Category: 112-63-0

Ma, Mengying; Cai, Haoran; Xu, Chenlu; Huang, Renzhi; Wang, Shurong; Pan, Huilin; Hu, Yong-Sheng published the artcile< Engineering Solid Electrolyte Interface at Nano-Scale for High-Performance Hard Carbon in Sodium-Ion Batteries>, Reference of 112-63-0, the main research area is carbon engineering solid electrolyte interface nanoscale sodium ion battery.

Engineering the structure and chem. of solid electrolyte interface (SEI) on electrode materials is crucial for rechargeable batteries. Using hard carbon (HC) as a platform material, a correlation between Na+ storage performance, and the properties of SEI is comprehensively explored. It is found that a “”good”” SEI layer on HC may not be directly associated with certain kinds of SEI components, such as NaF and Na2O. Whereas, arranging nano SEI components with refined structures constructs the foundation of “”good”” SEI that enables fast Na+ storage and interface stability of HC in Na-ion batteries. A layer-by-layer SEI on HC with inorganic-rich inner layer and tolerant organic-rich outer flexible layer can facilitate excellent rate and cycling life. Besides, SEI layer as the gate for Na+ from electrolyte to HC electrode can modulate interfacial crystallog. structures of HC with pillar-solvent that function as “”pseudo-SEI”” for fast and stable Na+ storage in optimal 1 M NaPF6-TEGDME electrolytes. Such a layer-by-layer SEI combined with a “”pseudo-SEI”” layer for HC enables an outstanding rate of 192 mAh g-1 at 2 C and stable cycling over 1100 cycles at 0.5 C. This study provides valuable guidance to improve the electrochem. performance of electrode materials through regulation of SEI in optimal electrolytes.

Advanced Functional Materials published new progress about Correlation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Doebelin, Christelle; Patouret, Remi; Garcia-Ordonez, Ruben D.; Chang, Mi Ra; Dharmarajan, Venkatasubramanian; Novick, Scott; Ciesla, Anthony; Campbell, Sean; Solt, Laura A.; Griffin, Patrick R.; Kamenecka, Theodore M. published the artcile< Identification of potent RORβ modulators: Scaffold variation>, Application In Synthesis of 112-63-0, the main research area is aminothiophene preparation retinoid related orphan receptor RORbeta modulator; Aminothiophene; Nuclear receptor; RORβ; Selective ligand.

The authors sought to develop RORβ-selective probe mols. to investigate the function of the receptor in vitro and in vivo and its role in the pathophysiol. of disease. To accomplish this, the authors modified a potent dual RORβ/RORγ inverse agonist from the primary literature with the goal of improving selectivity for RORβ vs. RORγ. Truncation of the Western portion of the mol. ablated activity at RORγ and led to a potent series of RORβ modulators. Continued exploration of this series investigated alternate replacement cores for the aminothiazole ring. Numerous suitable replacements were found during the course of the authors’ SAR investigations and are reported herein.

Bioorganic & Medicinal Chemistry Letters published new progress about Acylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pajak, Beata published the artcile< Looking for the Holy Grail-Drug Candidates for Glioblastoma Multiforme Chemotherapy>, Computed Properties of 112-63-0, the main research area is review glioblastoma multiforme chemotherapy; clinical trials; drug candidates; glioblastoma multiforme (GBM); glycolysis inhibitors; immunomodulatory action; kinases inhibitors.

A review. Glioblastoma multiforme (GBM) is the deadliest and the most heterogeneous brain cancer. The median survival time of GBM patients is approx. 8 to 15 mo after initial diagnosis. GBM development is determined by numerous signaling pathways and is considered one of the most challenging and complicated-to-treat cancer types. Standard GBM therapy consist of surgery followed by radiotherapy or chemotherapy, and combined treatment. Current standard of care (SOC) does not offer a significant chance for GBM patients to combat cancer, and the selection of available drugs is limited. For almost 20 years, there has been only one drug, Temozolomide (TMZ), approved as a first-line GBM treatment. Due to the limited efficacy of TMZ and the high rate of resistant patients, the implementation of new chemotherapeutics is highly desired. However, due to the unique properties of GBM, many challenges still need to be overcome before reaching a ‘breakthrough’. This review article describes the most recent compounds introduced into clin. trials as drug candidates for GBM chemotherapy.

Biomedicines published new progress about Chemotherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Majumdar, K. C.; Muhuri, S. published the artcile< Regioselective synthesis of polyheterocyclic scaffolds by sequential [3,3] sigmatropic rearrangements and pyridine hydrotribromide mediated heterocyclization>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aryloxypropynyloxy methylpyranone preparation thionation Claisen rearrangement; aryloxymethyloxopyranothiopyran preparation sigmatropic rearrangement enolization pyridine hydrotribromide regioselective heterocyclization; tetracyclic polyhetero scaffold bromo methyltrihydropyranothiopyranobenzopyranone preparation.

A number of tetracyclic polyhetero scaffolds, e.g., I, have been regioselectively synthesized in 70-75% yield from 4-[(3-aryloxy-2-propynyl)oxy]-6-methyl-pyran-2-ones via thionation of the lactone carbonyl, sequential Claisen rearrangements and pyridine hydrotribromide mediated heterocyclization.

Journal of Heterocyclic Chemistry published new progress about [3,3]-Sigmatropic rearrangement. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Parzuchowski, Pawel; Maminski, Mariusz L. published the artcile< Poly-(3-ethyl-3-hydroxymethyl)oxetanes-synthesis and adhesive interactions with polar substrates>, Application of C19H34O2, the main research area is ethyl hydroxymethyl oxetane ring opening polymerization polar substrate; adhesive interaction; adhesion; hot melt adhesive; polyoxetanes.

Hyperbranched polyoxetanes are a relatively new class of polymers. These are branched polyethers that are synthesized from oxetanes-four-member cyclic ethers bearing hydroxymethyl groups-via ring-opening polymerization Four series of polyoxetanes were synthesized from 3-ethyl-3-(hydroxymethyl)oxetane and 1,1,1-tris(hydroxymethyl)propane as a core mol. Reagents ratios ranged from 1:5 to 1:50, theor. molar mass ranged from 714 g/mol to 5942 g/mol, and dispersities ranged from 1.77 to 3.75. The morphol. of the macromols. was investigated by a matrix-assisted laser desorption/ionization time of flight technique. The polyoxetanes’ adhesive interactions with polar materials were analyzed and provided results as follows: the work of adhesion was 101-105 mJ/m2, the bond-line tensile shear strengths were 0.39-1.32 MPa, and there was a brittle fracture mode within the polymer. The findings confirmed a good adhesion to polar substrates, but further research on polyoxetane modifications toward a reduction of brittleness is necessary.

Polymers (Basel, Switzerland) published new progress about Adhesion, physical. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Tingting; Zhao, Min; Zhang, Yumeng; Qiu, Zhaozhao; Zhang, Yixin; Zhao, Chunjie; Wang, Miao published the artcile< Pharmacokinetic-pharmacodynamic modeling analysis and anti-inflammatory effect of Wangbi capsule in the treatment of adjuvant-induced arthritis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Wangbi Capsule anti inflammatory rheumatoid arthritis pharmacokinetic pharmacodynamic; Wangbi capsule; adjuvant-induced arthritis; pharmacokinetic-pharmacodynamic model; rheumatoid arthritis; traditional Chinese medicine.

Clin., Wangbi Capsule (WBC) is widely used in the treatment of Rheumatoid arthritis (RA) because of its remarkable therapeutic effect. To reveal the mechanism, a pharmacokinetic-pharmacodynamic (PK-PD) model was developed for the first time to assess the relationship between time-concentration (dose)-effect. Freund’s Complete Adjuvant was used to induce the adjuvant-induced arthritis model. Multi-indexes were used to evaluate the therapeutic effect and an S-Imax PK-PD model was established based on the concentrations of osthole, 5-O-methylvisamminoside, cimifugin, albiflorin, paeoniflorin and icariin and the levels of interleukin-1β and prostaglandin E2 using a two-compartment PK model together with a PD model with an effect-site compartment. The results suggest that WBC can treat RA by regulating the levels of prostaglandin E2 and interleukin-1β . For the PK-PD model, the parameters indicated that WBC had a large safety margin and all six bioactive ingredients of WBC have therapeutic effects on RA. Among them icariin, osthole and 5-O-methylvisamminoside may be the main effective substances. This study provided a scientific basis for further study of population pharmacokinetics / population pharmacodynamics (PPK/PPD), to develop a reasonable administration plan and improve individualized drug therapy.

Biomedical Chromatography published new progress about Arthritis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Di; Wang, Qin; Yang, Jing; Zhang, Qing; Le, Yi; Liu, Li; Yan, Longjia published the artcile< Synthesis and biological evaluation of new pyrimidine derivatives as FAK inhibitors for development of antitumor agents>, Category: esters-buliding-blocks, the main research area is FAK inhibitor antitumor agent development pyrimidine derivative biol evaluation.

In this paper, a set of new pyrimidine derivatives was designed and synthesized. Subsequently, all the final targets were evaluated for antitumor activities in vitro on four human cancer cell lines including U-87 MG, MDA-MB-231, PC-3, and MCF-7, which were high expressed with focal adhesion kinase (FAK). The results were shown that these compounds performed well antitumor activities. Especially 2-((2-((4-((2-((2-acrylamidoethyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-N-methylbenzamide (7b) exhibited the highest antitumor activities with 2.16 μM, 2.03 μM, 6.19 μM, and 21.31 μM, resp. In addition, all the compounds were tested activities against FAK and compound 7b was also the best candidate with IC50 value of 5.9 nM.

Heterocycles published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bruce, S. O.; Nwafor, O. I.; Omoirri, M. A.; Adione, N. M.; Onyeka, I. P.; Ezeoru, V. C. published the artcile< GC-MS, FTIR and antiulcer screening of aqueous seed extract and oil of Nigella sativa in wistar rats>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Nigella seed extract antiulcer agent phytochem peptic ulcer.

Peptic ulcer disease (PUD) is a sore in the lining of the stomach or duodenal mucosa. This study was aimed at evaluating the antiulcer activity of the aqueous extract of Nigella sativa (black seed) and its constitutents. The pharmacognostic properties of the dry seeds were determined The seeds were extracted using two methods digestion and hydro-distillation The acute toxicity, phytochem. constituents and the antiulcer evaluation were performed on ethanol-induced ulcer in wistar rats using a standard method. FTIR and GC-MS anal. of the aqueous seed extract was also determined using standard methods. Nigella sativa seed shows the presence of starch grains, lignified tissues, tannins, cellulose, protein and oil globules. The aqueous extract has a high safety margin. The phytochem. studies revealed the presence of saponins, flavonoids, alkaloids, tannins, glycosides, fats and oil. The black seed aqueous and oil extract at 500 mg/kg significantly reduced the acidity, total acidity, and ulcer index, and pH of gastric content when compared with the pos. control (Famotidine). The FTIR anal. identified the presence of the following functional groups chloro, ether, amine, carboxylic acid, nitriles, methylene, alc., while the GC-MS identified five compounds such as glycerin, n-Hexadecanoic acid, 9, 12-octadecadienoic acid-Me ester, 9, 12-octadecadienoic acid and 9, 12-octadecadienoyl chloride. The pharmacognostic properties can act as a reliable tool for the standardization of the plant part. This study suggests that aqueous and oil extract possess antiulcer properties. Thus the aqueous and oil extract of black seed can be considered as antiulcer medication traditionally.

Journal of Drug Delivery and Therapeutics published new progress about Alkaloids Role: PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tomassoli, Isabelle; Gundisch, Daniela published the artcile< The twin drug approach for novel nicotinic acetylcholine receptor ligands>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nicotinic acetylcholine receptor ligand; 3D QSAR pharmacophore; Nicotinic acetylcholine receptor; Structure–activity relationship; Twin drugs; nAChR.

The association of two pharmacophoric entities generates so-called ‘twin drugs’ or dimer derivatives The authors applied this approach for the design of a small compound library for the interaction with α4β2* nicotinic acetylcholine receptors (nAChRs). In this compound series, the nAChR ligand N,N-dimethyl-2-(pyridin-3-yloxy)ethan-1-amine served as one pharmacol. entity and it was initially kept constant as one part of the ‘twin’ compound ‘Twin’ compounds with identical or nonidentical entities using the ‘no linker mode’ or ‘overlap’ mode were synthesized and evaluated for their nAChR affinities. Compound I showed the highest affinity for the α4β2* nAChR subtype (Ki = 0.188 nM) and its (di)fluoro analogs could retain nanomolar affinities, when replacing pyridine as the hydrogen bond acceptor system by mono- or difluoro-phenyls. The ‘twin drug’ approach proved to provide compounds with high affinity and subtype selectivity for α4β2* nAChRs.

Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Toyodome, Hisaya; Higo, Yuhei; Sasai, Ryo; Kurawaki, Junichi; Kaneko, Yoshiro published the artcile< Behavior of chiral induction from polysilsesquioxanes bearing chiral and ammonium groups to anionic pyrene derivatives>, Category: esters-buliding-blocks, the main research area is chiral ammonium side chain polysilsesquioxane chiral induction.

The behavior of chiral induction from ladder-like polysilsesquioxanes (R60- and S60-PSQs) bearing chiral and ammonium side-chain groups (compositional ratio = ca. 60:40) to the anionic pyrene derivative, 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt (PTSNa4), was investigated. The CD spectra of PTSNa4/(R60- and S60-PSQs) mixtures in methanol exhibited reverse peaks at 230-250, 280-290, and 310-370 nm, which were assigned to PTSNa4 and indicated that the achiral PTSNa4 mol. had chirality induced from the chiral PSQs. In addition, it was found that an excimer of PTSNa4 was formed by hybridization with the chiral PSQs, i.e., the emission peaks not only due to a monomer state at 385 and 408 nm but also due to an eximer at 460-520 nm were observed in the fluorescence spectrum excited at 377 nm. This result suggests that the neg. charged PTSNa4 formed an eximer along the pos. charged side-chain ammonium groups of PSQs. To investigate the influence of the structures of the pyrene derivatives on chiral induction behavior, the CD measurements of the mixtures of R60- and S60-PSQs in methanol with different pyrene derivative, 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (pyranine), were also performed. It was found that the intensities of the absorptions for the pyanine solutions were lower than those for PTSNa4 solutions These results suggest that the point-symmetry of the pyrene derivatives influences the level of chiral induction. Therefore, the point-symmetry of pyrene derivatives is an important factor for determining the behavior of chiral induction from chiral PSQs to these compounds

Journal of Nanoscience and Nanotechnology published new progress about Chiral induction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics