Category: 112-63-0

Gabes, W.; Stufkens, D. J.; Gerding, H. published the artcile< Structures, Raman, infrared, and electronic absorption spectra of pyridinium trihalides>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is pyridinium trihalide IR UV Raman.

Vibrational and electronic absorption spectra of PyHI3, PyHIBr2, PyHICl2, PyHBr3, and PyHBrCl2 (PyH+ = pyridinium) are explained in terms of the vibrations and electronic transitions, resp., of the pyridinium and trihalide ions. Two compounds, PyHI3 and PyHBr3, show charge transfer bands in the absorption spectra of the solids, and the vibrational spectrum of the PyH+ ion in solid PyHBr3 differs from the normal PyH+ spectrum. PyHBr3 as well as PyHI3 contains asym. trihalide ions in the solid state, as determined from the Raman and infrared spectra.

Journal of Molecular Structure published new progress about IR spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Duguet, Nicolas; Campbell, Craig D.; Slawin, Alexandra M. Z.; Smith, Andrew D. published the artcile< N-Heterocyclic carbene catalyzed β-lactam synthesis>, Reference of 112-63-0, the main research area is asym synthesis beta lactam cycloaddition ketene tosyl imine; heterocyclic carbene catalyst cycloaddition asym synthesis beta lactam.

N-Heterocyclic carbenes promote the formal [2 + 2] cycloaddition of ketenes with N-tosyl imines to give the corresponding β-lactams in good to excellent isolated yields; chiral NHCs give β-lactams, e.g. I, in high e.e. after crystallization

Organic & Biomolecular Chemistry published new progress about [2+2] Cycloaddition reaction, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shen, Jincheng; Shao, Wanlu; Li, Junmin; Lu, Hongfei published the artcile< Integrated metabolomic and transcriptomic analysis reveals factors underlying differences in fruit quality between Fragaria nilgerrensis and Fragaria pentaphylla>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Fragaria nilgerrensis pentaphylla fruit quality metabolomics transcriptomics; Fragaria nilgerrensis; Fragaria pentaphylla; fruit quality; metabolomics profiling; transcriptomics profiling.

Strawberries have become one of the most popular fruits because of their unique flavor and high nutritional value. Fruit quality and price are the most important criteria that determine consumer acceptability. Fragaria nilgerrensis and Fragaria pentaphylla are two wild Asian diploid strawberry species that differ in fruit color, taste, and aroma. To understand the mol. mechanisms involved in the formation of high-quality strawberry fruit, we integrated transcriptomics and metabolomics research methods to compare the metabolic and biosynthetic mechanisms of the two Fragaria species. F. nilgerrensis fruit has higher amino acid and lipid contents and a higher sugar-to-acid ratio than F. pentaphylla fruit does, underlying their superior nutritional value, aroma, firmness, and taste. Compared with F. nilgerrensis fruit, F. pentaphylla fruit contained more flavonoids, indicating its enhanced color and health benefits. In addition, candidate structural genes that regulate the biosynthesis of flavonoids, amino acids, and glycerophospholipids in the two strawberry fruit were screened. The differences in aroma, firmness, and taste between F. nilgerrensis fruit and F. pentaphylla fruit are probably due to differences in their amino acid and lipid contents, as well as the difference in their sugar-to-acid ratios. Eight key structural genes that may play important roles in the biosynthesis of amino acids, lipids, and flavonoids were identified. 2021 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about Alcohols Role: ANT (Analyte), FFD (Food or Feed Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

van Zanten, B.; Nauta, W. Th. published the artcile< Synthesis of alkyl-substituted 3-phenyl-4-hydroxycoumarins>, Related Products of 112-63-0, the main research area is .

As part of a study into the relationship between chem. structure and biol. activity, a number of 3-phenyl-4-hydroxycoumarins with alkyl substituents in the 3-phenyl group were prepared to be used as anticoagulants. The principal methods of preparation of the compounds O.CO.CHR.CO.C:C.CH:CH.CH:CH (I) were reviewed. Use was made of the following methods for preparation of the I: (a) cyclization of compounds of the type 2-RCH2CO2C6H4CO2Me (II) (R is an aliphatic or aromatic group or H); (b) reaction of PhOH with monosubstituted malonic esters; (c) coupling aryldiazonium compounds with I (R = H) in an acid medium in the presence of CuCl2. The following RCH2CO2Et (III) required for method b were prepared by (d) esterification of the arylacetic acid by refluxing with EtOH and some H2SO4; (e) esterification of the arylacetonitrile by refluxing with 3:1 EtOH-H2SO4; (f) treatment of the arylcarboxylic chloride with CH2N2 and then with EtOH and Ag2O. The following III were prepared (R, method, % yield, b.p./mm., procedure used to prepare required intermediate given): 3-MeC6H4, e, 80, 115°/15, from m-xylene by treatment with SO2Cl2 to give 70% 3-MeC6H4CH2Cl, b10 90-2°, this converted with NaCN in aqueous EtOH to 86% nitrile, b10 125-30°; 2,3-Me2C6H3, f, 66, 132-45°/15, by diazotization of 2,3-Me2C6H3NH2 in 40% aqueous HBr, conversion with Cu bronze into 45% 2,3-Me2C6H3Br, b14 88-92°, treatment of the Grignard with solid CO2 to obtain 76% 2,3-Me2C6H3CO2H, m. 146°, and conversion with SOCl2 to 95% acid chloride, b11 107-11°; 2,4-Me2C6H3, e, 64, 138-40°/17, by chloromethylation of m-xylene with paraformaldehyde (IV) in concentrated HCl to obtain 72% 2,4-Me2C6H3CH2Cl, b12 99-102°, and conversion as before into 94% nitrile, b18 138-41°; 2,5-Me2C6H3, f, 67, 118-29°/12, by bromination of p-xylene to 80% 2,5-Me2C6H3Br, b10 80°, conversion to a Grignard compound and treatment with solid CO2 to obtain 75% 2,5-Me2C6H3CO2H, m. 133°, and conversion by SOCl2 to 90% acid chloride, b14 108°; 2,6-Me2C6H3, d, 87, 93-5°/2, by diazotizing 2,6-Me2C6H3NH2 and converting as above to 44% bromo compound, b20 90-3°, treatment of the Grignard with solid CO2 to obtain 70% 2,6-Me2C6H3CO2H, m. 116°, esterification with CH2N2 to 95% Me ester, b12 98-100°, reduction with LiAlH4 to 91% 2,6-Me2C6H3CH2OH, m. 91-2°, conversion by SOCl2 into 94% chloride, b13 96-7°, m. 31°, then into 93% nitrile, b11 125-7°, m. 36°, and saponification by 50% aqueous H2SO4 to 89% 2,6-Me2C6H3CH2CO2H, m. 130°; 3,4-Me2C6H3 (V), f, 30, 120-30°/7, by converting 3,4-Me2C6H3NH2 as above into 57% 3,4-Me2C6H3Br, b13 88-90°, treatment of the Grignard with solid CO2 to obtain 90% acid, m. 163-5°, and conversion by SOCl2 into 60% acid chloride, b17 119-22°; V, e, 67, 123-8°/10, by chloromethylation of o-xylene with MeOCH2Cl to 7% 3,4-Me2C6H3CH2Cl, b16 105-15°, and conversion to 85% nitrile, b10 123-8°; 3,5-Me2C6H3, e, 80, 130-4°/14, by conversion of 3,5-Me2C6H3NH2 to the bromo compound, b14 84-7°, treatment of the Grignard with IV to give 20% 3,5-Me2C6H3CH2OH, b2 83-5°, conversion to 90% chloride, b15 100-10°, and then to 60% nitrile, b15 128-32°; 2,4,6-Me3C6H2, d, 64, 115°/2, by treating 2,4,6-C6H3Me3 with IV in concentrated HCl to give 47% 2,4,6-Me3C6H2CH2Cl, b16 119-23°, converting into 84% nitrile, b18 147-56°, and saponifying to 87% 2,4,6-Me3C6H2CH2CO2H, m. 167°; 2-EtC6H4, e, 87, 134°/20, by converting 2-EtC6H4NH2 to 40% bromo compound, b16 79-80°, treating the Grignard with solid CO2 to obtain 89% acid, m. 68°, esterifying to 96% Et ester, b16 114-16°, reducing by LiAlH4 to 100% 2-EtC6H4CH2OH, converting into 94% chloride (VI), b20 105°, and then into 96% nitrile, b20 138-40° (treatment of the Grignard of VI with Ac2O gave 52% 2-EtC6H4Ac, b13 99-103°; n25D 1.5222); 4-EtC6H4, e, 78, 152-4°/35, by chloromethylation of EtPh to 60% 4-EtC6H4CH2Cl, b16 100-2°, and conversion to 85% nitrile, b16 148-51°, n20D 1.5172; 2,6-Et2C6H3, d, 96, 135-6°/10, by converting 2,6-Et2C6H3NH2 to 52% 2,6-Et2C6H3Br, b16 109-14°, treating the Grignard with solid CO2 to give 86% 2,6-Et2C6H3CO2H, m. 85°, converting to 75% Me ester, b13 115-21°, reducing with LiAlH4 to 90% 2,6-Et2C6H3CH2OH, m. 65°, converting with SOCl2 to 98% chloride, b11 117°, and via the nitrile to 73% 2,6-Et2C6H3CH2CO2H, m. 72°; 2-iso-PrC6H4, e, 80, 135-6°/17, by conversion of 2-iso-PrC6H4NH2 to 46% 2-iso-PrC6H4Br, b15 90-3°, treatment of the Grignard reagent with solid CO2 to give 83% 2-iso-PrC6H4CO2H, m. 69°, conversion to 95% Et ester, b15 119-20°, reduction with LiAlH4 to 98% 2-iso-PrC6H4CH2OH, conversion by SOCl2 to 91% chloride, b20 109-11°, and conversion to 94% nitrile, b16 133-9°; 4-iso-PrC6H4, e, 81, 139-41°/15, by treating 4-iso-PrC6H4Me with SO2Cl2 to give 4-iso-PrC6H4CH2Cl, b17 112-14°, and converting to 92% nitrile, b10 130-3°; 2,6-iso-Pr2C6H3, e, 90, 108-9°/0.5, by conversion of 2,6-iso-Pr2C6H3NH2 to 44% 2,6-iso-Pr2C6H3Br, b15 128-30°, then as usual to 68% 2,6-iso-Pr2C6H3CO2H, esterification (Newman, CA 35, 73844) to 81% Me ester, b20 136-8°, m. 31°, reduction as usual to 98% 2,6-iso-Pr2C6H3CH2OH, b20 146-8°, m. 98°, conversion to 92% chloride, b18 136-7°, and then to 97% nitrile, b0.5 116-18°, m. 60°; 2-tert-BuC6H4, d, 90, 153-4°/19, by conversion of 2-tert-BuC6H4Br (VII) (b11 97°) (Crawford and Stewart, CA 48, 6398b) to 80% 2-tert-BuC6H4CO2H, m. 68°, esterification to 90% Me ester, b15 120-3°, reduction to 100% 2-tert-BuC6H4CH2OH, b16 130-3°, conversion to 90% chloride (VIII), b16 116-21°, conversion of VIII to 72% nitrile, b18 148-54°, n20D 1.5230, and saponification to 99% acid (IX), m. 84° [treatment of the Grignard reagent of X with CO2 gave only 20% IX, the main product obtained was 50% (2-tert-BuC6H4CH2)2, b0.001 140-50°, m. 83-4°; oxidation of 2-tert-BuC6H4CH2CH:CH2, b13 102-5° (obtained in 57% yield by coupling the Grignard (X) of VII with CH2:CHCH2Br in C6H6) did not yield IX; treatment of X with Ac2O at -20° gave 40% 2-tert-BuC6H4Ac, b12 112-22°, which did not give IX on oxidation]; 4-tert-BuC6H4, d, 88, 134-7°/8, by conversion of tech. 4-tert-BuC6H4CO2H into 93% Me ester, b16 136-8°, reduction to 95% 4-tert-BuC6H4CH2OH, conversion into 80% chloride, b16 122-30°, then to 90% nitrile, b16 149-52°, and saponification to 95% acid, m. 78-9°; 1-C10H7, e, 72, 140-5°/3, by chloromethylation of C10H8 to 65% 1-C10H7CH2Cl, b5 130-5°, and conversion to 83% nitrile, b2 155-65°; 2-C10H7, d, 90, 135-8°/2, by converting C10H8 to 80% 2-C10H7Ac, b11 155-61°, m. 30°, treating with S and morpholine to 84% crude thiomorpholide of 2-C10H7CH2CO2H (XI), and saponifying with AcOH and H2SO4 to 72% XI, m. 140-3°. The III (0.37 mole) and 0.70 mole (CO2Et)2 added at 40-50° during 1 min. with stirring to 0.40 mole NaOEt from which all traces of EtOH were removed in vacuo while distilling any volatiles formed, the mixture stirred and distilled while the temperature was raised to 130° and then to 180° at 10-20 mm., cooled, treated with 200 ml. H2O, 12-15 ml. concentrated H2SO4, and 500 ml. Et2O, the Et2O layer separated, the aqueous layer extracted 4 times with Et2O, the combined Et2O layers washed with 2N Na2CO3 and with H2O until neutral to litmus, evaporated, the residue dried azeotropically with C6H6, mixed with porcelain powder, heated in a bath at 180° at 10-20 mm. until CO no longer was evolved, and the residue twice distilled gave the following RCH(CO2Et)2 (XII) (R, % yield, and b.p./mm. given): 3-MeC6H4, 52, 125-32°/2; 2,3-Me2C6H3, 42, 127°/1; 2,4-Me2C6H3, 94, 151°/4; 2,5-Me2C6H3, 40, 128°/1.5; 2,6-Me2C6H3, 57, 122-8°/1; 3,4-Me2C6H3, 49, 137°/2; 3,5-Me2C6H3, 52, 127°/1.5; 2,4,6-Me3C6H2, 65, 150-60°/2 (m. 46-7°); 2-EtC6H4, 63, 117-18°/1; 4-EtC6H4, 60, 122-4°/1; 2,6-Et2C6H3, 42, 132-3°/1; 2-iso-PrC6H4, 75, 121°/1; 4-iso-PrC6H4, 68, 130°/1; 2,6-iso-Pr2C6H3, 36, 137-9°/1; 2-tert-BuC6H4 (XIII), 17, 130°/1 [an unsuccessful attempt to prepare XIII was made by coupling X with OC(CO2Et)2 at -70° to obtain 57% 2-tert-BuC6H4C(OH)(CO2Et)2, b0.05 158-62°, and converting with SOCl2 to 55% chloride, b0.01 130°, but the chloride could not be catalytically reduced]; 4-tert-BuC6H4, 57, 149-52°/1; 1-C10H7, 68, 176-7°/1 (m. 62°); 2-C10H7, 39, 180°/2 (m. 96-7°). Treatment of RCH2COCl with 2-HOC6H4CO2Me (XIV) (method g) or RCH2CO2H with XIV (method h) (Stahmann, et al., CA 38, 7417) gave the following II (R, method, % yield, m.p., b.p./mm., procedure used to obtain required intermediate given): Ph, g, 50, 54-5°, 160°/0.8, by conversion of PhCH2CO2H with SOCl2 to 90% PhCH2COCl, b20 99-102°; H, h, 90, 47-9°, -, S., et al., loc. cit.; 2-MeC6H4, g, 74, 58-61°, 180-95°/0.1, by treating PhCH2MgCl with IV to obtain 50% 2-MeC6H4CH2OH, b17 112°, converted successively into 85% chloride, b15 82-6°, 93% nitrile, b15 115-28°, 68% acid, m. 88-9°, and 85% acid chloride, b15 108-9°; 4-MeC6H4, g, 55, -, 175-200°/0.05, by chlorination of p-xylene with SO2Cl2 to obtain 79% 4-MeC6H4CH2Cl, b8 70-4°, converted successively to 80% nitrile, b12 115°, 80% acid, m. 90-1°, and 90% acid chloride, b9 98-9°; 2,4,6-Me3C6H2, g, 61, 64-5°, 175-85°/0.03, by converting 2,4,6-Me3C6H2CH2CO2H to 72% acid chloride, b15 134-7°. The procedures (a, b, c) used to obtain the I were as follows. (a) Na (0.2 g. atom) in 200 ml. paraffin oil heated to 250°, 0.2 mole II was added with stirring, the mixture heated and stirred 1 hr. at 250°, the paraffin oil decanted, the residue washed with petr. ether, dissolved in 600 ml. H2O, the solution acidified to pH 6-7, extracted with Et2O, and adjusted to pH 1-2 with acid gave the I. (b) The XII (0.1 mole) and 0.1 mole PhOH dried azeotropically with C6H6, the mixture heated 24-72 hrs. at 250-300° until a drop of the mixture solidified on cooling, poured into 400 ml. 5% aqueous NaHCO3, boiled 1 hr., the solution filtered, the filtrate acidified to pH 6-7, extracted with C6H6 or Et2O, and acidified to pH 1-2 gave the I. (c) PhNH2 (0.03 mole) in 12 ml. 12N HCl and 18 ml. H2O diazotized with 3 g. NaNO2 at -5°, the diazonium solution added slowly at -5° with stirring to 6 g. NaOAc and 5 g. I (R = H) in 20 ml. Me2CO, the mixture treated with 1 g. CuCl2, heated to 40-50°, heated and stirred 30 min. at 40-50°, the Me2CO distilled, the residue acidified, the precipitate filtered off, dissolved in 5% aqueous NaHCO3, and the solution treated as in b gave the I.

Recueil des Travaux Chimiques des Pays-Bas et de la Belgique published new progress about Blood coagulation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Heasley, Victor L.; Louie, Timothy J.; Luttrull, David K.; Millar, Mark D.; Moore, Hal B.; Nogales, Danny F.; Sauerbrey, Andreas M.; Shevel, Amy B.; Shibuya, Terry Y. published the artcile< Effect of N-bromosuccinimide (NBS) and other N-brominating agents on the bromination of α,β-unsaturated ketones in methanol>, HPLC of Formula: 112-63-0, the main research area is bromination unsaturated ketone ester regiochem; NBS bromine bromination unsaturated ketone regiochem; methoxybromoalkanone; alkanoate bromo methoxy.

Bromination of α,β-unsaturated ketones, e.g., RCH:CR1COR2 (I; R = R1 = H, R2 = Me, Ph; R = H, R1 = R2 = Me; R = R2 = Me, R1 = H) by Br in MeOH with and without NBS gave mixtures of Markovnikov bromides [e.g., RCHBrCR1(OMe)COR2], anti-Markovinkov bromides (e.g., MeOCHRCHBrCOR2), and dibromides (e.g., RCHBrCR1BrCOR2). The ratios of Markovnikov-anti-Markovnikov (M-AM) regioisomers were low without NBS and higher in the presence of NBS. The M-AM ratio for I (R = H, R1 = R2 = Me) was approx. the same with and without NBS. All of the ketones showed significantly less dibromide with NBS. The bromination rates decreased dramatically with NBS. Selected N-bromo amides (e.g., AcNHBr or AcNBr2) gave results similar to those of NBS with I (R = R1 = H, R2 = Me), showing small variations in the M-AM ratios. The ketones gave higher M-AM ratios with MeOBr-BF3. Bromination of esters (e.g., R3CH:CR4CO2Me; R3 = H, R4 = H, Me; R3 = Me, R4 = H), with and without NBS gave results parallel to those of the ketones, but with less change in the M-AM ratios. The mechanisms of the reactions are discussed. With the ketones, NBS functions by removing acid, causing a change from an acid-catalyzed mechanism to a bromonium ion-type mechanism, perhaps involving complexing between the olefin, NBS, and Br. The esters probably proceed by the latter mechanism in the presence of NBS.

Journal of Organic Chemistry published new progress about Bromination kinetics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Zichao; E, Jingjing; Ma, Rongze; Zhang, Jingya; Yao, Caiqing; Wang, Ruixue; Zhang, Qiaoling; Yang, Ying; Li, Jing; Wang, Junguo published the artcile< The effect of aspartic acid on the freeze-drying survival rate of Lactobacillus plantarum LIP-1 and its inherent mechanism>, Reference of 112-63-0, the main research area is Lactobacillus plantarum freeze drying survival aspartic acid inherent mechanism.

Amino acids are often used as growth factors to promote the growth of strains, but we found that adding aspartic acid to the medium could significantly improve the freeze-drying survival rate of some Lactobacillus plantarum (p < 0.05). Our research aimed at Lactobacillus plantarum LIP-1, after exploring its internal mechanism, it is proved that the addition of aspartic acid could significantly reduce the strain′s cell wall, cell membrane and DNA damage during the freeze-drying process. Further research concluded some critical points after adding aspartic acid into a medium as below: reduce cell wall damage by increasing the peptidoglycan content, protect the integrity of the cell membrane by increasing the content of long-chain fatty acids, unsaturated fatty acids and cyclopropane fatty acids in cell membranes, and reduce DNA damage by increasing the intracellular pH. Further studies are needed on improving the freeze-drying survival of strains by altering the composition of culture media. LWT--Food Science and Technology published new progress about Amino acids Role: FFD (Food or Feed Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meier, Herbert; Gerold, Juergen; Kolshorn, Heinz; Muehling, Bastian published the artcile< Extension of conjugation leading to bathochromic or hypsochromic effects in OPV series>, SDS of cas: 112-63-0, the main research area is donor acceptor OPV conjugation bathochromic hypsochromic effect.

Four OPV series 1-4 (a-d) defined as: A-p-C6H4-[CH:CH-C6H4-p-]n-N[CH2CH(hexyl)2]2 (with n = 1-4 as 1-4; A = H, CN, CHO, NO2 as a-d) with a terminal dialkylamino group as electron donor were prepared by Wittig-Horner reactions. To study the influence of the push-pull effect on the long-wavelength absorption, three of the four series contained terminal acceptor groups (CN, CHO, NO2). The length of the chromophores strongly affects the intramol. charge transfer (ICT)-an effect which superimposes upon the extension of the conjugation. Increasing numbers n of repeat units cause an overall bathochromic shift for the purely donor-substituted series 1a-4a and the series 1b-4b with CN as weak acceptor. The two effects annihilate each other in the series 1c-4c with terminal CHO groups, so that the absorption maxima are almost independent of the length of the chromophore. A hypsochromic shift is observed for the series 1d-4d, which contains the strong acceptor group NO2. This anomaly disappears on protonation of the dialkylamino group because the push-pull effect disappears in the ammonium salts. The results can be explained by semiempirical quantum mechanics (AM1, INDO/S). The HOMO-LUMO transition, which is mainly responsible for the ICT, becomes less important in the electron transitions S0→S1 when the distance between donor and acceptor is increased. The commonly used VB model, which contains an electroneutral and a zwitterionic resonance structure, is contrasted with a MO model with dipole segments at both ends of the OPV chains. The latter model turned out to be more appropriate-at least for donor-acceptor-substituted OPVs with n ≥ 2.

Chemistry – A European Journal published new progress about Bathochromic effect. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ding, Ling; Niu, Kaikai; Liu, Yuxiu; Wang, Qingmin published the artcile< Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cyanoalkyl quinoxalinone preparation green chem; cyclobutanone oxime ester quinoxalinone electro reductive cyanoalkylation.

Herein, authors report a practical electro-reductive protocol for the direct C-H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions proceed under metal-, reductant-, and reagent-free conditions to provide synthetically useful cyanoalkylated quinoxalin-2(1H)-ones.

Chinese Chemical Letters published new progress about Benzoyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rajeswari, Doodigama; Anil, Kumar V. published the artcile< Method development and validation for the simultaneous estimation of lamivudine and stavudine by RP-HPLC>, Electric Literature of 112-63-0, the main research area is lamivudine stavudine reversed phase high performance liquid chromatog.

The proposed method was found to be simple, sensitive, rapid and economical for the determination of Lamivudine and Stavudine in combined tablet formulation. The developed method was checked for the performance characteristics and has also been validated. The method was found to be linear (r>0.999), precise (RSD: 0.41 for Lamivudine, 0.10 for Stavudine) and accuracy (mean percentage recovery fields 98.7% for Lamivudine, 99.1% for Stavudine). The proposed HPLC method was simple, precise because of commonly used buffer and shorter run time. The mean percentage recovery above 95% indicates the reproducibility and accuracy of new developed method compared. The result of study include the proposed method is highly accurate, simple, precise and specific. The sample recoveries in all formulations were in good agreement with their resp. label claims and they suggest non-interference of formulation excipients in the estimation After validating proposed method as per ICH guidelines and correlating obtained values with the standard values, satisfactory results were obtained. Hence the method can easily and conveniently adopted for the estimation of combined dosage form of Lamivudine and Stavudine.

International Journal of Science and Research Methodology published new progress about Agrochemical tablets. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Danta, Chhanda Charan published the artcile< CNS Penetration Ability: A Critical Factor for Drugs in the Treatment of SARS-CoV-2 Brain Infection>, Category: esters-buliding-blocks, the main research area is drug treatment SARS CoV 2; CNS infection; CNS penetration; COVID19; SARS-CoV-2; drug treatment; log P.

Now, it has been evidenced that Covid19 (SARS-CoV-2) infects the brain tissues. Along with this, a challenge has been raised for research professionals to find effective drugs for its treatment since the recent spread of this virus from Wuhan, China. Targeting the treatment of brain infection, it has also been a challenge that the clin. drug should have good CNS penetration ability to cross the blood-brain barrier.

ACS Chemical Neuroscience published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics