Category: 112-63-0

Ried, Walter; Stahlhofen, Paul published the artcile< Heterocyclic seven-membered ring systems. VII. The course of the reaction between ο-phenylenediamine and alkylidenepyruvic acids>, Category: esters-buliding-blocks, the main research area is .

The product from the condensation of ο-C6H4(NH2)2 (I) and PhCH:CHCOCO2H (II) is 2-hydroxy-3-styrylquinoxaline (III) and not 7-phenyl-2,3-benzo-1,4-diazacyclohepta-2,7-dien-5-one (IV) which is excluded since III was also obtained from I and II Me ester when the presence of O was carefully avoided. IV was obtained from I and BzCH2CO2Et (V). Analogs of III were also prepared I (2.1 g.) in 20 cc. alc. treated at 40-50° with an equimolar amount of RCH:CHCOCO2H gave 3-alkylidenemethyl-2-hydroxyquinoxalines (R, % yield, m.p., and crystallization solvent given): Ph (III), 57, 256°, dioxane; p-MeOC6H4, 61, 257°, dioxane; 2-furyl, 76, 262°, xylene; 3,4-(CH2O2)C6H3, 59, 300°, dioxane. 2-Hydroxy-3-methylquinoxaline (3.2 g.), 75 cc. xylene, 2.1 g. BzH, and 5-10 drops piperidine refluxed 5 hrs., 30 cc. solvent distilled, and the residue let stand several days precipitated III. III (1 g.) in 800 cc. EtOAc hydrogenated over Raney Ni, filtered, the EtOAc distilled, the oil in HOAc treated dropwise with a saturated aqueous solution of 2 g. NaNO2, kept 2 hrs., and filtered gave 1,4-dinitroso-2-hydroxy-3-(β-phenylethyl)-1,2,3,4-tetrahydroquinoxaline, m. 131° (decomposition) (alc. H2O). V (12.8 g.) in 50 cc. xylene added dropwise during 0.5 hr. to a boiling solution of 7.2 g. I in 50 cc. xylene, 30 cc. solvent distilled during 0.5 hr., and the mixture cooled gave 11 g. IV, m. 206° (dioxane); picrate, m. 168° (alc.). IV (3.3 g.) in 300 cc. EtOAc hydrogenated over Raney Ni and the filtered solution concentrated to 20 cc. gave 7-phenyl-2,3-benzo-1,4-diazacyclohept-2-en-5-one (VI), m. 167° (EtOAc); 1-NO derivative, m. 181° (decomposition) (MeOH). Similarly prepared were the 7-(2-furyl) analog of IV, m. 250° (dioxane) [pic-rate, m. 195° (decomposition) (alc.)], and the 7-(2-furyl) analog of VI, m. 169° (C6H6).

Chemische Berichte published new progress about Heterocyclic compounds, oxygen. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Rodrigues-Junior, Dorival Mendes; Liu, Sijia; Webb, Anna Taylor; Gomez-Puerto, Maria Catalina; ten Dijke, Peter; Heldin, Carl-Henrik; Moustakas, Aristidis published the artcile< The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma>, Application of C19H34O2, the main research area is protein kinase LKB1 self renewal invasiveness glioblastoma; LKB1; cancer stem cells; glioblastoma; invasion; metformin.

The role of liver kinase B1 (LKB1) in glioblastoma (GBM) development remains poorly understood. LKB1 may regulate GBM cell metabolism and has been suggested to promote glioma invasiveness. After analyzing LKB1 expression in GBM patient mRNA databases and in tumor tissue via multiparametric immunohistochem., we observed that LKB1 was localized and enriched in GBM tumor cells that co-expressed SOX2 and NESTIN stemness markers. Thus, LKB1-specific immunohistochem. can potentially reveal subpopulations of stem-like cells, advancing GBM patient mol. pathol. We further analyzed the functions of LKB1 in patient-derived GBM cultures under defined serum-free conditions. Silencing of endogenous LKB1 impaired 3D-gliomasphere frequency and promoted GBM cell invasion in vitro and in the zebrafish collagenous tail after extravasation of circulating GBM cells. Moreover, loss of LKB1 function revealed mitochondrial dysfunction resulting in decreased ATP levels. Treatment with the clin. used drug metformin impaired 3D-gliomasphere formation and enhanced cytotoxicity induced by temozolomide, the primary chemotherapeutic drug against GBM. The IC50 of temozolomide in the GBM cultures was significantly decreased in the presence of metformin. This combinatorial effect was further enhanced after LKB1 silencing, which at least partially, was due to increased apoptosis. The expression of genes involved in the maintenance of tumor stemness, such as growth factors and their receptors, including members of the platelet-derived growth factor (PDGF) family, was suppressed after LKB1 silencing. The defect in gliomasphere growth caused by LKB1 silencing was bypassed after supplementing the cells with exogenous PFDGF-BB. Our data support the parallel roles of LKB1 in maintaining mitochondrial homeostasis, 3D-gliomasphere survival, and hindering migration in GBM. Thus, the natural loss of, or pharmacol. interference with LKB1 function, may be associated with benefits in patient survival but could result in tumor spread.

Journal of Cellular Physiology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Russo, Vincenzo; Rossano, Carmelina; Salucci, Emiliano; Tesser, Riccardo; Salmi, Tapio; Di Serio, Martino published the artcile< Intraparticle diffusion model to determine the intrinsic kinetics of ethyl levulinate synthesis promoted by Amberlyst-15>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Levulinic acid esterification kinetics Amberlyst catalyst intraparticle diffusion model.

Levulinic acid and its esters are considered very versatile chem. compounds used for a wide range of derivatives Traditionally Et levulinate is synthesized in batch reactors, using homogeneous catalysts (H2SO4, H3PO4). Several investigations were reported on solid acid catalysts, as zeolites, sulfated oxides, sulfonic ion-exchange resins. Amberlyst-15 showed high potentials: to design a continuous reactor, it is necessary to investigate the stability of the catalyst and the kinetics of the reaction. In the present work, we demonstrated that the resin is stable for more than 5 days. Kinetic and mass transfer phenomena were studied, evaluating the partition and take-up of the used resin when put in contact with reactants and products. Two different samples of Amberlyst-15 were used, characterized by different size, demonstrating that bigger particles lead to higher intraparticle diffusion limitations.

Chemical Engineering Science published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Yifan; Li, Chao; Zhang, Shu; Li, Qiaoling; Gholizadeh, Mortaza; Wang, Yi; Hu, Song; Xiang, Jun; Hu, Xun published the artcile< Pyrolysis of soybean residue: Understanding characteristics of the products>, Formula: C19H34O2, the main research area is soybean residue pyrolysis product.

Soybean residue (SR) is a main solid waste produced during the extraction of soybean oil with bulk volume In addition to the use as vegetable protein feed, SR could also be used as feedstock for producing biofuels and carbon materials via pyrolysis. In this study, the pyrolysis behaviors of SR at varied temperatures and heating rates were investigated. The results show that the pyrolysis of the organic components in SR could reach completion even at 500°C, due to the lower thermal stability of the organic component than that in the typical biomass. This also leads to the bio-oil with little heavy organics and also low carbon content of the resulting biochar, as the organic components decomposed to a significant extent while the charring reactions were insignificant. This leads to the biochar with low heating value and low energy yield when compared with that in the pyrolysis of typical biomass. In addition, the high content of proteins, amino acids and other nitrogen-containing nutrients make the SR derived bio-oil nitrogen-rich and a significant portion of nitrogen could also be retained in the biochar. These specialties have to be considered during their applications as either biofuels or functional carbon materials.

Renewable Energy published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Jinmeng; Liu, Yuhang; Liu, Lei; He, Song; Du, Zhuzhu; Wang, Ke; Xie, Linghai; Du, Hongfang; Ai, Wei published the artcile< Expediting Sulfur Reduction/Evolution Reactions with Integrated Electrocatalytic Network: A Comprehensive Kinetic Map>, COA of Formula: C19H34O2, the main research area is lithium sulfur battery reduction evolution reaction electrocatalytic kinetics; Electrocatalytic network; Li−S batteries; kinetic evolution map; practical conditions; versatile catalytic capability.

Electrocatalysts are considered the most promising candidates in ameliorating the slow kinetics of Li-S batteries (LSBs), however, the issue of insufficient catalytic capability remains to be addressed. Herein, we report an integrated catalytic network comprising graphitic carbon-encapsulated/bridged ultrafine NiCoP embedded in N, P-codoped carbon (GC-uNiCoP@NPC) as a highly competent catalyst for sulfur-based species conversions. By profiling the evolution map of Li-S chem. via operando kinetic analyses, GC-uNiCoP@NPC is demonstrated to possess versatile yet efficient catalytic activity for sulfur reduction/evolution reactions, especially the rate-determining heterogeneous phase transitions. As a result, GC-uNiCoP@NPC enables high capacity and stable cycling of sulfur cathode under high areal loading and lean electrolyte. Moreover, pouch cells assembled under practical conditions present promising performance with a specific energy of 302 Wh kg-1. This work not only conceptually expands the catalyst design for LSBs but also provides a comprehensive insight into the catalyst performance for Li-S chem.

Nano Letters published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Muqun; Liang, Shaofeng; Gao, Wei; Qin, Yuxuan published the artcile< The effect of promoting hydrogen bond aggregation based on PEMTC on the mechanical properties and shape memory function of polyurethane elastomers>, COA of Formula: C19H34O2, the main research area is polyurethane elastomer carbamate hydrogen bond aggregation shape memory property; hydrogen bond elastomer; polyurethane; shape memory; toughness.

In this work, small mol. diols named PEMTC were synthesized from isophorone diisocyanate, N-(2-hydroxyethyl) acrylamide and trimethylolpropane by a semi-directional method. PEMTC (2-(prop-2-enamido)ethyl N-{3-[({[2-ethyl-3-hydroxy-2(hydroxymethyl)propoxy]carbonyl}amino)methyl]-3, 5,5-trimethylcyclohexyl}carbamate) contains hydrogen bond active site and light-initiated C=C. We introduced it as a branch chain block into poly(ε-caprolactone) (PCL). By feeding and monitoring the reaction process, we synthesized a large number of polyurethane elastomers, hydrogen bonds PCL-based elastomer (HPE), which contain a large number of dynamic hydrogen bonds. Under UV irradiation, PEMTC can make HPE mols. aggregate and crosslink, improve the degree of internal hydrogen bonding interaction of HPE materials and endow HPE materials with good elasticity, toughness, heat resistance and shape memory ability. After 270 nm UV irradiation, the elongation at break of HPE materials decreased from 607.14-1463.95% to 426.60-610.36%, but the strength at break of HPE materials increased from 3.36-13.52 to 10.28-41.52 MPa, and the toughness increased from 16.36-129.71 to 40.48-172.22 MJ m-3. In addition, the highest shape fixation rate of HPE after UV irradiation was 98.0%, and the recovery rate was 93.7%.

Royal Society Open Science published new progress about Breaking strength. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Curd, Matthew E.; Morrison, Neil F.; Smith, Michael J. A.; Gajjar, Parmesh; Yousaf, Zeshan; Parnell, William J. published the artcile< Geometrical and mechanical characterization of hollow thermoplastic microspheres for syntactic foam applications>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hollow thermoplastic microsphere syntactic foam property.

Recently, hollow thermoplastic microspheres, have emerged as an innovative filler material for use in polymer-matrix composites. The resulting all-polymer syntactic foam takes on excellent damage tolerance properties, strong recoverability under large strains, and favorable energy dissipation characteristics. Aside from syntactic foams, thermoplastic microspheres are finding increasing usage in a variety of applications and industries. Despite this, there is an absence of statistical geometrical and mech. data for certain classes of thermoplastic microspheres. In this work we characterize two classes of thermoplastic microsphere using X-ray computed tomog., focused ion beam and electron microscopy. We observe the spatial distribution of these microspheres within a polyurethane-matrix syntactic foam and show that the volume-weighted polydisperse shell diameters follow a normal distribution. Interestingly, polydispersity of the shell wall thickness is not observed and furthermore the wall thickness is not correlated to the shell diameter We utilize the geometrical information obtained in anal. micromech. techniques in the small strain regime to determine, for the first time, estimates of the Young’s modulus and Poisson’s ratio of the microsphere shell material itself. Our results contribute to potential future improvements in the design and fabrication of materials that employ thermoplastic microspheres, including syntactic foams.

Composites, Part B: Engineering published new progress about Bulk modulus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Scott, Nicholas A.; Lawson, Melissa A. E.; Hodgetts, Ryan James; Le Gall, Gwenaelle; Hall, Lindsay J.; Mann, Elizabeth R. published the artcile< Macrophage metabolism in the intestine is compartment specific and regulated by the microbiota>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is intestine macrophage metabolism microbiota; gut; macrophage; metabolism; microbiota.

Intestinal macrophages play a vital role in the maintenance of gut homeostasis through signals derived from the microbiota. We previously demonstrated that microbial-derived metabolites can shape the metabolic functions of macrophages. Here, we show that antibiotic-induced disruption of the intestinal microbiota dramatically alters both the local metabolite environment and the metabolic functions of macrophages in the colon. Broad-spectrum antibiotic administration in mice increased the expression of the large neutral amino acid transporter LAT1 and accordingly, amino acid uptake. Subsequently, antibiotic administration enhanced the metabolic functions of colonic macrophages, increasing phosphorylation of components of mammalian/mechanistic target of rapamycin signalling pathways, with increased expression of genes involved in glycolysis and oxidative phosphorylation (OXPHOS), increased mitochondrial function, increased rate of extracellular acidification (ECAR; measure of glycolysis) and increased rate of oxygen consumption (OCR; measure of OXPHOS). Small bowel macrophages were less metabolically active than their colonic counterparts, with macrophage metabolism in the small intestine being independent of the microbiota. Finally, we reveal tissue-resident Tim4+ CD4+ macrophages exhibit enhanced fatty acid uptake alongside reduced fatty acid synthesis compared to recruited macrophages. Thus, the microbiota shapes gut macrophage metabolism in a compartment-specific manner, with important implications for monocyte recruitment and macrophage differentiation.

Immunology published new progress about Acidification (extracellular). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Buker, Nicholas; Firestone, Kimberly A.; Haller, Marnie; Purvis, Lafe; Lao, David; Snoeberger, Robert; Jen, Alex K.-Y.; Dalton, Larry R. published the artcile< Functionalized guanidines for electro-optic materials>, Computed Properties of 112-63-0, the main research area is guanidine imidazole benzimidazole preparation nonlinear optical chromophore; UV visible absorption hyperpolarizability guanidine containing nonlinear optical chromophore; functionalized guanidine electrooptical material.

Guanidines derived from imidazoles or benzimidazoles such as I are prepared as potential nonlinear optical chromophores. Condensation of 4-nitrobenzaldehyde with 4,5,5-trimethyl-3-cyano-2,5-dihydrofuranylidenemalononitrile, reduction of the nitro group, and substitution of 1,3-dimethyl-2-chloroimidazolidinium chloride by the aromatic amine yields I. Olefination of 3,4-dibutyl-2-thiophenecarboxaldehyde with di-Et 4-nitrophenylphosphonate, formylation of the thiophene ring, condensation with 4,5,5-trimethyl-3-cyano-2,5-dihydrofuranylidenemalononitrile, reduction of the nitro group, and reaction with either 1,3-dimethyl-2-chloroimidazolidinium chloride or 1,3-dimethyl-2-chlorobenzimidazolium chloride provides the thiophene-containing chromophores. I has both a lower UV-visible absorption wavelength maximum and a higher hyperpolarizability than the comparable chromophore lacking the guanidine; guanidine-containing chromophores with a divinylthiophene linker have decreased hyperpolarizabilities compared to the chromophore lacking the guanidine. Guanidine-containing chromophores are more stable to heat than the related diethylamino chromophores.

Materials Research Society Symposium Proceedings published new progress about Chromophores. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Qihong; Dong, Shi; Shi, Yuanyuan; Lu, Tiangong published the artcile< Guizhi-Fuling formula inhibits ovarian cancer progression by targeting STAT3 signaling network>, Formula: C19H34O2, the main research area is guizhi fuling formula ovarian cancer progression STAT3 signal transduction.

Ovarian cancer (OC) is the most lethal gynecol. malignancy. Frequent peritoneal dissemination is the main cause of low survival rate. Guizhi-Fuling formula (GZFL) is a classical traditional Chinese herbal formula, and has been clin. used for treating ovarian cancer with good outcome. However, its therapeutic mechanism for treating OC has not been clearly elucidated. Network pharmacol. anal. was used to predict potential mol. mechanisms of GZFL in treating OC. In vitro and in vivo anal., including STAT3 KO/WT cells proliferation assay, scratch assay and antitumor efficacy study were performed to assess the biol. activity of GZFL on targeting STAT3 in OC cells. We generated a “”GZFL target – OC – STAT3″” gene interaction network, and predicted that GZFL is tightly associated with IL6/JAK/STAT3 signal pathway and cancer metastasis. Our preliminary data showed that GZFL inhibited OC cell proliferation in a STAT3 dependent manner. It suppressed cell migration and downregulated p-STAT3 expression. In a tumor bearing mouse model, GZFL displayed a safety profile. GZFL inhibits OC progression by targeting STAT3 signaling network. Our newly proposed pharmacol. mechanisms of Guizhi-Fuling formula will provide a new insight for its clin. use in treating OC.

TMR Modern Herbal Medicine published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics