Category: 112-63-0

Singh, Vandana; Johansson, Pegah; Lin, Yii-Lih; Hammarsten, Ola; Westerlund, Fredrik published the artcile< Shining light on single-strand lesions caused by the chemotherapy drug bleomycin>, Related Products of 112-63-0, the main research area is bleomycin shining light chemotherapy human; BER inhibition; DNA damage; Damage mechanism of drugs; Fluorescence microscopy; Personalizing chemotherapy; Single molecule imaging; Single-strand breaks.

Quantification of the DNA damage induced by chemotherapy in patient cells may aid in personalization of the dose used. However, assays to evaluate individual patient response to chemotherapy are not available today. Here, we present an assay that quantifies single-stranded lesions caused by the chemotherapeutic drug Bleomycin (BLM) in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals. We use base excision repair (BER) enzymes to process the DNA damage induced by BLM and then extend the processed sites with fluorescent nucleotides using a DNA polymerase. The fluorescent patches are quantified on single DNA mols. using fluorescence microscopy. Using the assay, we observe a significant variation in the in vitro induced BLM damage and its repair for different individuals. Treatment of the cells with the BER inhibitor CRT0044876 leads to a lower level of repair of BLM-induced damage, indicating the ability of the assay to detect a compromised DNA repair in patients. Overall, the data suggest that our assay could be used to sensitively detect the variation in BLM-induced DNA damage and repair in patients and can potentially be able to aid in personalizing patient doses.

DNA Repair published new progress about Chemotherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhi; Yuan, Hong published the artcile< An alumina-coated UiO-66 nanocrystalline solid superacid with high acid density as a catalyst for ethyl levulinate synthesis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is sulfate impregnated zirconia alumina catalyst preparation property; glucose dehydration ethyl levulinate.

The zirconium-containing metal-organic framework (MOF) UiO-66 was used as a cell to synthesize SO42-/ZrO2@Al2O3, a high-d. superacid with relatively strong Bronsted acidity. The UiO-66 MOF was first coated with alumina to form ZrO2@Al2O3. Impregnation with ammonium sulfate and calcination at 500°C afforded the bimetallic composite solid superacid SO42-/ZrO2@Al2O3. RESULTS : Scanning and transmission electron microscopy images confirmed that UiO-66 was successfully coated with aluminum oxide, and its octahedral structure and uniform size (400-600 nm) were retained. SO42-/ZrO2@Al2O3 had a Brunauer-Emmett-Teller sp. surface area of 301-330 m2 g-1 and average pore diameter of 9.6-10.7 nm. XPS and Fourier transform IR anal. showed that SO42-/ZrO2@Al2O3 contained S6+ and Al3+. Temperature-programmed ammonia desorption anal. showed that SO42-/ZrO2@Al2O3 contained super-strong acid sites. The total volume of desorbed ammonia reached 90-109 cm3 g-1. IR spectra of adsorbed pyridine indicated that SO42-/ZrO2@Al2O3 contained mainly Lewis acid sites and was relatively rich in Bronsted acid sites. Thermogravimetric anal. showed that the thermal stability of SO42-/ZrO2@Al2O3 was high. SO42-/ZrO2@Al2O3-3M (the impregnation concentration of ammonium sulfate was 3 mol L-1) and glucose were used to synthesize Et levulinate (EL) in ethanol. The highest EL yield of 37.5 mol% was obtained after reacting the mixture at 200°C for 5 h. An EL yield of 28.8 mol% was obtained after four consecutive reuses of the SO42-/ZrO2@Al2O3-3M catalyst.

Journal of Chemical Technology and Biotechnology published new progress about Dehydration catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hunter, James H.; Prendergast, Lisa; Valente, Louis F.; Madin, Andrew; Pairaudeau, Garry; Waring, Michael J. published the artcile< High Fidelity Suzuki-Miyaura Coupling for the Synthesis of DNA Encoded Libraries Enabled by Micelle Forming Surfactants>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is DNA encoded biaryl library preparation micelle surfactant Suzuki coupling.

DNA encoded chem. libraries provide a highly efficient means of screening vast numbers of small mols. against an immobilized protein target. Their potential is currently restricted by the constraints of carrying out library synthesis in the presence of attached DNA tags, for which a limited number of reactions and substrates can be used. Even established reactions, such as Suzuki-Miyaura couplings, do not give efficient coupling reactions across a wide range of substrates and can lead to significant DNA degradation We developed an efficient protocol for carrying out Suzuki-Miyaura couplings on DNA tagged substrates that proceeds with unprecedented efficiency to the desired biaryl products (>98% on average with no detectable DNA degradation) across a wide range of drug-like substrates using a micellar promoted process with com. TPGS-750-M surfactant. We have demonstrated the applicability of this method in DEL synthesis by preparing a prototypical two-dimensional 36-member library employing the Suzuki-Miyaura coupling methodol. as the final library synthesis step. This work shows, for the first time, that standard micellar surfactants can promote reactions for encoded library synthesis, leading to libraries of exceptional fidelity, and demonstrates the potential to expand the range of accessible DNA compatible chem.

Bioconjugate Chemistry published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crittall, MatthewR.; Rzepa, Henry S.; Carbery, David R. published the artcile< Design, Synthesis, and Evaluation of a Helicenoidal DMAP Lewis Base Catalyst>, Computed Properties of 112-63-0, the main research area is helical dimethylaminopyridine analog preparation Lewis base catalyst enantioselective esterification; alc benzylic secondary enantioselective esterification anhydride kinetic resolution.

The design, synthesis, and study of helical dialkylaminopyridine Lewis base catalysts (P)-I and (M)-I is reported. These catalysts displayed good to excellent levels of selectivity (S ≤ 116) in the kinetic resolution of chiral secondary alcs. R1CH(OH)R2 (R1 = Ph, R2 = Me, Et, t-Bu; R1 = 4-FC6H4, 2-MeC6H4, 2-naphthyl, 9-anthryl, etc., R2 = Me). Catalysts I displayed excellent reactivity with exceptionally low loadings of 0.05 mol.% effecting practical levels of selectivity in kinetic resolutions

Organic Letters published new progress about Aralkyl alcohols Role: PUR (Purification or Recovery), RCT (Reactant), SPN (Synthetic Preparation), PREP (Preparation), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Wei; Li, Weiyi; Qin, Song published the artcile< Origins of enantioselectivity in the chiral diphosphine-ligated CuH-catalyzed asymmetric hydrosilylation of ketones>, COA of Formula: C19H34O2, the main research area is chiral diphosphine copper hydride catalyzed asym hydrosilylation acetophenone DFT; optimized geometry copper hydride catalyzed asym hydrosilylation acetophenone DFT; silyl ether preparation.

Computational studies on the asym. hydrosilylation of acetophenone over ligated CuH catalysts were performed with the DFT method. The calculations predict that the catalytic reaction involves two steps: (1) CuH addition to the carbonyl group via a four-membered transition state (TS) with the formation of Cu-alkoxide intermediates; (2) regeneration of the ligated CuH catalyst by an external SiH4 through a metathesis process to yield the corresponding silyl ether. The calculations in the chiral diphosphine-ligated CuH systems suggest that the metathesis process is the rate-determining step (RDS). The CuH addition step is vital for the distribution of the racemic products and therefore represents the stereo-controlling step (SCT). In this step, the greater steric hindrance between the aromatic rings of the ligands and the substrate is identified as the major factor for enantioselectivity. The corresponding TS in the face-to-face mode, suffering less steric hindrance, is more stable than its analog in the edge-to-face mode. The enantioselectivities are related not only to the P-Cu-P bite angles in the stereo-controlling TSs, but also to the substituents at the P-aryl rings of the chiral ligands. In short, a larger P-Cu-P bite angle and suitably modified P-aryl rings together are necessary to achieve excellent ee values.

Organic & Biomolecular Chemistry published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Sung-Bae; Lee, Jin-Seok; Moon, Sung-Ok; Lee, Hwa-Dong; Yoon, Yoo-Sik; Son, Chang-Gue published the artcile< A standardized herbal combination of Astragalus membranaceus and Paeonia japonica, protects against muscle atrophy in a C26 colon cancer cachexia mouse model>, HPLC of Formula: 112-63-0, the main research area is albiflorin paeoniflorin formononetin Astragalus antiinflammatory agent muscle atrophy; Astragalus membranaceus; Cancer cachexia; Muscle atrophy; Paeonia japonica.

Astragalus membranaceus (Fisch.) and Bunge and Paeonia japonica (Makino)Miyabe & H. Takeda have been traditionally used to improve the poor quality of life such as weakness, lack of appetite, fatigue, and malaise which is considered with cachexia condition. We investigated anti-cachectic effects of a herbal formula composed of Astragalus membranaceus and Paeonia japonica (APX) and the mol. mechanisms of APX in C26 cancer-induced cachexia mice and TNF-a-treated C2C12 myotubes. Addnl. synergistic anti-cachectic effects of APX were compared to those of individual herbal extracts and megestrol acetate. The forty-two BALB/c mice were randomly divided into 6 groups: normal (nontreatment), control (C26 injection), AM (C26 injection with Astragalus membranaceus), PJ (C26 injection with Paeonia japonica), APX C26 injection with combination of Astragalus membranaceus and Paeonia japonica and MA (C26 injection with megestrol acetate). All mice were orally administered DW (normal and control groups) or 100 mg/kg AM, PJ, APX or MA for 10 days. In the animal model, several tissues were weighed, and muscle tissue and blood were used to measure pro-inflammatory cytokines. C2C12 myotubes were exposed to 100 ng/mL TNF- α with or without 10μg/mL of AM, PJ, APX or MA for 48 h. The cells were used to immunofluorescence staining and western blot analyses. C26 injection induced notable body and muscle weight loss while APX administration significantly attenuated these alterations and the decrease of muscle weights and strength. APX also significantly attenuated the abnormal elevations in the concentration of three muscle atrophy-inducible cytokines; serum and muscle TNF-α,muscle TWEAK and IL-6 in C26 tumor-bearing mice. In the TNF-α-treated C2C12 myotube model, TNF-α treatment notably decreased MyH but activated atrophic proteins (MuRF and Fbx32) along with p38 and NFκB while these mol. alterations were significantly ameliorated by APX treatment. These pharmacol. actions of APX were supported by the results of immunofluorescence staining to MyH expression and the translocation of NFκB into the nucleus in C2C12 myotubes. Our data indicate the potential of an herbal formula, APX as an anti-cachexia agent; the effect of APX was superior to that of megestrol acetate overall especially for muscle atrophy. The underlying mechanisms of this herbal formula may involve the modulation of muscle atrophy-promoting mols. including p38, NFκB, TNF-α and TWEAK.

Journal of Ethnopharmacology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Huihua; Morshedi, Mahbod; Kodikara, Mahesh S.; Moxey, Graeme J.; Wang, Genmiao; Wang, Huan; Quintana, Cristobal; Stranger, Rob; Zhang, Chi; Cifuentes, Marie P.; Humphrey, Mark G. published the artcile< Synthesis, Optical, Electrochemical, and Theoretical Studies of Dipolar Ruthenium Alkynyl Complexes with Oligo(phenylenevinylene) Bridges>, Quality Control of 112-63-0, the main research area is dipolar ruthenium alkynyl oligophenylenevinylene bridged preparation crystal mol structure; electrochem redox quadratic nonlinear optical property alkynyl ruthenium oligophenylenevinylene; mol structure calculation alkynyl ruthenium oligophenylenevinylene bridged; computational chemistry; electrochemistry; nonlinear optics; organometallic chemistry; transition metals.

The syntheses of oligo(p-phenylenevinylene)s (OPVs) end-functionalized with a ligated ruthenium alkynyl unit as a donor and a nitro as acceptor, namely trans-[Ru{CC-1-C6H4-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H4-4-NO2}Cl(dppe)2] (Ru4), trans-[Ru{CC-1-C6H4-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H4-4-NO2}Cl(dppe)2] (Ru6), and trans-[Ru{CC-1-C6H4-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(2-ethyl-n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(2-ethyl-n-hexyl)2-4-(E)-CH:CH-1-C6H4-4-NO2}Cl(dppe)2] (Ru8), are reported, together with those of precursor alkynes. Their electrochem. properties were assessed by cyclic voltammetry (CV), their linear optical and quadratic nonlinear optical (NLO) properties assayed by UV/Vis-NIR spectroscopy and hyper-Rayleigh scattering studies at 1064 nm, resp., and their linear optical properties in the formally RuIII state examined by UV/Vis-NIR spectroelectrochem. Computational studies employing time-dependent d. functional theory were undertaken on model complexes to rationalize the optical observations.

ChemPlusChem published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shibata, Norio; Ishimaru, Takehisa; Suzuki, Emiko; Kirk, Kenneth L. published the artcile< Enantioselective fluorination mediated by N-fluoroammonium salts of cinchona alkaloids: first enantioselective synthesis of BMS-204352 (MaxiPost)>, COA of Formula: C19H34O2, the main research area is BMS 204352 asym synthesis; enantioselective fluorination cinchona alkaloid fluoroammonium salt mediated; Selectfluor fluoroammonium salt mediated enantioselective fluorination oxindole derivative.

We have employed a cinchona alkaloid/Selectfluor-mediated enantioselective fluorination of the oxindole I (R = H) to achieve the first enantioselective synthesis of BMS-204352 [MaxiPost, (S)-I (R = β-F)], an effective opener of maxi-K channels. Fluorination occurred to produce (S)-I (R = β-F) with 84% ee using the bis-cinchona alkaloid (DHQ)2AQN. Recrystallization produced enantiomerically pure (>99% ee) product. Quinidine-mediated fluorination of I (R = H) gave the (R)-antipode I (R = α-F) with 68% ee.

Journal of Organic Chemistry published new progress about Chiral auxiliary (Cinchona alkaloid N-fluoroammonium salts). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Jianhua; Li, Xiaoxun published the artcile< Asymmetric β-arylation of cyclopropanols enabled by photoredox and nickel dual catalysis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is beta aryl ketone preparation enantioselective; cyclopropanol aryl bromide beta arylation photoredox nickel catalyst.

The enantioselective functionalization and transformation of readily available cyclopropyl compounds are synthetically appealing yet challenging topics in organic synthesis. Here authors report an asym. β-arylation of cyclopropanols with aryl bromides enabled by photoredox and nickel dual catalysis. This dual catalytic transformation features a broad substrate scope and good functional group tolerance at room temperature, providing facile access to a wide array of enantioenriched β-aryl ketones bearing a primary alc. moiety in good yields with satisfactory enantioselectivities (39 examples, up to 83% yield and 90% ee). The synthetic value of this protocol was illustrated by the concise asym. construction of natural product calyxolane B analogs.

Chemical Science published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lalitha, R.; Palani, S. published the artcile< Phytochemical analysis of Scinaia bengalica by GCMS>, Quality Control of 112-63-0, the main research area is Scinaia marine extract phytochem GCMS.

Marine red algae consist of various medicinal activities. Marine sources are more active than the other natural sources. One of the most important red algae is Scinaia Bengalica (SB) known for its phytochem. anal. by GC-MS revealed 19 chem. constituents. SB consist major constituents like oleic acid, octanoic acid, 2 hexyl-1-octanol,hexadecanol, calcitriol, bromine compounds

International Journal of MediPharm Research published new progress about High resolution gas chromatography-high resolution mass spectrometry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics