Category: 112-63-0

Xu, Chunfa; Ma, Bingqing; Shen, Qilong published the artcile< N-[(Trifluoromethyl)thio]saccharin: An Easily Accessible, Shelf-Stable, Broadly Applicable Trifluoromethylthiolating Reagent>, Category: esters-buliding-blocks, the main research area is electrophilic substitution sulfur fluorine; NMR spectroscopy; electrophilic substitution; fluorine; sulfur; synthetic methods.

A new, electrophilic trifluoromethylthiolaton agent N-[(trifluoromethyl)thio]saccharin, was developed and can be synthesized in two steps from saccharin within 30 min. N-[(trifluoromethyl)thio]saccharin is a powerful trifluoromethylthiolation agent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcs., amines, thiols, electron-rich arenes, aldehydes, ketones, acyclic β-keto esters, and alkynes under mild reaction conditions. The synthesis of the target compounds was achieved using 2-[(trifluoromethyl)thio]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide as a key reactant.

Angewandte Chemie, International Edition published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahmadi, Vahid; Nie, Chuanxiong; Mohammadifar, Ehsan; Achazi, Katharina; Wedepohl, Stefanie; Kerkhoff, Yannic; Block, Stephan; Osterrieder, Klaus; Haag, Rainer published the artcile< One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors>, Synthetic Route of 112-63-0, the main research area is virucidal heparin mimicking polymer antiviral agent Herpes simplex virus.

A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.

Chemical Communications (Cambridge, United Kingdom) published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Buesker, Soeren; Jaeger, Walter; Poschner, Stefan; Mayr, Lisa; Al Jalali, Valentin; Gojo, Johannes; Azizi, Amedeo A.; Ullah, Sami; Bilal, Muhammad; El Tabei, Lobna; Fuhr, Uwe; Peyrl, Andreas published the artcile< Pharmacokinetics of metronomic temozolomide in cerebrospinal fluid of children with malignant central nervous system tumors>, Category: esters-buliding-blocks, the main research area is temozolomide anticancer CSF pharmacokinetic central nervous system tumor child; Central nervous system; Cerebrospinal fluid; Pediatrics; Pharmacokinetic; Temozolomide.

Although temozolomide is widely used in the treatment of childhood central nervous system (CNS) tumors, information on its pharmacokinetic profile in the brain or cerebrospinal fluid (CSF) is sparse. This study aimed at investigating whether measurable and clin. relevant concentrations of temozolomide are reached and maintained in CSF for continuous oral administration in pediatric patients. A population pharmacokinetic model was developed to quantify CSF penetration of temozolomide. Eleven pediatric CNS tumor patients (aged 4-14 years) treated with oral temozolomide using a metronomic schedule (24-77 mg/m2/day) were included. Temozolomide concentrations in 28 plasma samples and 64 CSF samples were analyzed by high-performance liquid chromatog. Population pharmacokinetic modeling and simulations were performed using non-linear mixed effects modeling (NONMEM 7.4.2). Median temozolomide concentrations in plasma and CSF were 0.96 (range 0.24-5.99) μg/mL and 0.37 (0.06-1.76) μg/mL, resp. A two-compartment model (central/plasma [1], CSF [2]) with first-order absorption, first-order elimination, and a transit compartment between CSF and plasma adequately described the data. Population mean estimates for clearance (CL) and the volume of distribution in the central compartment (Vc) were 3.29 L/h (95% confidence interval (CI) 2.58-3.95) and 10.5 L (8.17-14.32), resp. Based on simulations, we found a median area under the concentration vs. time curve ratio (AUCCSF / AUCplasma ratio) of 37%. Metronomic oral temozolomide penetrates into the CSF in pediatric patients, with even higher concentration levels compared to adults.

Cancer Chemotherapy and Pharmacology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Precup-Blaga, F. S.; Garcia-Martinez, J. C.; Schenning, A. P. H. J.; Meijer, E. W. published the artcile< Highly Emissive Supramolecular Oligo(p-phenylene vinylene) Dendrimers>, Formula: C19H34O2, the main research area is preparation oligomeric phenylene vinylene guest polypropylene imine dendrimer host; luminescence oligomeric phenylene vinylene guest hydrogen bonded dendritic host.

π-Conjugated oligo(p-phenylene vinylene) (OPV) guest mols. for interaction with dendritic hosts were synthesized and fully characterized by NMR spectroscopy, MALDI-TOF-MS, elemental anal. and optical measurements. The binding properties of the five different OPV guests to a N,N-bis[(3-adamantyl ureido) propyl] methylamine host were studied. The guests that contained an aryl urea glycine spacer were bound with the highest association constant Subsequently, an adamantyl urea modified fifth generation poly(propylene imine) dendrimer was synthesized as a multivalent host which contains 32 N,N-bis[(3-adamantyl ureido) propyl] amine binding sites. Size exclusion chromatog. showed that 32 of the OPV guests strongly bind to the fifth generation adamantyl functionalized dendritic host. In the case of the supramol. dendritic host/guest system smooth homogeneous thin films could be obtained by spin coating. The dendritic guest-host complexes showed a significantly higher emission upon binding then that of the individual mols. due to the three-dimensional orientation of the OPV guest mols. In the solid state, this enhancement in luminescence was a factor of 10. The π-conjugated oligomers are less aggregated in the supramol. assemblies presumably because of a shielding effect of the bulky adamantyl units present in the hosts.

Journal of the American Chemical Society published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hao, Fuling; Wu, Muqian; Wu, Sixin; Ge, Xiangjun; Sun, Qihan; Zhao, Jing; Xue, Hao; Fang, Congbing published the artcile< Transcriptome analysis reveals the involvement of nitrate transporters in regulating strawberry fruit development>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is transcriptome strawberry fruit nitrate transporter.

Adequate nitrate availability throughout the strawberry life cycle improves fruit quality and productivity. However, the gene expression and metabolism patterns during nitrate-triggered developmental processes in fruits remain unknown. This transcriptome study reports the involvement of nitrate transporters and their correlated transcription factors (TFs) in the coordinate regulation of strawberry fruit development after nitrate treatment. Nitrate supply promoted plant growth and slightly delayed fruit ripening compared with the control. Nitrate also increased the contents of nitrogen, nitrogen-related metabolites, glucose, fructose, and sorbitol, but decreased the contents of several acid-related metabolites. Moreover, nitrate activated carbon and nitrogen metabolism at 25, 30, and 35 days post-anthesis (DPA). Nitrate treatment induced 10,206 differentially expressed genes (DEGs), which enriched carbon and nitrogen metabolism, amino acid, phenylpropanoid, flavonoid, terpenoid, carotenoid biosynthesis, and other metabolic pathways at 35 DPA. The DEGs also enriched GO terms for nitrate, nitrogen compound, and peptide transporter activities. Nitrate treatment significantly regulated 79 out of 164 nitrate transporter genes (FaNRTs) at 25, 30, and 35 DPA. Correlation anal. showed that strawberry adaptation to nitrate availability during fruit development involves dynamic multi-combinations between FaNRT and different TF families. qRT-PCR anal. showed that FaNPF6.3, FaNPF4.6, and FaNPF7.2 are potential nitrate signaling mols. and transporters for root nitrate uptake or removing nitrate from xylem vessels. Nitrate treatment induced FaNPF6.3, FaNPF4.6, and FaNPF7.2 expression while their correlated TFs (FaSPL8, FaNAC77-like, FaMYB1R1, and FaMYB44-like) transcription levels were down-regulated at 25 DPA. These results indicate that the spatio-temporal expression of nitrate transporters correlated with the increased nitrogen use efficiency (NUE) to enhance metabolism The results provide a fertilizer and water management strategy for improving quality and productivity in the strawberry industry.

Scientia Horticulturae (Amsterdam, Netherlands) published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mitsuzuka, Masahiko; Kinbara, Yuho; Fukuhara, Mizuki; Nakahara, Maki; Nakano, Takashi; Takarada, Jun; Wang, Zhongkui; Mori, Yoshiki; Kageoka, Masakazu; Tawa, Tsutomu; Kawamura, Sadao; Tajitsu, Yoshiro published the artcile< Relationship between photoelasticity of polyurethane and dielectric anisotropy of diisocyanate, and application of high-photoelasticity polyurethane to tactile sensor for robot hands>, Product Details of C19H34O2, the main research area is polyurethane diisocyanate tactile sensor robot hand photoelasticity dielec anisotropy; dielectric anisotropy; photoelasticity; polyurethane; tactile sensor.

Eight types of polyurethane were synthesized using seven types of diisocyanate. It was found that the elasto-optical constant depends on the concentration of diisocyanate groups in a unit volume of a polymer and the magnitude of anisotropy of the dielec. constant of diisocyanate groups. It was also found that incident light scattered when bending stress was generated inside photoelastic polyurethanes. A high sensitive tactile sensor for robot hands was devised using one of the developed polyurethanes with high photoelasticity.

Polymers (Basel, Switzerland) published new progress about Complex modulus, tan δ. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Xi; Hu, Sumeng; Li, Lingqiao; Torkelson, John M. published the artcile< Dynamic Covalent Polyurethane Networks with Excellent Property and Cross-Link Density Recovery after Recycling and Potential for Monomer Recovery>, Synthetic Route of 112-63-0, the main research area is dynamic covalent polyurethane network crosslink density recovery recycling; tensile polyurethane recycling alcoholysis.

Dynamic urethane chem., which involves both associative and dissociative mechanisms, can be used to achieve reprocessability in cross-linked polyurethane (PU) networks. We discovered that property recovery and thermal stability of dynamic covalent PU networks can be enhanced by incorporating excess free hydroxyl groups, and thus performing polymerization reactions at slight stoichiometric imbalance of hydroxyl and isocyanate groups, and by increasing the crosslinker functionality from three to four. While free hydroxyl groups suppress the reversion of urethane links and minimize side reactions associated with liberated isocyanate groups under reprocessing conditions, tetrafunctional crosslinkers help to maintain network integrity in the presence of small levels of side reactions. Using these strategies, we developed a PU network that, within exptl. error, exhibits 100% recovery of crosslink d. and tensile properties after multiple reprocessing steps, which has not been reported before. We also demonstrated the potential of recovering monomer from PU networks by alcoholysis under relatively mild conditions. Our study not only offers a solution to the long-standing issue of PU network recycling, but also provides simple strategies to improve property recovery of reprocessable networks.

ACS Applied Polymer Materials published new progress about Complex modulus, tan δ. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jain, Suman L.; Sharma, Vishal B.; Sain, Bir published the artcile< Highly efficient and selective oxidation of secondary alcohols to ketones under organic solvent and transition metal free conditions>, SDS of cas: 112-63-0, the main research area is oxidation secondary alc ketone organic solvent transition metal free; secondary alc oxidation ketone solid oxidant green chem.

The aqueous HBr/H2O2 was found to be highly efficient and green catalytic system for the selective oxidation of the secondary alcs. to ketones in excellent yields under organic solvent free conditions. The results of the oxidation of the secondary alcs. with solid alternatives of the aqueous hydrogen peroxide like SPC or SPB are also described.

Tetrahedron published new progress about Green chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yongkang; Chi, Shuyan; Zhang, Shuang; Dong, Xiaohui; Yang, Qihui; Liu, Hongyu; Tan, Beiping; Xie, Shiwei published the artcile< Evaluation of Methanotroph (Methylococcus capsulatus, Bath) bacteria meal on body composition, lipid metabolism, protein synthesis and muscle metabolites of Pacific white shrimp (Litopenaeus vannamei)>, Reference of 112-63-0, the main research area is Methylococcus body composition protein lipid metabolism.

A feeding trial was conducted to evaluate a new dietary protein Methanotroph (Methylococcus capsulatus, Bath) bacteria meal (BPM) on nutritional profile of Litopenaeus vannamei. The basal diet was formulated to contain 25% fish meal and then 15%, 30% and 45% of fish meal protein were replaced with BPM in three exptl. diets, which were labeled FM, BPM15, BPM30, and BPM45, resp. A total of 480 uniform-sized shrimp were equally distributed to four groups with three replicates and fed exptl. diets four times daily for seven weeks. Results showed that dietary BPM had no significant effect on the growth performance of shrimp (P > 0.05) but significantly reduced the crude lipid content of the whole body in shrimp fed the BPM30 diet compared to the FM diet (P < 0.05). Total cholesterol and triglyceride in the hemolymph fell significantly with the increase BPM substitution (P < 0.05). Expression of fas (fatty acid synthetase) significantly decreased with increasing BPM substitution, but the expression of cpt-1 (carnitine palmitoyltransferase) significantly increased in shrimp fed BPM30 (P < 0.05). Expression of tor (target of rapamycin) significantly decreased in hepatopancreas, while an opposite change was exhibited in the intestine of shrimp fed BPM45 (P < 0.05). Results of metabolomics indicated that dietary BPM affected the TCA cycle, ascorbate and aldarate metabolism, and glutathione metabolism in shrimp. In conclusion, BPM is an alternative to FM as a novel protein source for shrimp feed, but the changes in whole body composition, lipolysis and fatty acid synthesis, and protein synthesis and muscle metabolites of L.vannamei are noted. Aquaculture published new progress about Fish meal. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sohn, Jiwon; Hwang, Jaehoon; Park, Soo Young; Lee, Geon Joon published the artcile< Carbazole-based photorefractive organic glass showing high diffraction efficiency at low external electric field>, Formula: C19H34O2, the main research area is carbazole photorefractive organic glass diffraction efficiency elec field.

Photorefractive organic glass, 9-(2-ethylhexyl)-3-[2-(4-nitrophenyl)vinyl]-9H-carbazole (EHCN), showing large coupling gain and high diffraction efficiency at low external elec. field was synthesized and characterized. EHCN showed the glass transition at 25° and the good thermal stability up to 400°. Photorefractivity of EHCN was studied by using 100 μm thick films (S1, S2, S3) doped with 0%, 0.5%, and 1% 2,4,7-trinitrofluorenone (TNF), resp. Two-beam coupling net gain of 50.8 cm-1 was obtained for the 0.5% TNF-doped EHCN sample (S2) at 40 V/μm field. The highest internal diffraction efficiency, obtained from the degenerate four-wave mixing at 30 V/μm field, reached 90% for the 1% TNF-doped EHCN sample (S3).

Japanese Journal of Applied Physics, Part 1: Regular Papers, Short Notes & Review Papers published new progress about Charge transfer complexes Role: FMU (Formation, Unclassified), PEP (Physical, Engineering or Chemical Process), PRP (Properties), TEM (Technical or Engineered Material Use), FORM (Formation, Nonpreparative), PROC (Process), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics