Category: 112-63-0

Pinarbasi-Degirmenci, Nareg; Sur-Erdem, Ilknur; Akcay, Vuslat; Bolukbasi, Yasemin; Selek, Ugur; Solaroglu, Ihsan; Bagci-Onder, Tugba published the artcile< Chronically Radiation-Exposed Survivor Glioblastoma Cells Display Poor Response to Chk1 Inhibition under Hypoxia>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is radiation glioblastoma cell Chk1 inhibition hypoxia radiotherapy DNA damage; Chk1; DNA damage response; glioblastoma; hypoxia; radioresistance; radiotherapy.

Glioblastoma is the most malignant primary brain tumor, and a cornerstone in its treatment is radiotherapy. However, tumor cells surviving after irradiation indicates treatment failure; therefore, better understanding of the mechanisms regulating radiotherapy response is of utmost importance. In this study, we generated clin. relevant irradiation-exposed models by applying fractionated radiotherapy over a long time and selecting irradiation-survivor (IR-Surv) glioblastoma cells. We examined the transcriptomic alterations, cell cycle and growth rate changes and responses to secondary radiotherapy and DNA damage response (DDR) modulators. Accordingly, IR-Surv cells exhibited slower growth and partly retained their ability to resist secondary irradiation Concomitantly, IR-Surv cells upregulated the expression of DDR-related genes, such as CHK1, ATM, ATR, and MGMT, and had better DNA repair capacity. IR-Surv cells displayed downregulation of hypoxic signature and lower induction of hypoxia target genes, compared to naÏve glioblastoma cells. Moreover, Chk1 inhibition alone or in combination with irradiation significantly reduced cell viability in both naÏve and IR-Surv cells. However, IR-Surv cells′ response to Chk1 inhibition markedly decreased under hypoxic conditions. Taken together, we demonstrate the utility of combining DDR inhibitors and irradiation as a successful approach for both naÏve and IR-Surv glioblastoma cells as long as cells are refrained from hypoxic conditions.

International Journal of Molecular Sciences published new progress about Adhesion G protein-coupled receptor L2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wagner, Annette; Dussling, Stefan; Scansani, Stefano; Bach, Peter; Ludwig, Michael; Steingass, Christof B.; Will, Frank; Schweiggert, Ralf published the artcile< Comparative Evaluation of Juices from Red-Fleshed Apples after Production with Different Dejuicing Systems and Subsequent Storage>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is ascorbic acid anthocyanin polyphenol red fleshed apple juice storage; UHPLC-DAD-ESI-QTOF-HR-MS/MS; red-fleshed ‘Weirouge’ apples; reductive juice processing; spiral filter press; vacuum dejuicing.

In this work, two vintages (2019 and 2020) of red-fleshed ′Weirouge′ apples were processed with the innovative spiral filter press technol. to investigate juice production in an oxygen-reduced atm. After pressing, a more brilliant red color and appreciably higher amounts of oxidation-sensitive constituents (ascorbic acid, anthocyanins, and colorless (poly)phenols) were seen in spiral filter pressed juices compared to those produced with conventional systems (horizontal filter press and decanter). In a subsequent stability study (24 wk storage at 4, 20, and 37 °C), the color and phenolic compounds were monitored and differences in the juices produced with the different pressing-systems were widely maintained during the storage period. The analyses of the anthocyanins and colorless (poly)phenols were conducted by UHPLC-DAD-ESI-QTOF-HR-MS/MS and UHPLC-DAD. The spiral filter press emerged as a promising technol. for the production of juices with a more attractive color and a better retention of oxidation-sensitive constituents during processing and storage compared to conventional juices.

Molecules published new progress about Apple (red-fleshed). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lakouraj, Moslem M.; Ghodrati, Keivan published the artcile< Carboxy pyridinium bromide perbromide reagents. Part I. Selective oxidation of thiols and sulfides>, Electric Literature of 112-63-0, the main research area is thiol selective oxidation pyridinium hydrobromide perbromide oxidant; sulfide selective oxidation pyridinium hydrobromide perbromide oxidant; disulfide preparation; sulfoxide preparation.

Efficient and convenient oxidation of aliphatic and aromatic thiols to disulfides and of sulfides to sulfoxides with pyridinium hydrobromide perbromide (PHBP), nicotinic acid hydrobromide perbromide (NAHBP), and 2,6-dicarboxy pyridinium hydrobromide perbromide (DCPHBP) in a solvent or under solvent free conditions and at ambient temperature is introduced.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Disulfides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fregeau-Proulx, Lilianne; Lacouture, Aurelie; Berthiaume, Line; Weidmann, Cindy; Harvey, Mario; Gonthier, Kevin; Pelletier, Jean-Francois; Neveu, Bertrand; Jobin, Cynthia; Bastien, Dominic; Bergeron, Alain; Fradet, Yves; Lacombe, Louis; Laverdiere, Isabelle; Atallah, Chantal; Pouliot, Frederic; Audet-Walsh, Etienne published the artcile< Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion>, Quality Control of 112-63-0, the main research area is citrate anticancer agent tricarboxylic acid cycle secretion prostate cancer; Androgen; Fertility; Organoids; Prostate cancer; TCA cycle.

The prostate is metabolically unique: it produces high levels of citrate for secretion via a truncated tricarboxylic acid (TCA) cycle to maintain male fertility. In prostate cancer (PCa), this phenotype is reprogrammed, making it an interesting therapeutic target. However, how the truncated prostate TCA cycle works is still not completely understood.We optimized targeted metabolomics in mouse and human organoid models in ex vivo primary culture. We then used stable isotope tracer analyses to identify the pathways that fuel citrate synthesis.First, mouse and human organoids were shown to recapitulate the unique citrate-secretory program of the prostate, thus representing a novel model that reproduces this unusual metabolic profile. Using stable isotope tracer anal., several key nutrients were shown to allow the completion of the prostate TCA cycle, revealing a much more complex metabolic profile than originally anticipated. Indeed, along with the known pathway of aspartate replenishing oxaloacetate, glutamine was shown to fuel citrate synthesis through both glutaminolysis and reductive carboxylation in a GLS1-dependent manner. In human organoids, aspartate entered the TCA cycle at the malate entry point, upstream of oxaloacetate. Our results demonstrate that the citrate-secretory phenotype of prostate organoids is supported by the known aspartate-oxaloacetate-citrate pathway, but also by at least three addnl. pathways: glutaminolysis, reductive carboxylation, and aspartate-malate conversion.Our results add a significant new dimension to the prostate citrate-secretory phenotype, with at least four distinct pathways being involved in citrate synthesis. Better understanding this distinctive citrate metabolic program will have applications in both male fertility as well as in the development of novel targeted anti-metabolic therapies for PCa.

Molecular Metabolism published new progress about Androgen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zeng, Tengchao; He, Guiping; Li, Xinxiang; Wang, Chaoxia published the artcile< Synthesis of reactive self-adhesive branched polyurethane dispersant for textile pigment printing>, Application In Synthesis of 112-63-0, the main research area is cotton fabric printing polyurethane dispersant.

A series of reactive branched polyurethane dispersants (BPUs) were successfully synthesized based on epoxy as reactive group and nitrogen-containing heterocycles as anchoring group. The branched polyurethane was adopted an ”A2 + B3” approach with diisocyanate prepolymer and trimethylolpropane. The structure, mol. weight, and thermodn. property of BPUs were characterized. The pigment dispersions were prepared with BPUs as the dispersant by ball milling, and then the characteristic parameters such as pigment particle size, viscosity, stability, color properties, and fastness were evaluated. Excellent dispersing performances were observed that the particle size of five dispersions were below 200 nm, with the viscosity as low as 6-9 mPa·s. It is worth noting that the pigment dispersion prepared by BPU exhibited excellent stability and self-adhesive performance. These dispersions were printed on cotton fabrics without adhesives, their water washing fastness was approx. grade 4. And the dry rubbing and wet rubbing fastnesses were 3 and 2-3, resp.

Journal of Applied Polymer Science published new progress about Cotton textiles. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Junheng; Gong, Zhangjie; Wu, Cheng; Li, Tingcheng; Tang, Yuanyu; Wu, Jingde; Jiang, Can; Miao, Menghe; Zhang, Daohong published the artcile< Itaconic acid-based hyperbranched polymer toughened epoxy resins with rapid stress relaxation, superb solvent resistance and closed-loop recyclability>, Electric Literature of 112-63-0, the main research area is itaconic acid hyperbranched polymer toughened epoxy resin stress relaxation.

The development of epoxy vitrimers with excellent overall properties and recyclability has been a great challenge. In this work, an itaconic acid-based hyperbranched polymer (IAHBP) was synthesized and incorporated as a curing agent for diglycidyl ether of bisphenol-A (DGEBA) to prepare epoxy vitrimers. The tensile strength, flexural strength and impact strength of DGEBA/IAHBP were 91.0 MPa, 121.8 MPa and 18.4 kJ m-2 resp. The hyperbranched topol. structure of IAHBP promoted dynamic transesterification and DGEBA/IAHBP exhibited outstanding malleability, shape reconfiguration and reprocessibility. DGEBA/IAHBP showed high shape fixity (Rf ∼ 97%) and recovery ratio (Rr ∼ 99%) over ten shape memory cycles, which involved grasping and loosening motions and the recovery of complex objects such as flower-shaped and 3D butterfly-shaped objects. Due to the increased free volume and crosslinking d., DGEBA/IAHBP demonstrated excellent solvent resistance. DGEBA/IAHBP can be efficiently degraded using sodium hydroxide aqueous solution, with the degraded epoxy reused to cure DGEBA to produce new epoxy vitrimers. The recycled epoxy vitrimers presented similar mech. properties and Tg to the original samples. This work demonstrated a green and convenient strategy for the production of epoxy vitrimers with excellent mech. performance and environment friendly reprocessibility.

Green Chemistry published new progress about Bending strength. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Holm Hansen, Rikke; Hoejsgaard Chow, Helene; Sellebjerg, Finn; Rode von Essen, Marina published the artcile< Dimethyl fumarate therapy suppresses B cell responses and follicular helper T cells in relapsing-remitting multiple sclerosis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is dimethyl fumarate follicular helper T B cell multiple sclerosis; B cells; Multiple sclerosis; cytokines; dimethyl fumarate; follicular helper T cells.

Background:: Di-Me fumarate (DMF) is a disease-modifying therapy used for patients with relapsing-remitting multiple sclerosis (RRMS). B cells are important contributors to the pathogenesis of RRMS, where they regulate the inflammatory immune responses and participate in development of lesions in the central nervous system (CNS). The impact of DMF on B cell subpopulations remains incompletely understood. Objectives:: In this study, we evaluated the effects of DMF on B cell subpopulations and their effector functions. Methods:: Blood from 21 DMF-treated and 18 untreated patients with RRMS was analyzed by flow cytometry. Results:: We found that DMF reduces the frequency of circulating antigen-experienced B cells, a reduction likely related to a reduced frequency of follicular helper T (TFH) cells and an increased frequency of follicular regulatory T (TFR) cells. Studying the impact of monomethyl fumarate (MMF), the primary metabolite of DMF, on B cell effector function in vitro showed that MMF increased the frequency of transforming growth factor (TGF)-β-producing B cells and decreased the frequency of B cells secreting lymphotoxin (LT)-α, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and to a lesser extent IL-10. Conclusion:: In summary, these data suggest an anti-inflammatory role of DMF and its metabolite MMF on the B cell compartment.

Multiple Sclerosis Journal published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nakai, Diogo K.; Ribeiro, Jose A. A.; Martins, Pedro A.; Soares, Itania P.; Salum, Thais F. C.; Costa, Patricia P. K. G. published the artcile< Evaporative light scattering detection based reversed-phase ultra-high-performance liquid chromatography method to quantify intermediates and end products of biodiesel production>, Formula: C19H34O2, the main research area is biodiesel production evaporative light scattering high performance liquid chromatog; Acylglycerol; Biodiesel; ELSD; Ester; Free fatty acid; UHPLC.

A fast method based on reversed-phase ultra-high-performance liquid chromatog. using evaporative light scattering detection (RP-UHPLC-ELSD) was developed for monitoring the intermediates and end products of biodiesel production Gradient elution of water, acetonitrile, and a mixture of acetonitrile:2-propanol:n-hexane was used. With a minimal and easy sample preparation, fatty acid Me esters (FAME), fatty acid Et esters (FAEE), free fatty acids (FFA), monoacylglycerols (MAG), diacylglycerols (DAG), and triacylglycerols (TAG) were successfully separated The developed method was used to monitor an ethylic enzymic transesterification of soybean oil and to characterize the ester content of Me and Et biodiesel. The ester content obtained was compared with the reference method by gas chromatog. and flame ionization detector (GC-FID), with similar results for both Me and Et biodiesel. The presented method is a simple and fast alternative, a 17 min run, to monitor the transesterification process, simultaneously quantifying all the analytes produced in the reaction: biodiesel and its intermediates. Limits of detection (LOD, between 29 and 307 ng) and quantification (LOQ, between 48 and 614 ng), linearity (R2>0.99), precision (between 0.30 and 6.58%), and accuracy (between 81.6 and 119.9%) were determined for the twenty-one compounds

Journal of Chromatography A published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meimetis, Labros G.; Boros, Eszter; Carlson, Jonathan C.; Ran, Chongzhao; Caravan, Peter; Weissleder, Ralph published the artcile< Bioorthogonal Fluorophore Linked DFO-Technology Enabling Facile Chelator Quantification and Multimodal Imaging of Antibodies>, Electric Literature of 112-63-0, the main research area is zirconium 89 DFO BODIPY trastuzumab PET fluorescence imaging.

Herein we describe the development and application of a bioorthogonal fluorogenic chelate linker that can be used for facile creation of labeled imaging agents. The chelate linker is based on the trans-cyclooctene(TCO)-tetrazine(Tz) chem. platform and incorporates deferoxamine (DFO) as a 89Zr PET tracer and a BODIPY fluorophore for multimodal imaging. The rapid (<3 min) ligation between mAb-TCO and Tz-BODIPY-DFO chelator is monitored using fluorescence and allows for determination of labeling completion. Utilizing BODIPY as the linker between mAb and DFO facilitates in chelator quantification using spectrophotometry, allowing for an alternative to traditional methods (mass and isotope dilution assay). Radiolabeling with 89Zr to form 89Zr-DFO-BODIPY-trastuzumab was found to be quant. after incubation at room temperature for 1 h (1.5 mCi/mg specific activity). The cell binding assay using HER2+ (BT474) and HER2- (BT20) cell lines showed significant binding to 89Zr-DFO-BODIPY-trastuzumab (6.45 ± 1.87% in BT474 vs. 1.47 ± 0.39% in BT20). In vivo PET imaging of mice bearing BT20 or BT474 xenografts with 89Zr-DFO-BODIPY-trastuzumab showed high tumor conspicuity, and biodistribution confirmed excellent, specific probe uptake of 237.3 ± 14.5% ID/g in BT474 xenografts compared to low, nonspecific probe uptake in BT20 xenografts (16.4 ± 5.6% ID/g) 96 h p.i. . Ex vivo fluorescence (465ex/520em) of selected tissues confirmed superb target localization and persistence of the fluorescence of 89Zr-DFO-BODIPY-trastuzumab. The described platform is universally adaptable for simple antibody labeling. Bioconjugate Chemistry published new progress about Chelating agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Jin; Hua, Wei; Zhao, Xinyuan; Yang, Fan; Guo, Ting; Zhang, Jianhua; Zheng, Xuerong; Liang, Wanqi published the artcile< Paeoniflorin alleviates endothelial dysfunction caused by overexpression of soluble fms-like tyrosine kinase 1 and soluble endoglin in preeclampsia via VEGFA upregulation.>, HPLC of Formula: 112-63-0, the main research area is endothelial dysfunction; paeoniflorin; preeclampsia; soluble endoglin; soluble fms-like tyrosine kinase 1.

This study assessed the protective effects of paeoniflorin against preeclampsia-related endothelial damage (ED). Human umbilical vein endothelial cells (HUVECs) isolated from healthy puerperae were identified by immunofluorescence assay. After paeoniflorin treatment, HUVECs were induced by soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) to establish ED. Cell viability, migration, invasion, tube formation, and apoptosis were assessed by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium MTT assay, Scratch assay, Transwell assay, tube formation assay, and flow cytometry. VEGFA expression in HUVECs was analyzed by Western blot. HUVECs were successfully isolated and identified as Von Willebrand factor (vWF) positive. Individual treatment or cotreatment of sFlt-1 and sEng inhibited migration, invasion and tube formation, enhanced apoptosis, and decreased VEGFA expression in HUVECs. Paeoniflorin pretreatment partially reversed the effects delivered by cotreatment of sFlt-1 and sEng in HUVECs. Paeoniflorin alleviated preeclampsia-related ED caused by overexpression of sFlt-1 and sEng by upregulating VEGFA.

Bioscience, biotechnology, and biochemistry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics