Category: 112-63-0

Maity, Asim; Hyun, Sung-Min; Powers, David C. published the artcile< Oxidase catalysis via aerobically generated hypervalent iodine intermediates>, Reference of 112-63-0, the main research area is hypervalent iodine reagent preparation oxidase catalysis aryl iodide.

The development of sustainable oxidation chem. demands strategies to harness O2 as a terminal oxidant. Oxidase catalysis, in which O2 serves as a chem. oxidant without necessitating incorporation of oxygen into reaction products, would allow diverse substrate functionalization chem. to be coupled to O2 reduction Direct O2 utilization suffers from intrinsic challenges imposed by the triplet ground state of O2 and the disparate electron inventories of four-electron O2 reduction and two-electron substrate oxidation Here, we generate hypervalent iodine reagents-a broadly useful class of selective two-electron oxidants-from O2. This is achieved by intercepting reactive intermediates of aldehyde autoxidation to aerobically generate hypervalent iodine reagents for a broad array of substrate oxidation reactions. The use of aryl iodides as mediators of aerobic oxidation underpins an oxidase catalysis platform that couples substrate oxidation directly to O2 reduction We anticipate that aerobically generated hypervalent iodine reagents will expand the scope of aerobic oxidation chem. in chem. synthesis.

Nature Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fushimi, Nobuhiko; Fujikura, Hideki; Shiohara, Hiroaki; Teranishi, Hirotaka; Shimizu, Kazuo; Yonekubo, Shigeru; Ohno, Kohsuke; Miyagi, Takashi; Itoh, Fumiaki; Shibazaki, Toshihide; Tomae, Masaki; Ishikawa-Takemura, Yukiko; Nakabayashi, Takeshi; Kamada, Noboru; Ozawa, Tomonaga; Kobayashi, Susumu; Isaji, Masayuki published the artcile< Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia>, SDS of cas: 112-63-0, the main research area is preparation structure benzyl pyrazolyl glucopyranoside derivative SGLT1 inhibitor hyperglycemia.

Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of glucose in the gut and is considered a promising target in the development of treatments for postprandial hyperglycemia. A series of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives have been synthesized, and its inhibitory activity toward SGLTs has been evaluated. By altering the substitution groups at the 5-position of the pyrazole ring, and every position of the Ph ring, we studied the structure-activity relationship (SAR) profiles and identified a series of potent and selective SGLT1 inhibitors. Representative derivatives showed a dose-dependent suppressing effect on the escalation of blood glucose levels in oral mixed carbohydrate tolerance tests (OCTT) in streptozotocin-nicotinamide-induced diabetic rats (NA-STZ rats).

Bioorganic & Medicinal Chemistry published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balannik, Victoria; Wang, Jun; Ohigashi, Yuki; Jing, Xianghong; Magavern, Emma; Lamb, Robert A.; De Grado, William F.; Pinto, Lawrence H. published the artcile< Design and Pharmacological Characterization of Inhibitors of Amantadine-Resistant Mutants of the M2 Ion Channel of Influenza A Virus>, Related Products of 112-63-0, the main research area is spiroundecane preparation influenza virus M2 channel blockade SAR.

The A/M2 proton channel of influenza A virus is a target for the anti-influenza drugs amantadine and rimantadine, whose effectiveness was diminished by the appearance of naturally occurring point mutants in the A/M2 channel pore, among which the most common are S31N, V27A, and L26F. We have synthesized and characterized the properties of a series of compounds, originally derived from the A/M2 inhibitor BL-1743. A lead compound emerging from these investigations, spiro[5.5]undecan-3-amine, is an effective inhibitor of wild-type A/M2 channels and L26F and V27A mutant ion channels in vitro and also inhibits replication of recombinant mutant viruses bearing these mutations in plaque reduction assays. Differences in the inhibition kinetics between BL-1743, known to bind inside the A/M2 channel pore, and amantadine were exploited to demonstrate competition between these compounds, consistent with the conclusion that amantadine binds inside the channel pore. Inhibition by all of these compounds was shown to be voltage-independent, suggesting that their charged groups are within the N-terminal half of the pore, prior to the selectivity filter that defines the region over which the transmembrane potential occurs. These findings not only help to define the location and mechanism of binding of M2 channel-blocking drugs but also demonstrate the feasibility of discovering new inhibitors that target this binding site in a number of amantadine-resistant mutants.

Biochemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Lin; Wang, Hui; Zhao, Shuping; Zhao, Yuan; Chen, Yongping; Zhang, Jiuyan; Wang, Chuqiao; Sun, Ning; Fan, Honggang published the artcile< Paeoniflorin ameliorates lipopolysaccharide-induced acute liver injury by inhibiting oxidative stress and inflammation via SIRT1 / FOXO1a / SOD2 signaling in rats>, HPLC of Formula: 112-63-0, the main research area is inflammation oxidative stress paeoniflorin ameliorates lipopolysaccharide acute liver injury; NLRP3 inflammasome; Paeoniflorin; SIRT1/FOXO1a/SOD2 signaling; acute liver injury; mitochondrial ROS.

Acute liver injury (ALI) is a poor prognosis and high mortality complication of sepsis. Paeoniflorin (PF) has remarkable anti-inflammatory effects in different disease models. Here, we explored the protective effect and underlying mol. mechanisms of PF against lipopolysaccharide (LPS)-induced ALI. Sprague-Dawley rats received i.p. (i.p.) injection of PF for 7 days, 1 h after the last administration, and rats were injected i.p. 10 mg/kg LPS. PF improved liver structure and function, reduced hepatic reactive oxygen species (ROS) and methane dicarboxylic aldehyde (MDA) levels, and increased superoxide dismutase (SOD) activity. Western blot anal. suggested that PF significantly inhibited expression of inflammatory cytokines (TNF-α, IL-1β, and IL-18) and inhibited activation of the NLRP3 inflammasome. PF or mitochondrial ROS scavenger (mito-TEMPO) significantly improved liver mitochondrial function by scavenging mitochondrial ROS (mROS), restoring mitochondrial membrane potential loss and increasing level of ATP and enzyme activity of complex I and III. In addition, PF increased expression of sirtuin-1 (SIRT1), forkhead box O1 (FOXO1a) and manganese superoxide dismutase (SOD2), and increased FOXO1a nuclear retention. However, the inhibitor of SIRT1 (EX527) abolished the protective effect of PF. Taken together, PF promotes mROS clearance to inhibit mitochondrial damage and activation of the NLRP3 inflammasome via SIRT1/FOXO1a/SOD2 signaling.

Phytotherapy Research published new progress about Acute liver failure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quek, Lake-Ee; van Geldermalsen, Michelle; Guan, Yi Fang; Wahi, Kanu; Mayoh, Chelsea; Balaban, Seher; Pang, Angel; Wang, Qian; Cowley, Mark J.; Brown, Kristin K.; Turner, Nigel; Hoy, Andrew J.; Holst, Jeff published the artcile< Glutamine addiction promotes glucose oxidation in triple-negative breast cancer>, Reference of 112-63-0, the main research area is breast cancer glucose oxidation glutamine addiction.

Glutamine is a conditionally essential nutrient for many cancer cells, but it remains unclear how consuming glutamine in excess of growth requirements confers greater fitness to glutamine-addicted cancers. By contrasting two breast cancer subtypes with distinct glutamine dependencies, we show that glutamine-indispensable triple-neg. breast cancer (TNBC) cells rely on a non-canonical glutamine-to-glutamate overflow, with glutamine carbon routed once through the TCA cycle. Importantly, this single-pass glutaminolysis increases TCA cycle fluxes and replenishes TCA cycle intermediates in TNBC cells, a process that achieves net oxidation of glucose but not glutamine. The coupling of glucose and glutamine catabolism appears hard-wired via a distinct TNBC gene expression profile biased to strip and then sequester glutamine nitrogen, but hampers the ability of TNBC cells to oxidise glucose when glutamine is limiting. Our results provide a new understanding of how metabolically rigid TNBC cells are sensitive to glutamine deprivation and a way to select vulnerable TNBC subtypes that may be responsive to metabolic-targeted therapies.

Oncogene published new progress about Amino acid transporter ASCT2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Russo, Vincenzo; Tesser, Riccardo; Rossano, Carmelina; Cogliano, Tommaso; Vitiello, Rosa; Leveneur, Sebastien; Di Serio, Martino published the artcile< Kinetic study of Amberlite IR120 catalyzed acid esterification of levulinic acid with ethanol: From batch to continuous operation>, COA of Formula: C19H34O2, the main research area is levulinic acid ethanol esterification cation exchanger kinetics ethyl levulinate.

Levulinic acid (LA) is 1 of the most important platform chems. as it is a versatile building block for a variety of high value-added products, fine chems. and pharmaceutical intermediates. Catalytic esterification of LA with alkyl alcs. leads to levulinate esters which can be used as fragrances, flavoring agents and fuel additives. The kinetics of the levulinic acid esterification with EtOH in the presence of Amberlite IR120 was studied in a batch reactor. The collected exptl. data were interpreted with a reliable model taking into account also for the mass transfer phenomena involved in the reaction network. The kinetic model was further validated by conducting experiments in a fixed bed reactor. The reactor was characterized in terms of fluid-dynamics and the collected kinetic data were interpreted with a reliable reactor model, considering the extent of the reaction and fluid-solid mass transfer limitation.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Density. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garcia de Jalon, Elvira; Ruiz de Garibay, Gorka; Haug, Bengt Erik; McCormack, Emmet published the artcile< CytoCy5S, a compound of many structures. in vitro and in vivo evaluation of four near-infrared fluorescent substrates of nitroreductase (NTR)>, SDS of cas: 112-63-0, the main research area is nitroreductase fluorescent probe imaging.

CytoCy5S, a quenched, red-shifted fluorescent probe, has been used to exploit the imaging potential of the nitroreductase (NTR) reporter gene platform. Its use has been reported in a number of publications, however there are discrepancies in both the reported structure and its physicochem. properties. Herein, we aim to highlight these discrepancies and to define the best candidate of the four substrates under study for preclin. work in NTR reporting by optical applications. We report the synthesis, purification and characterization of four NTR substrates, including alternately described structures currently referred by the name CytoCy5S. A comparative NTR enzymic assay was performed to assess the spectroscopic characteristics of the different reductively activated probes. The NTR expressing triple-neg. breast carcinoma cell line, MDA-MB-231 NTR+, was employed to compare, both in vitro and in vivo, the suitability of these fluorescent probes as reporters of NTR activity. Comparison of the reporting properties was achieved by flow cytometry, fluorescence microscopy and optical imaging, both in vivo and ex vivo. This study evaluated the different spectroscopic and biol. characteristics of the four substrates and concluded that substrate 1 presents the best features for oncol. in vivo preclin. optical imaging.

Dyes and Pigments published new progress about Fluorescence imaging. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kandpal, Charu; Pandey, J. D.; Dey, Ranjan; Singh, Arvind Kumar; Singh, Vinod Kumar published the artcile< Comparative study of viscosity, diffusion coefficient, thermal conductivity and Gibbs free energy for binary liquid mixtures at varying temperatures>, HPLC of Formula: 112-63-0, the main research area is dynamic viscosity diffusion coefficient thermal conductivity free energy.

Comparative evaluation of useful transport properties (viscosity, thermal conductivity, diffusion coefficient) and Gibbs free energy has been carried out at 298.15 K and 323.15 K. Fourteen different approaches have been employed to compute the viscosity coefficient for ether-alkane mixtures with self-associated alcs. Thermal conductivity (λ) has been computed using six different models. Diffusion coefficient and Gibbs free energy has also been elucidated by fourteen approaches. The calculated values obtained from this work have been compared. The aim of this investigation is to check the variations occurred for ether-alkane mixtures due to application of different models at different temperatures and to get better understanding of the nature of the intermol. interactions in the mixture

Journal of Molecular Liquids published new progress about Binary mixtures. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Xiao; Song, Xiaosheng; Guo, Zhijie; Bian, Tengfei; Zhang, Jin; Zhao, Yong published the artcile< Biphasic Electrolyte Inhibiting the Shuttle Effect of Redox Molecules in Lithium-Metal Batteries>, Product Details of C19H34O2, the main research area is lithium metal battery shuttle effect biphasic electrolyte; biphasic electrolytes; lithium redox flow batteries; lithium-oxygen batteries; redox mediators; shuttle effects.

Redox mols. (RMs) as electron carriers have been widely used in electrochem. energy-storage devices (ESDs), such as lithium redox flow batteries and lithium-O2 batteries. Unfortunately, migration of RMs to the lithium (Li) anode leads to side reactions, resulting in reduced coulombic efficiency and early cell death. Our proof-of-concept study utilizes a biphasic organic electrolyte to resolve this issue, in which nonafluoro-1,1,2,2-tetrahydrohexyl-trimethoxysilane (NFTOS) and ether (or sulfone) with lithium bis(trifluoromethane)sulfonimide (LiTFSI) can be separated to form the immiscible anolyte and catholyte. RMs are extracted to the catholyte due to the enormous solubility coefficients in the biphasic electrolytes with high and low polarity, resulting in inhibition of the shuttle effect. When coupled with a lithium anode, the Li-Li sym., Li redox flow and Li-O2 batteries can achieve considerably prolonged cycle life with biphasic electrolytes. This concept provides a promising strategy to suppress the shuttle effect of RMs in ESDs.

Angewandte Chemie, International Edition published new progress about Cell cycle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Altarawneh, Ibrahem; Altarawneh, Mohammednoor; Rawadieh, Saleh published the artcile< Theoretical study on thermochemical parameters and IR spectra of chlorinated isomers of nitrobenzene>, HPLC of Formula: 112-63-0, the main research area is theor thermochem parameter IR spectra nitrobenzene chlorinated isomer.

Thermochem. and geometrical parameters and internal rotation barriers of all chlorinated nitrobenzene isomers were calculated with the G3MP2B3 composite method. Standard entropies, standard Gibbs free energies of formation, standard enthalpies of formation, and heat capacities were calculated and compared with their corresponding available exptl. data. Our calculated enthalpy values agree well with the corresponding exptl. data. The temperature dependence of entropy and heat capacity has been analyzed. All isomers with ortho-chlorine substituents were found to be less stable than other corresponding isomers. Rotational barriers and distortions of the benzene rings were incorporated in the calculations of values for entropy and heat capacity. The IR spectra were calculated and found to be in reasonable agreement with the exptl. spectra.

Canadian Journal of Chemistry published new progress about Bond angle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics