Category: 112-63-0

Pouretedal, H. R.; Keshavarz, M. H. published the artcile< Prediction of toxicity of nitroaromatic compounds through their molecular structures>, Category: esters-buliding-blocks, the main research area is QSAR nitroarom compound toxicity.

In this paper, a new simple method is presented for the estimation of the toxicity of nitroarom. compounds including some well-known explosives. This method can predict the 50% LD concentration for rats (LD50) as the estimation of toxicity in vivo. The prediction of LD50 of nitroaroms. through a new general correlation is based on the number of alkyl and nitro groups per mol. weight of the nitroarom. compound as a core function. The existence of some specific structural parameters can decrease or increase the predicted results on the basis of the core function. The predicted results of various nitroarom. compounds afford reliable prediction of LD50 with respect to exptl. data. Prediction of toxicity for 28 nitroarom. compounds, where the exptl. data were available, and new nitroarom. derivatives produce comparable results to those of several models of Quant. Structure Activity Relation (QSAR).

Journal of the Iranian Chemical Society published new progress about Aromatic nitro compounds Role: ADV (Adverse Effect, Including Toxicity), PRP (Properties), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Lijun; Li, Aiwu; Zhang, Qiangye published the artcile< 6'-O-galloylpaeoniflorin exerts inhibitory bioactivities in human neuroblastoma cells via modulating AMPK/miR-489/XIAP pathway>, Application of C19H34O2, the main research area is human neuroblastoma cell galloylpaeoniflorin bioactivity AMPK miR XIAP pathway.

Although therapies against neuroblastoma (NBM) have advanced, the patients still suffer from poor prognoses due to distal metastasis or the occurrence of multidrug resistance. Accumulating evidence has proved that chems. derived from natural products possess potent anti-NBM properties or can be used as adjuvants for chemotherapy. In the present study, we demonstrated that 6′-O-galloylpaeoniflorin (GPF), a galloylated derivative of paeoniflorin isolated from the roots of Paeonia lactiflora Pall, exerted significant inhibitory effects on proliferation and invasion of SH-SY5Y cells (an NBM cell line) and enhanced the sensitivity of SH-SY5Y cells to cisplatin in vitro. Further studies showed that GPF treatment upregulated miR-489 in NBM cells via activating AMP-activated protein kinase (AMPK). We also demonstrated that similar to GPF treatment, miR-489 exhibited a significant anti-NBM capacity. Further studies showed that miR-489 directly targeted the X-linked inhibitor of apoptosis protein (XIAP). Overall, our results indicated that GPF possessed an evident anti-NBM capacity dependent on AMPK/miR-489/XIAP pathway, providing an emerging strategy for clin. treatment of NBM.

BioMed Research International published new progress about 3′-Untranslated region Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mittal, Saurabh; Ali, Javed; Baboota, Sanjula published the artcile< DoE Engineered Development and Validation of an RP-HPLC Method for Simultaneous Estimation of Temozolomide and Resveratrol in Nanostructured Lipid Carrier.>, Formula: C19H34O2, the main research area is .

BACKGROUND: Temozolomide is drug of choice for the treatment of glioblastoma, but dose-related side effects limit its use. Resveratrol suppresses tumor growth and promotes apoptosis. Many studies showed synergistic activity of resveratrol and temozolomide against glioblastoma. There are methods reported for the assessment of temozolomide and resveratrol individually, but no analytical method has been reported for assessment of temozolomide and resveratrol simultaneously. OBJECTIVE: Therefore, the present study aimed to develop and optimize an HPLC analytical method for the simultaneous assessment of temozolomide and resveratrol in a developed nanostructured lipid carrier. METHOD: A Central composite rotable design was used to optimize the method. The method was developed using a C18 column. The composition of the mobile phase was 30% methanol and 70% glacial acetic acid (0.1% v/v in HPLC grade water); detecting wavelength was 310 nm. Forced degradation test was also performed to demonstrate the proposed HPLC method’s ability to indicate stability. RESULTS: The LOD for temozolomide and resveratrol was found to be 1.10 and 0.83 µg/mL, respectively, while LOQ was 3.33 and 2.52 µg/mL, respectively. The drug loading and entrapment efficacy of the formulation, as determined using the aforementioned method, was found to be 6.73 and 96.28% for temozolomide and 3.45 and 89.39% for resveratrol, respectively. CONCLUSIONS: The developed HPLC method was simple, rapid, economical, precise, accurate, and reproducible, and it had high selectivity with good detection limits. Standard guidelines of ICH Q2 (R1) including linearity, specificity, system suitability, robustness, precision, accuracy, the LOQ, and LOD gave satisfactory results. Forced degradation studies showed a good stability-indicating capacity of the developed HPLC method. HIGHLIGHTS: Analytical Quality by Design is a powerful tool that could be used for the development of the analytical method. Central composite rotable design was used for optimizing the method. The percent of methanol and concentration of glacial acetic acid were selected as two independent variables for optimization.

Journal of AOAC International published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lei, Yali; Zhou, Xu; Zhao, Yang; Zhang, Jianfa published the artcile< Effects of exogenous ATP on melanoma growth and tumor metabolism in C57BL/6 mice>, HPLC of Formula: 112-63-0, the main research area is ATP LDHA LDHB anticancer agent melanoma.

Altered energy metabolism (glucose, lipid, amino acid) is a hallmark of cancer growth that provides the theor. basis for the development of metabolic therapies as cancer treatments. ATP is one of the major biochem. constituents of the tumor microenvironment. ATP promotes tumor progression or suppression depending on various factors, including concentration and tumor type. Here we evaluated the antitumor effect of extracellular ATP on melanoma and the potential underlying mechanisms. A s.c. tumor model in mice was used to investigate the antitumor effects of ATP. Major lymphocyte cell changes and intratumoral metabolic changes were assessed. Metabolomic anal. (1H NMR spectroscopy) was performed on tumor samples. We measured the activities of lactate dehydrogenase A (LDHA) and LDHB in the excised tumors and serum and found that ATP and its metabolites affected the proliferation of and LDHA activity in B16F10 cells, a murine melanoma cell line. In addition, treatment with ATP dose-dependently reduced tumor size in melanoma-bearing mice. Moreover, flow cytometry anal. demonstrated that the antitumor effect of ATP was not achieved through changes in T-cell or B-cell subsets. Metabolomics anal. revealed that ATP treatment simultaneously reduced multiple intratumoral metabolites related to energy metabolism as well as serum and tumor LDHA activities. Furthermore, both ATP and its metabolites significantly suppressed both tumor cell proliferation and LDHA activity in the melanoma cell line. Our results in vivo and in vitro indicate that exogenous ATP inhibits melanoma growth in association with altered intratumoral metabolism

Comparative Medicine published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koohgard, Mehdi; Hosseini-Sarvari, Mona published the artcile< Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine>, HPLC of Formula: 112-63-0, the main research area is visible light mediated phosphonylation reaction phosphonate formation zinc phthalocyanine.

In this work, we developed a ligand- and base-free visible-light-mediated protocol for the photoredox syntheses of arylphosphonates and, for the first time, alkyl phosphonates. Zinc phthalocyanine-photocatalyzed Csp2-P and Csp3-P bond formations were efficiently achieved by reacting aryl/alkylhydrazines with trialkylphosphites in the presence of air serving as an abundant oxidant. The reaction conditions tolerated a wide variety of functional groups.

Organic & Biomolecular Chemistry published new progress about Air. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Sun; Wang, Lei; Chauhan, Pankaj; Peuronen, Anssi; Rissanen, Kari; Enders, Dieter published the artcile< Asymmetric Synthesis of Five-Membered Spiropyrazolones via N-Heterocyclic Carbene (NHC)-Catalyzed [3+2] Annulations>, Quality Control of 112-63-0, the main research area is spiropyrazolone preparation enantioselective diastereoselective; enal unsaturated pyrazolone annulation heterocyclic carbene catalyst.

A new synthetic strategy for the asym. synthesis of five-membered spiropyrazolones via N-heterocyclic carbene-catalyzed [3+2] annulations employing enals and unsaturated pyrazolones as substrates has been developed. The new protocol allows the flexible variation of all four substituents of the pharmaceutically important spiropyrazolones in moderate to very good yields and in most cases with excellent diastereoselectivities and good to excellent enantioselectivities.

Synthesis published new progress about Cyclization ([3+2]). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kazmierski, Wieslaw M.; McDermed, John published the artcile< Synthesis of the carbonic acid benzotriazol-1-yl-ester-(2-biotinylamino)-9H-fluoren-9-ylmethyl ester: a convenient transient-biotinylation reagent for use in affinity chromatography>, HPLC of Formula: 112-63-0, the main research area is biotinylaminofluorenylmethoxycarbonyl peptide protective group preparation; affinity chromatog biotinylated fluorenylmethoxycarbonyl peptide.

Stepwise synthesis of hydrophobic peptides frequently yields deletion products, which often require extensive purification and identification. A new transient-biotinylation reagent I was prepared, which was conveniently used in affinity chromatog. of crude products to afford pure peptides. Unlike conventional affinity chromatog., reagent I leads to free N-terminal peptides, which are thus amenable to further chem. manipulations.

Tetrahedron Letters published new progress about Affinity chromatography. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cote, Adrien P.; El-Kaderi, Hani M.; Furukawa, Hiroyasu; Hunt, Joseph R.; Yaghi, Omar M. published the artcile< Reticular Synthesis of Microporous and Mesoporous 2D Covalent Organic Frameworks>, HPLC of Formula: 112-63-0, the main research area is boronic acid derivative condensation triphenylene; covalent organic framework microporous organoborane preparation gas adsorption isotherm.

Three new crystalline microporous and mesoporous 2-dimensional covalent organic frameworks termed COF-6, -8, and -10 from boronic acid building blocks and 2,3,6,7,10,11-hexahydroxytriphenylene were synthesized and structurally characterized. These materials constructed of C2O2B rings form eclipsed layered structures with pore sizes ranging from 6.4 to 34.1 Å and have high thermal stability, low d., and high porosity as indicated by the surface areas of 980, 1400, and 2080 m2 g-1 for COF-6, -8, and -10, resp. The control of pore size and structure demonstrates the effectiveness of reticular chem. methods toward materials design.

Journal of the American Chemical Society published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Roztocki, Kornel; Formalik, Filip; Bon, Volodymyr; Krawczuk, Anna; Goszczycki, Piotr; Kuchta, Bogdan; Kaskel, Stefan; Matoga, Dariusz published the artcile< Tuning Adsorption-Induced Responsiveness of a Flexible Metal-Organic Framework JUK-8 by Linker Halogenation>, Reference of 112-63-0, the main research area is pyridyl benzenedicarbohalohydrazide zinc oxydibenzoic carboxylate MOF preparation crystal structure; gas adsorption responsiveness flexible zinc metal organic framework; crystal mol structure pyridyl benzenedicarbohalohydrazide zinc oxydibenzoic carboxylate MOF.

Flexible stimuli-responsive metal-organic frameworks have become promising candidates for numerous applications in gas-related technologies; however, the methods of fine tuning their responses are still limited and sought after. In this work, authors demonstrate control over the adsorption properties of a flexible platform by incorporating halogen substituents (X = F, Cl, Br, I) into an eightfold interpenetrated isoreticular series [Zn(oba)(X-pip)]n (JUK-8X; X-pip = 4-pyridyl-functionalized benzene-1,3-dicarbo-5-halogenohydrazide; oba2- = 4,4′-oxydibenzoic carboxylate). The introduced halogen atoms allow for precise tuning of CO2 gate-opening pressures from p/p0 = 0.08 for the parental JUK-8 to 0.78 for the chlorine-functionalized JUK-8Cl. The presence of fluorine or chlorine substituent in the X-pip linker practically does not influence the maximum molar CO2 uptake as compared to JUK-8, whereas larger bromine or iodine atoms increase this uptake by 59 and 48%, resp. Utilizing in situ powder x-ray diffraction (PXRD) during CO2 adsorption for a model JUK-8F, they propose a detailed mechanism of phase transitions including positions of the adsorbed gas mols. for the two loaded phases. D. functional theory calculations supported by in situ PXRD measurements at a saturation pressure shed light on the unusual CO2 adsorption properties of JUK-8Br and JUK-8I. Overall, their report demonstrates the use of halogen interactions for the control of a gas-responsive system and provides insightful guidance for the further development of flexible, adaptable materials.

Chemistry of Materials published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seo, Chang-Seob; Lee, Mee-Young published the artcile< Simultaneous Determination of Fourteen Marker Compounds in the Traditional Herbal Prescription, Geumgwesingihwan, Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry>, Formula: C19H34O2, the main research area is geumgwesingihwan traditional herbal prescription UPLCMS; Geumgwesingihwan; UPLC–MS/MS; simultaneous determination; traditional herbal prescription.

Geumgwesingihwan (GSH) is a traditional herbal prescription composed of eight medicinal herbs: Rehmannia glutinosa (Gaertn.) DC., Dioscorea japonica Thunb., Cornus officinalis Siebold and Zucc., Poria cocos Wolf, Paeonia suffruticosa Andrews, Alisma plantago-aquatica subsp. orientale (Sam.) Sam., Achyranthes bidentate Blume, and Plantago asiatica L. This study developed and validated an ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS) method in the multiple reaction monitoring (MRM) mode for simultaneous determination of 14 compounds (allantoin, gallic acid, 5-(hydroxymethyl)furfural, geniposidic acid, oxypaeoniflorin, loganin, geniposide, paeoniflorin, ecdysterone, verbascoside, cornuside, benzoylpaeoniflorin, paeonol, and alisol B acetate) in GSH. The chromatog. separation of all marker analytes was carried out on an Acquity UPLC BEH C18 column (100 mm × 2.1 mm, 1.7μm) using gradient elution of a mobile phase of distilled water-acetonitrile containing 0.1% acetic acid. The newly established UPLC-MS/MS MRM method was validated by evaluating the linearity, the limits of detection and quantification, recovery, and precision. All markers were detected at concentrations of 6.94-4126.28 mg/kg. In addition, the recovery was 76.65-119.49% and the relative standard deviation value of the precision was 0.19-9.91%. The newly developed and validated UPLC-MS/MS assay will provide useful information for quality assessment of GSH.

Molecules published new progress about Achyranthes bidentata. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics