Category: 112-63-0

Campbell, Craig D.; Duguet, Nicolas; Gallagher, Katherine A.; Thomson, Jennifer E.; Lindsay, Anita G.; O’Donoghue, AnnMarie C.; Smith, Andrew D. published the artcile< Tandem multi-step synthesis of C-carboxyazlactones promoted by N-heterocyclic carbenes>, HPLC of Formula: 112-63-0, the main research area is azlactone phenoxycarbonyl preparation; oxazolinone phenoxycarbonyl preparation; amino acid anisoyl tandem cyclization coupling chloroformate carboxyl transfer; carbene heterocyclic catalyst amino acid cascade coupling chloroformate.

Cascade reaction sequences incorporating N-heterocyclic carbene-based organocatalysis have been developed that allow the direct preparation of a range of (±)-4-phenoxycarbonylazlactones I (R1 = 4-MeOC6H4; R2 = Me, n-Bu, i-Bu, PhCH2, 4-PhCH2OC6H4CH2) in good isolated yields (66-84%) from the corresponding racemic N-p-anisoyl amino acids II.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amino acids, acyl Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Mingming; Wang, Chenliang; Zhou, Mi; Bao, Lei; Wang, Yanan; Kumar, Ashwani; Xing, Chao; Luo, Weibo; Wang, Yingfei published the artcile< KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response.>, Electric Literature of 112-63-0, the main research area is .

Poly(ADP-ribose) polymerase-1 (PARP-1) is a DNA damage sensor and contributes to both DNA repair and cell death processes. However, how PARP-1 signaling is regulated to switch its function from DNA repair to cell death remains largely unknown. Here, we found that PARP-1 plays a central role in alkylating agent-induced PARthanatic cancer cell death. Lysine demethylase 6B (KDM6B) was identified as a key regulator of PARthanatos. Loss of KDM6B protein or its demethylase activity conferred cancer cell resistance to PARthanatic cell death in response to alkylating agents. Mechanistically, KDM6B knockout suppressed methylation at the promoter of O6-methylguanine-DNA methyltransferase (MGMT) to enhance MGMT expression and its direct DNA repair function, thereby inhibiting DNA damage-evoked PARP-1 hyperactivation and subsequent cell death. Moreover, KDM6B knockout triggered sustained Chk1 phosphorylation and activated a second XRCC1-dependent repair machinery to fix DNA damage evading from MGMT repair. Inhibition of MGMT or checkpoint response re-sensitized KDM6B deficient cells to PARthanatos induced by alkylating agents. These findings provide new molecular insights into epigenetic regulation of PARP-1 signaling mediating DNA repair or cell death and identify KDM6B as a biomarker for prediction of cancer cell vulnerability to alkylating agent treatment.

Nucleic acids research published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Geraghty, Benjamin J.; Dasgupta, Archya; Sandhu, Michael; Malik, Nauman; Maralani, Pejman Jabehdar; Detsky, Jay; Tseng, Chia-Lin; Soliman, Hany; Myrehaug, Sten; Husain, Zain; Perry, James; Lau, Angus; Sahgal, Arjun; Czarnota, Gregory J. published the artcile< Predicting survival in patients with glioblastoma using MRI radiomic features extracted from radiation planning volumes>, Computed Properties of 112-63-0, the main research area is glioblastoma MRI radiomic survival patient radiation planning volume; Glioblastoma multiforme (GBM); Magnetic resonance imaging (MRI); Radiomics; Radiotherapy.

Quant. image anal. using pre-operative magnetic resonance imaging (MRI) has been able to predict survival in patients with glioblastoma (GBM). The study explored the role of postoperative radiation (RT) planning MRI-based radiomics to predict the outcomes, with features extracted from the gross tumor volume (GTV) and clin. target volume (CTV). Patients with IDH-wildtype GBM treated with adjuvant RT having MRI as a part of RT planning process were included in the study. 546 features were extracted from each GTV and CTV. A LASSO Cox model was applied, and internal validation was performed using leave-one-out cross-validation with overall survival as endpoint. Cross-validated time-dependent area under curve (AUC) was constructed to test the efficacy of the radiomics model, and clin. features were used to generate a combined model. Anal. was done for the entire group and in individual surgical groups-gross total excision (GTR), subtotal resection (STR), and biopsy. 235 Patients were included in the study with 57, 118, and 60 in the GTR, STR, and biopsy subgroup, resp. Using the radiomics model, binary risk groups were feasible in the entire cohort (p < 0.01) and biopsy group (p = 0.04), but not in the other two surgical groups individually. The integrated AUC (iAUC) was 0.613 for radiomics-based classification in the biopsy subgroup, which improved to 0.632 with the inclusion of clin. features. Imaging features extracted from the GTV and CTV regions can lead to risk-stratification of GBM undergoing biopsy, while the utility in other individual subgroups needs to be further explored. Journal of Neuro-Oncology published new progress about Biomarkers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Hanwen; Lai, Wei-Hong; Yang, Qiuran; Lei, Yaojie; Wu, Can; Wang, Nana; Wang, Yun-Xiao; Chou, Shu-Lei; Liu, Hua Kun; Dou, Shi Xue published the artcile< Understanding sulfur redox mechanisms in different electrolytes for room-temperature Na-S batteries>, COA of Formula: C19H34O2, the main research area is carbonate ester ether sodium sulfur battery diffusion property; Carbonate ester electrolyte; Ether electrolyte; Room-temperature sodium–sulfur batteries; Sulfur cathode; Sulfur redox reactions.

This work reports influence of two different electrolytes, carbonate ester and ether electrolytes, on the sulfur redox reactions in room-temperature Na-S batteries. Two sulfur cathodes with different S loading ratio and status are investigated. A sulfur-rich composite with most sulfur dispersed on the surface of a carbon host can realize a high loading ratio (72% S). In contrast, a confined sulfur sample can encapsulate S into the pores of the carbon host with a low loading ratio (44% S). In carbonate ester electrolyte, only the sulfur trapped in porous structures is active via ‘solid-solid’ behavior during cycling. The S cathode with high surface sulfur shows poor reversible capacity because of the severe side reactions between the surface polysulfides and the carbonate ester solvents. To improve the capacity of the sulfurrich cathode, ether electrolyte with NaNO3 additive is explored to realize a ‘solid-liquid’ sulfur redox process and confine the shuttle effect of the dissolved polysulfides. As a result, the sulfur-rich cathode achieved high reversible capacity (483 mAh g-1), corresponding to a specific energy of 362 Wh kg-1 after 200 cycles, shedding light on the use of ether electrolyte for high-loading sulfur cathode.

Nano-Micro Letters published new progress about Binding energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Hua; Wang, Guibin published the artcile< PyHBr3/TBN/H2O as catalytic system for the oxidation of sulfides to sulfoxides with air as the oxidant>, Electric Literature of 112-63-0, the main research area is sulfide air oxidation pyridinium bromide perbromide tertbutyl nitrite catalyst; sulfoxide preparation.

Pyridinium bromide perbromide (PyHBr3) and tert-Bu nitrite (TBN) catalytic system was used for the oxidation of sulfides with air as the oxidant. Under mild conditions (at room temperature), a series of sulfide substrates were oxidized to their corresponding sulfoxides with high conversion rate. To the best of our knowledge, for the first time, the PyHBr3/TBN/H2O is reported as exceptional catalyst system for the oxidation discussed in this Letter.

Tetrahedron Letters published new progress about Air. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Ying; Belt, Katharina; Alqahtani, Saad F.; Saha, Saurabh; Fenske, Ricarda; Van Aken, Olivier; Whelan, James; Millar, A. Harvey; Murcha, Monika W.; Huang, Shaobai published the artcile< The mitochondrial LYR protein SDHAF1 is required for succinate dehydrogenase activity in Arabidopsis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Arabidopsis mitochondrial LYR protein succinate dehydrogenase activity; assembly factors; complex II; iron-sulfur cluster insertion; mitochondrial metabolism; succinate dehydrogenase.

Succinate dehydrogenase (SDH, complex II), which plays an essential role in mitochondrial respiration and tricarboxylic acid metabolism, requires the assembly of eight nuclear-encoded subunits and the insertion of various cofactors. Here, we report on the characterization of an Arabidopsis thaliana leucine-tyrosine-arginine (LYR) protein family member SDHAF1, (At2g39725) is a factor required for SDH activity. SDHAF1 is located in mitochondria and can fully complement the yeast SDHAF1 deletion strain. Knockdown of SDHAF1 using RNA interference resulted in a decrease in seedling hypocotyl elongation and reduced SDH activity. Proteomic analyses revealed a decreased abundance of various SDH subunits and assembly factors. Protein interaction assays revealed that SDHAF1 can interact exclusively with the Fe-S cluster-containing subunit SDH2 and HSCB, a cochaperone involved in Fe-S cluster complex recruitment. Therefore, we propose that in Arabidopsis, SDHAF1 plays a role in the biogenesis of SDH2 to form the functional complex II, which is essential for mitochondrial respiration and metabolism

Plant Journal published new progress about Arabidopsis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Claveau, Romain; Twamley, Brendan; Connon, Stephen J. published the artcile< Dynamic kinetic resolution of bis-aryl succinic anhydrides: enantioselective synthesis of densely functionalised γ-butyrolactones>, Product Details of C19H34O2, the main research area is butyrolactone enantioselective preparation; bisarylsuccinic anhydride preparation arylaldehyde dynamic kinetic resolution organocatalyst.

The efficient Dynamic Kinetic Resolution (DKR) of disubstituted anhydrides has been shown to be possible for the first time. Using an ad hoc designed organocatalyst and an enantio- and diastereoselective cycloaddition process with aldehydes, stereochem. complex γ-butyrolactone derivatives can be obtained – with control over three contiguous stereocentres, one of which is all carbon quaternary.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peerzada, Zoya; Kanhed, Ashish M.; Desai, Krutika B. published the artcile< Effects of active compounds from Cassia fistula on quorum sensing mediated virulence and biofilm formation in Pseudomonas aeruginosa>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Cassia fruit phytoconstituent quorum sensing biofilm formation antimicrobial Pseudomonas.

Pseudomonas aeruginosa infections are attributed to its ability to form biofilms and are difficult to eliminate with antibiotic treatment. Biofilm formation is regulated by quorum sensing (QS), an intracellular bacterial communication mechanism that allows the activation of numerous virulence factors and secondary metabolites. Targeting the QS pathway is a potential approach that prevents QS-controlled phenotypes and biofilm formation. For the first time, the current work has identified antiquorum sensing activity in the partially purified four fractions from the hot Et acetate extract of Cassia fistula fruit pods. Of the four fractions, only fraction-1 gave decreased AHL activity; the phytoconstituents in this fraction were identified as rhein, 3-aminodibenzofuran, 5-(hydroxymethyl)-2-(dimethoxymethyl)furan, and dihydrorhodamine. Fraction-1 (1 mg ml-1) and rhein (0.15 mg ml-1) showed 63% and 42.7% reduction in short-chain AHL production, resp., without hindering the bacterial growth. Fraction-1 inhibited QS-mediated extracellular virulence factors viz. protease, elastase, pyocyanin, and rhamnolipid (p < 0.05). Quant. anal. of biofilm formation showed 77% & 62.4% reduction by fraction-1 (1 mg ml-1) and rhein (0.15 mg ml-1) resp. Confocal laser microscopy (CLMS) & SEM (SEM) confirmed the reduction of biofilm formation in Pseudomonas aeruginosa upon treatment with fraction-1 and rhein. Moreover, the in vivo study displayed that fraction-1 and rhein (standard) significantly enhanced the survival of Caenorhabditis elegans by suppressing the potency of virulence factors of Pseudomonas aeruginosa. Quant. real-time polymerase chain reaction results demonstrated the down-regulation of QS-related genes, lasI, lasR, rhlI, and rhlR. In addition, in silico anal. divulged that a component identified by GC-MS displayed a strong affinity towards LasI and LasR. These findings suggest that potent phytochems. from fraction-1, including rhein, could serve as novel phytotherapeutics in controlling emerging infections of antibiotic-resistant bacterial pathogens like Pseudomonas aeruginosa. RSC Advances published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schroeder, Chad E.; Yao, Tuanli; Sotsky, Julie; Smith, Robert A.; Roy, Sudeshna; Chu, Yong-Kyu; Guo, Haixun; Tower, Nichole A.; Noah, James W.; McKellip, Sara; Sosa, Melinda; Rasmussen, Lynn; Smith, Layton H.; White, E. Lucile; Aube, Jeffrey; Jonsson, Colleen B.; Chung, Donghoon; Golden, Jennifer E. published the artcile< Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus>, Electric Literature of 112-63-0, the main research area is amidinophenylbenzamide preparation venezuelan equine encephalitis virus inhibitor antiviral.

Venezuelan equine encephalitis virus (VEEV) is an emerging pathogenic alphavirus that can cause significant disease in humans. Given the absence of therapeutic options available and the significance of VEEV as a weaponized agent, an optimization effort was initiated around a quinazolinone screening hit with promising cellular antiviral activity (EC50 = 0.8 μM), limited cytotoxic liability (CC50 > 50 μM), and modest in vitro efficacy in reducing viral progeny (63-fold at 5 μM). Scaffold optimization revealed a novel rearrangement affording amidines, specifically compound I, which was found to potently inhibit several VEEV strains in the low nanomolar range without cytotoxicity (EC50 = 0.02-0.04 μM, CC50 > 50 μM) while limiting in vitro viral replication (EC90 = 0.17 μM). Brain exposure was observed in mice with I. Significant protection was observed in VEEV-infected mice at 5 mg kg-1 day-1 and viral replication appeared to be inhibited through interference of viral nonstructural proteins.

Journal of Medicinal Chemistry published new progress about Amidines Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Guangming; Ren, Hongyu; Zhang, Nanjing; Lennox, William; Turpoff, Anthony; Paget, Steven; Li, Chunshi; Almstead, Neil; Njoroge, F. George; Gu, Zhengxian; Graci, Jason; Jung, Stephen P.; Colacino, Joseph; Lahser, Fred; Zhao, Xin; Weetall, Marla; Nomeir, Amin; Karp, Gary M. published the artcile< 6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B>, Application In Synthesis of 112-63-0, the main research area is azaindolylpyridinesulfonamide preparation antiviral hepatitis virus pharmacokinetics; 6-(Azaindol-2-yl)pyridine-3-sulfonamides; HCV inhibitors; NS4B; Replicon; Structure–activity relationship.

A structure-activity relationship investigation of various 6-(azaindol-2-yl)pyridine-3-sulfonamides using the HCV replicon cell culture assay led to the identification of a potent series of 7-azaindoles that target the hepatitis C virus NS4B. Compound I, identified via further optimization of the series, has excellent potency against the HCV 1b replicon with an EC50 of 2 nM and a selectivity index of >5000 with respect to cellular GAPDH RNA. Compound I also has excellent oral plasma exposure levels in rats, dogs and monkeys and has a favorable liver to plasma distribution profile in rats.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics