of NAD may contribute to oxidative stress associated cell degeneration as observed with aging, diabetes and heart failure.

Toxicology and Applied Pharmacology published new progress about Aging, animal. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wong, Thomas Y.; Zhang, Kevin S.; Gandhi, Ripal T.; Collins, Zachary S.; O’Hara, Ryan; Wang, Eric A.; Vaheesan, Kirubahara; Matsuoka, Lea; Sze, Daniel Y.; Kennedy, Andrew S.; Brown, Daniel B. published the artcile< Long-term outcomes following 90Y Radioembolization of neuroendocrine liver metastases: evaluation of the radiation-emitting SIR-spheres in non-resectable liver tumor (RESiN) registry>, Reference of 112-63-0, the main research area is yttrium90 radiation therapy prognosis neuroendocrine tumor hepatotoxicity liver metastasis; Liver cancer; Metastases; Neuroendocrine tumor.

The goal of this study was to evaluate efficacy and safety of 90Y radioembolization for neuroendocrine liver metastases (NELM) in a multicenter registry. One hundred-seventy patients with NELM were enrolled in the registry (NCT 02685631). Prior treatments included hepatic resection (n = 23, 14%), arterial therapy (n = 62, 36%), octreotide (n = 119, 83%), cytotoxic chemotherapy (n = 58, 41%), biol. therapy (n = 49, 33%) and immunotherapy (n = 10, 6%). Seventy-seven (45%) patients had extrahepatic disease. Seventy-eight (48%), 61 (37%), and 25 (15%) patients were Eastern Cooperative Oncol. Group (ECOG) performance status of 0, 1, or ≥ 2. Tumor grade was known in 81 (48%) patients: 57 (70%) were well-, 12 (15%) moderate-, and 12 (15%) poorly-differentiated. Kaplan-Meier anal. and log rank tests were performed to compare overall and progression-free survival (OS/PFS) by tumor location and grade. Toxicities were reported using Common Terminol. Criteria for Adverse Events v.5. Cox Proportional Hazards were calculated for pancreatic primary, performance status, extrahepatic disease at treatment, unilobar treatment, baseline ascites, and > 25% tumor burden. One, 2, and 3-yr OS rates were 75, 62 and 46%, resp. Median OS was 33 mo 95% CI: 25-not reached. The longest median OS was in patients with pancreatic (42 mo, 95% CI: 33-NR) and hindgut (41 mo, 95% CI: 12-NR) primaries. The shortest OS was in foregut primaries (26 mo; 95% CI: 23-NR; X2 = 7, p = 0.1). Median OS of well-differentiated tumors was 36 mo (95% CI: 10-NR), compared to 44 (95% CI: 7-NR) and 25 (95% CI: 3-NR) months for moderate and poorly differentiated tumors. Median progression-free survival (PFS) was 25 mo with 1, 2, and 3-yr PFS rates of 70, 54, and 35%, resp. Thirteen patients (7.6%) developed grade 3 hepatic toxicity, most commonly new ascites (n = 8, 5%) at a median of 5.5 mo. Performance status of ≥2 (HR 2.7, p = 0.01) and baseline ascites (HR 2.8, P = 0.049) predicted shorter OS. Discussion: In a population with a high incidence of extrahepatic disease, 90Y was effective and safe in treatment of NELM, with median OS of 41 mo for well differentiated tumors. Grade 3 or greater hepatic toxicity was developed in 7.6% of patients. Trial registration: NCT 02685631.

BMC Cancer published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics