Category: 112-63-0

Shi, Lan-xiang; Zhang, Bao-hua; Zhang, Xing-chen published the artcile< Synthesis of 4-bromo-N,N-dimethylaniline>, Quality Control of 112-63-0, the main research area is bromo dimethylaniline preparation pyridinium tribromide.

A method for the synthesis of the title compound is reported here. In presence of pyridine, 4-bromo-N,N-dimethylaniline was synthesized by a substitution reaction starting from N,N-dimethylaniline and bromine. In this reaction, the easy-to-handle bromination agent pyridinium tribromide was formed and the regioselectivity of the substitution reaction was enhanced. The optimal molar ratio was n(C8H11N):n(Br2):n(C5H5N) = 1:1.1:1.1, the reaction was at 10-15° for 6 h (product yield 68%).

Hebei Shifan Daxue Xuebao, Ziran Kexueban published new progress about Bromination, regioselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sghaier, Randa; Nury, Thomas; Leoni, Valerio; Caccia, Claudio; Pais De Barros, Jean-Paul; Cherif, Ameur; Vejux, Anne; Moreau, Thibault; Limem, Khalifa; Samadi, Mohammad; Mackrill, John J.; Masmoudi, Ahmed Slaheddine; Lizard, Gerard; Zarrouk, Amira published the artcile< Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol>, Category: esters-buliding-blocks, the main research area is oligodendrocyte oxiapoptophagy dimethyl monomethyl fumarate oxidative stress mitochondrial dysfunction; 158N cells; 7β-hydroxycholesterol; Apoptosis; Autophagy; Dimethyl fumarate; Lipid profile; Mitochondria; Monomethyl fumarate; Oxiapoptophagy; Oxidative stress; Peroxisome.

The cytoprotective effects of dimethylfumarate, used in the treatment of relapsing remitting multiple sclerosis and of MMF, its main metabolite, were evaluated on murine oligodendrocytes 158 N exposed to 7β-OHC (50μM, 24 h) with or without DMF or MMF (25μM). The activity of 7β-OHC in the presence or absence DMF or MMF was evaluated on several parameters: cell adhesion; plasma membrane integrity measured with PI, trypan blue and FDA assays; LDH activity; antioxidant enzyme activities ; generation of lipid peroxidation products (MDA, CDs) and CPs; ROS overproduction conducted with DHE and DHR123. Apoptosis and autophagy were characterized by staining with Hoechst 33,342, Giemsa and acridine orange, and with antibodies raised against caspase-3 and LC3. DMF and MMF attenuate 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction (decrease of succinate dehydrogenase activity, loss of ΔΨm, increase of mitochondrial O·-2 production, alteration of the TCA cycle, and cardiolipins content); oxidative stress induction; changes in fatty acid and cholesterol metabolism; and cell death induction (caspase-3 cleavage, activation of LC3-I in LC3-II). Ultrastructural alterations of mitochondria and peroxisomes were prevented. These results demonstrate that DMF and MMF prevent major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.

Journal of Steroid Biochemistry and Molecular Biology published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rahman, Masum; Olson, Ian; Mansour, Moustafa; Carlstrom, Lucas P.; Sutiwisesak, Rujapope; Saber, Rehan; Rajani, Karishma; Warrington, Arthur E.; Howard, Adam; Schroeder, Mark; Chen, Sisi; Decker, Paul A.; Sananikone, Eliot F.; Zhu, Yi; Tchkonia, Tamar; Parney, Ian F.; Burma, Sandeep; Brown, Desmond; Rodriguez, Moses; Sarkaria, Jann N.; Kirkland, James L.; Burns, Terry C. published the artcile< Selective vulnerability of senescent glioblastoma cells to BCL-XL inhibition>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

Glioblastoma (GBM) is a rapidly fatal malignancy typically treated with radiation and temozolomide (TMZ), an alkylating chemotherapeutic. These cytotoxic therapies cause oxidative stress and DNA damage, yielding a senescent-like state of replicative arrest in surviving tumor cells. Unfortunately, recurrence is inevitable and may be driven by surviving tumor cells eventually escaping senescence. A growing number of so-called “”senolytic”” drugs have been recently identified that are defined by their ability to selectively eliminate senescent cells. A growing inventory of senolytic drugs is under consideration for several diseases associated with aging, inflammation, DNA damage, as well as cancer. Ablation of senescent tumor cells after radiation and chemotherapy could help mitigate recurrence by decreasing the burden of residual tumor cells at risk of recurrence. This strategy has not been previously explored for GBM. We evaluated a panel of 10 previously described senolytic drugs to determine whether any could exhibit selective activity against human GBM persisting after exposure to radiation or TMZ. Three of the 10 drugs have known activity against BCL-XL and preferentially induced apoptosis in radiated or TMZ-treated glioma. This senolytic activity was observed in 12 of 12 human GBM cell lines. Efficacy could not be replicated with BCL-2 inhibition or senolytic agents acting against other putative senolytic targets. Knockdown of BCL-XL decreased survival of radiated GBM cells, whereas knockdown of BCL-2 or BCL-W yielded no senolytic effect. Implications: These findings imply that molecularly heterogeneous GBM lines share selective senescence-induced BCL-XL dependency increase the significance and translational relevance of the senolytic therapy for latent glioma.

Molecular Cancer Research published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xiaoyang; Hou, Yaqin; Peng, Cheng; Wang, Chu; Wang, Xiang; Liang, Zhigang; Lu, Jing; Chen, Baian; Dai, Jiapei; Liu, Boli; Cui, Mengchao published the artcile< Oligoethyleneoxy-Modified 99mTc-Labeled β-Amyloid Imaging Probes with Improved Brain Pharmacokinetics for Single-Photon Emission Computed Tomography>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is technetium oligoethyleneoxy amyloid SPECT imaging brain pharmacokinetics.

An oligoethyleneoxy linker was introduced for conjugation between 99mTc/Re-bis(aminoethanethiol) (BAT) and β-amyloid (Aβ) binding scaffolds. Rhenium complexes exhibited high to moderate binding affinity to Aβ1-42 aggregates and efficient fluorescent staining to Aβ plaques in brain tissue. After radiolabeling, the 99mTc-labeled probes revealed improved brain pharmacokinetics in normal ICR mice. Probe [99mTc]15 with potent binding affinity (Ki = 13.4 nM) and the highest initial brain uptake (2.10% ID/g at 2 min) in normal ICR mice was evaluated further. In vitro autoradiog. showed specific labeling of Aβ plaques by [99mTc]15 in transgenic (Tg) mouse brain tissue. Ex vivo autoradiog. further demonstrated its efficient labeling of Aβ plaques in a living Tg mouse. In vivo single photon emission computed tomog. (SPECT)/CT imaging in six rhesus monkeys revealed remarkably improved brain uptakes (1.94-2.63% ID within 20 min) of [99mTc]15, making it highly potential to be used in humans for Aβ plaques imaging in the brain.

Journal of Medicinal Chemistry published new progress about Brain. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wadsworth, D. H.; Schupp, III O. E.; Sous, E. J.; Ford, Jr. J. A. published the artcile< The stereochemistry of the phosphonate modification of the Wittig reaction>, COA of Formula: C19H34O2, the main research area is .

A number of olefins prepared by the phosphonate carbanion modification of the Wittig reaction were shown to have trans configurations.. Vapor phase chromatography of the intact reaction mixtures showed, at most, only trace amounts of cis isomers. To determine the degree of stereospecificity of the reaction under adverse circumstances, several experiments were devised with systems which, based on the generally accepted reaction mechanism, should be more favorable for the preparation of cis olefins. In only one case, however, was a significant amount of a cis isomer formed [6.4% cis-1,2-(1,1′-dinaphthyl)ethylene in a 1:10 cis-trans mixture], demonstrating the great stereospecific tendency of the reaction. Possible interpretations of the observed differences in stereospecificity of olefin formation from phosphonate carbanions and phosphorus ylides are discussed.

Journal of Organic Chemistry published new progress about NMR (nuclear magnetic resonance). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bai, Zhang-Zhen; Ni, Jing; Tang, Jun-Man; Sun, Dao-Yang; Yan, Zhen-Guo; Zhang, Jing; Niu, Li-Xin; Zhang, Yan-Long published the artcile< Bioactive components, antioxidant and antimicrobial activities of Paeonia rockii fruit during development>, COA of Formula: C19H34O2, the main research area is transresveratrol benzoic acid paeoniflorin luteolin Paeonia antioxidant antimicrobial activity; Albiflorin (PubChem CID: 24868421); Antibacterial activity; Antioxidant activity; Benzoic acid (PubChem CID: 243); LC-ESI-QqQ-MS; Luteolin (PubChem CID: 5280445); Methyl gallate (PubChem CID: 7428); Monoterpene glycosides; OPLS-DA; PCA; Paeonia rockii fruit; Paeoniflorin (PubChem CID: 442534); Phenolic compounds; Trans-resveratrol (PubChem CID: 445154).

In last ten years, much attention focused on tree peony fruit (TPF) for edible oil production despite other potential utilization. The present study identified and quantified 29 bioactive components by liquid chromatog.-electrospray ionization-triple quadrupole-mass spectrometry (LC-ESI-QqQ-MS) targeted approach during the development of TPF. Trans-resveratrol, benzoic acid, luteolin, and Me gallate were selected as predominant chem. markers between seeds and pods through principal component anal. (PCA) and orthogonal partial least square-discriminant anal. (OPLS-DA). Extremely high levels of paeoniflorin (1893 mg/100 g) and trans-resveratrol (1793 mg/100 g) were observed at stage 2 (S2) and S6 in seeds, resp. Antioxidant activities determined by ABTS+·, DPPH·, and FRAP assays showed significant correlations with total phenolic content (TPC) and total flavonoid content (TFC). The strongest antibacterial effects of pod and seed against Staphylococcus aureus and Proteus vulgaris occurred at initial stages and maturation stages. TPF could be a potential source of bioactive compounds with functional properties.

Food Chemistry published new progress about Antimicrobial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Temburnikar, Kartik W.; Zimmermann, Sarah C.; Kim, Nathaniel T.; Ross, Christina R.; Gelbmann, Christopher; Salomon, Christine E.; Wilson, Gerald M.; Balzarini, Jan; Seley-Radtke, Katherine L. published the artcile< Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antiproliferative activity cancer fungus halogenated thienopyrimidine structure; Antifungal; Apoptosis; Cytostatic; Heterocyclic chemistry; Thieno[3,2-d]pyrimidine.

The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relation study indicated the necessity of the chlorine at the C4-position for biol. activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Addnl., the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed The synthesis and preliminary biol. results are reported herein.

Bioorganic & Medicinal Chemistry published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Matousek, Vaclav; Pietrasiak, Ewa; Schwenk, Rino; Togni, Antonio published the artcile< One-Pot Synthesis of Hypervalent Iodine Reagents for Electrophilic Trifluoromethylation>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is preparation hypervalent iodine reagent; electrophilic trifluoromethylation.

Simplified syntheses suited for large scale preparations of the two hypervalent iodine reagents I and II for electrophilic trifluoromethylation are reported. In both cases, the stoichiometric oxidants sodium metaperiodate and tert-Bu hypochlorite have been replaced by trichloroisocyanuric acid. Reagent I is accessible in a one-pot procedure from 2-iodobenzoic acid in 72% yield. Reagent II was prepared via fluoroiodane III in a considerably shorter reaction time and with no need of an accurate temperature control.

Journal of Organic Chemistry published new progress about Iodanes Role: IMF (Industrial Manufacture), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Xingdong; Hou, Jinjun; Zhang, Zijia; Chen, Lingmin; Ni, Hui; Qian, Yong; Wu, Wenyong; Long, Huali; Zhang, Linlin; Li, FeiFei; Lei, Min; Huang, Yong; Guo, Dean; Wu, Wanying published the artcile< In-depth exploration and comparison of chemical constituents from two Lilium species through offline two-dimensional liquid chromatography combined with multimode acquisition of high-resolution mass spectrometry>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Lilium compound 2D LC HRMS; Comparative components; Lilium; Offline 2D LC; Phenylpropanoid derivatives; Steroidal saponins.

Lilium lancifolium and Lilium brownii viridulum were two common cultivars of Lilium in China, which have been used as a source of food in ancient China, and as a traditional herbal medicine in most northern hemispheres countries continues today. However, only a few secondary metabolites in Lilium closely related to human health have been reported. In this research, an offline two-dimensional (HILIC and RP C18) separation system combined with multimode high-resolution mass spectrometry data acquisition was established for in-depth exploration and comparison of the chem. components in Lilium. In total, 331 components were identified, among which phenylpropanoid derivatives and steroidal saponins were the most abundant components. Furthermore, sulfur derivatives and steroidal alkaloids were systematically characterized in Lilium for the first time. These results provided valuable information for in-depth differentiating types of components characterization, which may be applied to assess and improve the edible and medicinal values of Lilium.

Journal of Chromatography A published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kost, A. N.; Minkin, V. I.; Sagitullin, R. S.; Gorbunov, V. I.; Sadekov, I. D. published the artcile< Transfer of substituent effects across the indole ring>, Reference of 112-63-0, the main research area is charge transfer indoles; indoles charge transfer.

The pK values and σ constants (Taft, Hammett, Webster, and Dewar constants) were determined for substituted indole-2-carboxylic acids (I). The transfer of the elec. charges in this ring system is weaker than in carbocyclic systems. The electron-donating groups have very little effect. The relation of structure with the pK of I is best expressed in terms of the Dewar theory.

Zhurnal Organicheskoi Khimii published new progress about Ionization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics