Category: 112-63-0

Maimo-Barcelo, Albert; Martin-Saiz, Lucia; Fernandez, Jose A.; Perez-Romero, Karim; Garfias-Arjona, Santiago; Lara-Almunia, Monica; Pierola-Lopetegui, Javier; Bestard-Escalas, Joan; Barcelo-Coblijn, Gwendolyn published the artcile< Polyunsaturated Fatty Acid-Enriched Lipid Fingerprint of Glioblastoma Proliferative Regions Is Differentially Regulated According to Glioblastoma Molecular Subtype>, Quality Control of 112-63-0, the main research area is Glioblastoma proliferative region polyunsaturated fatty acid lipid fingerprint; MALDI-IMS lipidomics; glioblastoma; lipid metabolism; modular gene expression; molecular subtypes; temozolomide.

Glioblastoma (GBM) represents one of the deadliest tumors owing to a lack of effective treatments. The adverse outcomes are worsened by high rates of treatment discontinuation, caused by the severe side effects of temozolomide (TMZ), the reference treatment. Therefore, understanding TMZ′s effects on GBM and healthy brain tissue could reveal new approaches to address chemotherapy side effects. In this context, we have previously demonstrated the membrane lipidome is highly cell type-specific and very sensitive to pathophysiol. states. However, little remains known as to how membrane lipids participate in GBM onset and progression. Hence, we employed an ex vivo model to assess the impact of TMZ treatment on healthy and GBM lipidome, which was established through imaging mass spectrometry techniques. This approach revealed that bioactive lipid metabolic hubs (phosphatidylinositol and phosphatidylethanolamine plasmalogen species) were altered in healthy brain tissue treated with TMZ. To better understand these changes, we interrogated RNA expression and DNA methylation datasets of the Cancer Genome Atlas database. The results enabled GBM subtypes and patient survival to be linked with the expression of enzymes accounting for the observed lipidome, thus proving that exploring the lipid changes could reveal promising therapeutic approaches for GBM, and ways to ameliorate TMZ side effects.

International Journal of Molecular Sciences published new progress about 5-Lipoxygenase-activating protein inhibitors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Yibing; Canturk, Belgin; Jo, Hyunil; Ma, Chunlong; Gianti, Eleonora; Klein, Michael L.; Pinto, Lawrence H.; Lamb, Robert A.; Fiorin, Giacomo; Wang, Jun; DeGrado, William F. published the artcile< Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel>, Electric Literature of 112-63-0, the main research area is amantadine antiviral influenza virus proton channel inhibitor.

Influenza virus infections lead to numerous deaths and millions of hospitalizations each year. One challenge facing anti-influenza drug development is the heterogeneity of the circulating influenza viruses, which comprise several strains with variable susceptibility to antiviral drugs. For example, the wild-type (WT) influenza A viruses, such as the seasonal H1N1, tend to be sensitive to antiviral drugs, amantadine and rimantadine, while the S31N mutant viruses, such as the pandemic 2009 H1N1 (H1N1pdm09) and seasonal H3N2, are resistant to this class of drugs. Thus, drugs targeting both WT and the S31N mutant are highly desired. The authors report the design of a novel class of dual inhibitors along with their ion channel blockage and antiviral activities. The potency of the most active compound 11 in inhibiting WT and the S31N mutant influenza viruses is comparable with that of amantadine in inhibiting WT influenza virus. Solution NMR studies and mol. dynamics (MD) simulations of drug-M2 interactions supported the design hypothesis: namely, the dual inhibitor binds in the WT M2 channel with an aromatic group facing down toward the C-terminus, while the same drug binds in the S31N M2 channel with its aromatic group facing up toward the N-terminus. The flip-flop mode of drug binding correlates with the structure-activity relationship (SAR) and has paved the way for the next round of rational design of broad-spectrum antiviral drugs.

Journal of the American Chemical Society published new progress about Antiviral agent resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Drakulic, Danijela; Schwirtlich, Marija; Petrovic, Isidora; Mojsin, Marija; Milivojevic, Milena; Kovacevic-Grujicic, Natasa; Stevanovic, Milena published the artcile< Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma>, Application In Synthesis of 112-63-0, the main research area is BMP signaling; GBM subtypes; Hippo signaling; Notch signaling; RA signaling; SHH signaling; TGFβ signaling; Wnt/β-catenin signaling; glioblastoma.

Glioblastoma (GBM) is the most common and highly lethal type of brain tumor, with poor survival despite advances in understanding its complexity. After current standard therapeutic treatment, including tumor resection, radiotherapy and concomitant chemotherapy with temozolomide, the median overall survival of patients with this type of tumor is less than 15 mo. Thus, there is an urgent need for new insights into GBM mol. characteristics and progress in targeted therapy in order to improve clin. outcomes. The literature data revealed that a number of different signaling pathways are dysregulated in GBM. In this review, we intended to summarize and discuss current literature data and therapeutic modalities focused on targeting dysregulated signaling pathways in GBM. A better understanding of opportunities for targeting signaling pathways that influences malignant behavior of GBM cells might open the way for the development of novel GBM-targeted therapies.

Cells published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wani, Gulzar A.; Sprenger, Hans-Georg; Ndoci, Kristiano; Chandragiri, Srikanth; Acton, Richard James; Schatton, Desiree; Kochan, Sandra M. V.; Sakthivelu, Vignesh; Jevtic, Milica; Seeger, Jens M.; Mueller, Stefan; Giavalisco, Patrick; Rugarli, Elena I.; Motori, Elisa; Langer, Thomas; Bergami, Matteo published the artcile< Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L>, SDS of cas: 112-63-0, the main research area is mitochondrial protease adult neural stem cell selfrenewal metabolic control; OMA1; YME1L; adult neurogenesis; metabolic rewiring; mitochondria; mitochondrial dynamics; mitochondrial proteome; neural stem cells; proliferation; self-renewal.

The transition between quiescence and activation in neural stem and progenitor cells (NSPCs) is coupled with reversible changes in energy metabolism with key implications for lifelong NSPC self-renewal and neurogenesis. How this metabolic plasticity is ensured between NSPC activity states is unclear. We find that a state-specific rewiring of the mitochondrial proteome by the i-AAA peptidase YME1L is required to preserve NSPC self-renewal. YME1L controls the abundance of numerous mitochondrial substrates in quiescent NSPCs, and its deletion activates a differentiation program characterized by broad metabolic changes causing the irreversible shift away from a fatty-acid-oxidation-dependent state. Conditional Yme1l deletion in adult NSPCs in vivo results in defective self-renewal and premature differentiation, ultimately leading to NSPC pool depletion. Our results disclose an important role for YME1L in coordinating the switch between metabolic states of NSPCs and suggest that NSPC fate is regulated by compartmentalized changes in protein network dynamics.

Cell Reports published new progress about Adult, mammalian. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seemaisamy, Revathi; Faruck, Lukmanul Hakkim; Gattu, Sampath; Neelamegam, Rameshkumar; Bakshi, Hamid A.; Rashan, Luay; Al-Buloshi, Mohammed; Hasson, Sidgi Syed Anwar Abdo; Nagarajan, Kayalvizhi published the artcile< Anti-microbial and anti-cancer activity of Aegle marmelos and gas chromatography coupled spectrometry analysis of their chemical constituents>, Formula: C19H34O2, the main research area is Staphylococcus Bacillus Aegle breast cancer cell anticancer antimicrobial.

In this study, we investigated anti-cancer and antimicrobial activity of Aegle marmelos leaf extracts and their chem. profile characterized by gas chromatog. coupled mass spectrometry (GC-MS). A. marmelos leaves were extracted with acetone, methanol, ethanol, and chloroform. Presence of phenolic compounds was identified in these extracts by qual. anal. All the extracts were subjected for anti-bacterial activity against the different strains of bacteria (Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Bacillus ariyabattai, Bacillus megaterium, Pseudomonas putida, Klebsiella pneumonia, Serratia marcescens, and Escherichia coli). It is noteworthy that acetone extract elicited maximum growth inhibition on Serratia marcescens. Based on profound anti bacterial activity, acetone and methanol extract of A. marmelos were checked for cytotoxicity against MDA-MB-231, HEp-2 and vero cells. MDA-MB-231 cells were more sensitive to acetone extract of A. marmelos with an IC50 value of 79.62 μg/mL where as HEp-2 cells are more sensitive to methanol extract of A. marmelos with an IC50 value of 47.08 μg/mL. Vero cells withstand 24 h treatment of both extract, and it is evidenced that both acetone and methanol extract of A. marmelos exhibited chemo sensitive property towards cancer cells. GCMS anal. was performed to characterize the active principles of acetone and methanol extracts of A. marmelos. GC MS data revealed the presence of ten major components. Overall, both acetone and methanol extract of A. marmelos found to be promising anti antibacterial and anti-cancer agent however the active principle of these should be isolated and characterized before reaching a concrete scientific conclusion.

International Journal of Pharmaceutical Sciences and Research published new progress about Aegle marmelos. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Anand, Namrata; Koley, Suvajit; Ramulu, B. Janaki; Singh, Maya Shankar published the artcile< Metal-free aerobic one-pot synthesis of substituted/annulated quinolines from alcohols via indirect Friedlander annulation>, Synthetic Route of 112-63-0, the main research area is quinoline preparation green chem; aminobenzyl alc aminobenzophenone alc tandem oxidation Friedlander annulation.

Metal-free, operationally simple, and highly efficient one-pot aerobic process for the synthesis of functionalized/annulated quinolines e.g., I is devised from easily available 2-aminobenzyl alc./2-aminobenzophenones and alkyl/aryl alcs. for the first time. The process involves two sequential reactions, namely in situ aerial oxidation of alcs. to the corresponding aldehydes/ketones followed by Friedlander annulation.

Organic & Biomolecular Chemistry published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peeters, Emiel; Van Hal, Paul A.; Meskers, Stefan C. J.; Janssen, Rene A. J.; Meijer, E. W. published the artcile< Photoinduced electron transfer in a mesogenic donor-acceptor-donor system>, COA of Formula: C19H34O2, the main research area is photoinduced electron transfer mesogenic oligophenylenevinylene; liquid crystalline mesogenic oligophenylenevinylene photoinduced electron transfer.

A novel donor-acceptor-donor mol. consisting of two oligo(p-phenylene vinylene) (OPV4) units attached to a central perylene bisimide (PERY) core is described. This OPV4-PERY-OPV4 is the first mesogenic mol. that incorporates both p- and n-type semiconducting properties and possesses a liquid-crystalline mesophase, in which donor and acceptor functionalities self-assemble into an ordered material. Upon photoexcitation of the donor, a subpicosecond electron-transfer reaction occurs in OPV4-PERY-OPV4, both in solution and in (ordered) thin solid films. The lifetime of the charge-separated state is significantly longer in (ordered) thin films than in solution as a result of a reduction of geminate recombination by migration and spatial separation of charges in the film.

Chemistry – A European Journal published new progress about Electrooptical effect. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Demiray, Hatice; Estep, Alden S.; Tabanca, Nurhayat; Becnel, James J.; Demirci, Betul published the artcile< Chemical constituents from Rheum ribes shoots and its insecticidal activity against Aedes aegypti>, Category: esters-buliding-blocks, the main research area is methyl linoleate insecticidal Rheum Aedes.

A phytochem. investigation of hexane extract of Rheum ribes L., Polygonaceae, shoots was analyzed by gas chromatog. with flame ionization dection and mass specrometry and revealed seven components including Me hexadecanoate (Me palmitate) (2.4%), (Z)-9-Me octadecenoate (Me oleate) (2.9%), (Z,Z,Z)-9,12,15-Me octadecatrienoate (Me linolenate) (3.5%), 1-octadecanol (4.3%), (Z,Z)-9,12-Me octadecadienoate (Me linoleate) (5.7%), heptacosane (13.5%), and hexadecanoic acid (palmitic acid) (67.7%). The hexane extract was bioassayed for larvicidal and adult topical activity against an insecticide susceptible strain of Aedes aegypti, the yellow fever mosquito. Results demonstrated a 90% mortality against adults at 5μg/mosquito and first instar larvae at 1μg/μl. The major compound hexadecanoic acid showed 20% mortality at 6.25 ppm against adults whereas the compound provided 100% mortality at the highest screening dose of 1000 ppm against 1st instar larvae. The mosquitocidal activity of the analyzed plant material may be related to a specific combination of compounds present in the hexane extract Graphical abstract

Revista Brasileira de Farmacognosia published new progress about Aedes aegypti. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sherin, D. R.; Manojkumar, T. K. published the artcile< Exploring the selectivity of guanine scaffold in anticancer drug development by computational repurposing approach>, Computed Properties of 112-63-0, the main research area is exploring selectivity guanine scaffold anticancer drug development computational repurposing.

Drug repurposing is one of the modern techniques used in the drug discovery to find out the new targets for existing drugs. Insilico methods have a major role in this approach. We used 60 FDA approved antiviral drugs reported in the last 50 years to screen against different cancer cell receptors. The thirteen compounds selected after virtual screening are analyzed for their druggability based on ADMET parameters and found the selectivity of guanine derivatives-didanosine, entecavir, acyclovir, valganciclovir, penciclovir, ganciclovir and valacyclovir as suitable candidates. The pharmacophore model, AARR, suggested based on the common feature alignment, shows that the two fused rings as in guanine and two acceptors-one from keto-oxygen (A5) and other from the substituent attached to nitrogen of imidazole ring (A4) give the druggability to the guanine derivatives The NBO anal. on N9 is indicative of charge distribution from the ring to substituents, which results in delocalization of neg. character in most of the ligands. The mol. dynamics simulations also pointed out the importance of guanine scaffold, which stabilizes the ligands inside the binding pocket of the receptor. All these results are indicative of the selectivity of guanine scaffold in anticancer drug development, especially as PARP1 inhibitors in breast, ovarian and prostate cancer. As these seven mols. are already approved by FDA, we can safely go for further preclin. trials.

Scientific Reports published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koenig, Wilfried A.; Benecke, Ingrid; Sievers, Susanne published the artcile< New results in the gas chromatographic separation of enantiomers of hydroxy acids and carbohydrates>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is chiral phase enantiomer gas chromatog; hydroxyisopentanoic acid packing gas chromatog; hydroxyoctanoic acid packing gas chromatog; phenylethylamine packing gas chromatog enantiomer; valinephenylethylamide packing gas chromatog enantiomer; amino acid modified polysiloxane packing; amine enantiomer separation gas chromatog; amino acid enantiomer gas chromatog; hydroxy acid enantiomer gas chromatog; carbohydrate enantiomer gas chromatog.

New chiral stationary phases for gas chromatog. separation of the enantiomers of amines, amino alcs., hydroxy acids and carbohydrates are described. Hydroxy acids were separated on stationary phases prepared from S-2-hydroxyisopentanoic acid and S-2-hydroxyoctanoic acid by coupling with S-α-phenylethylamine. For the first time, separation of carbohydrate enantiomers was achieved on a stationary phase obtained by connecting L-valine-S-α-phenylethylamide to the functionalized cyanoethyl side-chains of the polysiloxane XE-60.

Journal of Chromatography published new progress about Amines. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics