Category: 112-63-0

Zhang, Hua; Wang, Guibin published the artcile< PyHBr3/TBN/H2O as catalytic system for the oxidation of sulfides to sulfoxides with air as the oxidant>, Electric Literature of 112-63-0, the main research area is sulfide air oxidation pyridinium bromide perbromide tertbutyl nitrite catalyst; sulfoxide preparation.

Pyridinium bromide perbromide (PyHBr3) and tert-Bu nitrite (TBN) catalytic system was used for the oxidation of sulfides with air as the oxidant. Under mild conditions (at room temperature), a series of sulfide substrates were oxidized to their corresponding sulfoxides with high conversion rate. To the best of our knowledge, for the first time, the PyHBr3/TBN/H2O is reported as exceptional catalyst system for the oxidation discussed in this Letter.

Tetrahedron Letters published new progress about Air. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ait Belale, Rachid; M’hamdi Alaoui, Fatima Ezzahrae; Chhiti, Younes; Sahibeddine, Abdelaziz; Munoz Rujas, Natalia; Aguilar, Fernando published the artcile< Study on the thermophysical properties of waste cooking oil biodiesel fuel blends with 1-butanol>, COA of Formula: C19H34O2, the main research area is waste cooking oil biodiesel fuel blend butanol thermophys property.

An Anton Paar vibrating tube densimeter HPM DMA calibrated with an uncertainty of ±0.7 kg·m-3 has been used for accurate measurements of liquid densities of waste cooking oil biodiesel (WCOB) and 1-butanol as pure fluids and binary liquid mixtures The densities measurements were performed at temperatures (298.15 K to 393.15 K) and pressures (0.1 MPa to 140 MPa) and showing an absolute deviation of less than 0.007 g/cm-3 compared to the literature data. Using these new exptl. data (908 points), excess molar volumes VE, isobaric thermal expansivity, αp, and isothermal compressibility, κT, have been calculated The Tait and PC-SAFT equations correlate successfully the densities with a small absolute average deviation (AAD), the PC-SAFT model performs very well in all concentration range with a global absolute average deviation (AAD) of 0.325% and for Tait equation a global absolute average deviation of 0.086% for each concentration PC-SAFT equation correlates satisfactorily the d. and shows that it can explain the same interactions between fluid mols. contrary to the Tait equation. Excess volumes values were calculated from the exptl. data and show a pos. parabolic shape in all composition range almost sym. in the fraction molar 0.5. Furthermore, VE values were fitted to the Redlich-Kister equation and showed satisfactory correlation with very small standard deviation values with a global of 4.23·10-5 cm3·mol-1.

Fuel published new progress about Binary mixtures, liquid. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Ying; Belt, Katharina; Alqahtani, Saad F.; Saha, Saurabh; Fenske, Ricarda; Van Aken, Olivier; Whelan, James; Millar, A. Harvey; Murcha, Monika W.; Huang, Shaobai published the artcile< The mitochondrial LYR protein SDHAF1 is required for succinate dehydrogenase activity in Arabidopsis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Arabidopsis mitochondrial LYR protein succinate dehydrogenase activity; assembly factors; complex II; iron-sulfur cluster insertion; mitochondrial metabolism; succinate dehydrogenase.

Succinate dehydrogenase (SDH, complex II), which plays an essential role in mitochondrial respiration and tricarboxylic acid metabolism, requires the assembly of eight nuclear-encoded subunits and the insertion of various cofactors. Here, we report on the characterization of an Arabidopsis thaliana leucine-tyrosine-arginine (LYR) protein family member SDHAF1, (At2g39725) is a factor required for SDH activity. SDHAF1 is located in mitochondria and can fully complement the yeast SDHAF1 deletion strain. Knockdown of SDHAF1 using RNA interference resulted in a decrease in seedling hypocotyl elongation and reduced SDH activity. Proteomic analyses revealed a decreased abundance of various SDH subunits and assembly factors. Protein interaction assays revealed that SDHAF1 can interact exclusively with the Fe-S cluster-containing subunit SDH2 and HSCB, a cochaperone involved in Fe-S cluster complex recruitment. Therefore, we propose that in Arabidopsis, SDHAF1 plays a role in the biogenesis of SDH2 to form the functional complex II, which is essential for mitochondrial respiration and metabolism

Plant Journal published new progress about Arabidopsis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Claveau, Romain; Twamley, Brendan; Connon, Stephen J. published the artcile< Dynamic kinetic resolution of bis-aryl succinic anhydrides: enantioselective synthesis of densely functionalised γ-butyrolactones>, Product Details of C19H34O2, the main research area is butyrolactone enantioselective preparation; bisarylsuccinic anhydride preparation arylaldehyde dynamic kinetic resolution organocatalyst.

The efficient Dynamic Kinetic Resolution (DKR) of disubstituted anhydrides has been shown to be possible for the first time. Using an ad hoc designed organocatalyst and an enantio- and diastereoselective cycloaddition process with aldehydes, stereochem. complex γ-butyrolactone derivatives can be obtained – with control over three contiguous stereocentres, one of which is all carbon quaternary.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peerzada, Zoya; Kanhed, Ashish M.; Desai, Krutika B. published the artcile< Effects of active compounds from Cassia fistula on quorum sensing mediated virulence and biofilm formation in Pseudomonas aeruginosa>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Cassia fruit phytoconstituent quorum sensing biofilm formation antimicrobial Pseudomonas.

Pseudomonas aeruginosa infections are attributed to its ability to form biofilms and are difficult to eliminate with antibiotic treatment. Biofilm formation is regulated by quorum sensing (QS), an intracellular bacterial communication mechanism that allows the activation of numerous virulence factors and secondary metabolites. Targeting the QS pathway is a potential approach that prevents QS-controlled phenotypes and biofilm formation. For the first time, the current work has identified antiquorum sensing activity in the partially purified four fractions from the hot Et acetate extract of Cassia fistula fruit pods. Of the four fractions, only fraction-1 gave decreased AHL activity; the phytoconstituents in this fraction were identified as rhein, 3-aminodibenzofuran, 5-(hydroxymethyl)-2-(dimethoxymethyl)furan, and dihydrorhodamine. Fraction-1 (1 mg ml-1) and rhein (0.15 mg ml-1) showed 63% and 42.7% reduction in short-chain AHL production, resp., without hindering the bacterial growth. Fraction-1 inhibited QS-mediated extracellular virulence factors viz. protease, elastase, pyocyanin, and rhamnolipid (p < 0.05). Quant. anal. of biofilm formation showed 77% & 62.4% reduction by fraction-1 (1 mg ml-1) and rhein (0.15 mg ml-1) resp. Confocal laser microscopy (CLMS) & SEM (SEM) confirmed the reduction of biofilm formation in Pseudomonas aeruginosa upon treatment with fraction-1 and rhein. Moreover, the in vivo study displayed that fraction-1 and rhein (standard) significantly enhanced the survival of Caenorhabditis elegans by suppressing the potency of virulence factors of Pseudomonas aeruginosa. Quant. real-time polymerase chain reaction results demonstrated the down-regulation of QS-related genes, lasI, lasR, rhlI, and rhlR. In addition, in silico anal. divulged that a component identified by GC-MS displayed a strong affinity towards LasI and LasR. These findings suggest that potent phytochems. from fraction-1, including rhein, could serve as novel phytotherapeutics in controlling emerging infections of antibiotic-resistant bacterial pathogens like Pseudomonas aeruginosa. RSC Advances published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schroeder, Chad E.; Yao, Tuanli; Sotsky, Julie; Smith, Robert A.; Roy, Sudeshna; Chu, Yong-Kyu; Guo, Haixun; Tower, Nichole A.; Noah, James W.; McKellip, Sara; Sosa, Melinda; Rasmussen, Lynn; Smith, Layton H.; White, E. Lucile; Aube, Jeffrey; Jonsson, Colleen B.; Chung, Donghoon; Golden, Jennifer E. published the artcile< Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus>, Electric Literature of 112-63-0, the main research area is amidinophenylbenzamide preparation venezuelan equine encephalitis virus inhibitor antiviral.

Venezuelan equine encephalitis virus (VEEV) is an emerging pathogenic alphavirus that can cause significant disease in humans. Given the absence of therapeutic options available and the significance of VEEV as a weaponized agent, an optimization effort was initiated around a quinazolinone screening hit with promising cellular antiviral activity (EC50 = 0.8 μM), limited cytotoxic liability (CC50 > 50 μM), and modest in vitro efficacy in reducing viral progeny (63-fold at 5 μM). Scaffold optimization revealed a novel rearrangement affording amidines, specifically compound I, which was found to potently inhibit several VEEV strains in the low nanomolar range without cytotoxicity (EC50 = 0.02-0.04 μM, CC50 > 50 μM) while limiting in vitro viral replication (EC90 = 0.17 μM). Brain exposure was observed in mice with I. Significant protection was observed in VEEV-infected mice at 5 mg kg-1 day-1 and viral replication appeared to be inhibited through interference of viral nonstructural proteins.

Journal of Medicinal Chemistry published new progress about Amidines Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Guangming; Ren, Hongyu; Zhang, Nanjing; Lennox, William; Turpoff, Anthony; Paget, Steven; Li, Chunshi; Almstead, Neil; Njoroge, F. George; Gu, Zhengxian; Graci, Jason; Jung, Stephen P.; Colacino, Joseph; Lahser, Fred; Zhao, Xin; Weetall, Marla; Nomeir, Amin; Karp, Gary M. published the artcile< 6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B>, Application In Synthesis of 112-63-0, the main research area is azaindolylpyridinesulfonamide preparation antiviral hepatitis virus pharmacokinetics; 6-(Azaindol-2-yl)pyridine-3-sulfonamides; HCV inhibitors; NS4B; Replicon; Structure–activity relationship.

A structure-activity relationship investigation of various 6-(azaindol-2-yl)pyridine-3-sulfonamides using the HCV replicon cell culture assay led to the identification of a potent series of 7-azaindoles that target the hepatitis C virus NS4B. Compound I, identified via further optimization of the series, has excellent potency against the HCV 1b replicon with an EC50 of 2 nM and a selectivity index of >5000 with respect to cellular GAPDH RNA. Compound I also has excellent oral plasma exposure levels in rats, dogs and monkeys and has a favorable liver to plasma distribution profile in rats.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yue, Yingying; Chen, Yu; Liu, Hao; Xu, Lesi; Zhou, Xian; Ming, Hao; Chen, Xin; Chen, Miaoqi; Lin, Yunya; Liu, Lin; Zhao, Yingqian; Liu, Songlin published the artcile< Shugan Hewei Decoction alleviates cecum mucosal injury and improves depressive- and anxiety-like behaviors in chronic stress model rats by regulating cecal microbiota and inhibiting NLRP3 inflammasome>, Formula: C19H34O2, the main research area is IL1B IL18 NLRP3 depression anxiety chronic stress; NLRP3 inflammasome; Shugan Hewei Decoction; cecal microbiota; chronic stress; traditional Chinese medicine.

Chronic stress is a significant cause of depression, anxiety, and intestinal mucosal injury. Gut microbiota disturbances are also associated with these disorders. Shugan Hewei Decoction (SHD), which is a traditional Chinese medicine formula developed by our team, has shown superior therapeutic effects in the treatment of depression, anxiety, and functional gastrointestinal diseases caused by chronic stress. We investigated the modulatory effect of SHD on the cecal microbiota and cecum mucosal NOD-like receptor protein 3 (NLRP3) inflammasome in a chronic unpredictable stress (CUS)/social isolation rat model. After the SHD intervention, the CUS model rats showed improvements in their depressive- and anxiety-like behaviors, as well as sustained body weight growth and improved fecal characteristics. SHD improved the cecal microbiota diversity and changed the abundance of six microbial genera. A Spearman’s correlation anal. showed a strong correlation between the NLRP3 inflammasome and CUS-perturbed cecal biomarker microbiota. SHD regulated the excessive expression of NLRP3, ASC, caspase-1, interleukin-1β (IL-1β), and IL-18 in the serum and cecum mucosa induced by CUS, as well as the activation of the Toll-like receptor 4/nuclear factor-κB signaling cascades. Our reveal the pharmacol. mechanisms of SHD and provide a validated therapeutic method for the treatment of depression, anxiety, and cecum mucosal injury.

Frontiers in Pharmacology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Robertson, Alexander; Sandrock, Wm. F. published the artcile< Constituents of Filix mas. II. Synthesis of filicinic acid>, Formula: C19H34O2, the main research area is .

Partial hydrolysis of Me2C(CO2Et)2 gives the acid ester, b6 114-16°, b12 135-6°; PCl5 gives the acid chloride, b19 74-8° (anilide, m. 47-8°); with the Na derivative of CO(CH2CO2Et)2 there results Et 1,1-dimethylpentane-2,4-dione-1,3,5-tricarboxylate, yellow, b5 175-80°; ring closure with EtONa gives Et 1,1-dimethylcyclohexane-2,4,6-trione-3,5-dicarboxylate, m. 147-8°; simultaneous hydrolysis and decarboxylation gives filicinic acid (Boehm, Ann. 329, 289, 321(1903)), which is 1,1-dimethylcyclohexane-2,4,6-trione.

Journal of the Chemical Society published new progress about Ferns. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Clark, Robin D.; Jahangir, Alam published the artcile< Lateral lithiation reactions promoted by heteroatomic substituents>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is review Reactions; review Promoted; review Heteroatomic; review Substituents; review Lithiation; review Lateral.

A review of the article Lateral lithiation reactions promoted by heteroat. substituents.

Organic Reactions (Hoboken, NJ, United States) published new progress about Organic synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics