Category: 112-63-0

Guggisberg, Yves; Faigl, Ferenc; Schlosser, Manfred published the artcile< Optional ortho or alpha hydroxymethylation of alkylarenes>, Synthetic Route of 112-63-0, the main research area is regioselective hydroxymethylation alkylarene; alkanol aryl; benzyl alc alkyl.

Treatment of arenes carrying Me or primary alkyl groups, e.g., EtPh, in THF with potassium tert-butoxide activated butyllithium followed by reaction with formaldehyde gives 2-arylalkanols, e.g., PhCHMeCH2OH. In contrast, if prior to the addition of the electrophile a stoichiometric amount of magnesium dibromide is added then the regioisomeric 2-alkylbenzyl alcs., e.g., 2-EtC6H4CH2OH, are formed.

Journal of Organometallic Chemistry published new progress about Regiochemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Ying; Zhang, Ling; Yang, Chao; Han, Jinsong; Wang, Chongqing; Zheng, Canhui; Zhou, Youjun; Lv, Jiaguo; Song, Yunlong; Zhu, Ju published the artcile< Discovery of benzenesulfonamide derivatives as potent PI3K/mTOR dual inhibitors with in vivo efficacies against hepatocellular carcinoma>, Product Details of C19H34O2, the main research area is benzene sulfonamide derivative preparation dual PI3K mTOR inhibitor hepatoma; Antitumor; Benzenesulfonamide derivatives; Dual inhibitors; Hepatocellular carcinoma; Mammalian target of rapamycin (mTOR); Phosphoinositide 3-kinase (PI3K).

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is related to cellular activities. Abnormalities of this signaling pathway were discovered in various cancers, including hepatocellular carcinoma (HCC). The PI3K/mTOR dual inhibitors were proposed to have enhanced antitumor efficacies by targeting multiple points of the signaling pathway. We synthesized a series of propynyl-substituted benzenesulfonamide derivatives as PI3K/mTOR dual inhibitors. Compound 7k (NSC781406) was identified as a highly potent dual inhibitor, which exhibited potent tumor growth inhibition in the hepatocellular carcinoma BEL-7404 xenograft model. Compound 7k may be a potential therapeutic drug candidate for HCC.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ziemczonek, Piotr; Gosecka, Monika; Gosecki, Mateusz; Marcinkowska, Monika; Janaszewska, Anna; Klajnert-Maculewicz, Barbara published the artcile< Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies>, HPLC of Formula: 112-63-0, the main research area is PFGE block PGGE hydrogel nifuratel solubility gynaecol therapy; Trichomonas infections; candidiasis; drug delivery system; hydrophobic drug; nifuratel; poly(furfuryl glycidyl ether); poly(glyceryl glycerol ether); unimolecular copolymer micelle; vulvovaginitis.

In this paper, we present novel well-defined unimol. micelles constructed a on poly(furfuryl glycidyl ether) core and highly hydrophilic poly(glyceryl glycerol ether) shell, PFGE-b-PGGE. The copolymer was synthesized via anionic ring-opening polymerization of furfuryl glycidyl ether and (1,2-isopropylidene glyceryl) glycidyl ether, resp. MTT assay revealed that the copolymer is non-cytotoxic against human cervical cancer endothelial (HeLa) cells. The copolymer thanks to furan moieties in its core is capable of encapsulation of nifuratel, a hydrophobic nitrofuran derivative, which is a drug applied in the gynaecol. therapies that shows a broad antimicroorganism spectrum. The study shows high loading capacity of the copolymer, i.e., 146 mg of nifuratel per 1 g of copolymer. The load unimol. micelles were characterized using DLS and TEM microscopy and compared with the reference glyceryl glycerol ether homopolymer sample. The presence of numerous 1,2-diol moieties in the shell of PFGE-b-PGG macromols. enabled the formation of reversible crosslinks with 2-acrylamidephenylboronic acid-based polyacrylamide. The obtained hydrogels were both injectable and self-healable, which was confirmed with a rheol. study.

International Journal of Molecular Sciences published new progress about Anionic ring-opening polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Singh, Yashvir; Singh, Deepak; Singla, Amneesh; Sharma, Abhishek; Kumar Singh, Nishant published the artcile< Chemical modification of juliflora oil with trimethylolpropane (TMP) and effect of TiO2 nanoparticles concentration during tribological investigation>, Formula: C19H34O2, the main research area is chem juliflora oil trimethylolpropane titanium oxide nanoparticle tribol.

This study investigates the potential of juliflora oil for bio-based lubricant applications and it was chem. modified by a two-step trans esterification process with further treatment with trimethylolpropane. After the chem. modification process, TiO2 nanoparticles were added to the oil. The lubricants were examined for properties like kinematic viscosity, viscosity index, flash point, and iodine value. A scanning electron microscope (SEM) was used for the examination of the worn surfaces. The kinematic viscosity of the oil shows increment with chem. modification and during the addition of the nanoparticles. The maximum increment was observed with a 1.2% addition of nanoparticles. The flash point increases with the addition of the nanoparticles and the maximum value was attained at 0.6% concentration During the tribol. anal., 0.6% concentration of TiO2 nanoparticles demonstrated a reduction in the coefficient of friction (COF) and wear of the pin. The SEM images also show better surfaces when the nanoparticles were added up to 0.6% concentration which was due to effective lubrication to the surface. The optimum nanoparticle addition was found at 0.6% concentration to the chem. modified oil with an improved anti-wear mechanism.

Fuel published new progress about Fatty acids, Me esters Role: SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wilkerson, Jenny L.; Felix, Jasmine S.; Bilbrey, Joshua A.; McCurdy, Christopher R.; McMahon, Lance R. published the artcile< Characterization of a mouse neuropathic pain model caused by the highly active antiviral therapy (HAART) Stavudine>, HPLC of Formula: 112-63-0, the main research area is stavudine highly active antiviral therapy neuropathic pain model; HIV; Neuropathic pain; Opioid.

Although highly active antiviral therapies (HAART) exert control over viral replication in persons with Acquired Immunodeficiency Syndrome (AIDS), neuropathic pain is a side effect. Symptoms include hyperalgesia and allodynia. Stavudine, also known as D4T, is a HAART used to treat Human Immunodeficiency Virus (HIV). This study examined the extent to which D4T produces neuropathic pain and examined pharmacol. management with a standard opioid analgesic. Male and female C57BL/6 J mice were injected i.p. with one dose of vehicle or D4T (10-56 mg/kg). Mice were tested through day 92 post injection for mech. allodynia, assessed with von Frey filaments, and thermal hyperalgesia, assessed via the hotplate test. Sep. cohorts received vehicle or 56 mg/kg D4T, the presence of allodynia and thermal hyperalgesia confirmed, and mice received i.p. vehicle, morphine, or 0.032 mg/kg naltrexone + morphine. D4T produced dose- and time-dependent mech. allodynia and thermal hyperalgesia. The smallest effective D4T dose was 17.8 mg/kg. This dose produced mech. allodynia but not thermal hyperalgesia. Larger D4T doses (32 and 56 mg/kg) produced mech. allodynia and thermal hyperalgesia lasting 92 days. Morphine dose-dependently alleviated both mech. allodynia and thermal hyperalgesia in D4T-treated mice with ED50 values of 4.4 and 1.2 mg/kg, resp. Naltrexone produced a rightward shift of the morphine dose-response function, i.e., increased the ED50 value of morphine by at least 3.8-fold. Stavudine produced neuropathic pain as a function of dose and time in mice. Opioid analgesics appear to be effective in alleviating neuropathic pain in a D4T-induced mouse model.

Pharmacological Reports published new progress about AIDS (disease). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Azzena, Ugo; Demartis, Salvatore; Fiori, Maria Giovanna; Melloni, Giovanni; Pisano, Luisa published the artcile< Reductive electrophilic substitution of phthalans and ring expansion to isochroman derivatives>, Category: esters-buliding-blocks, the main research area is reductive ring cleavage phthalan lithium; isochromanone preparation phthalan ring expansion; lithiomethylbenzyl alkoxide cycloaddition carbon dioxide; electrophilic alkylation lithiomethylbenzyl alkoxide; benzyl alc substituted preparation.

Reductive cleavage of phthalans I (R1 = H, R2 = H, Ph; R1R2 = CH2CH2) with Li and a catalytic amount of naphthalene forms stable aromatic dilithium compounds II, which undergo ring closure with CO2 to form isochromans III in yields >40%. II react with various alkyl halides, aldehydes and ketones to form o-substituted benzyl alcs. in yields > 60%.

Tetrahedron Letters published new progress about Electrophilic substitution reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gupta, Krishna D.; Shreeve, Jean’ne M.; Oberhammer, Heinz published the artcile< The gas-phase structure of dodecafluorooctahydrothiophene, c-C4F8SF4>, Quality Control of 112-63-0, the main research area is dodecafluorooctahydrothiophene geometry; pseudorotation barrier dodecafluorooctahydrothiophene.

The geometric structure of the title compound (I) has been determined by gas-phase electron diffraction. The five-membered ring has the twist form (C2 symmetry) with a puckering amplitude q = 0.42 (2) Å. The following principal geometric parameters (ra values) with estimated uncertainties have been derived: (C-C)av = 1.541(10), S-C = 1.896(7), S-Fe = 1.558(6), S-Fa = 1.594(6) Å, CSC = 90.0(9)°, SCC = 109.1(8)°, CCC = 106.5(12)°, FaSFe = 90.5 (15)° and FeSFe = 87.7(29)°. Vibrational amplitudes for long non-bonded C···F and F···F distances indicate a high barrier to pseudorotation of the ring.

Journal of Molecular Structure published new progress about Molecular structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liang, Xiaofei; Li, Feng; Chen, Cheng; Jiang, Zongru; Wang, Aoli; Liu, Xiaochuan; Ge, Juan; Hu, Zhenquan; Yu, Kailin; Wang, Wenliang; Zou, Fengming; Liu, Qingwang; Wang, Beilei; Wang, Li; Zhang, Shanchun; Wang, Yuxin; Liu, Qingsong; Liu, Jing published the artcile< Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor>, Category: esters-buliding-blocks, the main research area is phosphoinositide kinase delta PI3Kdelta inhibitor antitumor; Acute myeloid leukemia; Kinase inhibitor; PI3Kδ; Structure-activity relationship.

PI3Kδ, which is mainly expressed in leukocytes, plays a critical role in B-cell receptor mediated signaling pathway and has been extensively studied as a drug discovery target for B cell malignances such as AML, CLL etc. In this manuscript, we report the discovery, SAR optimization and pharmacol. evaluation of a novel series of aminothiazole-pyridine containing PI3Kδ inhibitors. Among them compound 15i (CHMFL-PI3KD-317) displays an IC50 of 6 nM against PI3Kδ in the ADP-Glo biochem. assays. It also exhibits over 10-1500-fold selectivity over other class I, II and III PIKK family isoforms. In addition, in the cellular context, 15i can selectively and potently inhibit PI3Kδ mediated phosphorylation of Akt T308 but not PI3Kα, β, γ mediated Akt phosphorylation. 15I also exhibits an excellent selectivity profile in the protein kinases including 468 kinases/mutants at the concentration of 1 μM. 15I has acceptable pharmacokinetic properties and can dose-dependently inhibit the tumor growth of AML cell line MOLM14 inoculated xenograft mouse model. The high selectivity and potency makes 15i a potential valuable addition to the current PI3Kδ armory.

European Journal of Medicinal Chemistry published new progress about Acute myeloid leukemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Hu; Xiong, Yi-Zhi; Wang, Tao-Fen; Zeng, Jian-Xian; Liu, Huan; Jian, Jian; Yuan, Zheng-Qiu; Zhou, Zhi-Hua; Zeng, Ling-Wei; Liu, Guo-Qing published the artcile< Synthesis of polyurethane hydrogel and polyurethane thermoplastic elastomer composite based separation membranes>, Product Details of C19H34O2, the main research area is polyurethane hydrogel thermoplastic elastomer composite separation membrane property.

A series of polyurethane hydrogel and polyurethane thermoplastic elastomer composite based separation membranes were successfully prepared via wet phase inversion method. The morphol., chem. structure, phase transition temperature and crystallinity of the polyurethane (PU) membranes were characterized by SEM, FTIR, DSC, and XRD, resp. The SEM observation showed that the PU membranes exhibited irregular porous structure on the surface and path of the hole was flexural and asym. in cross-section. The FTIR anal. demonstrated that thermalsensitive groups and pH-sensitive components (-N(CH3)-) were incorporated into the PU network. The DSC experiment and XRD experiment showed that the regular arrangement of PU network was destroyed partly due to the introduction of polyurethane thermoplastic elastomer. The equilibrium swelling ratio (ESR) and water flux (J) for PU membranes clearly decreased and increased with functional groups and sophisticated structure of PU membranes, resp.. In addition, the permeation experiments indicated that the permeation percentage (P) of the glycine was strongly affected by the external temperature and pH value.

Journal of Nanoscience and Nanotechnology published new progress about Bovine serum albumin Role: PEP (Physical, Engineering or Chemical Process), PROC (Process). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yunfeng; Mavila, Sudheendran; Podgorski, Maciej; Kowalski, Jamie E.; McLeod, Robert R.; Bowman, Christopher N. published the artcile< Manipulating the Relative Rates of Reaction and Diffusion in a Holographic Photopolymer Based on Thiol-Ene Chemistry>, Product Details of C19H34O2, the main research area is thiol ene reaction rate diffusion holog photopolymer.

Properly balanced reaction and diffusion kinetics are crucial for achieving optimal performance in holog. photopolymers. However, a comprehensive study on the effect of reaction and diffusion on the performance of thiol-ene-based holog. photopolymers has not been performed previously. To determine the relationship between reaction and diffusion, the refractive index modulation (Δn) of holog. gratings recorded in a model thiol-ene photopolymer system was evaluated with controlling the rates of reaction and diffusion processes. By changing the mol. weight of the polymer binder, the diffusion rate was varied over orders of magnitudes with the highest Δn of 0.026 achieved at a mol. weight of 2.9 x 104 Da. Meanwhile, the haze was significantly reduced in binders of higher mol. weight Similarly, as the reaction rate was reduced in accordance with lowering the light intensity, the Δn reached a peak value of 0.023 at 7 mW/cm2 and was found to decrease at both higher (2500 lines/mm) and lower (1000 lines/mm) spatial frequencies. In particular, Δn approaching 0 was observed at a very low intensity (2 mW/cm2) and when the binder with a mol. weight as low as 0.5 x 104 Da was used. An analogous formulation incorporating a secondary thiol, which has slower reaction kinetics and a more stable thiyl radical relative to the primary thiol, exhibited a lower Δn , especially at higher spatial frequencies. Through one-step thiol-Michael addition, the functionality of a tetrathiol monomer was reduced to various extents to obtain a series of thiol-ene photopolymers with precise control over gel point conversions, among which the thiol with an average functionality of 3.5 realized the highest Δn of 0.028. An enhanced reactive binder with norbornene pendant groups was also synthesized, and holog. gratings recorded in it showed notably higher Δn at low light intensities compared to those recorded in non-reactive or less reactive binders.

Macromolecules (Washington, DC, United States) published new progress about Diffusion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics