Category: 112-63-0

Bollag, Anna E.; Guo, Tianyang; Ding, Ke-Hong; Choudhary, Vivek; Chen, Xunsheng; Zhong, Qing; Xu, Jianrui; Yu, Kanglun; Awad, Mohamed E.; Elsalanty, Mohammed; Johnson, Maribeth H.; McGee-Lawrence, Meghan E.; Bollag, Wendy B.; Isales, Carlos M. published the artcile< Monomethylfumarate protects against ovariectomy-related changes in body composition>, Computed Properties of 112-63-0, the main research area is ovariectomy monomethylfumarate body composition.

Osteoporosis, low bone mass that increases fracture susceptibility, affects approx. 75 million individuals in the United States, Europe and Japan, with the number of osteoporotic fractures expected to increase by more than three-fold over the next 50 years. Bone mass declines with age, although the mechanisms for this decrease are unclear. Aging enhances production of reactive oxygen species, which can affect bone formation and breakdown. The multiple sclerosis drug Tecfidera contains dimethylfumarate, which is rapidly metabolized to monomethylfumarate (MMF); MMF is thought to function through nuclear factor erythroid-derived-2-like-2 (NRF2), a transcription factor activated by oxidative stress which induces the expression of endogenous anti-oxidant systems. We hypothesized that MMF-elicited increases in anti-oxidants would inhibit osteopenia induced by ovariectomy, as a model of aging-related osteoporosis and high oxidative stress. We demonstrated that MMF activated NRF2 and induced anti-oxidant NRF2 target gene expression in bone marrow-derived mesenchymal stem cells. Sham-operated or ovariectomized adult female mice were fed chow with or without MMF and various parameters were monitored. Ovariectomy produced the expected effects, decreasing bone mineral d. and increasing body weight, fat mass, bone marrow adiposity and serum receptor activator of nuclear factor-kappa-B ligand (RANKL) levels. MMF decreased fat but not lean mass. MMF improved trabecular bone microarchitecture after adjustment for body weight, although the unadjusted data showed few differences; MMF also tended to increase adjusted cortical bone and to reduce bone marrow adiposity and serum RANKL levels. Because these results suggest the possibility that MMF might be beneficial for bone, further investigation seems warranted.

Journal of Endocrinology published new progress about Adipose tissue. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Inoa, Joan; Patel, Mansi; Dominici, Grecia; Eldabagh, Reem; Patel, Anjali; Lee, John; Xing, Yalan published the artcile< Benzylic Hydroperoxidation via Visible-light Induced Csp3-H activation>, COA of Formula: C19H34O2, the main research area is benzylic hydroperoxidn carbon hydrogen activation catalyst.

A highly efficient benzylic hydroperoxidn. e.g., C6H5CH2CH2C6H5 has been realized through a visible-light induced Csp3-H activation. It believe that this reaction undergoes a direct HAT mechanism catalyzed by eosin Y. This approach features the use of a metal-free catalyst (Eosin Y), an energy-economical light source (blue LED), and a sustainable oxidant (mol. oxygen). A variety of benzylic hydroperoxides e.g., C6H5CH(OOH)CH2C6H5 and several endoperoxides e.g., 4-NO2C6H4CH(CH3)OOC(O)CH3 was successfully prepared with good yields and excellent functional group compatibility.

Journal of Organic Chemistry published new progress about Alkylarenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fernandez, Lesly Paradina; Brasca, Romina; Attademo, Andres M.; Peltzer, Paola M.; Lajmanovich, Rafael C.; Culzoni, Maria J. published the artcile< Bioaccumulation and glutathione S-transferase activity on Rhinella arenarum tadpoles after short-term exposure to antiretrovirals>, Application of C19H34O2, the main research area is Rhinella lamivudine stavudine zidovudine nevirapine glutathione S transferase bioaccumulation; Antiretrovirals; Bioaccumulation; Tadpoles; Toxicological biomarkers; UHPLC-DAD.

The aim of the present study was to investigate the bioaccumulation and toxicol. effects of four antiretrovirals (lamivudine, stavudine, zidovudine and nevirapine) on Rhinella arenarum tadpoles, after short-term (48 h) exposure to these drugs at sublethal concentrations The anal. procedure involved a simple extraction method followed by ultra-high performance liquid chromatog. with diode array detection and chemometric anal. for data processing. Under the conditions studied, the analytes investigated, particularly nevirapine, showed possible bioaccumulation in tadpoles. Besides, an increase in the bioaccumulation was observed when increasing the exposure concentration In addition, the enzymic biomarkers measured to evaluate the toxicol. effects showed that acethylcholinesterase activity was similar to that of the control group, while glutathione S-transferase activity was increased, indicating potential oxidative stress damage. Our results also allowed demonstrating the usefulness of chemometric algorithms to quantitate analytes in complex matrixes, such as those absorbed by tadpoles in aquatic ecosystems. The results also evidenced the short-term antiretroviral bioaccumulation in tadpoles and the alteration of antioxidant systems, highlighting the need of environmental studies to elucidate the ecotoxicol. risk of antiretrovirals in humans and wildlife.

Chemosphere published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Imai, Kinichi published the artcile< Nucleic acid antagonists. VII. Synthesis and characterization of 1,4,6-triazaindenes (5H-pyrrolo[3,2-d]pyrimidines)>, Synthetic Route of 112-63-0, the main research area is ANTIMETABOLITES; CHEMISTRY, PHARMACEUTICAL; EXPERIMENTAL LAB STUDY; HETEROCYCLIC COMPOUNDS; NUCLEIC ACIDS; PYRIMIDINES; PYRROLES.

2-Carbethoxy-5,7-diethoxy-1,4,6-triazaindene (I) (2 g.) and 10 cc. HCl refluxed 6 h. gave 1.3 g. 2-CO2H derivative (II) of 5,7-dioxo-4,5,6,7-tetrahydro-1,4,6-triazaindene (III), m. above 360° (H2O). II (1 g.) and 100 mg. Cu powder heated at 330-40° until the CO2 evolution ceased gave 600 mg. III, m. above 360° (H2O). I (1 g.) and 500 mg. Cu powder heated 10 min. in vacuo at 220-40° yielded 700 mg. 2-CO2Et derivative (IV) of 4,6-diethyl-5,7-dioxo-4,5,6,7-tetrahydro-1,4,6-triazene (V), m. 205° (aqueous EtOH). IV (840 mg.) in 15 cc. EtOH heated 2 h. on the water bath with 1.5 g. NaOH in 2 cc. H2O gave 700 mg. 2-CO2H derivative (VI) of V, m. 306° (MeOH). VI (150 mg.) heated at 310-20° during 10 min. yielded 100 mg. V, m. 142° (reprecipitated from C6H6 with petr. ether). IV (300 mg.), 5 cc. EtOH, and 3 cc. 28% NH4OH heated 5 h. in a sealed tube at 140-50° gave 200 mg. 2-CONH2 derivative of V, crystal powder, m. 298° (aqueous EtOH). 5-Me derivative (VII) (4.7 g.) of 2-methyl-7-oxo-6,7-dihydro-1,4,6-triazaindene (VIII) refluxed 3 h. with 27 cc. POCl3 yielded 4.8 g. 5-Me derivative (IX) of X, m. 158-60° (AcOEt). VIII (5 g.) and 24 cc. POCl3 gave similarly 4 g. X, m. 178° (decomposition). III (5 g.), 400 cc. POCl3, and 10 cc. Me2NPh refluxed 2 h. gave 2 g. 5,7-dichloro-1,4,6-triazaindene (XI), m. 224° (50% MeOH). III (3 g.) and 24 cc. pyrophosphoryl chloride (upper layer of a mixture prepared by heating POCl3 with 0.5 equivalent H2O 1.5 h.) yielded 2.1 g. XI, m. 226-8° (aqueous MeOH). 7-Oxo-6,7-dihydro-1,4,6-triazaindene (XII) (850 mg.) refluxed 2 h. with 20 cc. POCl3 gave 7-chloro-1,4,6-triazaindene (XIII), m. 186-8° (decomposition) (50% aqueous EtOH). XI (3 g.) and 30 cc. 2N KOH refluxed 4.5 h. yielded 1.6 g. 5-Cl derivative (XIV) of XII, m. 270° (decomposition) (H2O). XI (500 mg.) and 400 mg. CS(NH2)2 in 13 cc. EtOH refluxed 5 h. gave 250 mg. 5,7-dimercapto-1,4,6-triazaindene (XV), pale yellow, m. above 360° (H2O). III (500 mg.), 3 g. P2S5, and 20 cc. Tetralin stirred 1.5 h. at 170-200° and 4 h. at 200-5° gave 150 mg. XV. XV (70 mg.) and 2 cc. 0.5N NaOH shaken with 0.1 cc. Me2SO4 gave the 5,7-di-MeS analog of XV, m. 230° (60% MeOH). XIII (700 mg.) and 350 mg. CS(NH2)2 in 20 cc. EtOH refluxed 4 h. yielded 300 mg. 7-mercapto-1,4,6-triazaindene (XVI), pale yellow needles, m. above 300° (H2O). VII (700 mg.), 3.8 g. P2S5, and 16 cc. Tetralin heated 12 h. at 190-200° gave 2,5-dimethyl-7-mercapto-1,4,6-triazaindene (XVII), crystal powder, m. 314-15° (decomposition) (30% MeOH). IX (1.5 g.), 40 mg. Cu powder, 6.3 cc. alc. NH3, and 2 cc. concentrated NH4OH heated 13 h. in a sealed tube at 160-70° gave 750 mg. 2,5-di-Me derivative of 7-amino-1,4,6-triazaindene (XVIII), needles, m. 300-2° (MeOH). X (400 mg.), 20 mg. Cu powder, 1.8 cc. alc. NH3, and 6 cc. concentrated NH4OH yielded similarly 250 mg. 2-Me derivative (XIX) of XVIII, m. 327-8° (decomposition) (MeOH). XI (3 g.) and 60 cc. alc. NH3 heated 12 h. in an autoclave at 120° yielded 1.6 g. 5-Cl derivative (XX) of XVIII, needles, m. 264° (decomposition) XI (4 g.) and 60 cc. alc. NH3 heated 20 h. in an autoclave at 200° yielded 3.6 g. 5-NH2 derivative of XVIII, needles, m. 285° (decomposition). XIV (4 g.) gave similarly 850 mg. 5-amino-7-oxo-6,7-dihydro-1,4,6-triazaindene, m. above 300° (H2O). IX (2.2 g.) and 1.2 g. MgO in 120 cc. EtOH hydrogenated 2 h. over Pd-C gave 1.3 g. 2,5-dimethyl-1,4,6-triazaindene (XXI), m. 211-12° (AcOEt). X, XIV, and XX gave similarly 66% 2-methyl-1,4,6-triazaindene (XXII), m. 237° (decomposition) (AcOEt), 7-oxo-6,7-dihydro-1,4,6-triazaindene (XXIII), m. above 300° with discoloration from about 290° (H2O), and XVIII, decomposed at 320° with browning from about 280° (H2O), resp. XV (400 mg.) in 30 cc. EtOH refluxed 2 h. with 4 g. Raney Ni and kept overnight gave 210 mg. 1,4,6-triazaindene (XXIV), m. 177° (AcOEt). XI (1 g.) in 80 cc. MeOH hydrogenated over Pd-C gave XXIV, m. 175° (decomposition). XI (3 g.) in 120 cc. MeOH hydrogenated 1.5 h. over Pd-C, and the crude product dissolved in 40 cc. H2O, mixed with 18 cc. 30% KOH, treated dropwise with 11.8 g. K3Fe(CN)6 in 50 cc. hot H2O, and stirred 0.5 h. at room temperature yielded 1.3 g. XXIV, m. 172-4° (AcOEt). I (1.1 g.) in 1.5 cc. AcOH treated 20 min. with cooling with 500 mg. 40% aqueous Me2NH, 1.5 cc. AcOH, and 440 mg. 37% aqueous CH2O and the mixture heated 2 h. on the water bath and kept overnight yielded 500 mg. 3-Me2NCH2 derivative (XXV) of I, needles, m. 103-4° (petr. ether). XXV (200 mg.), 2 cc. EtOH, and 100 mg. MeI gave XXV.MeI, needles, m. 180° (1:2 Me2CO-AcOEt). The UV spectra of I, IV, VIII, XVIII, XXI, XXII, XXIII, XXIV, XXIX, and the dihydro derivative of XXIV.HCl, and the IR spectrum of XXIV were recorded.

Chemical & Pharmaceutical Bulletin published new progress about IR spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

McGahey, Lawrence published the artcile< The stereochemistry of additions to trans-anethole>, Quality Control of 112-63-0, the main research area is anethole electrophilic addition laboratory experiment; safety anethole electrophilic addition laboratory experiment; stereochem anethole electrophilic addition laboratory experiment.

A laboratory experiment is described that explores the electrophilic additions to trans-anethole in which the product composition and stereochem. are established by NMR spectroscopy. The author warns that the experiments should be conducted in a hood to prevent inhalation of toxic vapors.

Journal of Chemical Education published new progress about Electrophilic addition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamamizu, Takafumi; Akiyama, Minoru; Takeda, Kunihiko published the artcile< A new styrene derivative and its application to reactive polymer synthesis>, Quality Control of 112-63-0, the main research area is divinylbenzene selective bromination; bromoethylstyrene copolymer divinylbenzene styrene; pyridinium perbromide divinylbenzene selective bromination; chain transfer bromoethylstyrene.

One of the vinyl groups of 1,3-divinylbenzene (I) [108-57-6] was selectively brominated by pyridinium hydrobromide perbromide  [39416-48-3] to form 3-(1,2-dibromoethyl)styrene (II) [95386-00-8]. The high selectivity is apparently the result of an electron-inductive effect by the 1,2-dibromoethyl group and the relatively mild activity of the brominating agent. The resulting monomer exhibits Q = 1.26 and e = 0.06 in its copolymerization with styrene. The chain-transfer constant to II was also estimated From II-styrene copolymer [95386-12-2] or I-II copolymer [97126-69-7], polymers with pendant vinyl groups were synthesized.

Reactive Polymers, Ion Exchangers, Sorbents published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Guizhuan; Zhang, Shaohao; Zheng, Zhangbin; Wang, Chen; Wang, Shijie; Tao, Hongge published the artcile< Direct conversion of fructose to 5-ethoxymethylfurfural catalyzed by ultra stable Y zeolite>, Application of C19H34O2, the main research area is fructose ethoxymethylfurfural ultra stable Y zeolite catalyst.

5-Ethoxymethylfurfural (EMF) is a new type of biofuel with a high energy d. and excellent fuel properties. One-pot production of EMF from renewable carbohydrate catalyzed by heterogeneous catalysts has the potential to be an attractive reaction pathway. In this study, fructose was directly converted to EMF in ethanol medium catalyzed by ultra stable Y zeolite (USY). The effects of different reaction conditions on EMF yields were investigated, and an optimum reaction condition was obtained by utilizing response surface methodol. Under the optimum reaction conditions, which were a temperature of 132°C, substrate d. of 60 g/L, and catalyst dosage of 2.1 wt%, a maximum EMF yield of 73.8 mol% with the prediction error of 1.6% was achieved in 25 min. Moreover, the reusability of USY and characterization were evaluated. This study demonstrated a promising strategy for EMF production from fructose.

BioResources published new progress about Response surface methodology. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Douglas, James; Ling, Kenneth B.; Concellon, Carmen; Churchill, Gwydion; Slawin, Alexandra M. Z.; Smith, Andrew D. published the artcile< NHC-Mediated Chlorination of Unsymmetrical Ketenes: Catalysis and Asymmetry>, Related Products of 112-63-0, the main research area is chlorination asym unsaturated ketene nitrogen heterocyclic carbene catalyst.

NHCs promote the efficient chlorination of unsym. disubstituted ketenes with a range of chlorinating agents; chiral NHCs display promising levels of asym. induction in the chlorination process with up to 61 % ee observed using 2,3,4,5,6,6-hexachlorocyclohexa-2,4-dienone.

European Journal of Organic Chemistry published new progress about Chlorination catalysts (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yi-Yang; You, Jin-Hai; Zhang, Shao-Jian; Lin, Hua; Ren, Wen-Feng; Deng, Li; Pan, Si-Yu; Huang, Ling; Zhou, Yao; Li, Jun-Tao; Sun, Shi-Gang published the artcile< Li0.5PAA domains filled in porous sodium alginate skeleton: A 3D bicontinuous composite network binder to stabilize micro-silicon anode for high-performance lithium ion battery>, COA of Formula: C19H34O2, the main research area is lithium PAA domain filled porous sodium alginate skeleton; bicontinuous composite network binder silicon anode lithium battery.

An important strategy to improve energy d. of Li-ion batteries is to substitute the traditional graphite anode by Si-based anode which is endowed with ultra-high theor. specific capacity. However, the commercialization of Si anodes is hindered by its huge volume variation that results in electrode pulverization. In the current study, the authors fill up the pores of Na alginate (SA) network with lithiated polyacrylic acid (LixPAA) to form a cross-linked bicontinuous composite network binder (b-Li0.5PAA@SA), in which the pores of the SA skeleton are dominated with the Li0.5PAA domains; within such composite the SA and Li0.5PAA interlock tightly each other via extensive interfacial ester bonding. The resulting b-Li0.5PAA@SA network binder can effectively buffer the volume variation of Si microparticles (m-Si) during repeating cycling and prevent pulverization of the electrode, which is evidenced by a cycling capacity of 2762 mAh g-1 in the 1st cycle and a retention of 1584 mAh g-1 after 150 cycles. As a comparison, the m-Si electrode with only SA binder suffers from fatal capacity degradation after merely 20 cycles under the same conditions. Also, since the Li0.5PAA domains are ionic conductive and significantly reduce the porosity of the SA network, the b-Li0.5PAA@SA network binder could also enable a stable solid electrolyte interphase (SEI) film and fast electron/ion transfer, leading to an enhanced rate capability of the m-Si anodes.

Electrochimica Acta published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Babushkina, T. A.; Robas, V. I.; Semin, G. K. published the artcile< Temperature dependences of the nuclear quadrupole resonance frequencies in molecular crystals>, Related Products of 112-63-0, the main research area is temperature nuclear quadrupole resonances; nuclear quadrupole resonances temperature; quadrupole resonances nuclear temperature; resonances nuclear quadrupole temperature; benzenes halo derivative; halobenzenes; nitrobenzenes.

About 90 temperature dependences of the nuclear quadrupole resonance frequencies (ω) of the nuclei 35Cl, 79Br, and 127I in mol. crystals of different aliphatic and C6H6 halogen derivatives were studied. The chief contribution to the temperature dependence of ω comes from torsional vibrations of the mols. in the crystal. In the temperature region 77-295°., ω is a linear function of temperature; hence, measurements at 3 temperatures (77, 195, and 295°K.) were sufficient. An exception was nitrohalogen derivatives of C6H6 (Br and I) and m-F2C6Br4 where the point of inflection of the temperature curve takes place on the side opposite that predicted by the Baeyer theory. Values of ω were measured for the compounds EtSiCl3 and CCl2(NO2)2 which had phase transformations. Although the relative changes in ω for CCl2(NO2)2 during phase transformations do not exceed 1.5%, T1 was equal to 130, 12, and 2.5 msec. for the α, β, and γ phases, resp., at 77°K. A statistical treatment of crystal shifts (∼600 splittings) showed that the most probable splitting values were in the range of 0.2-0.3% of the signal frequency.

Radiospektrosk. Tverd. Tela published new progress about Nuclear quadrupole resonance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics