Category: 112-63-0

Cabaj, John E.; Kairys, David; Benson, Thomas R. published the artcile< Development of a Commercial Process to Produce Oxandrolone>, Related Products of 112-63-0, the main research area is Oxandrolone preparation.

A manufacturing scale process for the preparation of the anabolic steroid Oxandrolone was developed. Key elements included the following: the bromination of methylandrostanolone with perbromide to give the 2-bromoketone in ca. 80% yield with minimal dehydration, subsequent elimination of the bromide with Li2CO3/LiBr to give the 2-enone in ca. 70% yield with minimal formation of methyltestosterone, and an ozonolysis procedure to give the penultimate intermediate in ca. 90% yield. The overall yield from methylandrostanolone to Oxandrolone using the described process was 45% as compared to the original Searle yield of 8%.

Organic Process Research & Development published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Scheuerman, R. A.; Tumelty, D. published the artcile< The reduction of aromatic nitro groups on solid supports using sodium hydrosulfite (Na2S2O4)>, Category: esters-buliding-blocks, the main research area is reduction aromatic nitro group hydrosulfite solid support; polyethyleneglycol polystyrene resin reduction nitroarom hydrosulfite; tin dichloride reduction nitroarom solid support.

An improved method for reducing aromatic nitro compounds on solid-phase supports using sodium hydrosulfite is presented. Conditions have been optimized to enable the use of this reagent for reductions on both polyethyleneglycol-polystyrene resins and traditional polystyrene resins.

Tetrahedron Letters published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Matsuda, Shoichi; Yamaguchi, Shoji; Yasukawa, Eiki; Asahina, Hitoshi; Kakuta, Hirofumi; Otani, Haruhiko; Kimura, Shin; Kameda, Takashi; Takayanagi, Yoshiki; Tajika, Akihiko; Kubo, Yoshimi; Uosaki, Kohei published the artcile< Effect of Electrolyte Filling Technology on the Performance of Porous Carbon Electrode-Based Lithium-Oxygen Batteries>, Computed Properties of 112-63-0, the main research area is lithium oxygen batteries electrolyte carbon electrode.

Although the theor. energy densities of lithium-oxygen batteries (LOBs) far exceed those of lithium-ion batteries, the practical values of the LOBs are usually much lower because of the use of large electrolyte excesses. Thus, to realize LOBs with a high practical energy d., the electrolyte amount should be minimized without compromising their performance. To address this challenge, we herein investigate the influence of several electrolyte filling techniques on the performance of LOBs, revealing that the battery discharge/charge profiles are strongly influenced by the uniformity of electrolyte distribution in the porous carbon electrode. The obtained results show the importance of electrolyte filling technol. for realization of practical high-energy-d. LOBs and facilitate their further development.

ACS Applied Energy Materials published new progress about Battery electrodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dong, Jianyang; Yue, Fuyang; Liu, Jianhua; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin published the artcile< Visible-light-mediated three-component Minisci reaction for heteroarylethyl alcohols synthesis>, HPLC of Formula: 112-63-0, the main research area is heteroarylethyl alc green diastereoselective preparation; heteroaryl alkene three component Minisci visible light iridium catalyst.

Herein, a mild, modular, practical Minisci reaction for catalytic synthesis of heteroarylethyl alcs. such as ArCH(R1)CHR2OH [Ar = quinol-2-yl, isoquinolin-1-yl, 2-benzothiazolyl, etc.; R1R2 = CH2(CH2)2CH2, CH2CH2CH2; R1 = On-Bu, Me; R2 = H, Me] via sequential addition of H2O and N-heteroarenes across olefinic double bonds was reported. This scalable protocol was used for direct hydroxy-heteroarylation of olefins with a wide range of N-heteroarenes and could be expected to permit rapid conversion of abundant feedstock materials into medically relevant mols.

Green Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation) (heteroarylethyl). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Wei; Guo, Xiaoli; Ren, Jing; Chen, Yujiao; Wang, Jingyu; Gao, Ai published the artcile< GCN5-mediated PKM2 acetylation participates in benzene-induced hematotoxicity through regulating glycolysis and inflammation via p-Stat3/IL17A axis>, Reference of 112-63-0, the main research area is GCN5 PKM2 acetylation benzene hematotoxicity glycolysis inflammation Stat3 IL17A; Acetylation; Benzene; Glycolysis; Hematotoxicity; Inflammation; PKM2.

Benzene is a common environmental carcinogen that induces leukemia. Studies suggest that metabolic disorder has a relationship with the toxicity of benzene. Pyruvate kinase M2 (PKM2) is a key rate-limiting enzyme in glycolysis. However, the upstream and downstream regulatory mechanisms of PKM2 in benzene-induced hematotoxicity and the therapeutic effects of targeting PKM2 in vivo are unclear. This study aims to provide insights into the new mechanism of benzene-induced hematotoxicity and reveal the therapeutic significance of targeting PKM2. Herein, we demonstrated that PKM2-dependent glycolysis contributes to benzene-induced hematotoxicity by regulating inflammation reaction. Mechanistically, acetylated proteomics revealed that 1,4-benzoquinone (1,4-BQ) induced acetylation of PKM2 at position K66, and this modification contributed to the increase of PKM2 expression and can be inhibited by inhibition of acetyltransferase GCN5. Meanwhile, the elevated PKM2 was shown to prompt the activation of nuclear phosphorylated Stat3 (p-Stat3) and IL17A. Clin., pharmacol. inhibition of PKM2 alleviated the blood toxicity induced by benzene, which was mainly characterized by an increase in routine blood parameters and improvement of hematopoietic imbalance. Besides, elevated PKM2 is a promising biomarker in people occupationally exposed to benzene. Overall, we identified PKM2/p-Stat3/IL-17A axis participates in the hematotoxicity of benzene, and targeting PKM2 has certain therapeutic implications in hematol. diseases.

Environmental Pollution (Oxford, United Kingdom) published new progress about Acetylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gowrisankar, Saravanan; Neumann, Helfried; Beller, Matthias published the artcile< A convenient and practical synthesis of anisoles and deuterated anisoles by palladium-catalyzed coupling reactions of aryl bromides and chlorides>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is deuterated anisole preparation; aryl halide methanol coupling reaction palladium.

A palladium-catalyzed coupling reaction of aryl halides with methanol is described. A variety of substituted anisoles have been prepared in moderate to good yields from activated and nonactivated (hetero)aryl substrates. Meanwhile, deuterated anisoles could be obtained via coupling of aryl halides with CD3OD.

Chemistry – A European Journal published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Olaizola, Olatz; Iriarte, Igor; Zanella, Giovanna; Gomez-Bengoa, Enrique; Ganboa, Inaki; Oiarbide, Mikel; Palomo, Claudio published the artcile< Bronsted Base Catalyzed One-Pot Synthesis of Stereodefined Six-Member Carbocycles Featuring Transient Trienolates and a Key Intramolecular 1,6-Addition>, Quality Control of 112-63-0, the main research area is substituted cyclohexene derivative enantioselective preparation; diene nitroalkene enantioselective addition cyclization Bronsted base catalyst; 1,6-conjugate additions; Brønsted bases; organocatalysis; synthetic methods; trienolates.

A catalyst-driven one-pot reaction sequence is developed for the enantio- and diastereoselective synthesis of tetrasubstituted cyclohexenes from simple unsaturated ketones or thioesters. The method involves a tertiary amine/squaramide-catalyzed α-selective addition of transiently generated trienolates to nitroolefins, subsequent base-catalyzed double bond isomerization, and an intramol. (vinylogous) 1,6-addition reaction, a rare key carbocyclization step that proceeded with essentially perfect stereocontrol.

Angewandte Chemie, International Edition published new progress about Addition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fialkov, Yu. A.; Sevast’yan, A. P.; Khranovskii, V. A.; Yagupol’skii, L. M. published the artcile< Study of the transfer of electron effects in conjugated perfluoropolyene systems. II. Asymmetric derivatives of α,β-difluorostilbene and 1,4-diphenyl-1,3-perfluorobutadiene>, Formula: C19H34O2, the main research area is conjugation aromatic butadiene stilbene; fluoro aromatic butadiene stilbene; NMR aromatic butadiene stilbene; UV aromatic butadiene stilbene.

UV and 19F NMR data for trans-4-RC6H4CF:CFC6H4R1-4 (R,R1 = H, Me; H, CO2H; H, CO2Et; H, NH2; H, NO2; NO2, NMe2; H, NMe2) and trans,trans-4-RC6H4CF:CFCF:CFC6H4R1-4 (R,R1 = H, NO2; NO2, NO2; NO2, NMe2; NMe2, NMe2; H, NMe2) showed that, although they were not coplanar, they transmitted conjugation effects.

Zhurnal Organicheskoi Khimii published new progress about Conjugation (bond). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Babu, Sukumaran Santhosh; Praveen, Vakayil K.; Kartha, Kalathil K.; Mahesh, Sankarapillai; Ajayaghosh, Ayyappanpillai published the artcile< Effect of the Bulkiness of the End Functional Amide Groups on the Optical, Gelation, and Morphological Properties of Oligo(p-phenylenevinylene) π-Gelators>, Formula: C19H34O2, the main research area is bulkiness amide group optical gelation morphol oligophenylenevinylene gelator; gels; hydrogen bonds; phenylenevinylenes; pi interactions; self-assembly.

Herein, we describe the role of end functional groups in the self-assembly of amide-functionalized oligo(p-phenylenevinylene) (OPV) gelators with different end-groups. The interplay between hydrogen-bonding and π-stacking interactions was controlled by the bulkiness of the end functional groups, thereby resulting in aggregates of different types, which led to the gelation of a wide range of solvents. The variable-temperature UV/Vis absorption and fluorescence spectroscopic features of gelators with small end-groups revealed the formation of 1D H-type aggregates in CHCl3. However, under fast cooling in toluene, 1D H-type aggregates were formed, whereas slow cooling resulted in 2D H-type aggregates. OPV amide with bulky dendritic end-group formed hydrogen-bonded random aggregates in toluene and a morphol. transition from vesicles into fibrous aggregates was observed in THF. Interestingly, the presence of bulky end-group enhanced fluorescence in the xerogel state and aggregation in polar solvents. The difference between the aggregation properties of OPV amides with small and bulky end-groups allowed the preparation of self-assembled structures with distinct morphol. and optical features.

Chemistry – An Asian Journal published new progress about Aggregation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Danyun; Li, Zhijun; Chen, Yue; Fan, Yan; Yu, Tao published the artcile< Paeoniflorin reduces the inflammatory response of THP-1 cells by up-regulating microRNA-124 - Paeoniflorin reduces the inflammatory response of THP-1 cells through microRNA-124>, Reference of 112-63-0, the main research area is paeoniflorin THP cell microRNA inflammatory response; Apoptosis; Paeoniflorin; Proliferation; THP-1 cells; miRNA-124.

The activation of macrophages and the release of inflammatory cytokines are the main reasons for the progress of systemic lupus erythematosus (SLE). MicroRNA (miRNA)-124 is involved in the regulation of macrophages and is a key regulator of inflammation and immunity. To explore whether paeoniflorin (PF) regulates the biol. functions of macrophages depends on miR-124. RT-PCR, WB, ELISA, CCK-8 and flow cytometry were used to evaluate that PF regulated the biol. functions of THP-1 cells through miR-124. PF significantly inhibited the proliferation while promotes the apoptosis of THP-1 cells, and inhibited the release of IL-6, TNF-α and IL-1β in THP-1 cells. RT-PCR results shown that PF up-regulated the expression of miR-124 in THP-1 cells. Functional recovery experiments showed that compared with the LPS + mimic-NC group, LPS + miR-124 mimic significantly inhibited the proliferation and the release of IL-6, TNF-α and IL-1β, but promoted the apoptosis of THP-1 cells. In addition, compared with the LPS + PF + inhibitor-NC group, LPS + PF + miR-124 inhibitor significantly promoted the proliferation and the release of IL-6, TNF-α and IL-1β, but inhibited the apoptosis of THP-1 cells. By down-regulating miR-124, PF inhibits the proliferation and inflammation of THP-1 cells, and promotes the apoptosis of THP-1 cells.

Genes & Genomics published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics