Category: 112-63-0

Rajappan, Sinu C.; Davis, Brad J.; Dishner, Isaiah T.; Thornell, Travis L.; Peyrefitte, John J.; Simon, Yoan C. published the artcile< Reversible hetero-Diels-Alder amine hardener as drop-in replacement for healable epoxy coatings>, Reference of 112-63-0, the main research area is reversible hetero Diels Alder amine hardener healable epoxy coating.

We describe a new amine-hardener that enables intrinsic thermally activated healing in epoxy-amine coatings. A hetero-Diels Alder (HDA) adduct bridges biosourced fatty acids and serves as the thermoreversible linker. We validated the thermal reversion of the adduct in solution and the HDA-containing diamine served as a drop-in replacement for com. hardeners.

Polymer Chemistry published new progress about Castor oil Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Liang; Gu, Xiaorong; Hong, Li; Laird, James; Jaffe, Keeve; Choi, Jaewoo; Crabb, John; Salomon, Robert G. published the artcile< Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: mediators of age-related macular degeneration>, Synthetic Route of 112-63-0, the main research area is age related macular degeneration carboxyethylpyrrole modified protein.

Protein modifications in which the ε-amino group of lysyl residues is incorporated into a 2-(ω-carboxyethyl)pyrrole (CEP) are mediators of age-related macular degeneration (AMD). They promote both angiogenesis into the retina (wet AMD’) and geog. retinal atrophy (dry AMD’). Blood levels of CEPs are biomarkers for clin. prognosis of the disease. To enable mechanistic studies of their role in promoting AMD, for example, through the activation of B- and T-cells, interaction with receptors, or binding with complement proteins, we developed an efficient synthesis of CEP derivatives, that is especially effective for proteins. The structures of tryptic peptides derived from CEP-modified proteins were also determined A key finding is that 4,7-dioxoheptanoic acid 9-fluorenylmethyl ester reacts with primary amines to provide 9-fluorenylmethyl esters of CEP-modified proteins that can be deprotected in situ with 1,8-diazabicyclo[5.4.0]undec-7-ene without causing protein denaturation. The introduction of multiple CEP-modifications with a wide variety of CEP:protein ratios is readily achieved using this strategy.

Bioorganic & Medicinal Chemistry published new progress about Age-related macular degeneration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Yin-Hsun; Lim, Sher-Wei; Lin, Hong-Yi; Wang, Shao-An; Hsu, Sung-Po; Kao, Tzu-Jen; Ko, Chiung-Yuan; Hsu, Tsung-I. published the artcile< Allopregnanolone suppresses glioblastoma survival through decreasing DPYSL3 and S100A11 expression>, Quality Control of 112-63-0, the main research area is glioblastoma cell survival DPYSL3 S100A11 allopregnanolone; Allopregnanolone; Glioblastoma; iTRAQ.

Allopregnanolone (allo) is a physiol. regulator of neuronal activity that treats multiple neurol. disorders. Allo penetrates the blood-brain barrier with very high efficiency, implying that allo can treat CNS-related diseases, including glioblastoma (GBM), which always recurs after standard therapy. Hence, this study aimed to determine whether allo has a therapeutic effect on GBM. We found that allo enhanced temozolomide (TMZ)-suppressed cell survival and proliferation of TMZ-resistant cells. In particular, allo enhanced TMZ-inhibited cell migration and TMZ-induced apoptosis. Addnl., allo strongly induced DNA damage characterized by γH2Ax. Furthermore, quant. proteomic anal., iTRAQ, showed that allo significantly decreased the levels of DPYSL3, S100A11, and S100A4, reflecting the poor prognosis of patients with GBM confirmed by differential gene expression and survival anal. Moreover, single-cell RNA-Seq revealed that S100A11, expressed in malignant cells, oligodendrocytes, and macrophages, was significantly associated with immune cell infiltration. Furthermore, overexpression of DPYSL3 or S100A11 prevented allo-induced cell death. In conclusion, allo suppresses GBM cell survival by decreasing DPYSL3/S100A11 expression and inducing DNA damage.

Journal of Steroid Biochemistry and Molecular Biology published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koevilein, Aline; Aschmann, Vera; Hohmann, Silja; Ochsenreither, Katrin published the artcile< Immobilization of Aspergillus oryzae DSM 1863 for L-Malic Acid Production>, Application of C19H34O2, the main research area is Aspergillus oryzae malic acid production immobilization.

Whole-cell immobilization by entrapment in natural polymers can be a tool for morphol. control and facilitate biomass retention. In this study, the possibility of immobilizing the filamentous fungus Aspergillus oryzae for L-malic acid production was evaluated with the two carbon sources acetate and glucose. A. oryzae conidia were entrapped in alginate, agar, and κ-carrageenan and production was monitored in batch processes in shake flasks and 2.5-L bioreactors. With glucose, the malic acid concentration after 144 h of cultivation using immobilized particles was mostly similar to the control with free biomass. In acetate medium, production with immobilized conidia of A. oryzae in shake flasks was delayed and titers were generally lower compared to cultures with free mycelium. While all immobilization matrixes were stable in glucose medium, disintegration of bead material and biomass detachment in acetate medium was observed in later stages of the fermentation Still, immobilization proved advantageous in bioreactor cultivations with acetate and resulted in increased malic acid titers. This study is the first to evaluate immobilization of A. oryzae for malic acid production and describes the potential but also challenges regarding the application of different matrixes in glucose and acetate media.

Fermentation published new progress about Aspergillus oryzae. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Cai; Ferreira de Almeida Fiuza, Ludmila; Cardoso Santos, Camila; Ferreira Nunes, Daniela; Cruz Moreira, Otacilio; Bouton, Jakob; Karalic, Izet; Maes, Louis; Caljon, Guy; Hulpia, Fabian; de Nazare C. Soeiro, Maria; Van Calenbergh, Serge published the artcile< 6-Methyl-7-Aryl-7-Deazapurine Nucleosides as Anti-Trypanosoma cruzi Agents: Structure-Activity Relationship and in vivo Efficacy>, HPLC of Formula: 112-63-0, the main research area is purine nucleoside preparation human parasiticide parasitemia prodrug; 7-deazapurine nucleosides; Trypanosoma cruzi; in vivo efficacy; structure-activity relationships.

Chagas disease is a tropical infectious disease resulting in progressive organ-damage and currently lacks efficient treatment and vaccine options. By modifying the pyrimidine part of a previously identified 7-aryl-7-deazapurine nucleoside, we found that substitution of a 6-Me for a 6-amino group allows retaining T. cruzi amastigote growth inhibitory activity but confers improved selectivity towards mammalian cells. The 7-(4-chlorophenyl) analog I, which was stable in microsomes, was evaluated in an acute mouse model. Oral administration of 25 mg/kg b.i.d. suppressed peak parasitemia and protected mice from infection-related mortality, gave similar reductions as the reference drug of blood parasite loads determined by qPCR, but as benznidazole failed to induce sterile cure in the short time period of drug exposure (5 days).

ChemMedChem published new progress about Biological uptake. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Curran, Dennis P.; Ko, Sung-Bo published the artcile< Synthesis of Optically Active α-Hydroxy Lactones by Sharpless Asymmetric Dihydroxylations of Ketene Acetals, Enol Ethers, and Ene Lactones>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Sharpless asym dihydroxylation hydroxy lactone synthesis; ketene acetal Sharpless asym dihydroxylation; enol ether Sharpless asym dihydroxylation; unsaturated lactone Sharpless asym dihydroxylation.

Three different AD routes to optically active α-hydroxy lactones of good to excellent optical purity are reported. The substrates for the AD reaction are endocyclic ketene acetals, endocyclic enol ethers, and exocyclic α,β-unsaturated lactones.

Journal of Organic Chemistry published new progress about Acetals, ketene Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peixoto, Andreia F.; Soliman, Mohamed M. A.; Pinto, Tania V.; Silva, Sonia M.; Costa, Paula; Alegria, Elisabete C. B. A.; Freire, Cristina published the artcile< Highly active organosulfonic aryl-silica nanoparticles as efficient catalysts for biomass derived biodiesel and fuel additives>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is organosulfonic aryl silica nanoparticle catalyst biodiesel aldol condensation.

Post-grafting methodologies were used to prepare aryl-organosulfonic acid functionalized silica nanoparticles (SO3H-aryl-SiO2NPs) as highly active heterogeneous acid catalysts for catalytic esterification of free fatty acids (FFA) and levulinic acid (LA), and aldol condensation of furfural with 3-methylfuran, well known renewable feedstocks for biodiesel and fuel additives production The chem. and structural characterization of the SO3H-aryl-SiO2NPs confirmed the success of the functionalization. Complete conversion for all FFA was observed using SO3H-aryl-SiO2NPs after 2 h of reaction. SiO2NPs_CSPTMS showed to be the most active and stable catalyst with no significant loss of activity in the first 5 cycles. In the LA esterification in the presence of an alc., complete conversion and selectivity and high reusability were observed (e.g., 83.2% yield after 10 cycles in the presence of 1-propanol, SiO2NPs 10_CSPTMS, at 120°C and 2h reaction). Finally, aldol condensation of furfural and 3-methylfuran had been performed using SiO2NPs_CSPTMS catalysts with almost 100% yield after 10 min at 65°C, high stability and reusability for 7 catalytic cycles. In general, the prepared SO3H-aryl-SiO2NPs have demonstrated promising catalytic performance for transformation of biomass-derived feedstocks into biodiesel and fuel additives.

Biomass and Bioenergy published new progress about Aldol condensation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Attiku, Keren; Bonney, Joseph; Agbosu, Esinam; Bonney, Evelyn; Puplampu, Peter; Ganu, Vincent; Odoom, John; Aboagye, James; Mensah, John; Agyemang, Seth; Awuku-Larbi, Yaw; Arjarquah, Augustina; Mawuli, Gifty; Quaye, Osbourne published the artcile< Circulation of hepatitis delta virus and occult hepatitis B virus infection amongst HIV/HBV co-infected patients in Korle-Bu, Ghana>, COA of Formula: C19H34O2, the main research area is human HIV HDV hepatitis B virus infection circulation.

Within HIV/HBV infected patients, an increase in HDV infection has been observed; there is inadequate information on HDV prevalence as well as virol. profile in Ghana. This study sought to determine the presence of HDV in HIV/HBV co-infected patients in Ghana. This was a longitudinal purposive study which enrolled 113 HIV/HBV co-infected patients attending clinic at Korle-Bu Teaching Hospital (KBTH) in Accra, Ghana. After consenting, 5 mL whole blood was collected at two-time points (baseline and 4-6 mo afterwards). The sera obtained were tested to confirm the presence of HIV, HBV antibodies and/or antigens, and HBV DNA. Antibodies and viral RNA were also determined for HDV. Amplified HBV DNA and HDV RNA were sequenced and phylogenetic anal. carried out with reference sequences from the GenBank to establish the genotypes. Of the 113 samples tested 63 (55.7%) were females and 50 (44.25%) were males with a median age of 45 years. A total of 100 (88.5%) samples had detectable HBV surface antigen (HBsAg), and 32 out of the 113 had detectable HBV DNA. Nucleotide sequences were obtained for 15 and 2 samples of HBV and HDV, resp. Phylogenetic anal. was predominantly genotype E for the HBVs and genotype 1 for the HDVs. Of the 13 samples that were HBsAg unreactive, 4 (30.8%) had detectable HBV DNA suggesting the incidence of occult HBV infections. The percentage occurrence of HDV in this study was observed to be 3.54. Our data suggest the presence and circulation of HDV and incidence of occult HBV infection in HIV/HBV co-infected patients in Ghana. This informs health staff and makes it imperative to look out for the presence of HDV and occult HBV in HIV/HBV co-infected patients presenting with potential risk of liver cancers and HBV transmission through hemodialysis and blood transfusions.

PLoS One published new progress about Antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Huafang; Tong, Zongbo; Ren, Zhaoyang; Mishra, Kanchan; Morita, Shunya; Edouarzin, Edruce; Gorla, Lingaraju; Averkiev, Boris; Day, Victor W.; Hua, Duy H. published the artcile< Synthesis and Characterization of Bimetallic Nanoclusters Stabilized by Chiral and Achiral Polyvinylpyrrolidinones. Catalytic C(sp3)-H Oxidation>, Application In Synthesis of 112-63-0, the main research area is polyvinylpyrrolidinone stabilizer bimetallic nanocluster catalytic carbon hydrogen bond oxidation.

Second-generation chiral-substituted poly-N-vinylpyrrolidinones (CSPVPs) (-)-1R and (+)-1S were synthesized by free-radical polymerization of (3aR,6aR)- and (3aS,6aS)-5-ethenyl-tetrahydro-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyrrol-4-one, (I and II, resp.), using thermal and photochem. reactions. They were produced from resp. D-isoascorbic acid and D-ribose. In addition, chiral polymer (-)-2 was also synthesized from the polymerization of (S)-3-(methoxymethoxy)-1-vinylpyrrolidin-2-one (III). Mol. weights of these chiral polymers were measured using HRMS, and the polymer chain tacticity was studied using 13C NMR spectroscopy. Chiral polymers (-)-1R, (+)-1S, and (-)-2 along with poly-N-vinylpyrrolidinone (PVP, MW 40K) were sep. used in the stabilization of Cu/Au or Pd/Au nanoclusters. CD spectra of the bimetallic nanoclusters stabilized by (-)-1R and (+)-1S showed close to mirror-imaged CD absorption bands at wavelengths 200-300 nm, revealing that bimetallic nanoclusters’ chiroptical responses are derived from chiral polymer-encapsulated nanomaterials. Chemo-, regio-, and stereo-selectivity was found in the catalytic C-H group oxidation reactions of complex bioactive natural products, such as ambroxide, menthofuran, boldine, estrone, dehydroabietylamine, 9-allogibberic acid, and sclareolide, and substituted adamantane mols., when catalyst Cu/Au (3:1) or Pd/Au (3:1) stabilized by CSPVPs or PVP and oxidant H2O2 or t-BuOOH were applied. Oxidation of (+)-boldine N-oxide 23 using NMO as an oxidant yielded 4,5-dehydroboldine 27, and oxidation of (-)-9-allogibberic acid yielded C6,15 lactone 47 and C6-ketone 48.

Journal of Organic Chemistry published new progress about Amine oxides, heterocyclic Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (N-oxide group as oxygen source for C-H oxidation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Xin; Hu, Shaoqi; Yang, Qiao; Sang, Xianan; Tang, Dongxin; Cao, Gang published the artcile< Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy>, Category: esters-buliding-blocks, the main research area is paeoniflorin airway inflammation immune response asthma oxidative stress; Asthma; Immune; Inflammatory; Paeoniflorin; Pulmonary injury.

Asthma characterized by airway remodeling is a multiple pulmonary disease, which is associated with various physiol. processes including inflammation reaction, immune response, oxidative stress and autophagy. This study aimed to investigate whether these processes are modulated by the total glucosides of Paeonia lactiflora Pall (TGP), and its active compound paeoniflorin (PF) with anti-inflammatory and immune-regulatory effects could alleviate ovalbumin (OVA)-induced mouse asthma. In vivo, models of mouse asthma were established by i.p. with a mixture of OVA and aluminum hydroxide, plus a single nasal injected with OVA to female C57BL/6 mice. The results were observed with PET imaging, TEM, RT-PCR, western blotting. In vitro, CD4+ T cells were isolated and detected with flow cytometry. TGP, either in its crude or processed form, and PF effectively ameliorated lung injury in mice induced by OVA, regulated immune/inflammatory response by inhibiting the release of pro-inflammatory cytokines, thereby decreasing Th2 cell proportion, inhibited oxidative stress by recovering mitochondrial membrane potential and regulating metabolic activity in dose-dependent manner. Moreover, PF could inhibit autophagy by regulating mitochondrial function. In addition, the therapeutic effects of TGP and PF on pulmonary injury in asthmatic mice were not affected by processing. PF may be a valuable agent in ameliorating inflammation and immune response in asthmatic mice, and the possible mechanism involved in this response rang may from oxidative stress to autophagy.

Phytomedicine published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics