Category: 112-63-0

Mphahlele, Malose J.; Moekwa, Thwanthwadi B. published the artcile< Iodo- and bromo-enolcyclization of 2-(2-propenyl)cyclohexanediones and 2-(2-propenyl)cyclohexenone derivatives using iodine in methanol and pyridinium hydrobromide perbromide in dichloromethane>, Related Products of 112-63-0, the main research area is iodo bromo enolcyclization propenylcyclohexanedione propenylcyclohexenone; iodomethyltetrahydrobenzofuranone preparation aromatization; tetrahydrobenzofuranone iodomethyl preparation aromatization; tetrahydrobenzopyranone bromomethyl preparation aromatization.

α-Allylcyclohexane-1,3-diones undergo one-pot iodine-methanol promoted iodocyclization and oxidative aromatization to afford variously substituted 2-iodomethyltetrahydrobenzofuran-4-ones (minor) and 2-iodomethyl-4-methoxydihydrobenzofuran derivatives (major). On the other hand, the α-allyl-1,3-cyclohexanediones react with pyridinium hydrobromide perbromide in dichloromethane to afford mixtures of 2-bromomethyltetrahydrobenzofuran-4-ones (major) and 3-bromomethyltetrahydrobenzopyran-5-ones (minor). The prepared products and their derivatives were characterized using a combination of NMR, FT-IR and mass spectroscopic techniques.

Organic & Biomolecular Chemistry published new progress about Aromatization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Xiao-Chen; Tremblay, Pier-Luc; Xue, Miao; Song, Xinyi; Zhang, Tian published the artcile< Fumarate disproportionation by Geobacter sulfurreducens and its involvement in biocorrosion and interspecies electron transfer>, SDS of cas: 112-63-0, the main research area is Geobacter fumarate disproportionation biocorrosion electron transfer; Biocorrosion; C4-dicarboxylate; Geobacter; Interspecies electron transfer; Metabolic disproportionation; iron-rich sediment.

The model electroactive bacterium Geobacter sulfurreducens can acquire electrons directly from solid donors including metals and other species. Reports on this physiol. concluding that solid donors are the only electron sources were conducted with fumarate believed to serve exclusively as the terminal electron acceptor (TEA). Here, G. sulfurreducens was repeatedly transferred for adaptation within a growth medium containing only fumarate and no other solid or soluble substrate. The resulting evolved strain grew efficiently with either the C4-dicarboxylate fumarate or malate acting simultaneously as electron donor, carbon source, and electron acceptor via disproportionation. Whole-genome sequencing identified 38 mutations including one in the regulator PilR known to repress the expression of the C4-dicarboxylate antiporter DcuB essential to G. sulfurreducens when growing with fumarate. Futhermore, the PilR mutation was identical to the sole mutation previously reported in an evolved G. sulfurreducens grown in a co-culture assumed to derive energy solely from direct interspecies electron transfer, but cultivated with fumarate as the TEA. When cultivating the fumarate-adapted strain in the presence of stainless steel and fumarate, biocorrosion was observed and bacterial growth was accelerated 2.3 times. These results suggest that G. sulfurreducens can conserve energy concomitantly from C4-dicarboxylate disproportionation and the oxidation of a solid electron donor. This co-metabolic capacity confers an advantage to Geobacter for survival and colonization and explains in part why these microbes are omnipresent in different anaerobic ecosystems.

Science of the Total Environment published new progress about Biocorrosion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rai, Vishal; Mobin, Shaikh M.; Namboothiri, Irishi N. N. published the artcile< Cinchonine catalyzed diastereo- and enantioselective Michael addition of α-lithiated phosphonates to nitroalkenes>, Quality Control of 112-63-0, the main research area is cinchonine catalyst stereoselective Michael addition phosphonate lithiated nitroalkene; phosphonate stereoselective preparation; crystal mol structure phosphonate chlorophenylnitrophenylpropyl preparation.

Conjugate addition of α-lithiated benzyl- and alkylphosphonates to a variety of aromatic and heteroaromatic nitroalkenes in the presence of 50 mol % of cinchonine-Li catalyst system proceeded in high yields, diastereo- and enantioselectivities in most cases.

Tetrahedron: Asymmetry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent) (nitroalkenes). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brittain, Harry G. published the artcile< Optical activity in mixed-ligand terbium(III) complexes containing pyridine-2,6-dicarboxylic acid and chiral hydroxycarboxylic acids>, HPLC of Formula: 112-63-0, the main research area is optical activity terbium chiral hydroxycarboxylic.

The optical activity associated with the f-f emission bands of Tb(III) complexes which contain chiral hydroxycarboxylic acids was studied by means of circularly polarized luminescence (CPL) spectroscopy. Complexes having the general formulas Tb(DPA)(L) and Tb(DPA)2(L) were studied (where DPA signifies pyridine-2,6-dicarboxylate), with the chiral L ligand being L-lactic acid, L-α-hydroxyisocaproic acid, L-argininic acid, L-mandelic acid, L-phenyllactic acid, L-malic acid, L-hydroxyglutaric acid, and D-isocitric acid. The CPL spectra were sensitive to the mode of bonding existing between the metal and the chiral ligand and therefore enabled predictions to be made regarding how the hydroxycarboxylic acid ligands attach to the Tb(III) ion. In addition, the degree of optical activity varied systematically with the concentration of chiral ligand, and this dependence was used to calculate formation constants for the addition of a hydroxycarboxylic acid ligand to the Tb/DPA complexes. Finally, the line shapes and magnitudes of the CPL spectra provide information regarding the type of chirality experienced by the Tb(III) ion.

Inorganic Chemistry published new progress about Circularly polarized luminescence. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Wenying; Lin, Yanjun; Kong, Xianggui; Zhang, Shitong; Jia, Yankun; Wei, Min; Evans, David G.; Duan, Xue published the artcile< Fabrication of pyrenetetrasulfonate/layered double hydroxide ultrathin films and their application in fluorescence chemosensors>, Application of C19H34O2, the main research area is fabrication pyrenetetrasulfonate layered hydroxide ultrathin film fluorescence chemosensor.

This paper reports the fabrication of fluorescence indicator/layered double hydroxide (LDH) ultrathin films (UTFs) by alternate assembly of 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt (PTS) and Zn-Al LDH nanosheets on quartz substrates using the layer-by-layer (LBL) deposition technique, and demonstrates their application as a fluorescence chemosensor for Cu2+. UV-visible absorption spectroscopy indicates a stepwise and regular growth of the PTS/LDH UTFs upon increasing deposition cycles. X-ray diffraction, at. force microscopy and SEM demonstrate that the UTFs possess a periodical layered structure perpendicular to the substrates with a thickness of 1.93-1.98 nm per bilayer. Also, the fluorescence chemosensor with film thickness of 48 nm (24 bilayers) exhibits a broad linear response range for Cu2+ solution (0.6-50 μM), good repeatability (relative standard deviation <5% in 20 consecutive measurements), high photostability and storage stability (∼93.2% of its initial fluorescence intensity remains after one month) as well as excellent selectivity. The study on mechanism of measurement-regeneration cycle of the fluorescence chemosensor shows that Cu2+ enters/departs from the PTS/LDH UTF with reversible change in chem. composition, surface morphol. and fluorescence anisotropy. Therefore, this work provides new opportunities for fabrication and application of chromophore/LDH UTFs which can be used as fluorescence chemosensors. Journal of Materials Chemistry published new progress about Fluorescence quenching. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. published the artcile< Pyrazolo-[1,5-a]-1,3,5-triazine corticotropin-releasing factor (CRF) receptor ligands>, HPLC of Formula: 112-63-0, the main research area is pyrazolotriazine preparation corticotropin releasing factor receptor ligand.

The syntheses and rat CRF receptor binding affinities of retro-pyrazolotriazine’ corticotropin-releasing factor (CRF) ligands are reported. Some have high affinity for rat CRF receptors (Ki≤10 nM). The data provide addnl. support for the hypothesis that it is possible to interchange isosteric cores with similar electronic properties in the design of high-affinity CRF receptor ligands, provided the peripheral pharmacophore elements are maintained in the same three-dimensional array.

Bioorganic & Medicinal Chemistry published new progress about Corticotropin releasing factor receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Santhana Kumar, V.; Das Sarkar, Soma; Das, Basanta Kumar; Sarkar, Dhruba Jyoti; Gogoi, Pranab; Maurye, Praveen; Mitra, Tandrima; Talukder, Anjon Kumar; Ganguly, Satabdi; Nag, Subir Kumar; Munilkumar, Sukham; Samanta, Srikanta published the artcile< Sustainable biodiesel production from microalgae Graesiella emersonii through valorization of garden wastes-based vermicompost>, Related Products of 112-63-0, the main research area is biodiesel Graesiella valorization garden waste vermicompost; Biodiesel; Culture media; Graesiella sp.; Microalgae; Vermicompost extract; Waste management.

Biodiesel production from microalgae has gained significant interest recently due to the growing energy demand and non-renewable nature of petroleum. However, high cost of production and environmental health related issues like excess use of inorganic fertilizers, eutrophication are the major constraints in com.-scale biodiesel production Besides this, solid wastes (garden-based) management is also a global concern. In the present study, to overcome these limitations vermicompost extract was tested as nutrient source to enhance growth performance and lipid production from a freshwater microalga (Graesiella emersonii MN877773). Garden wastes were first converted into vermicompost manure and its extract (aerobic and anaerobically digested) was prepared The efficacy of the extract was then tested in combination with BG11 medium. The mixotrophic cultivation of microalgae in anaerobically digested vermicompost extract at 50:50 combination with BG11 medium enhanced the cell biomass (0.64 g d. weight L-1) and lipid productivity (3.18 mg L-1 day-1) of microalgae by two times. Moreover, the combination also improved the saturated (Me palmitate) and monounsaturated fatty acids (oleic acid) content in the test algae. The quality of biodiesel also complies with all the properties of biodiesel standard provided by India, the USA, and Europe except the cold filter plugging property. The combination was also found to improve the cell biomass (0.041 g L-1) as compared to BG11 medium in mass-scale cultivation. Hence, the study proved that G. emersonii grown in media supplemented with garden waste-based vermicompost extract had significant potential for mass-scale biodiesel and bioproduct production

Science of the Total Environment published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lombardi, Francesca; Augello, Francesca Rosaria; Artone, Serena; Gugu, Mitilda Karoli; Cifone, Maria Grazia; Cinque, Benedetta; Palumbo, Paola published the artcile< Up-Regulation of Cyclooxygenase-2 (COX-2) Expression by Temozolomide (TMZ) in Human Glioblastoma (GBM) Cell Lines>, Related Products of 112-63-0, the main research area is cyclooxygenase upregulation expression temozolomide human glioblastoma; COX-2; COX-2 inhibitor; MGMT; NS398; SOX-2; T98G; U251MG; glioblastoma; temozolomide; β-catenin.

TMZ-resistance remains a main limitation in glioblastoma (GBM) treatment. TMZ is an alkylating agent whose cytotoxicity is modulated by O6-methylguanine-DNA methyltransferase (MGMT), whose expression is determined by MGMT gene promoter methylation status. The inflammatory marker COX-2 has been implicated in GBM tumorigenesis, progression, and stemness. COX-2 inhibitors are considered a GBM add-on treatment due to their ability to increase TMZ-sensitivity. We investigated the effect of TMZ on COX-2 expression in GBM cell lines showing different COX-2 levels and TMZ sensitivity (T98G and U251MG). β-catenin, MGMT, and SOX-2 expression was analyzed. The effects of NS398, COX-2 inhibitor, alone or TMZ-combined, were studied evaluating cell proliferation by the IncuCyte system, cell cycle/apoptosis, and clonogenic potential. COX-2, β-catenin, MGMT, and SOX-2 expression was evaluated by RT-PCR, Western blotting, and immunofluorescence and PGE2 by ELISA. Our findings, sustaining the role of COX-2/PGE2 system in TMZ-resistance of GBM, show, for the first time, a relevant, dose-dependent up-regulation of COX-2 expression and activity in TMZ-treated T98G that, in turn, correlated with chemoresistance. Similarly, all the COX-2-dependent signaling pathways involved in TMZ-resistance also resulted in being up-modulated after treatment with TMZ. NS398+TMZ was able to reduce cell proliferation and induce cell cycle arrest and apoptosis. Moreover, NS398+TMZ counteracted the resistance in T98G preventing the TMZ-induced COX-2, β-catenin, MGMT, and SOX-2 up-regulation.

International Journal of Molecular Sciences published new progress about Antitumor agent resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luecking, Ulrich; Scholz, Arne; Lienau, Philip; Siemeister, Gerhard; Kosemund, Dirk; Bohlmann, Rolf; Briem, Hans; Terebesi, Ildiko; Meyer, Kirstin; Prelle, Katja; Denner, Karsten; Boemer, Ulf; Schaefer, Martina; Eis, Knut; Valencia, Ray; Ince, Stuart; von Nussbaum, Franz; Mumberg, Dominik; Ziegelbauer, Karl; Klebl, Bert; Choidas, Axel; Nussbaumer, Peter; Baumann, Matthias; Schultz-Fademrecht, Carsten; Ruehter, Gerd; Eickhoff, Jan; Brands, Michael published the artcile< Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer>, Related Products of 112-63-0, the main research area is atuveciclib BAY1143572 preparation PTEFb CDK9 inhibitor antitumor; CDK; PTEFb; antitumor agents; drug design; sulfoximines.

Selective inhibition of exclusively transcription-regulating PTEFb/CDK9 is a promising new approach in cancer therapy. Starting from lead compound BAY-958, lead optimization efforts strictly focusing on kinase selectivity, physicochem. and DMPK properties finally led to the identification of the orally available clin. candidate atuveciclib (BAY 1143572). Structurally characterized by an unusual benzyl sulfoximine group, BAY 1143572 exhibited the best overall profile in vitro and in vivo, including high efficacy and good tolerability in xenograft models in mice and rats. BAY 1143572 is the first potent and highly selective PTEFb/CDK9 inhibitor to enter clin. trials for the treatment of cancer.

ChemMedChem published new progress about Acute myeloid leukemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Isilar, Ozer; Bulut, Adnan; Sahin Yaglioglu, Ayse; Demirtas, Ibrahim; Arat, Esra; Turk, Mustafa published the artcile< Synthesis and biological evaluation of novel urea, thiourea and squaramide diastereomers possessing sugar backbone>, Reference of 112-63-0, the main research area is antiproliferative antitumor aminoglycoside disaccharide preparation; aminoglycoside disaccharide preparation urea thiourea squaramide human; Antiproliferative activity; Cytotoxicity; Squaramide; Sugar; Thiourea; Urea.

A series of novel chiral 14 urea, thiourea and squaramide stereoisomers possessing carbohydrate backbones as well as amide functional groups was synthesized and characterized by their, 1H NMR, 13C NMR, FT-IR, HRMS, optical rotation, and m.ps. Their antiproliferative activities were investigated against HeLa and PC3 cell lines. Aminoglycosides I (X = S, O) showed better activities at 25μM against PC3 cell line with respect to the standard 5-fluorouracil (5-FU). Especially, the compounds 9 and 11 showed higher activities than the standard 5-FU even at low concentration (5μM) against HeLa cell line. IC50 results also confirm these activities. The compounds I (X = S, O) have the IC50 values of 1.10μM and 1.02μM, resp. while 5-FU has 2.51μM.

Carbohydrate Research published new progress about Aminoglycosides Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics