Category: 112-63-0

Hao, Lin; Chuen, Chan Wei; Ganguly, Rakesh; Chi, Yonggui Robin published the artcile< NHC-catalyzed ester activation: access to sterically congested spirocyclic oxindoles via reaction of α-aryl esters and unsaturated imines>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is spirocyclic oxindole preparation; aryl ester imine heterocyclic carbene.

Carboxylic esters can be readily obtained at low cost. Therefore, asym. catalytic activation of esters should provide useful strategies for organic synthesis. Here we report a N-heterocyclic carbene (NHC)-mediated reaction of α-aryl acetic esters with oxindole-derived α,β-unsaturated imines. The reaction involves the formation of NHC-bound ester enolate intermediate from an ester as a key step, and furnishes spirocyclic oxindole products. The sterically congested spirocyclic oxindole e. g., I, bears a newly formed six-membered δ-lactams and cannot be easily prepared using other methods.

Synlett published new progress about Aromatic esters Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adauto, Anais; Khan, Sabir; Augusto da Silva, Matheus; Gomes Neto, Jose Anchieta; Picasso, Gino; Sotomayor, Maria del Pilar Taboada published the artcile< Synthesis, characterization and application of a novel ion hybrid imprinted polymer to adsorb Cd(II) in different samples>, SDS of cas: 112-63-0, the main research area is ion imprinted polymer cadmium adsorption kinetics river water; Atomic absorption spectroscopy; Cadmium (II) adsorption; Hybrid materials; Ion imprinted polymer; Polymers.

Two new ionic imprinted hybrid polymers (IIHP) and their corresponding non imprinted hybrid polymers (NIHP) were synthesized. The prepared IIHP was highly selective to Cd2+. To prepare the IIHP, 1-vinylimidazole (VIN) was used as the functional monomer, (3-mercaptopropyl) trimethoxysilane (MP) or (3-aminopropyl) trimethoxysilane (AMP) was used as the functional organosilane, trimethylolpropane (TRIM) was used as the crosslinking agent, AIBN was used as a radical initiator and TEOS was used as a functional precursor. The functional monomer was selected considering calculations based on the d. functional theory (DFT). The fabricated materials were characterized via field emission gun SEM (FEG-SEM), Fourier transform IR spectroscopy (FTIR), energy dispersive X-ray spectroscopy (EDX) and thermogravimetric anal. (TGA). The maximum adsorption capacity of Cd2+ was achieved at a pH of 7.2 in the tris-HCl medium. The adsorption test indicated that the reaction followed pseudo second order kinetics, and the equilibrium sorption data fitted well into the Langmuir isotherm model. The relative selectivity coefficients of polymers IIHP-VIN-AMP and IIHP-VIN-MP, as evaluated in binary mixtures of Cd2+ and interferent cations (Pb2+, Zn2+, Hg2+, Cu2+, Ni2+, Ca2+, Mg2+, and Na+) at different molar ratios, were greater than one due to the presence of specific recognition sites for Cd2+ ions. Moreover, the selective materials exhibited a high reusability and reproducibility in the context of Cd2+ adsorption. These adsorbent materials, specifically IIHP-VIN-MP, exhibited a % removal efficiency of more than 90% for the Cd2+ in river water samples.

Environmental Research published new progress about Adsorbents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kothe, Vinicius; Melfi, Diego Trevisan; dos Santos, Kallynca Carvalho; Corazza, Marcos Lucio; Ramos, Luiz Pereira published the artcile< Thermodynamic analysis, experimental and kinetic modeling of levulinic acid esterification with ethanol at supercritical conditions>, Quality Control of 112-63-0, the main research area is levulinic acid esterification ethanol thermodn kinetic model.

Et levulinate is an environmentally friendly biomass-derived ester that is an alternative to the classic petroleum-derived fuel additives. Several studies have been addressed to its chem. production pathways. The supercritical esterification of levulinic acid to Et levulinate, however, remains understudied. This work reports the effect of process variables and a kinetic study for the esterification of levulinic acid with ethanol under sub and supercritical conditions. Exptl. data were obtained in a continuous tubular reactor at a fixed pressure of 100 bar. The reaction temperature varied from 220 to 280 °C, and the ethanol to levulinic acid molar ratios from (2:1) to (9:1). Et levulinate was synthesized with high selectivity under all evaluated reaction conditions, achieving conversions up to 80% and 93% when ethanol to levulinic acid molar ratios of (2:1) and (9:1) were used, resp. A PFR model approach was considered with an elementary reversible self-catalyzed rate law, and the effect of considering the mixture d. behavior through the reactor using the PC-SAFT equation of state was discussed. The proposed kinetic approach was able to correlate the kinetic exptl. data for all exptl. conditions used in this study. Furthermore, a thermodn. anal. was performed to elucidate trends in reaction performance.

Fuel published new progress about Density. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chmielewski, Piotr J.; Latos-Grazynski, Lechoslaw published the artcile< EPR and 2H NMR studies on the oxidation of nickel(II) tetraphenylcarbaporphyrin to form novel organometallic Ni(III) complexes>, Synthetic Route of 112-63-0, the main research area is EPR oxidation nickel 2 tetraphenylcarbaporphyrin complex; NMR oxidation nickel 2 tetraphenylcarbaporphyrin complex; electrochem oxidation nickel 2 tetraphenylcarbaporphyrin complex.

One-electron oxidation of nickel(II) 5,10,15,20-tetraaryl-2-aza-21-carbaporphyrin ((CTPP)NiII) and nickel(II) 2-methyl-5,10,15,20-tetraaryl-2-aza-21-carbaporphyrin ((MeCTPP)NiII) gave rare organonickel(III) derivatives The half-wave potential for the 1st oxidation of (CTPP)NiII and (MeCTPP)NiII is 0.66 V and 0.72 V, resp. (vs. SCE, CH2Cl2 solution, TBAP). The EPR spectral patterns of the 1-electron-oxidized species were determined at 293 and 77 K. In both temperatures the spectral parameters markedly depend on the axial ligand introduced by oxidants or in metathesis. In each case the spin-Hamiltonian parameters (gav > 2.1 (77 K) or giso > 2.1 (293 K)) reveal a metal-centered oxidation rather than a cation radical formation (giso ≈ 2.002). The localization of the 1-electron oxidation on the nickel ion was supported by the observation of 61Ni hyperfine splitting. The 2H NMR studies, carried out for pyrrole deuterated derivatives: (CTPP-d7)NiIIIBr, (CTPP-d7)NiIII(NO3), and (MeCTPP-d3)NiIIIOH, confirmed independently by the nickel(III) electronic structure.

Inorganic Chemistry published new progress about Electrochemical oxidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Das, Srabani; Ghosal, Pradyot K.; Ray, Bimalendu published the artcile< Structural studies of a polysaccharide from the seeds of Salmalia malabarica>, Related Products of 112-63-0, the main research area is Salmalia seed polysaccharide.

The polysaccharides isolated from the defatted seeds of Salmalia malabarica (Bombacaceae) were fractionated into Fractions I (48%), II (30%), III (14%), and IV (8%) using a column of Sephadex G-100 in pyridine-acetate buffer. The principal polysaccharide fraction, Fraction I (carbohydrate content 98%), was found to be electrophoretically homogeneous. Hydrolysis (M sulfuric acid, 16 h, 100°) of Fraction I revealed galactose and arabinose by paper chromatog. in a relative ratio of 7:3 as determined by gas-liquid chromatog. of their alditol acetates using myo-inositol as the internal standard The configuration of the galactose and arabinose were determined as D and L, resp., from their optical rotation measurements. Complete methylation of Fraction I by the Hakomori method (1964) and hydrolysis of the methylated polysaccharide yielded 2,3,5-tri-O-methyl-L-arabinofuranose (4.1 mol. equivalent), 2,3,4-tri-O-methyl-L-arabinopyranose (11 mol. equivalent), 2,3,4,6-tetra-O-methyl-D-galactose (0.85 mol. equivalent), 2,3,6-tri-O-methyl-D-galactopyranose (10.8 mol. equivalent), 2,4,6-tri-O-methyl-D-galactopyranose (2.2 mol. equivalent), 3,6-di-O-methyl-D-galactose (12.4 mol. equivalent), and 3,4-di-O-methyl-D-galactose (7.0 mol. equivalent). These products reveal that both L-arabinopyranose and L-arabinofuranose are present at the nonreducing ends. A small number of the nonreducing termini are occupied by D-galactose. Appearance of a large molar proportion of the tri-O-Me pentoses shows that the polysaccharide is highly branched. The major portion of the interior part consists of D-galactose residues linked (1→2,6) and (1→2,4). A portion of the chain was made by D-galactose linked principally (1→4). There was a small portion of D-galactose residues linked (1→3). The polysaccharide Fraction I consumed about 0.9 mol. equivalent of periodate per mol of hexosyl residue as was monitored spectrophotometrically. Only D-galactose was detected in the paper chromatogram when the periodate-oxidized, borohydride-reduced material was hydrolyzed with sulfuric acid (0.5 M). This observation was in fair agreement with the linkage pattern as suggested from the methylation anal.

Carbohydrate Research published new progress about Bombax ceiba. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Varn, Frederick S.; Johnson, Kevin C.; Martinek, Jan; Huse, Jason T.; Nasrallah, MacLean P.; Wesseling, Pieter; Cooper, Lee A. D.; Malta, Tathiane M.; Wade, Taylor E.; Sabedot, Thais S.; Brat, Daniel; Gould, Peter V.; Woehrer, Adelheid; Aldape, Kenneth; Ismail, Azzam; Sivajothi, Santhosh K.; Barthel, Floris P.; Kim, Hoon; Kocakavuk, Emre; Ahmed, Nazia; White, Kieron; Datta, Indrani; Moon, Hyo-Eun; Pollock, Steven; Goldfarb, Christine; Lee, Ga-Hyun; Garofano, Luciano; Anderson, Kevin J.; Nehar-Belaid, Djamel; Barnholtz-Sloan, Jill S.; Bakas, Spyridon; Byrne, Annette T.; D’Angelo, Fulvio; Gan, Hui K.; Khasraw, Mustafa; Migliozzi, Simona; Ormond, D. Ryan; Paek, Sun Ha; Van Meir, Erwin G.; Walenkamp, Annemiek M. E.; Watts, Colin; Weiss, Tobias; Weller, Michael; Palucka, Karolina; Stead, Lucy F.; Poisson, Laila M.; Noushmehr, Houtan; Iavarone, Antonio; Verhaak, Roel G. W. published the artcile< Glioma progression is shaped by genetic evolution and microenvironment interactions>, Category: esters-buliding-blocks, the main research area is transcriptome CDKN2A IDH mutation neoplastic signaling prognosis glioma; genomics; glioblastoma; glioma; hypermutation; macrophages; microenvironment; neurons; single-cell; spatial imaging; treatment resistance.

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and attributable to changes in histol. feature composition, somatic alterations, and microenvironment interactions. Hypermutation and acquired CDKN2A deletions were associated with an increase in proliferating neoplastic cells at recurrence in both glioma subtypes, reflecting active tumor growth. IDH-wild-type tumors were more invasive at recurrence, and their neoplastic cells exhibited increased expression of neuronal signaling programs that reflected a possible role for neuronal interactions in promoting glioma progression. Mesenchymal transition was associated with the presence of a myeloid cell state defined by specific ligand-receptor interactions with neoplastic cells. Collectively, these recurrence-associated phenotypes represent potential targets to alter disease progression.

Cell (Cambridge, MA, United States) published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (CCND2). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

van Rijssel, Erwin R.; Goumans, Theodorus P. M.; Lodder, Gerrit; Overkleeft, Herman S.; van der Marel, Gijsbert A.; Codee, Jeroen D. C. published the artcile< Chiral Pyrroline-Based Ugi-Three-Component Reactions Are under Kinetic Control>, Application of C19H34O2, the main research area is chiral pyrroline Ugi kinetic control.

Although it is often assumed that the stereochem. in Ugi multicomponent reactions is determined in the final Mumm rearrangement step, exptl. and computational evidence that Ugi reactions on hydroxylated pyrrolines proceed under kinetic control is reported. The stereochem. of the reaction is established with the addition of the isocyanide to the intermediate iminium ion, whose conformation is determined by its substitution pattern.

Organic Letters published new progress about Addition reaction, stereoselective (isocyanide). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ried, Walter; Stahlhofen, Paul published the artcile< Heterocyclic seven-membered ring systems. VII. The course of the reaction between ο-phenylenediamine and alkylidenepyruvic acids>, Category: esters-buliding-blocks, the main research area is .

The product from the condensation of ο-C6H4(NH2)2 (I) and PhCH:CHCOCO2H (II) is 2-hydroxy-3-styrylquinoxaline (III) and not 7-phenyl-2,3-benzo-1,4-diazacyclohepta-2,7-dien-5-one (IV) which is excluded since III was also obtained from I and II Me ester when the presence of O was carefully avoided. IV was obtained from I and BzCH2CO2Et (V). Analogs of III were also prepared I (2.1 g.) in 20 cc. alc. treated at 40-50° with an equimolar amount of RCH:CHCOCO2H gave 3-alkylidenemethyl-2-hydroxyquinoxalines (R, % yield, m.p., and crystallization solvent given): Ph (III), 57, 256°, dioxane; p-MeOC6H4, 61, 257°, dioxane; 2-furyl, 76, 262°, xylene; 3,4-(CH2O2)C6H3, 59, 300°, dioxane. 2-Hydroxy-3-methylquinoxaline (3.2 g.), 75 cc. xylene, 2.1 g. BzH, and 5-10 drops piperidine refluxed 5 hrs., 30 cc. solvent distilled, and the residue let stand several days precipitated III. III (1 g.) in 800 cc. EtOAc hydrogenated over Raney Ni, filtered, the EtOAc distilled, the oil in HOAc treated dropwise with a saturated aqueous solution of 2 g. NaNO2, kept 2 hrs., and filtered gave 1,4-dinitroso-2-hydroxy-3-(β-phenylethyl)-1,2,3,4-tetrahydroquinoxaline, m. 131° (decomposition) (alc. H2O). V (12.8 g.) in 50 cc. xylene added dropwise during 0.5 hr. to a boiling solution of 7.2 g. I in 50 cc. xylene, 30 cc. solvent distilled during 0.5 hr., and the mixture cooled gave 11 g. IV, m. 206° (dioxane); picrate, m. 168° (alc.). IV (3.3 g.) in 300 cc. EtOAc hydrogenated over Raney Ni and the filtered solution concentrated to 20 cc. gave 7-phenyl-2,3-benzo-1,4-diazacyclohept-2-en-5-one (VI), m. 167° (EtOAc); 1-NO derivative, m. 181° (decomposition) (MeOH). Similarly prepared were the 7-(2-furyl) analog of IV, m. 250° (dioxane) [pic-rate, m. 195° (decomposition) (alc.)], and the 7-(2-furyl) analog of VI, m. 169° (C6H6).

Chemische Berichte published new progress about Heterocyclic compounds, oxygen. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Rodrigues-Junior, Dorival Mendes; Liu, Sijia; Webb, Anna Taylor; Gomez-Puerto, Maria Catalina; ten Dijke, Peter; Heldin, Carl-Henrik; Moustakas, Aristidis published the artcile< The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma>, Application of C19H34O2, the main research area is protein kinase LKB1 self renewal invasiveness glioblastoma; LKB1; cancer stem cells; glioblastoma; invasion; metformin.

The role of liver kinase B1 (LKB1) in glioblastoma (GBM) development remains poorly understood. LKB1 may regulate GBM cell metabolism and has been suggested to promote glioma invasiveness. After analyzing LKB1 expression in GBM patient mRNA databases and in tumor tissue via multiparametric immunohistochem., we observed that LKB1 was localized and enriched in GBM tumor cells that co-expressed SOX2 and NESTIN stemness markers. Thus, LKB1-specific immunohistochem. can potentially reveal subpopulations of stem-like cells, advancing GBM patient mol. pathol. We further analyzed the functions of LKB1 in patient-derived GBM cultures under defined serum-free conditions. Silencing of endogenous LKB1 impaired 3D-gliomasphere frequency and promoted GBM cell invasion in vitro and in the zebrafish collagenous tail after extravasation of circulating GBM cells. Moreover, loss of LKB1 function revealed mitochondrial dysfunction resulting in decreased ATP levels. Treatment with the clin. used drug metformin impaired 3D-gliomasphere formation and enhanced cytotoxicity induced by temozolomide, the primary chemotherapeutic drug against GBM. The IC50 of temozolomide in the GBM cultures was significantly decreased in the presence of metformin. This combinatorial effect was further enhanced after LKB1 silencing, which at least partially, was due to increased apoptosis. The expression of genes involved in the maintenance of tumor stemness, such as growth factors and their receptors, including members of the platelet-derived growth factor (PDGF) family, was suppressed after LKB1 silencing. The defect in gliomasphere growth caused by LKB1 silencing was bypassed after supplementing the cells with exogenous PFDGF-BB. Our data support the parallel roles of LKB1 in maintaining mitochondrial homeostasis, 3D-gliomasphere survival, and hindering migration in GBM. Thus, the natural loss of, or pharmacol. interference with LKB1 function, may be associated with benefits in patient survival but could result in tumor spread.

Journal of Cellular Physiology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Russo, Vincenzo; Rossano, Carmelina; Salucci, Emiliano; Tesser, Riccardo; Salmi, Tapio; Di Serio, Martino published the artcile< Intraparticle diffusion model to determine the intrinsic kinetics of ethyl levulinate synthesis promoted by Amberlyst-15>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Levulinic acid esterification kinetics Amberlyst catalyst intraparticle diffusion model.

Levulinic acid and its esters are considered very versatile chem. compounds used for a wide range of derivatives Traditionally Et levulinate is synthesized in batch reactors, using homogeneous catalysts (H2SO4, H3PO4). Several investigations were reported on solid acid catalysts, as zeolites, sulfated oxides, sulfonic ion-exchange resins. Amberlyst-15 showed high potentials: to design a continuous reactor, it is necessary to investigate the stability of the catalyst and the kinetics of the reaction. In the present work, we demonstrated that the resin is stable for more than 5 days. Kinetic and mass transfer phenomena were studied, evaluating the partition and take-up of the used resin when put in contact with reactants and products. Two different samples of Amberlyst-15 were used, characterized by different size, demonstrating that bigger particles lead to higher intraparticle diffusion limitations.

Chemical Engineering Science published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics