Category: 112-63-0

Wu, Yichao; Jiang, Yuanyuan; Zhang, Li; Zhou, Jing; Yu, Yan; Zhou, Yonghong; Kang, Tairan published the artcile< Chemical profiling and antioxidant evaluation of Paeonia lactiflora Pall. ""Zhongjiang"" by HPLC-ESI-MS combined with DPPH assay>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Paeonia lactiflora stem leaf antioxidant DPPH HPLC ESI MS.

Paeonia lactiflora Pall. “”Zhongjiang”” is one of the four major medicinal P. lactiflora plants in China. In this research, a high-performance liquid chromatog. (HPLC)-diode array detector (DAD)-electrospray ionization-mass spectrometry method was established to identify various components in the extracts of P. lactiflora “”Zhongjiang”” (root extract or RE, stem and leaf extract or SLE and flower extract or FE). A total of 40 compounds, including 19 monoterpenoid glycosides, five tannins, 10 phenolic acids and their esters, and six other compounds, were determined or temporarily inferred from RE (35 species), SLE (20 species) and FE (15 species). Antioxidant evaluation indicates among the monomer compounds, catechin, gallic acid and Et gallate showed strong antioxidant activity close to vitamin C, ascorbic acid (Vc). Paeoniflorin, albiflorin, benzoylpaeoniflorin and 6′-O-benzoylalbiflorin had certain antioxidant activities, which were much lower than Vc. Furthermore, 19, 15 and 15 antioxidant-reactive components were screened from RE, SLE and FE by using the 1,1-diphenyl-2- picrylhydrazyl (DPPH)-HPLC test results. Results indicated that the ethanol extracts of P. lactiflora “”Zhongjiang”” had strong antioxidant activity, and the antioxidant active material basis was mainly composed of phenolic acids and gallic acid tannins. The main components of P. lactiflora “”Zhongjiang””, monoterpenoid glycosides, had weak antioxidant capacity. Paeonia lactiflora stems, leaves and flowers were good sources of antioxidants.

Journal of Chromatographic Science published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lejeune, R.; Thunus, L. published the artcile< Study on mercaptopyridinecarboxylic acids. Part III. Preparation of esters, ethers and ether-esters of mercaptopyridinecarboxylic acids>, Application of C19H34O2, the main research area is pyridinecarboxylic acid mercapto; mercaptopyridinecarboxylic acid; halopyridine conversion pyridinethiol.

Pyridinecarboxylic acids I (R = halo) were treated with thiourea, KSH, and Na2S-S and the products were converted to the resp. mercapto acids II. Thus, 2-chloro-3-pyridinecarboxylic acid was heated with thiourea, and the product was treated with N2H4 to yield the resp. II. II were etherified by MeI and esterified by MeOH and CH2N2.

Journal de Pharmacie de Belgique published new progress about Esterification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kuz’min, Victor E.; Muratov, Eugene N.; Artemenko, Anatoly G.; Gorb, Leonid; Qasim, Mohammad; Leszczynski, Jerzy published the artcile< The effects of characteristics of substituents on toxicity of the nitroaromatics: HiT QSAR study>, Application of C19H34O2, the main research area is toxicity nitroarom HiT QSAR.

The present study applies the Hierarchical Technol. for Quant. Structure-Activity Relationships (HiT QSAR) for (i) evaluation of the influence of the characteristics of 28 nitroarom. compounds (some of which belong to a widely known class of explosives) as to their toxicity; (ii) prediction of toxicity for new nitroarom. derivatives; (iii) anal. of the effects of substituents in nitroarom. compounds on their toxicity in vivo. The 50% LD concentration for rats (LD50) was used to develop the QSAR models based on simplex representation of mol. structure. The preliminary 1D QSAR results show that even the information on the composition of mols. reveals the main tendencies of changes in toxicity. The statistic characteristics for partial least squares 2D QSAR models are quite satisfactory (R 2 = 0.96-0.98; Q 2 = 0.91-0.93; R 2 test = 0.89-0.92), which allows us to carry out the prediction of activity for 41 novel compounds designed by the application of new combinations of substituents represented in the training set. The comprehensive anal. of toxicity changes as a function of substituent position and nature was carried out. Mol. fragments that promote and interfere with toxicity were defined on the basis of the obtained models. It was shown that the mutual influence of substituents in the benzene ring plays a crucial role regarding toxicity. The influence of different substituents on toxicity can be mediated via different C-H fragments of the aromatic ring.

Journal of Computer-Aided Molecular Design published new progress about Aromatic nitro compounds Role: ADV (Adverse Effect, Including Toxicity), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Versluis, Frank; Tomatsu, Itsuro; Kehr, Seda; Fregonese, Carlo; Tepper, Armand W. J. W.; Stuart, Marc C. A.; Ravoo, Bart Jan; Koning, Roman I.; Kros, Alexander published the artcile< Shape and Release Control of a Peptide Decorated Vesicle through pH Sensitive Orthogonal Supramolecular Interactions>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is protein peptide decorated vesicle cyclodextrin encapsulation.

A pH sensitive carrier is obtained by coating a cyclodextrin vesicle with an adamantane-terminated octapeptide through the formation of an inclusion complex. Upon lowering the pH from 7.4 to 5.0, the formation of peptide β-sheets on the vesicle surface induces a transition of the bilayer from a sphere to a fiber. This transition is fully reversible and repeatable. The vesicles release their cargo upon fiber formation.

Journal of the American Chemical Society published new progress about Conformational transition. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Barros, Jessica A. S.; Cavalcanti, Joao Henrique F.; Pimentel, Karla G.; Medeiros, David B.; Silva, Jose C. F.; Condori-Apfata, Jorge A.; Lapidot-Cohen, Taly; Brotman, Yariv; Nunes-Nesi, Adriano; Fernie, Alisdair R.; Avin-Wittenberg, Tamar; Araujo, Wagner L. published the artcile< The significance of WRKY45 transcription factor in metabolic adjustments during dark-induced leaf senescence>, COA of Formula: C19H34O2, the main research area is WRKY transcription factor metabolic adjustment dark leaf senescence; Arabidopsis thaliana; alternative pathways; energy depletion; mitochondria; transcription factor.

Plants are constantly exposed to environmental changes that affect their performance. Metabolic adjustments are crucial to controlling energy homoeostasis and plant survival, particularly during stress. Under carbon starvation, coordinated reprogramming is initiated to adjust metabolic processes, which culminate in premature senescence. Notwithstanding, the regulatory networks that modulate transcriptional control during low energy remain poorly understood. Here, we show that the WRKY45 transcription factor is highly induced during both developmental and dark-induced senescence. The overexpression of Arabidopsis WRKY45 resulted in an early senescence phenotype characterized by a reduction of maximum photochem. efficiency of photosystem II and chlorophyll levels in the later stages of darkness. The detailed metabolic characterization showed significant changes in amino acids coupled with the accumulation of organic acids in WRKY45 overexpression lines during dark-induced senescence. Furthermore, the markedly upregulation of alternative oxidase (AOX1a, AOX1d) and electron transfer flavoprotein/ubiquinone oxidoreductase (ETFQO) genes suggested that WRKY45 is associated with a dysregulation of mitochondrial signalling and the activation of alternative respiration rather than amino acids catabolism regulation. Collectively our results provided evidence that WRKY45 is involved in the plant metabolic reprogramming following carbon starvation and highlight the potential role of WRKY45 in the modulation of mitochondrial signalling pathways.

Plant, Cell & Environment published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mishra, Jigni; Khan, Washim; Ahmad, Sayeed; Misra, Kshipra published the artcile< Supercritical carbon dioxide extracts of Cordyceps sinensis: chromatography-based metabolite profiling and protective efficacy against hypobaric hypoxia>, Product Details of C19H34O2, the main research area is Cordyceps sinensis hypobaric hypoxia carbon dioxide chromatog metabolite profiling; Cordyceps sinensis (Berk) Sacc.; GC-MS; HPTLC; hypobaric hypoxia (HH); metabolomics; supercritical fluid extract.

The toxicity and disposal concerns of organic solvents used in conventional extraction purposes has entailed the need for greener alternatives. Among such techniques, supercritical fluid extraction (SFE) has gained popularity by yielding extracts of high purity in a much faster manner. Carbon dioxide (CO2) is generally preferred as a supercritical solvent because of its lower temperature requirements, better diffusivity and easy removal. The present study describes the characterization of supercritical CO2 extracts of Indian variety of Cordyceps sinensis (CS)- a high-altitude medicinal mushroom widely revered in traditional medicine for its extensive anti-hypercholesterolemic, anti-inflammatory, anti-proliferative and energy-enhancing properties. Exptl. parameters viz. 300 and 350 bar of extraction pressure, 60°C of temperature, 0.4°L/h CO2 of flow rate and use of 1% (volume/volume) of ethanol as entrainer were optimized to prepare three different extracts namely, CSF1, CSF2 and CSF3. High-performance thin-layer chromatog. (HPTLC) was used for assessing the quality of all the extracts in terms of cordycepin, the pivot biomarker compound in CS. Characterization by HPTLC and GC-MS confirmed the presence of flavonoids and nucleobases and, volatile organic compounds (VOCs), resp. The chromatog. data acquired from metabolite profiling were subjected to chemometric anal. in an open source R studio which illustrated interrelatedness between CSF1 and CSF2 in terms of two major principal components. i.e. Dim 1 and Dim 2 whose values were 40.33 and 30.52% in variables factor map plotted using the HPTLC-generated retardation factor values. The factor maps based on retention times of the VOCs exhibited a variance of Dim 1 = 43.95% and Dim 2 = 24.85%. Furthermore, the extracts demonstrated appreciable antibacterial activity against Escherichia coli and Salmonella typhi by generation of reactive oxygen species (ROS), protein leakage and efflux pump inhibition within bacterial pathogens. CSFs were elucidated to be significantly cytoprotective (p < 0.05) in a simulated hypobaric hypoxia milieu (0.5% oxygen). CSF2 showed the best results by effectively improving the viability of human embryonic kidney (HEK 293) cells to 82.36 ± 1.76% at an optimum dose of 100 μg/mL. Levels of hypoxia inducible factor-1 alpha (HIF-1α) were modulated four-fold upon supplementation with CSF2. The results collectively evinced that the CSF extracts are substantially bioactive and could be effectively utilized as mycotherapeutics for multiple bioeffects. Frontiers in Pharmacology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kisel, V. M.; Kovtunenko, V. A.; Tyltin, A. K.; Babichev, F. S. published the artcile< Imino(amino) derivatives of isoquino[2,3-a]quinazoline and dibenz[b,f]azocine>, Related Products of 112-63-0, the main research area is condensation bromomethylphenylacetonitrile anthranilonitrile solvent effect; benzeneacetonitrile bromomethyl condensation anthranilonitrile; isoquinoquinazoline; dibenzazocine.

o-BrCH2C6H4CH2CN condensed with o-H2NC6H4CN to give 49% isoquinoquinazolinimine I (Z = NH2+ Br-) (II) in refluxing MeNO2, 40% o-NCCH2C6H4CH2NRC6H4CN-o (III, R = H) (IV) in refluxing Me2CHOH containing NaOAc, and 34% isoquinolinium salt V in Me2CHOH at 70-75°. Refluxing II with 40% H2SO4 in EtOH gave 40.5% I (Z = O). Acetylating IV with AcCl in dioxane containing NaOAc gave 78% III (R = Ac), which underwent intramol. cycloaddition in refluxing Me3COH containing KOCMe3 to give 52% dibenzazocine VI.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about Condensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Daff, Simon; Manson, Forbes D. C.; Reid, Graeme A.; Chapman, Stephen K. published the artcile< Strategic manipulation of the substrate specificity of Saccharomyces cerevisiae flavocytochrome b2>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cytochrome b5 lactate dehydrogenase substrate specificity; Saccharomyces cytochrome b5 lactate dehydrogenase specificity.

Flavocytochrome b2 from Saccharomyces cerevisiae acts physiol. as an L-lactate dehydrogenase. Although L-lactate is its primary substrate, the enzyme is also able to utilize a variety of other (S)-2-hydroxy acids. Structural studies and sequence comparisons with several related flavoenzymes have identified the key active-site residues required for catalysis. However, the residues Ala-198 and Leu-230, found in the X-ray-crystal structure to be in contact with the substrate Me group, are not well conserved. The authors propose that the interaction between these residues and a prospective substrate mol. has a significant effect on the substrate specificity of the enzyme. In an attempt to modify the specificity in favor of larger substrates, three mutant enzymes have been produced: A198G, L230A and the double mutant A198G/L230A. As a means of quantifying the overall kinetic effect of a mutation, substrate-specificity profiles were produced from steady-state experiments with (S)-2-hydroxy acids of increasing chain length, through which the catalytic efficiency of each mutant enzyme with each substrate could be compared with the corresponding wild-type efficiency. The Ala-198 → Gly mutation had little influence on substrate specificity and caused a general decrease in enzyme efficiency. However, the Leu-230 → Ala mutation caused the selectivity for 2-hydroxyoctanoate over lactate to increase by a factor of 80.

Biochemical Journal published new progress about Enzyme kinetics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Zhuang; An, Zhenzhen; Guo, Yongyang; Zhang, Kangning; Chen, Xiaoling; Zhang, Dongxia; Xue, Zhonghua; Zhou, Xibin; Lu, Xiaoquan published the artcile< Au-Pt bimetallic nanoparticles supported on functionalized nitrogen-doped graphene for sensitive detection of nitrite>, Product Details of C19H34O2, the main research area is gold platinum bimetallic nanoparticle nitrogen doped graphene detection nitrite; Electrocatalytic oxidation; Gold-platinum bimetallic nanoparticles; Nitrite; Nitrogen-doped graphene; Sensor.

In this work, we report a novel Au-Pt bimetallic nanoparticles (Au-PtNPs) decorated on the surface of nitrogen-doped graphene (NG) functionalized with 1,3,6,8-pyrenetetrasulfonic acid sodium salt (PyTS) by direct electrodeposition method. The results of SEM, energy dispersive X-ray spectroscopy (EDS) and electrochem. impedance spectrum (EIS) reveal that the Au-PtNPs were successfully anchored on the surface of NG sheets with a diameter of 20-40 nm. Further, the prepared Au-PtNPs/PyTS-NG nanocomposite exhibits superior catalytic activity for the oxidation of nitrite. Under optimal exptl. conditions, an amperometric sensor with a linear range of 0.5-1621 μM and a detection limit of 0.19 μM (S/N=3) for the detection of nitrite was set up and applied to real samples.

Talanta published new progress about Amperometric sensors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Goldinger, Simone M.; Buder-Bakhaya, Kristina; Lo, Serigne N.; Forschner, Andrea; McKean, Meredith; Zimmer, Lisa; Khoo, Chloe; Dummer, Reinhard; Eroglu, Zeynep; Buchbinder, Elizabeth I.; Ascierto, Paolo A.; Gutzmer, Ralf; Rozeman, Elisa A.; Hoeller, Christoph; Johnson, Douglas B.; Gesierich, Anja; Kolblinger, Peter; Bennannoune, Naima; Cohen, Justine V.; Kahler, Katharina C.; Wilson, Melissa A.; Cebon, Jonathan; Atkinson, Victoria; Smith, Jessica L.; Michielin, Olivier; Long, Georgina V.; Hassel, Jessica C.; Weide, Benjamin; Haydu, Lauren E.; Schadendorf, Dirk; McArthur, Grant; Ott, Patrick A.; Blank, Christian; Robert, Caroline; Sullivan, Ryan; Hauschild, Axel; Carlino, Matteo S.; Garbe, Claus; Davies, Michael A.; Menzies, Alexander M. published the artcile< Chemotherapy after immune checkpoint inhibitor failure in metastatic melanoma: a retrospective multicentre analysis>, SDS of cas: 112-63-0, the main research area is human metastatic melanoma immune checkpoint inhibitor chemotherapy; Anti-PD-1 antibodies; Cancer; Checkpoint inhibitors; Chemotherapy; Immunotherapy; Melanoma.

Despite remarkably improved outcomes with immune checkpoint inhibition, many patients with metastatic melanoma will eventually require further therapy. Chemotherapy has limited activity when used first-line but can alter the tumor microenvironment and does improve efficacy when used in combination with immunotherapy in lung cancer. Whether chemotherapy after checkpoint inhibitor failure has relevant activity in patients with metastatic melanoma is unknown.Patients with metastatic melanoma treated with chemotherapy after progression on immunotherapy with checkpoint inhibitors were identified retrospectively from 24 melanoma centers. Objective response rate (ORR), progression-free survival (PFS), overall survival (OS) and safety were examinedIn total, 463 patients were treated between 2007 and 2017. Fifty-six per cent had received PD-1-based therapy before chemotherapy. Chemotherapy regimens included carboplatin + paclitaxel (32%), dacarbazine (25%), temozolomide (15%), taxanes (9%, nab-paclitaxel 4%), fotemustine (6%) and others (13%). Median duration of therapy was 7.9 wk (0-108). Responses included 0.4% complete response (CR), 12% partial response (PR), 21% stable disease (SD) and 67% progressive disease (PD). Median PFS was 2.6 mo (2.2, 3.0), and median PFS in responders was 8.7 mo (6.3, 16.3), resp. Twelve-month PFS was 12% (95% CI 2-15%). In patients who had received anti-PD-1 before chemotherapy, the ORR was 11%, and median PFS was 2.5 mo (2.1, 2.8). The highest activity was achieved with single-agent taxanes (N = 40), with ORR 25% and median PFS 3.9 mo (2.1, 6.2). Median OS from chemotherapy start was 7.1 mo (6.5, 8.0). Subsequent treatment with checkpoint inhibitors achieved a response rate of 16% with a median PFS of 19.1 mo (2.0-43.1 mo). No unexpected toxicities were observedChemotherapy has a low response rate and short PFS in patients with metastatic melanoma who have failed checkpoint inhibitor therapy, although activity varied between regimens. Chemotherapy has a limited role in the management of metastatic melanoma.

European Journal of Cancer published new progress about Antibodies and Immunoglobulins Role: PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses) (Anti-PD-1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics