Category: 112-63-0

Naidu, Mamta D.; Mason, James M.; Pica, Raymond V.; Fung, Hua; Pena, Louis A. published the artcile< Radiation resistance in glioma cells determined by DNA damage repair activity of Apel/Ref-1>, Application of C19H34O2, the main research area is X ray radiotherapy radioresistance Ape1 DNA damage repair glioma.

Since radiation therapy remains a primary treatment modality for gliomas, the radioresistance of glioma cells and targets to modify their radiation tolerance are of significant interest. Human apurinic endonuclease 1 (Ape1, Ref-1, APEX, HAP1, AP endo) is a multifunctional protein involved in base excision repair of DNA and a redox-dependent transcriptional co-activator. This study investigated whether there is a direct relationship between Ape1 and radioresistance in glioma cells, employing the human U87 and U251 cell lines. U87 is intrinsically more radioresistant than U251, which is partly attributable to more cycling U251 cells found in G2/M, the most radiosensitive cell stage, while more U87 cells are found in S and G1, the more radioresistant cell stages. But observed radioresistance is also related to Ape1 activity. U87 has higher levels of Ape1 than does U251, as assessed by Western blot and enzyme activity assays (∼1.5-2 fold higher in cycling cells, and ∼10 fold higher at G2/M). A direct relationship was seen in cells transfected with CMV-Ape1 constructs; there was a dose-dependent relationship between increasing Ape1 overexpression and increasing radioresistance. Conversely, knock down by siRNA or by pharmacol. down regulation of Ape1 resulted in decreased radioresistance. The inhibitors lucanthone and CRT004876 were employed, the former a thioxanthene previously under clin. evaluation as a radiosensitizer for brain tumors and the latter a more specific Ape1 inhibitor. These data suggest that Ape1 may be a useful target for modifying radiation tolerance.

Journal of Radiation Research published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balmaseda, Aitor; Rozes, Nicolas; Bordons, Albert; Reguant, Cristina published the artcile< Modulation of a defined community of Oenococcus oeni strains by Torulaspora delbrueckii and its impact on malolactic fermentation>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Torulaspora delbrueckii Oenococcus oeni malolactic fermentation winemaking.

Torulaspora delbrueckii is being used increasingly as a starter for alc. fermentation (AF) because of its chem. modulation of wine. Previous studies on this yeast in a natural must have shown a different Oenococcus oeni population by the end of MLF. In this study we aim to evaluate this aspect in a defined O. oeni strain consortium in a sterile grape must during winemaking. Before commencing AF with either S. cerevisiae or both T. delbrueckii and S. cerevisiae, the must was inoculated with a defined population of O. oeni strains. The use of T. delbrueckii determined the bacterial population at the end of MLF. Also, the inoculation of a selected strain after AF produced wines with different chem. composition to those fermented with the initial bacterial community. Different yeast inoculation strategies modulate the O. oeni population, and this has an impact on the chem. composition of the wines. Moreover, the inoculation of a small O. oeni population in must leads to a process similar to spontaneous MLF. Torulaspora delbrueckii can be used as a tool to modulate the O. oeni population and enhance the aromas related to MLF.

Australian Journal of Grape and Wine Research published new progress about Biomass. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Roh, Tae Hoon; Lee, Ji-Hyun; Kim, Seo Jin; Shim, Jin-Kyoung; Park, Junseong; Yoon, Seon-Jin; Teo, Wan-Yee; Kim, Se Hoon; Chang, Jong Hee; Kang, Seok-Gu published the artcile< A novel biguanide (IM1761065) inhibits bioenergetics of glioblastoma tumorspheres>, Application In Synthesis of 112-63-0, the main research area is biguanide anticancer bioenergetics tumorsphere glioblastoma; Biguanide; Bioenergetics; Glioblastoma; IM1761065; Tumorsphere.

Glioblastoma (GBM) is a rapidly growing tumor in the central nervous system with altered metabolism Depleting the bioenergetics of tumors with biguanides have been suggested as an effective therapeutic approach for treating GBMs. The purpose of this study was to determine the effects of IM1761065, a novel biguanide with improved pharmacokinetics, on GBM-tumorspheres (TSs). The biol. activities of IM1761065 on GBM-TSs, including their effects on viability, ATP levels, cell cycle, stemness, invasive properties, and transcriptomes were examined The in vivo efficacy of IM1761065 was tested in a mouse orthotopic xenograft model. IM1761065 decreased the viability and ATP levels of GBM-TSs in a dose-dependent manner, and reduced basal and spare respiratory capacity in patient-derived GBM-TS, as measured by the oxygen consumption rate. Sphere formation, expression of stemness-related proteins, and invasive capacity of GBM-TSs were also significantly suppressed by IM1761065. A gene-ontol. comparison of IM1761065-treated groups showed that the expression levels of stemness-related, epithelial mesenchymal transition-related, and mitochondrial complex I genes were also significantly downregulated by IM1761065. An orthotopic xenograft mouse model showed decreased bioluminescence in IM1761065-treated cell-injected mice at 5 wk. IM1761065-treated group showed longer survival than the control group (P = 0.0289, log-rank test). IM1761065 is a potent inhibitor of oxidative phosphorylation. The inhibitory effect of IM1761065 on the bioenergetics of GBM-TS suggests that this novel compound could be used as a new drug for the treatment of GBM.

Journal of Neuro-Oncology published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Verhoog, Stefan; Pfeifer, Lukas; Khotavivattana, Tanatorn; Calderwood, Samuel; Collier, Thomas Lee; Wheelhouse, Katherine; Tredwell, Matthew; Gouverneur, Veronique published the artcile< Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is silver triflate mediated fluorine 18 labeling trifluoromethyl difluoromethyl arene.

We report the synthesis of [18F]arylCF3 and [18F]arylCHF2 derivatives from arylCF2Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [18F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce 18F-incorporation under very mild conditions.

Synlett published new progress about Radiochemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zolla, Lello; Ceci, Marcello published the artcile< Plasma Metabolomics Profile of ′′Insulin Sensitive′′ Male Hypogonadism after Testosterone Replacement Therapy>, Product Details of C19H34O2, the main research area is insulin sensitive male hypogonadism plasma metabolomic testosterone replacement therapy; Cori cycle; hypogonadism; insulin sensitivity; testosterone therapy.

Male hypogonadism is a disorder characterized by low levels of testosterone, but patients can either show normal insulin (insulin-sensitive (IS)) or over time they can become insulin-resistant (IR). Since the two groups showed different altered metabolisms, testosterone replacement therapy (TRT) could achieve different results. In this paper, we analyzed plasma from 20 IS patients with low testosterone (<8 nmol/L) and HOMAi < 2.5. The samples, pre- and post-treatment with testosterone for 60 days, were analyzed by UHPLC and mass spectrometry. Glycolysis was significantly upregulated, suggesting an improved glucose utilization. Conversely, the pentose phosphate pathway was reduced, while the Krebs cycle was not used. Branched amino acids and carnosine metabolism were pos. influenced, while β-oxidation of fatty acids (FFA) was not activated. Cholesterol, HDL, and lipid metabolism did not show any improvements at 60 days but did so later in the exptl. period. Finally, both malate and glycerol shuttle were reduced. As a result, both NADH and ATP were significantly lower. Interestingly, a significant production of lactate was observed, which induced the activation of the Cori cycle between the liver and muscles, which became the main source of energy for these patients without involving alanine. Thus, the treatment must be integrated with chems. which are not restored in order to reactivate energy production International Journal of Molecular Sciences published new progress about Blood plasma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sobhi, Rania; Farag, Nahla A.; Khalid, Haidy published the artcile< Lead discovery of new antiviral entities through the generation of 3D-QSAR pharmacophore hypothesis virtual screening and molecular docking study>, Application of C19H34O2, the main research area is QSAR pharmacophore hypothesis mol docking antiviral entity.

Sofosbuvir (Sovaldi) is the most successful clin. used antiviral agent targeted for the treatment of Hepatitis C. The study is aiming to discover new lead entities acting as specific inhibitors of the NS5B RNA-dependent RNA polymerase that is essential for viral replication. The recent approach of computer-aided drug design is a challenge nowadays in drug discovery. We generate a 3D-QSAR pharmacophore model from a training set of 17 nucleoside analog inhibitors including Sofosbuvir with congeneric structures and known (IC50) for each antiviral agent. A valid 3D- QSAR pharmacophore model has been successfully generated to identify the binding features responsible for the biol. activity using Discovery Studio software version The generated hypothesis is used for virtual screening of 3D databases which reveals 73 nucleoside analogs as coded compounds of expected nucleoside inhibitor antiviral activity. Followed by Mol. Docking of the compounds of highest fit values to the prepared HCV RNA dependent RNA polymerase NS5B enzyme which is downloaded from the protein data bank (4WTG) with its natural inhibitor SOFOSBUVIR DIPHOSPHATE GS-607596 to estimate the binding affinity and the geometrical orientation of the proposed compound in the HCV RNA dependent RNA polymerase NS5B binding site.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Artyukhin, Alexander B.; Bakajin, Olgica; Stroeve, Pieter; Noy, Aleksandr published the artcile< Layer-by-Layer Electrostatic Self-Assembly of Polyelectrolyte Nanoshells on Individual Carbon Nanotube Templates>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is carbon nanotube surface functionalization layer self assembly polyelectrolyte; polystyrene sulfonate sodium self assembly polydiallyldimethylammonium chloride nanotube.

A general procedure was implemented for modification of carbon nanotubes, based on polyelectrolyte layer-by-layer assembly. Multilayer structures were built around individual carbon nanotube bridges by first modifying the nanotube surface with a pyrene derivative followed by layer-by-layer deposition of polyelectrolyte macro-ions on the nanotube. Nanotubes were grown by the chem. vapor deposition (CVD) method using pyrolyzed ethylene as a carbon source. The polyelectrolytes used are poly(styrenesulfonate) sodium salt (PSS) and poly(diallyldimethylammonium chloride) (PDDA). The TEM and scanning confocal fluorescence microscopy images confirm the formation of nanometer-thick amorphous polymer nanoshells around the nanotubes. These multilayer polyelectrolyte shells on individual carbon nanotubes introduce nearly unlimited opportunities for the incorporation of various functionalities into nanotube devices, which, in turn, opens up the possibility of building more complex multicomponent structures.

Langmuir published new progress about Anionic polyelectrolytes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Xiaotian; Zhang, Yao; Song, Zijia; Yu, Kun; He, Changliu; Zhang, Xu published the artcile< Enzyme-catalyzed synthesis and properties of polyol ester biolubricant produced from Rhodotorula glutinis lipid>, SDS of cas: 112-63-0, the main research area is Rhodotorula glutinis polyol ester biolubricant lipid enzyme catalysis.

Biolubricants do not cause the environmental pollution resulting from the manufacturing and use of mineralbased lubricants, but the commonly adopted chem. method of preparing biolubricants using expensive vegetable oils as raw materials is still environmentally and economically unsatisfactory. In this study, R. glutinis lipid with a high oleic-acid content was esterified with trimethylolpropane (TMP) by using the Candida sp. 99-125 enzyme in a solvent-free system, and the effect of the microbial oil with the high oleic-acid content on the performance of resulting biolubricants was investigated. The purpose of this study was to solve the problems of pollution caused by the chem. synthesis of biolubricants and of the uneconomical use of vegetable oils as raw materials. Further, this study aimed to improve the performance of biolubricants by using the microbial lipid with a high oleic-acid content. As a result of optimization of the reaction conditions, the yield of trimethylolpropane fatty acid triester (TFAT) reached 89.5%. The synthesized biolubricants had excellent low-temperature lubrication performance (pour point = – 45°C), and the physicochem. performance reached the ISOVG-46 grade. The results of the high-frequency reciprocating friction test (HRFT) show that the products have better tribol. properties than mineral-based lubricants of the same viscosity grade (friction coefficient = 0.085; average wear scar diameter = 187μm).

Biochemical Engineering Journal published new progress about Biorheology. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Safri, Ahmad Yanuar; Gaff, Jessica; Octaviana, Fitri; Setiawan, Denise Dewanto; Imran, Darma; Cherry, Catherine L.; Laws, Simon M.; Price, Patricia published the artcile< Brief Report: Demographic and Genetic Associations With Markers of Small and Large Fiber Sensory Neuropathy in HIV Patients Treated Without Stavudine>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is demog genetic association fiber sensory neuropathy HIV Stavudine.

Neurotoxic antiretroviral therapy (ART) such as stavudine has been now replaced with safer therapies, reducing the prevalence of neuropathy from 34% to 15% in HIV+ Indonesians. However, it is unclear whether the residual cases display damage to small or large nerve fibers and whether both are influenced by known risk factors, including alleles of CAMKK2 associated with neuropathy in HIV patients. The encoded protein influences the growth and repair of nerve fibers. HIV-pos. adults on ART for >12 mo without exposure to stavudine were screened for neuropathy using the AIDS Clin. Trials Group Brief Peripheral Neuropathy Screen (BPNS). Large fiber neuropathy was assessed by nerve conduction (NC) and small fiber neuropathy using stimulated skin wrinkling (SSW) applied to the fingers. CAMKK2 alleles were assessed by TaqMan OpenArray technol. Neuropathy diagnoses were more common with SSW than BPNS (49/173 vs 26/185, X2; P = 0.0009), with poor alignment between these outcomes (P = 0.60). NC and BPNS diagnosed neuropathy at similar frequencies (29/151 vs 26/185; P = 0.12) and were aligned (P < 0.0001). In bivariate analyzes, all diagnoses were associated with patients' age and persistent HIV replication, with minor effects from CD4 T-cell counts and time on ART. CAMKK2 alleles associated with neuropathy diagnosed with BPNS and SSW but not NC. Multivariable analyzes confirmed the importance of age and HIV replication, with distinct CAMKK2 polymorphisms affecting BPNS and SSW. Paradoxically, height was protective against skin wrinkling. Overall the data link CAMKK2 genotypes with small rather than large fiber damage. SSW may reflect pathol. distinct from that identified using BPNS. JAIDS, Journal of Acquired Immune Deficiency Syndromes published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Gang; Liu, Richard Y.; Yang, Yang; Fang, Cheng; Lambrecht, Daniel S.; Buchwald, Stephen L.; Liu, Peng published the artcile< Ligand-Substrate Dispersion Facilitates the Copper-Catalyzed Hydroamination of Unactivated Olefins>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is unactivated olefin copper catalyzed hydroamination ligand substrate dispersion interaction.

The current understanding of ligand effects in transition metal catalysis is mostly based on the anal. of catalyst-substrate through-bond and through-space interactions, with the latter commonly considered to be repulsive in nature. The dispersion interaction between the ligand and the substrate, a ubiquitous type of attractive noncovalent interaction, is seldom accounted for in the context of transition-metal-catalyzed transformations. Herein we report a computational model to quant. analyze the effects of different types of catalyst-substrate interactions on reactivity. Using this model, we show that in the copper(I) hydride (CuH)-catalyzed hydroamination of unactivated olefins, the substantially enhanced reactivity of copper catalysts based on bulky bidentate phosphine ligands originates from the attractive ligand-substrate dispersion interaction. These computational findings are validated by kinetic studies across a range of hydroamination reactions using structurally diverse phosphine ligands, revealing the critical role of bulky P-aryl groups in facilitating this process.

Journal of the American Chemical Society published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics