Category: 112-63-0

Furukawa, Takayuki; Tobisu, Mamoru; Chatani, Naoto published the artcile< C-H Functionalization at Sterically Congested Positions by the Platinum-Catalyzed Borylation of Arenes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is platinum carbene complex preparation catalyst borylation arene heteroarene; phenylboronic ester preparation.

Despite significant progress in the area of C-H bond functionalization of arenes, no general method is reported for the functionalization of C-H bonds at the sterically encumbered positions of simple arenes, such as mesitylene. Herein, the authors report the development of the 1st Pt-based catalyst for C-H borylation of arenes and heteroarenes. Notably, this method exhibited high tolerance toward steric hindrance and provided rapid access to 2,6-disubstituted phenylboronic esters, valuable building blocks for further elaborations.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Belanger, Katherine; Ung, Timothy H.; Damek, Denise; Lillehei, Kevin O.; Ormond, D. Ryan published the artcile< Concomitant Temozolomide plus radiotherapy for high-grade and recurrent meningioma: a retrospective chart review>, HPLC of Formula: 112-63-0, the main research area is temozolomide radiotherapy anticancer recurrent meningioma; Chemotherapy; Local Recurrence; Meningioma; Radiation Therapy; Temozolomide.

High-grade and recurrent meningiomas are often treatment resistant and pose a therapeutic challenge after surgical and radiation therapy (RT) failure. Temozolomide (TMZ) is a DNA alkylating agent that appears to have a radiosensitizing effect when used in combination with RT and may be worthwhile in meningioma treatment. Thus, we investigated the potential efficacy of concomitant RT plus TMZ compared to historical controls of just RT used in the treatment of high-grade and recurrent meningiomas. We performed a retrospective anal. of patients with meningioma treated at the University of Colorado with TMZ chemoradiation. Progression free survival (PFS) and overall survival (OS) were calculated from the start of chemoradiation to local recurrence or death, resp. Eleven patients (12 tumors) were treated with chemoradiation with a median follow-up of 41.5 mo. There were two WHO grade 1, eight grade 2 and two grade 3 meningiomas. Three patients died during the follow-up period-one being disease related (11.1%). Two patients had meningioma recurrence-at 2.3 mo (WHO grade 3), and 5.4 years (WHO grade 2). Three-year OS and PFS for grade 2 meningiomas were each 88%. Historical controls demonstrate a 3-yr median OS and PFS of 83% and 75.8%, resp. Treatment options are limited for meningiomas after local failure. In this study, TMZ chemoradiation demonstrated no significant difference in PFS and OS in the treatment of grade 2 meningiomas compared to historic controls. Further study is warranted to find novel methods for the treatment of malignant and recurrent meningiomas.

BMC Cancer published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Daisy Precilla, S.; Kuduvalli, Shreyas S.; Angeline Praveena, E.; Thangavel, Saravanabhavan; Anitha, T. S. published the artcile< Integration of synthetic and natural derivatives revives the therapeutic potential of temozolomide against glioma- an in vitro and in vivo perspective>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioma therapeutic temozolomide chloroquine naringenin phloroglucinol antitumor apoptosis BCL2; Apoptosis; Chloroquine; Glioblastoma; Naringenin; Repurposing drugs; Temozolomide.

Malignant gliomas constitute one of the deadly brain tumors with high degeneration rate. Though temozolomide (TMZ) is the first-line drug for glioma, its efficacy has decreased due to chemo-resistance. Repurposing synthetic and natural compounds have gained increasing interest in glioma. Hence, we combined chloroquine (CHL) a synthetic drug, naringenin (NAR) and phloroglucinol (PGL) (natural derivatives), to investigate whether the apoptotic effect of these drugs both alone and in combination, enhances the anti-tumor effects of TMZ in an in vitro and in vivo orthotopic xenograft glioma model. The cytotoxic effect of the drugs was assessed in C6 (murine) glioma cells, U-87 MG and LN229 (human) glioblastoma cells, primary astrocytes (isolated from rat brain tissues) and HEK-293 T cells. Mitochondrial depolarization and alterations in the cell cycle was determined by confocal imaging and flow cytometry. The expression of angiogenic and apoptotic markers was evaluated using qRT-PCR and ELISA. The efficacy of the combinatorial treatment was assessed in an orthotopic xenograft model using U-87 MG cells. The combinatorial treatment inhibited cell proliferation, induced apoptosis and contributed to cell cycle arrest in glioma cells. The quadruple combinatorial cocktail down-regulated BCL-2 with a concomitant decrease in VEGF. As observed in vitro, the quadruple combinatorial treatment enhanced the median survival of glioma-induced rats with lower cellularity rate. The combination of CHL, NAR and PGL synergistically potentiated the efficacy of TMZ on glioma in vitro and in vivo. Hence, this combination may characterize an advanced strategy for glioma treatment, thereby providing a possible translation to clin. trial.

Life Sciences published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Knauer, Nadezhda; Arkhipova, Valeria; Li, Guanzhang; Hewera, Michael; Pashkina, Ekaterina; Nguyen, Phuong-Hien; Meschaninova, Maria; Kozlov, Vladimir; Zhang, Wei; Croner, Roland S.; Caminade, Anne-Marie; Majoral, Jean-Pierre; Apartsin, Evgeny K.; Kahlert, Ulf D. published the artcile< In Vitro Validation of the Therapeutic Potential of Dendrimer-Based Nanoformulations against Tumor Stem Cells>, Electric Literature of 112-63-0, the main research area is dendrimer nanoformulation tumor stem cell therapeutic target; 3D tumor models; Lyn; dendrimers; nanomedicine; nucleic acid therapeutics; phosphorus; polyelectrolyte complexes; tumor stem cells.

Tumor cells with stem cell properties are considered to play major roles in promoting the development and malignant behavior of aggressive cancers. Therapeutic strategies that efficiently eradicate such tumor stem cells are of highest clin. need. Herein, we performed the validation of the polycationic phosphorus dendrimer-based approach for small interfering RNAs delivery in in vitro stem-like cells as models. As a therapeutic target, we chose Lyn, a member of the Src family kinases as an example of a prominent enzyme class widely discussed as a potent anti-cancer intervention point. Our selection is guided by our discovery that Lyn mRNA expression level in glioma, a class of brain tumors, possesses significant neg. clin. predictive value, promoting its potential as a therapeutic target for future mol.-targeted treatments. We then showed that anti-Lyn siRNA, delivered into Lyn-expressing glioma cell model reduces the cell viability, a fact that was not observed in a cell model that lacks Lyn-expression. Furthermore, we have found that the dendrimer itself influences various parameters of the cells such as the expression of surface markers PD-L1, TIM-3 and CD47, targets for immune recognition and other biol. processes suggested to be regulating glioblastoma cell invasion. Our findings prove the potential of dendrimer-based platforms for therapeutic applications, which might help to eradicate the population of cancer cells with augmented chemotherapy resistance. Moreover, the results further promote our functional stem cell technol. as suitable component in early stage drug development.

International Journal of Molecular Sciences published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tilford, R. William; Gemmill, William R.; zur Loye, Hans-Conrad; Lavigne, John J. published the artcile< Facile Synthesis of a Highly Crystalline, Covalently Linked Porous Boronate Network>, Application of C19H34O2, the main research area is polyboronate ester synthesis dehydration.

A covalent organic framework (COF-18Å) based on poly(boronate ester)s has been successfully synthesized through a facile dehydration process in 85-95% isolated yield. Spectroscopic characterization confirms formation of the intended ester linkages as the key structural motif forming infinite 2D hexagonally porous sheets. Powder x-ray diffraction studies were used to determine the stacking orientation between the ester-linked sheets, such that atoms in adjacent layers lie directly over each other, resulting in a hexagonal array of 1D, 18 Å pores. COF-18Å exhibits rigid, thermally stable (to 500 °C) pores with high surface area (1260 m2/g) and a micropore volume of 0.29 cm3/g.

Chemistry of Materials published new progress about Polyesters Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (polyborate network). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Takeuchi, Toshifumi; Dobashi, Akira; Kimura, Kanako published the artcile< Molecular Imprinting of Biotin Derivatives and Its Application to Competitive Binding Assay Using Nonisotopic Labeled Ligands>, Application of C19H34O2, the main research area is mol imprinting biotin nonisotopic labeled ligand; polymer based competitive binding assay.

Synthetic biotin-binding polymers were prepared by mol. imprinting. Methacrylic acid (MAA) was copolymerized with ethylene glycol dimethacrylate in the presence of biotin Me ester (B-Me) in chloroform. Hydrogen-bonding-based complexation of B-Me with MAA generates the binding sites complementary to B-Me after extracting B-Me from the resulting copolymers. Data from NMR titration suggest a one-to-one prepolymerization complex formation of B-Me with MAA in chloroform. A possible complex structure was estimated by docking of the most stable conformers by intermol. Monte Carlo conformational search under the assumption of a one-to-one association The selectivity of the imprinted polymers was investigated and an imprinted polymer-based competitive binding assay for B-Me was demonstrated using biotin p-nitrophenyl ester as a nonisotopic-labeled ligand.

Analytical Chemistry published new progress about Analysis (polymer-based competitive binding assay). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Soo-Bin; Park, Jin-Sook published the artcile< Parashewanella hymeniacidonis sp. nov., isolated from marine sponge (Hymeniacidon sinapium)>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is marine sponge Hymeniacidon sinapium Parashewanella hymeniacidonis; 16S rRNA gene sequence; Parashewanella hymeniacidonis; polyphasic taxonomy; sponge.

A flagella bacterium, designated strain 202IG2-18T was isolated from a marine sponge Hymeniacidon sinapium from Ulleung-do in the Republic of Korea. Cells were Gram-stain-neg., motile, aerobic, rod-shaped and non-pigmented. The strain was able to grow at pH 5.5-9.5 (optimum, pH 7.5), in the presence of 1-5% (w/v) NaCl (optimum, 3%, w/v) and at 18-30°C (optimum, 30°C). Phylogenetic anal. based on 16S rRNA gene sequences revealed that strain 202IG2-18T belonged to the family Shewanellaceae, and was most closely related to [Shewanella] irciniae NRRL B-41466T (97.9%), followed by Parashewanella tropica KCCM 43304T (97.1%), Parashewanella curva KCTC 62318T (96.3%) and Parashewanella spongiae KCTC 22492T (96.2%). The predominant fatty acids were iso-C15:0 (25.7%), C17:1 ω8c (13.5%), summed feature 3 (C16:1 ω7c and/or C16:1 ω6c, 12.7%), iso-C13:0 (10.4%) and C16:0 (9.6%). The only detected respiratory quinone was ubiquinone Q-8. The major polar lipids were phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol, three unidentified glycolipids, two unidentified aminophospholipids, an unidentified phospholipid and an unidentified aminolipid. The G + C content of the genomic DNA was 39.8 mol%. The average nucleotide identity values compared to all other related species was below 72.8% and digital DNA-DNA hybridization values were 21.1-22.3%, all below the threshold for bacterial species delineation. Phenotypic, phylogenetic, genomic and chemotaxonomic characteristics showed that strain 202IG2-18T represents a novel species of the genus Parashewanella, for which the name Parashewanella hymeniacidonis sp. nov. is proposed. The type strain is 202IG2-18T (= KACC 22256T = LMG 32203T).

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Zhanpeng; Song, Bin; Zhang, Hong; Feng, Fan; Zhang, Wenli; Lu, Ke; Chen, Qianwang published the artcile< High-Capacity and Stable Sodium-Sulfur Battery Enabled by Confined Electrocatalytic Polysulfides Full Conversion>, COA of Formula: C19H34O2, the main research area is sodium sulfur battery electrocatalytic polysulfide full conversion.

The efficient polysulfide capture and reversible sulfur recovery during reverse charging process are critical to exploiting the full potential of room temperature Na-S batteries. Here, based on a core-shell design strategy, the structural and chem. synergistic manipulation of sodium polysulfides quasi-solid-state reversible conversion is proposed. The sulfur is encapsulated in the multi-pores of 3D interconnected carbon fiber as the core structure. The Fe(CN)64–doped polypyrrole film serves as a redox-active polar shell to lock up polysulfides and promote complete polysulfide conversion. Importantly, the short-chain Na2S4 polysulfides are reduced to Na2S directly leaving with a small fraction of soluble intermediates as the cation-transfer medium at the core/shell interface, and freeing up formation of solid Na2S2 incomplete product. Further, the redox mediator with open Fe species electrocatalytically lowers the Na2S oxidation energy barrier and renders the high reversibility of electrodeposited Na2S. The tunable quasi-solid-state reversible sulfur conversion under versatile polymer sheath greatly enhances sulfur utilization, affording a remarkable capacity of 1071 mAh g-1 and a stable high capacity of 700 mAh g-1 at 200 mA g-1 after 200 cycles. The confined electrocatalytic effect provides a strategy for tuning electrochem. pathway of sulfur species and guarantees high-efficiency sulfur electrochem.

Advanced Functional Materials published new progress about Carbon fibers Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kowar, T.; LeGoff, E. published the artcile< New synthesis of cyclobutadienequinones and benzocyclobutadienequinone>, COA of Formula: C19H34O2, the main research area is cyclobutadienequinone; benzocyclobutadienequinone; quinone benzocyclobutadiene.

Dropwise addition of pyridinium perbromide at -78° to I in anhydrous THF gave 27% II treatment of which with 1,5-diazabicyclo[4.3.0]non-5-ene gave 92% III.

Synthesis published new progress about Oxidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Chun-Lin; Ye, Song published the artcile< N-Heterocyclic Carbene-Catalyzed Construction of 1,3,5-Trisubstituted Benzenes from Bromoenals and α-Cyano-β-methylenones>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is heterocyclic carbene catalyst bromoenal cyanomethylenone cyclization; trisubstituted benzene preparation.

A direct and efficient approach to 1,3,5-trisubstituted benzenes has been developed via N-heterocyclic carbene-catalyzed [2 + 4] annulation of α-bromoenals and α-cyano-β-methylenones. The reaction worked well for both aryl- and alkylenones.

Organic Letters published new progress about Benzenoid aromatic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics