Category: 112-63-0

Qian, Kun; Seifert, Soenke; Winans, Randall E.; Li, Tao published the artcile< Understanding Solvation Behavior of the Saturated Electrolytes with Small/Wide-Angle X-ray Scattering and Raman Spectroscopy>, Related Products of 112-63-0, the main research area is solvation behavior saturated electrolytes small wide angle XRS Raman.

Concentrated electrolytes are attracting significant attention because the solvation structures could stabilize the interface, encouraging novel electrolyte development for high-voltage and long-cycle-life batteries. Saturated electrolytes, which have the highest salt concentrations, have been rarely studied because of their shortcomings of high viscosity and low ionic conductivity Nevertheless, the exciting solvation structure in saturated solution is still worth studying, significantly broadening the comprehensive understanding of the solvation processes. In this work, we investigate the saturated lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) dissolved in seven different organic solvents, including propylene carbonate (PC), THF, acetonitrile (ACN), DMF, 1,2-dimethoxyethane (DME), diethylene glycol di-Me ether (Diglyme), and tetraethylene glycol di-Me ether (Tetraglyme). The combined small/wide-angle X-ray scattering and Raman spectroscopy are employed to study the global and local solvation structure. This work demonstrates a method for detecting the structure of liquids, which will facilitate the study of structure-performance relationships and the screening of new electrolytes.

Energy & Fuels published new progress about Batteries (high-voltage). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Giron-Callejas, Amalia; Garcia-Morales, Claudia; Mendizabal-Burastero, Ricardo; Meza, Rita I.; Sierra, Tomasa; Tapia-Trejo, Daniela; Perez-Garcia, Marissa; Quiroz-Morales, Veronica S.; Paredes, Mayte; Rodriguez, Alizon; Juarez, Sandra I.; Farach, Nasim; Videa, Geraldina; Lara, Bredy; Rodriguez, Edith; Ardon, Elvia; Sajquim, Edgar; Lorenzana, Rolando; Ravasi, Giovanni; Northbrook, Sanny; Reyes-Teran, Gustavo; Avila-Rios, Santiago published the artcile< High level of pre-treatment and acquired HIV drug resistance in Honduras: a nationally representative survey, 2016-17>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nigh level pretreatment acquired HIV drug resistance.

Background: Pre-treatment HIV drug resistance (HIVDR) to NNRTIs has consistently increased in low-/middle-income countries during the last decade. Objectives: To estimate the prevalence of pre-treatment HIVDR and acquired HIVDR among persons living with HIV (PLHIV) on ART for 12 ± 3 mo (ADR12) and ≥48 mo (ADR48) in Honduras. Patients and methods: A nationwide cross-sectional survey with a two-stage cluster sampling was conducted from Oct. 2016 to Nov. 2017. Twenty-two of 54 total ART clinics representing >90% of the national cohort of adults on ART were included. HIVDR was assessed for protease and reverse transcriptase Sanger sequences using the Stanford HIVdb tool. Results: A total of 729 PLHIV were enrolled; 26.3% (95% CI 20.1%-33.5%) ART initiators reported prior exposure to antiretrovirals. Pre-treatment HIVDR prevalence was 26.9% (95% CI 20.2%-34.9%) to any antiretroviral and 25.9% (19.2%-33.9%) to NNRTIs. NNRTI pre-treatment HIVDR was higher in ART initiators with prior exposure to antiretrovirals (P = 0.001). Viral load (VL) suppression rate was 89.7% (85.1%-93.0%) in ADR12 and 67.9% (61.7%-73.6%) in ADR48. ADR12 to any drug among PLHIV with VL ≥1000 copies/mL was 86.1% (48.9%-97.6%); 67.1% (37.4%-87.5%) had HIVDR to both NNRTIs and NRTIs, and 3.8% (0.5%-25.2%) to PIs. ADR48 was 92.0% (86.8%-95.3%) to any drug; 78.1% (66.6%-86.5%) to both NNRTIs and NRTIs, and 7.3% (1.8%-25.1%) to PIs. Conclusions: The high prevalence of NNRTI pre-treatment HIVDR observed in Honduras warrants consideration of non-NNRTI-based first-line regimens for ART initiation. Programmatic improvements in HIVDR monitoring and adherence support may also be considered.

Journal of Antimicrobial Chemotherapy published new progress about Anti-HIV agents (anti-HIV-1 agents, anti-hiv-1 drugs). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dolan, Niamh; Gavin, Declan P.; Eshwika, Ahmed; Kavanagh, Kevin; McGinley, John; Stephens, John C. published the artcile< Synthesis, antibacterial and anti-MRSA activity, in vivo toxicity and a structure-activity relationship study of a quinoline thiourea>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is quinoline thiourea preparation antibacterial structure activity; Antibacterial; MRSA; Quinoline; Structure activity relationship; Thiourea.

We report the synthesis and antibacterial evaluation of a series of thiourea-containing compounds 1-[3,5-Bis(trifluoromethyl)phenyl]-[(quinuclidin-2-yl)methyl]thiourea I, was the most active against a range of Gram-pos. and Gram-neg. bacteria, and exhibited bacteriostatic activity against methicillin resistant Staphylococcus aureus (MRSA) comparable to that of the well-known antibacterial agent vancomycin. Quinoline thiourea I was subjected to a detailed structure-activity relationship study, with I and its derivatives evaluated for their bacteriostatic activity against both Gram-neg. and Gram-pos. bacteria. A number of structural features important for the overall activity of quinoline thiourea I have been identified. A selection of compounds, including I, was also evaluated for their in vivo toxicity using the larvae of the Greater wax moth, Galleria mellonella. Compound I, and a number of derivatives, were found to be non-toxic to the larvae of Galleria mellonella. A new class of antibiotic can result from the further development of this family of compounds

Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ohkubo, Mitsuru; Kuno, Atsushi; Nakanishi, Isao; Takasugi, Hisashi published the artcile< Studies on cerebral protective agents. VIII. Synthesis of 2-aminothiazoles and 2-thiazolecarboxamides with anti-anoxic activity>, Application of C19H34O2, the main research area is antianoxic aminothiazole thiazolecarboxamide structure cerebral protection; aminothiazole preparation antianoxic cerebral protection structure; thiazolecarboxamide preparation antianoxic cerebral protection structure.

Various 2-aminothiazoles and 2-thiazolecarboxamides, possessing a nitrogenous basic moiety at the C-2 position of the thiazole ring, were prepared and tested for anti-anoxic (AA) activity in mice. Among them, N-[2-(4-morpholinyl)ethyl]-4-(3-trifluoromethylphenyl)-2-thiazolecarboxyamide hydrochloride (FR108143) (min. EDs of 3.2 mg/kg i.p. and 10 mg/kg p.o., resp.) exhibited more potent AA activity than either FK360 or FR75039, each of which has a nitrogenous basic moiety at the C-5 position. The structure-activity relationships with regard to AA activity of this series of compounds are discussed, and the three-dimensional electrostatic potentials (3D-MEP) around the basic nitrogen atom of FK360 and the thiazole derivative (FR108143) are compared.

Chemical & Pharmaceutical Bulletin published new progress about Electrostatic potential. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Du, Zheng-Cai; Xia, Zhong-Shang; Huang, Yan-Feng; Peng, Yi; Cao, Bing-Bing; Li, Chun-Qi; Liang, Yun-Fei; Zhao, Fang-Hui; Zhang, Ming-Zhe; Chen, Zhang-Mei; Hou, Xiao-Tao; Hao, Er-Wei; Deng, Jia-Gang published the artcile< Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish>, Synthetic Route of 112-63-0, the main research area is zebrafish cardiotoxicity cochinchina momordica seed extract; CMSE; apoptosis; cardiotoxicity; inflammation; oxidative stress; zebrafish.

Momordica cochinchinensis (Lour.) Spreng is an indigenous South Asian edible fruit, and seeds of Momordica cochinchinensis have been used therapeutically in traditional Chinese medicine. Previous studies have shown that M. cochinchinensis seed (Momordicae Semen) has various pharmaceutical properties such as antioxidant and anti-ulcer effects as well as contains secondary metabolites with potential anticancer activities such as triterpenoids and saponins. Recent studies reported that water extract and ethanol extract of M. cochinchinensi seed were tested on mammals using an acute toxic classic method as OECD guidelines 420. No matter injected i.v. or i.m., animals died within several days. In this study, zebrafish embryos were exposed to various doses of Cochinchina momordica seed extract (CMSE) from 2 dpf (days post fertilization, dpf) to 3 dpf. CMSE-induced cardiotoxicity such as pericardial edema, cardiac apoptosis, increased ROS production, cardiac neutrophil infiltration, decreased blood flow velocity, and reduced expression of three marker genes of cardiac functions were found in zebrafish roughly in a dose-dependent manner. These results suggest that CMSE may induce cardiotoxicity through pathways involved in inflammation, oxidative stress, and apoptosis.

Journal of Applied Toxicology published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Demarchi, Gianina; Valla, Sofía; Perrone, Sofía; Chimento, Agustina; Bonadeo, Nadia; Vitale, Daiana Luján; Spinelli, Fiorella Mercedes; Cervio, Andrés; Sevlever, Gustavo; Alaniz, Laura; Berner, Silvia; Cristina, Carolina published the artcile< β-Catenin is reduced in membranes of human prolactinoma cells and it is inhibited by temozolomide in prolactin secreting tumor models.>, Electric Literature of 112-63-0, the main research area is Prolactinomas; Wnt; pituitary tumors; temozolomide; β-Catenin.

INTRODUCTION: Prolactinomas are the most frequent pituitary tumor subtype. Despite most of them respond to medical treatment, a proportion are resistant and become a challenge in clinical management. Wnt/β-Catenin pathway has been implicated in several cancers including pituitary tumors and other sellar region malignancies. Interestingly, Wnt/β-Catenin inhibition augments the cytotoxicity of the chemotherapeutic agent Temozolomide (TMZ) in different cancers. TMZ is now being implemented as rescue therapy for aggressive pituitary adenoma treatment. However, the molecular mechanisms associated with TMZ action in pituitary tumors remain unclear. OBJECTIVES: Our aims in the present study were to evaluate differential β-Catenin expression in human resistant prolactinomas and Wnt/β-Catenin signaling activation and involvement in Prolactin (PRL) secreting experimental models treated with TMZ. RESULTS: We first evaluated by immunohistochemistry β-Catenin localization in human resistant prolactinomas in which we demonstrated reduced membrane β-Catenin in prolactinoma cells compared to normal pituitaries, independently of the Ki-67 proliferation indexes. In turn, in vivo 15 mg/kg of orally administered TMZ markedly reduced PRL production and increased prolactinoma cell apoptosis in mice bearing xenografted prolactinomas. Intratumoral β-Catenin strongly correlated with Prl and Cyclin D1, and importantly, TMZ downregulated both β-Catenin and Cyclin D1, supporting their significance in prolactinoma growth and as candidates of therapeutic targets. When tested in vitro, TMZ directly reduced MMQ cell viability, increased apoptosis and produced G2/M cell cycle arrest. Remarkably, β-Catenin activation and VEGF secretion were inhibited by TMZ in vitro. CONCLUSIONS: We concluded that dopamine resistant prolactinomas undergo a β-Catenin relocalization in relation to normal pituitaries and that TMZ restrains experimental prolactinoma tumorigenicity by reducing PRL production and β-Catenin activation. Together, our findings contribute to the understanding of Wnt/β-Catenin implication in prolactinoma maintenance and TMZ therapy, opening the opportunity of new treatment strategies for aggressive and resistant pituitary tumors.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gadekar, Santosh C.; Dhayalan, Vasudevan; Nandi, Ashim; Zak, Inbal L.; Mizrachi, Meital Shema; Kozuch, Sebastian; Milo, Anat published the artcile< Rerouting the Organocatalytic Benzoin Reaction toward Aldehyde Deuteration>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aldehyde deuteration rerouting organocatalytic benzoin reaction.

Herein, studies aimed at stabilizing reactive intermediates in the N-heterocyclic carbene (NHC) catalytic cycle was described, which enabled the full shutdown of the known benzoin coupling pathway, while rerouting its intermediates toward deuteration. The reversible nature of NHC catalysis and the selective stabilization of reaction intermediates facilitated clean hydrogen-deuterium exchange reactions of aromatic aldehydes by D2O, even for challenging electron-withdrawing substrates. In several cases, the addition of catalytic amounts of Ph boronic acid was used to further stabilize highly reactive intermediates and mitigate the formation of benzoin coupling byproducts. The mechanistic understanding at the foundation of this work resulted in unprecedented mild conditions with base and catalyst loadings as low as 0.1 mol %, and a scalable deuteration reaction applicable to a broad substrate scope with outstanding functional group tolerance. More importantly, adopting this approach enabled the construction of a guideline for identifying the appropriate catalyst and conditions for different substrates. Exptl. studies combined with machine learning and computational methods shed light on the nontrivial mechanistic underpinnings of this reaction.

ACS Catalysis published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thio, Joanne P.; Liang, Christopher; Bajwa, Alisha K.; Wooten, Dustin W.; Christian, Bradley T.; Mukherjee, Jogeshwar published the artcile< Synthesis and evaluation of mefway analogs as ligands for serotonin 5HT1A receptors>, Reference of 112-63-0, the main research area is mefway analog preparation serotonin 5HT1A receptor ligand; Mefway; PET imaging; Serotonin.

18F-Mefway (N-{2-[4-(2′-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4′-18F-fluoro-methylcyclohexane)carboxamide) (I) was developed and evaluated for use as a PET ligand for imaging 5-HT1A receptors. Ongoing studies of 18F-Mefway have shown it to be an effective PET radiotracer. We have synthesized isomers of Mefway by changing the position of the Me group in attempts to evaluate stability for imaging purposes. 2-Methyl-, 3-methyl-, and 4-methyl-cyclohexane-1-carboxylic acids and 3-carbomethoxy-, 4-carbomethoxycyclohexane-1-carboxylic acids were coupled with WAY-100634 to provide the methylcyclohexyl derivatives (2-, 3-, and 4-methyl). Mefway and 3-Mefway analogs were prepared by reduction of carbomethoxy- derivatives followed by fluorination. In vitro binding affinities for the methylated derivatives in rat brain homogenates were found to be 10.4 nM (2-methyl), 77 nM (3-methyl), and 21.5 nM (4-methyl). Binding affinity of 3-Mefway and 4-Mefway was found to be 17.4 nM and 6.26 nM, resp. Our results suggest that 3-methyl/3-fluoromethyl substituent has approx. threefold lower affinities compared to the 4-methyl/4-fluoromethyl substituent.

Medicinal Chemistry Research published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Dan; Cheng, Shiping; Zou, Guoming; Ding, Xiongfei published the artcile< Paeoniflorin inhibits proliferation and migration of psoriatic keratinocytes via the lncRNA NEAT1/miR-3194-5p/Galectin-7 axis>, COA of Formula: C19H34O2, the main research area is keratinocyte proliferation migration paeoniflorin lncRNA NEAT1 microRNA3194 5p Galectin7.

To investigate the mechanism underlying the effect of paeoniflorin (PF) on the proliferation and migration of psoriatic keratinocytes. The expressions of long noncoding RNA NEAT1, miR-3194-5p and Galectin-7 in skin tissues from psoriatic patients and healthy controls were detected. Psoriatic HaCat cells were used to investigate the function of NEAT1 and Galectin-7 as well as the effect and mechanism of PF in psoriasis. MTT, colony formation and scratch assays were used to assess the proliferation and migration of psoriatic HaCat cells. Dual-luciferase reporter assay was used to validate the interactions among NEAT1, miR-3194-5p and Galectin-7. NEAT1 and Galectin-7 were lowly expressed and miR-3194-5p was highly expressed in psoriatic patients. PF suppressed the proliferation and migration of psoriatic HaCat cells by elevating the expressions of NEAT1 and Galectin-7. NEAT1 pos. mediated the expression of Galectin-7 by targeting miR-3194-5p. PF controls the proliferation and migration of psoriatic HaCat cells via the NEAT1/miR-3194-5p/Galectin-7 axis.

Anti-Cancer Drugs published new progress about Cell migration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meng, Fan-Bing; Zhou, Li; Li, Jia-Jia; Li, Yun-Cheng; Wang, Meng; Zou, Long-Hua; Liu, Da-Yu; Chen, Wei-Jun published the artcile< The combined effect of protein hydrolysis and Lactobacillus plantarum fermentation on antioxidant activity and metabolomic profiles of quinoa beverage>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Lactobacillus plantarum fermentation antioxidant activity metabolomic profiles quinoa beverage; Antioxidant activity; Lactobacillus plantarum fermentation; Nontargeted metabolomics; Protein hydrolysis; Quinoa beverage.

Lactic acid bacteria fermentation is a commonly applied technique to produce nutritional, functional, and organoleptic enhanced foods. In the present study, protein hydrolysis and Lactobacillus plantarum fermentation were coupled to develop quinoa beverages. Protein hydrolysis effectively promoted the growth and fermentation of L. plantarum. Fermentation alone did not significantly improve antioxidant activity, but the combined use of protein hydrolysis and L. plantarum fermentation significantly improved the antioxidant activity of the quinoa beverage. Nontargeted metabolomics based on UHPLC-Q Exactive HF-X/MS and multivariate statistical anal. were performed to reveal the metabolite profile alterations of the quinoa beverage by different processing methods. A total of 756 metabolites were identified and annotated, which could be categorized into 12 different classes. The significant differentially abundant metabolites were mainly involved in primary metabolite metabolism and secondary metabolite biosynthesis. Many of these metabolites were proven to be vitally important to the function and taste formation of the quinoa beverage. Most importantly, the coupled use of protein hydrolysis and L. plantarum fermentation significantly increased some functional ingredients compared with protein hydrolysis and L. plantarum fermentation alone. The above results indicate that protein hydrolysis coupled with L. plantarum fermentation is an effective strategy to develop functional quinoa beverages.

Food Research International published new progress about Amino acids Role: FFD (Food or Feed Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics