Category: 112-63-0

Kim, Young Sook; Yuk, Heung Joo; Kim, Dong Seon published the artcile< Effect of Jakyakgamcho-tang extracts on H2O2-induced C2C12 myoblasts>, Electric Literature of 112-63-0, the main research area is Jakyakgamcho tang extract hydrogen peroxide myoblast death; C2C12 cell; Jakyakgamcho-tang; antioxidant; muscle atrophy; oxidative stress.

Oxidative stress is a major contributor to muscle aging and loss of muscle tissue. Jakyakgamcho-tang (JGT) has been used in traditional Eastern medicine to treat muscle pain. Here, we compared the total phenolic and flavonoid contents in 30% ethanol and water extracts of JGT and tested the preventive effects against oxidative stress (hydrogen peroxide)-induced cell death in murine C2C12 skeletal muscle cells. The total phenolic content and total flavonoid content in 30% ethanol extracts of JGT were higher than those of water extracts of JGT. Ethanol extracts of JGT (JGT-E) had stronger antioxidant activities of 2,2”-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 2,2”-diphenyl-1-picrylhydrazyl-scavenging activity (DPPH) than water extracts of JGT (JGT-W). JGT-E contained 19-53% (1.8 to 4.9-fold) more active compounds (i.e., albiflorin, liquiritin, pentagalloylglucose, isoliquiritin apioside, isoliquiritin, liquiritigenin, and glycyrrhizin) than JGT-W. The ethanol extracts of JGT inhibited hydrogen peroxide-induced cell death and intracellular reactive oxygen species generation more effectively than the water extract of JGT in a dose-dependent manner. For the first time, these results suggest that ethanol extract of JGT is relatively more efficacious at protecting against oxidative stress-induced muscle cell death.

Molecules published new progress about Aging, animal. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kandoi, Deepika; Ruhil, Kamal; Govindjee, Govindjee; Tripathy, Baishnab C. published the artcile< Overexpression of cytoplasmic C4 Flaveria bidentis carbonic anhydrase in C3 Arabidopsis thaliana increases amino acids, photosynthetic potential, and biomass>, Formula: C19H34O2, the main research area is cytoplasmic Flaveria bidentis Arabidopsis thaliana amino acid photosynthesis biomass; Arabidopsis thaliana ; C3 photosynthesis; C4 photosynthesis; CO2 assimilation; Photosystem I; Photosystem II; carbonic anhydrase; water-use efficiency.

An important method to improve photosynthesis in C3 crops, such as rice and wheat, is to transfer efficient C4 characters to them. Here, cytosolic carbonic anhydrase (CA: βCA3) of the C4 Flaveria bidentis (Fb) was overexpressed under the control of 35S promoter in Arabidopsis thaliana, a C3 plant, to enhance its photosynthetic efficiency. Overexpression of CA resulted in a better supply of the substrate HCO3- for the endogenous phosphoenolpyruvate carboxylase in the cytosol of the overexpressers, and increased its activity for generating malate that feeds into the tricarboxylic acid cycle. This provided addnl. carbon skeleton for increased synthesis of amino acids aspartate, asparagine, glutamate, and glutamine. Increased amino acids contributed to higher protein content in the transgenics. Furthermore, expression of FbβCA3 in Arabidopsis led to a better growth due to expression of several genes leading to higher chlorophyll content, electron transport, and photosynthetic carbon assimilation in the transformants. Enhanced CO2 assimilation resulted in increased sugar and starch content, and plant dry weight In addition, transgenic plants had lower stomatal conductance, reduced transpiration rate, and higher water-use efficiency. These results, taken together, show that expression of C4CA in the cytosol of a C3 plant can indeed improve its photosynthetic capacity with enhanced water-use efficiency.

Plant Biotechnology Journal published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Joshi, K. B.; Vijaya Krishna, K.; Verma, Sandeep published the artcile< Self-Assembled Morphologies from C2- and C3-Symmetric Biotin Conjugates>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is biotin conjugate preparation self assembly.

Synthesis and characterization of C2- and C3-sym. D-biotin conjugates has been realized, followed by the investigation of solution state self-assembly behavior of these conjugates by various microscopy techniques. Interestingly, the C2-sym. conjugate affords the formation of fibrous structures, while the C3-sym. conjugate reveals the formation of marigold flower-like spherical morphologies.

Journal of Organic Chemistry published new progress about Self-assembly. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feldheim, Jonas; Kessler, Almuth F.; Feldheim, Julia J.; Schulz, Ellina; Wend, David; Lazaridis, Lazaros; Kleinschnitz, Christoph; Glas, Martin; Ernestus, Ralf-Ingo; Brandner, Sebastian; Monoranu, Camelia M.; Loehr, Mario; Hagemann, Carsten published the artcile< Effects of Long-Term Temozolomide Treatment on Glioblastoma and Astrocytoma WHO Grade 4 Stem-like Cells>, COA of Formula: C19H34O2, the main research area is glioblastoma temozolomide isocitrate dehydrogenase astrocytoma MGMT stem cell; IDH; MGMT; astrocytoma; cancer stem cells; glioblastoma; temozolomide; therapy.

Glioblastoma leads to a fatal course within two years in more than two thirds of patients. An essential cornerstone of therapy is chemotherapy with temozolomide (TMZ). The effect of TMZ is counteracted by the cellular repair enzyme O6-methylguanine-DNA methyltransferase (MGMT). The MGMT promoter methylation, the main regulator of MGMT expression, can change from primary tumor to recurrence, and TMZ may play a significant role in this process. To identify the potential mechanisms involved, three primary stem-like cell lines (one astrocytoma with the mutation of the isocitrate dehydrogenase (IDH), CNS WHO grade 4 (HGA)), and two glioblastoma (IDH-wildtype, CNS WHO grade 4) were treated with TMZ. The MGMT promoter methylation, migration, proliferation, and TMZ-response of the tumor cells were examined at different time points. The strong effects of TMZ treatment on the MGMT methylated cells were observed Furthermore, TMZ led to a loss of the MGMT promoter hypermethylation and induced migratory rather than proliferative behavior. Cells with the unmethylated MGMT promoter showed more aggressive behavior after treatment, while HGA cells reacted heterogenously. Our study provides further evidence to consider the potential adverse effects of TMZ chemotherapy and a rationale for investigating potential relationships between TMZ treatment and change in the MGMT promoter methylation during relapse.

International Journal of Molecular Sciences published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (IDH). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tajuddin, Hazmi; Harrisson, Peter; Bitterlich, Bianca; Collings, Jonathan C.; Sim, Neil; Batsanov, Andrei S.; Cheung, Man Sing; Kawamorita, Soichiro; Maxwell, Aoife C.; Shukla, Lena; Morris, James; Lin, Zhenyang; Marder, Todd B.; Steel, Patrick G. published the artcile< Iridium-catalyzed C-H borylation of quinolines and unsymmetrical 1,2-disubstituted benzenes: insights into steric and electronic effects on selectivity>, COA of Formula: C19H34O2, the main research area is quinoline derivative borylation iridium catalyst regiochem steric electronic effect; mol structure borylated quinoline preparation.

Borylation of quinolines provides an attractive method for the late-stage functionalization of this important heterocycle. The regiochem. of this reaction is dominated by sterptsic factors but, by undertaking reactions at room temperature, an underlying electronic selectivity becomes apparent, as exemplified by the comparative reactions of 7-halo-2-methylquinoline and 2,7-dimethylquinoline which afford variable amounts of the 5- and 4-borylated products. Similar electronic selectivities are observed for nonsym. 1,2-disubstituted benzenes. The site of borylation can be simply estimated by anal. of the 1H NMR spectrum of the starting material with preferential borylation occurring at the site of the most deshielded sterically accessible H or C atom. Such effects can be linked with C-H acidity. While DFT calculations of the pKa for the C-H bond show good correlation with the observed selectivity, small differences suggest that related alternative, but much more computationally demanding values, such as the M-C bond strength, may be better quant. predictors of selectivity.

Chemical Science published new progress about Acidity (calculated pKa). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dutta, Arghya; Ito, Kimihiko; Kubo, Yoshimi published the artcile< Nanoconfined growth of lithium-peroxide inside electrode pores: a noncatalytic strategy toward mitigating capacity-rechargeability trade-off in lithium-air batteries>, Category: esters-buliding-blocks, the main research area is lithium peroxide air battery electrode pore echargeability.

Capacity-rechargeability trade-off in lithium-air batteries remains as one of the major challenges before their practical realization. As the discharge capacity increases, an uncontrolled growth of lithium-peroxide leads to passivation of the conductive electrode by a thick insulating layer that limits charge transport and results in a high overpotential during recharge. In contrast, deposition of lithium-peroxide inside a spatially confined electrode-space can restrict the growth and improve the rechargeability of the cell. The small crystallite size of spatially confined lithium-peroxide inside a porous framework is expected to show higher charge-transport that should play a crucial role in its facile decomposition Here, a prototypical approach shows how a controlled increase in pore diameter, pore volume and electrochem. active surface area of a mesoporous carbon produces much higher discharge capacity by improving mass diffusion inside the mesoporous channels, yet simultaneously achieves an efficient rechargeability due to pore-confinement of lithium-peroxide.

Materials Advances published new progress about Anisotropy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lv, Tingting; Zhang, Zirui; Yu, Haoying; Ren, Shuyue; Wang, Jingrong; Li, Shang; Sun, Lan published the artcile< Tamoxifen Exerts Anticancer Effects on Pituitary Adenoma Progression via Inducing Cell Apoptosis and Inhibiting Cell Migration>, Related Products of 112-63-0, the main research area is pituitary adenoma progression cell apoptosis migration tamoxifen anticancer effect; apoptosis; genomics; migration; pituitary adenomas; tamoxifen; tumor-associated macrophages.

Although pituitary adenomas are histol. benign, they are often accompanied by multiple complications, such as cardiovascular disease and metabolic dysfunction. In the present study, we repositioned the Food and Drug Administration -approved immune regulator tamoxifen to target STAT6 based on the genomics anal. of PAs. Tamoxifen inhibited the proliferation of GH3 and AtT-20 cells with resp. IC50 values of 9.15 and 7.52μM and increased their apoptotic rates in a dose-dependent manner. At the mol. level, tamoxifen downregulated phosphorylated PI3K, phosphorylated AKT and the anti-apoptotic protein Bcl-2 and increased the expression of pro-apoptotic proteins p53 and Bax in GH3 and AtT-20 cells. Furthermore, tamoxifen also inhibited the migration of both cell lines by reprogramming tumor-associated macrophages to the M1 phenotype through STAT6 inactivation and inhibition of the macrophage-specific immune checkpoint SHP1/SHP. Finally, administration of tamoxifen (20, 50, 100 mg.g-1.;d-1, for 21 days) inhibited the growth of pituitary adenomas xenografts in nude mice in a dose-dependent manner. Taken together, tamoxifen is likely to be a promising combination therapy for pituitary adenomas and should be investigated further.

International Journal of Molecular Sciences published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lohse, Jonas; Swier, Lotteke J. Y. M.; Oudshoorn, Ruben C.; Medard, Guillaume; Kuster, Bernhard; Slotboom, Dirk-Jan; Witte, Martin D. published the artcile< Targeted Diazotransfer Reagents Enable Selective Modification of Proteins with Azides>, Category: esters-buliding-blocks, the main research area is diazotransfer reagent protein azide label.

In chem. biol., azides are used to chem. manipulate target structures in a bioorthogonal manner for a plethora of applications ranging from target identification to the synthesis of homogeneously modified protein conjugates. While a variety of methods have been established to introduce the azido group into recombinant proteins, a method that directly converts specific amino groups in endogenous proteins is lacking. Here, the authors report the first biotin-tethered diazotransfer reagent DtBio and demonstrate that it selectively modifies the model proteins streptavidin and avidin and the membrane protein BioY on cell surface. The reagent converts amines in the proximity of the binding pocket to azides and leaves the remaining amino groups in streptavidin untouched. Reagents of this novel class will find use in target identification as well as the selective functionalization and bioorthogonal protection of proteins.

Bioconjugate Chemistry published new progress about Avidins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Anli; Gong, Yingjie; Pei, Zhixin; Jiang, Ling; Xia, Lingling; Wu, Yonggui published the artcile< Paeoniflorin ameliorates diabetic liver injury by targeting the TXNIP-mediated NLRP3 inflammasome in db/db mice>, Product Details of C19H34O2, the main research area is paeoniflorin NLRP TXNIP diabetic liver injury inflammasome steatosis inflammation; Diabetic liver injury; Inflammation; Paeoniflorin; T2DM; TXNIP/NLRP3.

Diabetic liver injury (DLI) is a complication that damages the quality of life in diabetes patients. While paeoniflorin (PF) exhibits anti-inflammatory and antioxidant effects, no data are available on whether PF protects against DLI. Therefore, we evaluated the effects of PF on hepatic steatosis and inflammation in db/db mice, a type 2 diabetes model. In this study, we investigated the effects of PF on DLI using diabetic mice model (db/db mice) and high glucose (HG)-induced mouse AML12 cells. The effects of PF on TXNIP-mediated NLRP3 inflammasome in vivo and in vitro were evaluated by Western bloting, RT-PCR, immunohistochem. (IHC) and immunofluorescence (IF) anal. Through mol. docking experiments and cellular thermal shift assay (CETSA), we studied the binding ability of PF to thioredoxin-interacting protein (TXNIP). We use TXNIP siRNA to knock down TXNIP in AML12 cells. We found that PF reversed abnormal liver function and liver steatosis in db/db mice, while blocking the release of inflammatory cytokines. These effects are associated with PF inhibition of the TXNIP/NLRP3 signaling pathway. Mol. docking experiments and CETSA also demonstrated that TXNIP is a likely target of PF. In HG-treated AML12 cells, TXNIP knockdown eliminated the beneficial effects of PF. Using a combination of animal and in vitro experiments, this study demonstrated for the first time that PF ameliorates DLI through targeting the TXNIP-activated NLRP3 inflammasome. Thus, PF may be a potential therapeutic agent against DLI.

International Immunopharmacology published new progress about Adhesion G protein-coupled receptor E1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Prestes, Alessandro de Souza; dos Santos, Matheus Mulling; Kamdem, Jean Paul; Mancini, Gianni; Schuler da Silva, Luana Caroline; de Bem, Andreza Fabro; Barbosa, Nilda Vargas published the artcile< Methylglyoxal disrupts the functionality of rat liver mitochondria>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is liver mitochondria superoxide phosphorylation bioenergetics methylglyoxal; High-resolution respirometry; Methylglyoxal; Mitochondria; Oxidative stress.

Methylglyoxal (MG) is a reactive metabolite derived from different physiol. pathways. Its production can be harmful to cells via glycation reactions of lipids, DNA, and proteins. But, the effects of MG on mitochondrial functioning and bioenergetic responses are still elusive. Then, the effects of MG on key parameters of mitochondrial functionality were examined here. Isolated rat liver mitochondria were exposed to 0.1-10 mM of MG to determine its toxicity in the mitochondrial viability, membrane potential (Δψm), swelling and the superoxide (O·-2) production Besides, mitochondrial oxidative phosphorylation parameters were analyzed by high-resolution respiratory (HRR) assay. In this set of experiments, routine state, PM state (pyruvate/malate), oxidative phosphorylation (OXPHOS), LEAK respiration, electron transport system (ETS) and oxygen residual (ROX) states were evaluated. HRR showed that PM state, OXPHOS CI-Linked, LEAK respiration, ETS CI/CII-Linked and ETS CII-Linked/ROX were significantly inhibited by MG exposure. MG also inhibited the complex II activity, and decreased Δψm and the viability of mitochondria. Taken together, our data indicates that MG is an inductor of mitochondrial dysfunctions and impairs important steps of respiratory chain, effects that can alter bioenergetics responses.

Chemico-Biological Interactions published new progress about Cell viability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics