Category: 112-63-0

Wen, Genfa; Su, Yingpeng; Zhang, Guoxiang; Lin, Qiqiao; Zhu, Yujin; Zhang, Qianqian; Fang, Xinqiang published the artcile< Stereodivergent Synthesis of Chromanones and Flavanones via Intramolecular Benzoin Reaction>, Category: esters-buliding-blocks, the main research area is aldehyde aryl ketoalkoxy racemic triazolium intramol benzoin reaction catalyst; chromanone stereoselective preparation; flavanone stereoselective preparation.

The strategy of stereodivergent reactions on racemic mixtures (stereodivergent RRM) was employed for the first time in intramol. benzoin reactions and led to the rapid access of chromanones/flavanones with two consecutive stereocenters. The easily separable stereoisomers of the products were obtained with moderate to excellent enantioselectivities in a single step. Catechol type additives proved crucial in achieving the desired diastereo- and enantioselectivities.

Organic Letters published new progress about Aryl aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (ketoalkoxy). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jia, Wei; Zhuang, Pan; Wang, Qiao; Wan, Xuzhi; Mao, Lei; Chen, Xinyu; Miao, Hong; Chen, Dawei; Ren, Yiping; Zhang, Yu published the artcile< Urinary non-targeted toxicokinetics and metabolic fingerprinting of exposure to 3-monochloropropane-1,2-diol and glycidol from refined edible oils>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is refined edible oils metabolome toxicokinetics 3MCPD glycidol proline biomarkers; 3-Monochloropropane-1,2-diol; Glycidol; Metabolomics; Pathway analysis; Urinary biomarker.

The widespread presence of 3-monochloropropane-1,2-diol (3-MCPD) and glycidol in refined edible oils have raised food industrial and public health concerns, but their specific biomarkers of exposure and urinary metabolic pathways indicating nephrotoxicity remain largely unknown. Here, we unraveled the in vivo biotransformation of these two contaminants and revealed how they affect metabolic pathways in rats. Urine metabolomes in rats administered with glycidol or 3-MCPD were investigated using ultra-high performance liquid chromatog. combined with a quadrupole-orbitrap high-resolution mass spectrometry. Compared to the currently acknowledged metabolite which is only 2,3-dihydroxypropyl mercapturic acid, we identified 8 and 4 new specific exposure biomarkers of glycidol and 3-MCPD, resp., via mapping the glyceryl polymerization and glutathione and sulfur conjugation. The changes of metabolites in the surrounding metabolic network were investigated to further gain insight into their metabolic fates. Exposure to glycidol up-regulated citrate, isocitrate, ketoglutarate, malate, and pyruvate in the tricarboxylic acid cycle and glycolysis pathways, while 3-MCPD intake down-regulated these signal mols. in both pathways. Nonetheless, L-cysteine, proline, and arginine were significantly decreased by the effect of either glycidol or 3-MCPD. Our findings first map the urinary metabolomics of both contaminants from edible oils and advance the omics-level recognition for their observational health hazards.

Food Research International published new progress about Biomarkers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kwon, Hyeok-jin; Tang, Xiaowu; Shin, Seongjun; Hong, Jisu; Jeong, Wonkyo; Jo, Yohan; An, Tae Kyu; Lee, Jihoon; Kim, Se Hyun published the artcile< Facile Photo-cross-linking System for Polymeric Gate Dielectric Materials toward Solution-Processed Organic Field-Effect Transistors: Role of a Cross-linker in Various Polymer Types>, Computed Properties of 112-63-0, the main research area is optical crosslinking polymeric gate dielec polymer crosslinker OFET; cyclic olefin copolymer; gate dielectrics; organic field-effect transistors; photo-cross-linker; poly(vinylidene fluoride-co-hexafluoropropylene).

Energy-efficient solution-processed organic field-effect transistors (OFETs) are highly sought after in the low-cost printing industry as well as for the manufacture of flexible and other next-generation devices. The fabrication of such electronic devices requires high-functioning insulating materials that are chem. and mech. robust to avoid lowering insulating properties during the device fabrication process or utilization of devices. In this study, we report a facile, fluorinated, UV-assisted cross-linker series using a fluorophenyl azide (FPA), which reacts with the C-H groups of a conventional polymer. This demonstrates the application of the cross-linked films in OFET gate dielecs. The effects of the cross-linkable chem. structure of the FPA series on the crosslinking chem., photopatternability, and dielec. properties of the resulting films are investigated for low/high-k or amorphous/crystalline polymeric gate dielec. materials. The characteristics of insulating layers and behavior of OFETs containing these cross-linked gate dielecs. (for example, leakage c.d. (J), hysteresis, and charge trap d.) depend on the polymer type. Furthermore, an organic-based complementary inverter and various printable OFETs with excellent elec. characteristics are successfully fabricated. Thus, these reported cross-linkers that enable the solution process and patterning of well-developed conventional polymer dielec. materials are promising for the realization of a more sustainable next-generation industrial technol. for flexible and printable devices.

ACS Applied Materials & Interfaces published new progress about Crosslinking (optical). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Seok-Chan; Choi, Kwan-Min; Cheong, Chan-Seong published the artcile< Synthesis of amlodipine using aza Diels-Alder reaction>, COA of Formula: C19H34O2, the main research area is amlodipine synthesis Diels Alder alkene butynoate regioselective.

Amlodipine I was prepared via aza Diels Alder reaction of alkene II with Me butynoate.

Bulletin of the Korean Chemical Society published new progress about Diels-Alder reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Bo; Li, Yongliang; Tomkiewicz-Raulet, Celine; Dao, Pascal; Lietha, Daniel; Yen-Pon, Expedite; Du, Zhiyun; Coumoul, Xavier; Garbay, Christiane; Etheve-Quelquejeu, Melanie; Chen, Huixiong published the artcile< Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma>, Related Products of 112-63-0, the main research area is malignant glioblastoma FAK cell migration cell cycle autophosphorylation.

Human malignant glioblastoma (GBM) is a highly invasive and lethal brain tumor. Targeting of integrin downstream signaling mediators in GBM such as focal adhesion kinase (FAK) seems reasonable and recently demonstrated promising results in early clin. studies. Herein, we report the structure-guided development of a series of covalent inhibitors of FAK. These new compounds displayed highly potent inhibitory potency against FAK enzymic activity with IC50 values in the nanomolar range. Several inhibitors retarded tumor cell growth as assessed by a cell viability assay in multiple human glioblastoma cell lines. They also significantly reduced the rate of U-87 cell migration and delayed the cell cycle progression by stopping cells in the G2/M phase. Furthermore, these inhibitors showed a potent decrease of autophosphorylation of FAK in glioblastoma cells and its downstream effectors Akt and Erk as well as nuclear factor-κB. These data demonstrated that these inhibitors may have the potential to offer a promising new targeted therapy for human glioblastomas.

Journal of Medicinal Chemistry published new progress about Cell cycle checkpoint (cell cycle arrest, at G2/M phase). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Qin; Yin, Zheng-Lan; Ouyang, Ban-Lai; Peng, Yi-Yuan published the artcile< Pyridinium tribromide catalyzed condensation of indoles and aldehydes to form bisindolylalkanes>, Category: esters-buliding-blocks, the main research area is indole carbonyl aldehyde ketone condensation pyridinium bromide catalyst; alkane bisindolyl preparation.

An efficient synthetic method for bis(indol-3-yl)alkane derivatives was developed. In the presence of 5 mol% of pyridinium tribromide, the condensation of indoles and aldehydes proceeded smoothly under mild conditions, giving rise to the corresponding bis(indol-3-yl)alkanes in good to excellent yields.

Chinese Chemical Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zaleskaya-Hernik, Marta; Dobrzycki, Lukasz; Karbarz, Marcin; Romanski, Jan published the artcile< Fluorescence Recognition of Anions Using a Heteroditopic Receptor: Homogenous and Two-Phase Sensing>, Product Details of C19H34O2, the main research area is crown ether squaramide ion pair receptor fluorescent sensor; anthracene; crown ethers; fluorescent sensors; ion pair receptors; squaramides; sulfate extraction.

In contrast to monotopic receptor 3, the anthracene functionalized squaramide dual-host receptor 1 is capable of selectively extracting sulfate salts, as was evidenced unambiguously by DOSY, mass spectrometry, fluorescent and ion chromatog. measurements. The receptors were investigated in terms of anion and ion pair binding using the UV-vis and 1H NMR titrations method in acetonitrile. The reference anion receptor 3, lacking a crown ether unit, was found to lose the enhancement in anion binding induced by the presence of cations. Besides the ability to bind anions in an enhanced manner exhibited by ion pair receptors 2 and 4, changing the 1-aminoanthracene substituent resulted in their exhibiting a lower anion affinity than receptor 1. By using receptor 1 and adjusting the water content in organic phase it was possible to selectively detect sulfates both by “”turn-off”” and “”turn-on”” fluorescence, and to do so homogenously and under interfacial conditions. Such properties of receptor 1 have allowed the development of a new type of sensor capable of recognizing and extracting potassium sulfate from the aqueous medium across a phase boundary, resulting in an appropriate fluorescent response in the organic solution

International Journal of Molecular Sciences published new progress about Aqueous solutions. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Berger, Dan M.; Torres, Nancy; Dutia, Minu; Powell, Dennis; Ciszewski, Greg; Gopalsamy, Ariamala; Levin, Jeremy I.; Kim, Kyung-Hee; Xu, Weixin; Wilhelm, James; Hu, YongBo; Collins, Karen; Feldberg, Larry; Kim, Steven; Frommer, Eileen; Wojciechowicz, Donald; Mallon, Robert published the artcile< Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors>, SDS of cas: 112-63-0, the main research area is pyrazolopyrimidine preparation BRaf kinase inhibitor.

As part of our research effort to discover B-Raf kinase inhibitors, we prepared a series of C-3 substituted N-(3-(pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamides. X-ray crystallog. studies revealed that one of the more potent inhibitors bound to B-Raf kinase without forming a hinge-binding hydrogen bond. With basic amine residues appended to C-3 aryl residues, cellular activity and solubility were enhanced over previously described compounds of this class.

Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship (B-Raf kinase-inhibiting). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ali, Mohammed Hashmat; Stricklin, Susan published the artcile< Oxidation of sulfides with pyridinium tribromide in the presence of hydrated silica gel>, COA of Formula: C19H34O2, the main research area is sulfide oxidation pyridinium bromide; sulfoxide preparation.

A variety of sulfides were oxidized to sulfoxides utilizing pyridinium tribromide in the presence of hydrated silica gel in a non-aqueous media. A combination of pyridinium tribromide and hydrated silica gel releases mol. bromine slowly in the reaction, affecting the oxidation Hydrated silica gel also promotes decomposition of the bromosulfonium intermediate to the product. This procedure employs non-aqueous media for the first time in such a reaction.

Synthetic Communications published new progress about Oxidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gilmour, Sandra; Marder, Seth R.; Tiemann, Bruce G.; Cheng, Lap Tak published the artcile< Synthesis and first hyperpolarizabilities of acceptor-substituted β-apo-8'-carotenal derived compounds>, Related Products of 112-63-0, the main research area is hyperpolarizability apocarotenal derivative; optical property apocarotenal derivative; harmonic generation apocarotenal derivative.

The synthesis and second-order nonlinear optical properties of acceptor-substituted biol. derived β-apo-8′-carotenal compounds I [Z = C(CN)2, (E)-CHC6H4NO2-4] are reported. Elec. field-induced second harmonic generation (EFISH) measurements give values of β(0) which are 2-6 times greater than for 4-N,N-dimethylamino-4′-nitrostilbene (DANS).

Journal of the Chemical Society, Chemical Communications published new progress about Carotenes Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics