Category: 112-63-0

Beppu, Takaaki; Iwaya, Takeshi; Sato, Yuichi; Nomura, Jun-Ichi; Terasaki, Kazunori; Sasaki, Toshiaki; Yamada, Noriyuki; Fujiwara, Shunrou; Sugai, Tamotsu; Ogasawara, Kuniaki published the artcile< PET With 11C-Methyl-l-Methionine as a Predictor of Consequential Outcomes at the Time of Discontinuing Temozolomide-Adjuvant Chemotherapy in Patients With Residual IDH-Mutant Lower-Grade Glioma.>, Application of C19H34O2, the main research area is .

PURPOSE: The aim of this study was to clarify whether PET with 11C-methyl-l-methionine (11C-met PET) can predict consequential outcomes at the time of discontinuing temozolomide (TMZ)-adjuvant chemotherapy in patients with residual isocitrate dehydrogenase gene (IDH)-mutant lower-grade glioma. PATIENTS AND METHODS: Among 30 patients showing residual lesions of IDH-mutant lower-grade glioma, we compared the tumor-to-normal brain tissue ratio of standardized uptake values (SUVT/N) from 11C-met PET at the time of discontinuing TMZ-adjuvant chemotherapy with putative predictive factors including age, Karnofsky Performance Scale, number of courses of adjuvant therapy, residual tumor size, and promotor methylation status of O6-methylguanine-DNA methyl-transferase gene (MGMT). For each factor, progression-free survival (PFS) was compared between groups divided by cutoff values, determined to predict tumor relapse using receiver operating characteristic curves for each factor. Univariate and multivariate analyses were conducted using log-rank testing and Cox regression analysis, respectively. In addition, PFS was compared between patients grouped by combined findings from multiple predictors identified from univariate and multivariate analyses. RESULTS: Univariate and multivariate analyses identified SUVT/N from 11C-met PET and MGMT methylation status as independent predictors of outcomes after TMZ discontinuation. When comparing 3 groups assigned by the combination of MGMT and SUVT/N findings, PFS differed significantly among groups. CONCLUSIONS: The present study suggested that 11C-met PET at the time of discontinuing TMZ-adjuvant chemotherapy allows prediction of outcomes at least comparable to MGMT methylation status in patients with residual IDH-mutant lower-grade glioma. Further, 11C-met PET allows more precise prediction of outcomes by assessment in combination with MGMT findings.

Clinical nuclear medicine published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pan, Guihua; He, Changli; Chen, Min; Xiong, Qian; Cao, Weidi; Feng, Xiaoming published the artcile< Synthesis of dihydroisoquinoline and dihydropyridine derivatives via asymmetric dearomative three-component reaction>, Formula: C19H34O2, the main research area is dihydroisoquinoline dihydropyridine diastereoselective enantioselective; heteroarene allenoate methyleneindolinone asym dearomative three component reaction.

Authors report the first asym. three-component nucleophilic addition/dearomative [4+2] cycloaddition/isomerization cascade of transient dipoles generated from N-heteroarenes and allenoates with methyleneindolinones in the presence of chiral N,N’-dioxide/metal complexes. This tandem reaction enabled rapid access to versatile chiral polycyclic N-heterocycles with good to excellent enantioselectivities under mild reaction conditions in spite of the strong background reaction, including 1,2-dihydroisoquinoline, 1,2-dihydropyridine derivatives, and others. Meanwhile, a series of control experiments were conducted to elucidate the reaction mechanism and the roles of additives.

CCS Chemistry published new progress about [4+2] Cycloaddition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Becker, Jeffrey M.; Wilchek, Meir; Katchalski, Ephraim published the artcile< Irreversible inhibition of biotin transport in yeast by biotinyl-p-nitrophenyl ester>, Reference of 112-63-0, the main research area is biotin transport Saccharomyces inactivator; biotinylnitrophenyl yeast biotin transport.

Biotinyl-p-nitrophenyl ester (I) [33755-53-2] at .geq.10-7M irreversibly inactivated biotin [58-85-5] transport in Saccharomyces cerevisiae. The extent of inactivation increased with time, implying that I reacts with a transport component(s) to yield a covalently-bound biotinyl derivative I did not affect the transport of lysine [56-87-1], aspartic acid [56-84-8], or L-sorbose [87-79-6]. Inactivation of biotin transport by I was partially prevented in the presence of high concentrations of biotin (0.5mM). Biotinyl-p-nitroanilide [33755-54-3], (0.1mM) and acetyl-p-nitrophenyl ester (0.1mM) did not affect biotin transport when added to S. cerevisiae suspensions.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Saccharomyces cerevisiae. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Ju Won; Baek, Seungkwan; Jung, YeonSoo; Yoon, Wonjae; Ban, Hong Seop; Kwon, Sejin published the artcile< An alternative ADN based monopropellant mixed with tetraglyme>, COA of Formula: C19H34O2, the main research area is ammonium dinitramide water tetraglyme.

In this study, a new monopropellant which consists of ammonium dinitramide (ADN) water solution and tetraethylene glycol di-Me ether (Tetraglyme) fuel is reported. The purpose of research was to improve the specific impulse and to compensate for the preheating temperature and vapor pressure of LMP-103S (63 wt% ADN, 14 wt% water, 18.4 wt% methanol, and 4.6 wt% ammonia). Methanol, ethanol, acetone, and glycerol were also used as the organic fuels to prepare the ADN based monopropellant with and without ammonia solution Further, the characteristic properties and performance of ADN based monopropellants were determined and compared with each other. The thermal properties and explosive power of those monopropellants were performed by using thermogravimetric anal. and differential scanning calorimetry (TGA-DSC) anal. and the blasting cap test, resp. The TGA-DSC anal. revealed that a catalyst active material was an important factor more than the flash point and auto-ignition temperature of fuel for the propellant’s preheating temperature The ADN based monopropellant mixed with tetraglyme exhibited a similar explosive power as with the LMP-103S. Moreover, the theor. vacuum specific impulse of the propellants mixed with tetraglyme was of 1-6% higher than the propellants with other fuels. Overall, ADN water solution blended with tetraglyme may be one of the promising fuel candidates for the satellite application.

Acta Astronautica published new progress about Fuels. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghersetti, S.; Giorgianni, S.; Spunta, G. published the artcile< Far-infrared spectral studies and hydrogen bonding of quinolines>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is IR quinoline phenol H bond.

The far ir spectra of 14 quinolines with Me, MeO, Br, Cl substituents were analyzed and their absorption frequencies assigned. The intermol. H-bonded complexes obtained by addition of PhOH showed the H bond stretching mode OH…N at 120-30 cm-1 and addnl. bands at 148 cm-1 for the OH…O stretching motion in the methoxyquinoline derivatives A plot of the H bond stretching frequencies of quinolines against those of pyridines showed comparable electronic effects of the ring substituents in the 2 systems and the degree of coupling between the H bond stretching vibration and other low-energy vibrational modes was negligible.

Spectroscopy Letters published new progress about Hydrogen bond. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Rupeng; Cui, Can; Xiao, Rang; Ruinan, L.; Mu, Tiansheng; Huo, Hua; Ma, Yulin; Yin, Geping; Zuo, Pengjian published the artcile< Enabling the conventional TFSI-based electrolytes for high-performance Mg/Li hybrid batteries by Mg electrode interfacial regulation>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is magnesium lithium electrode interfacial regulation hybrid battery.

The Mg-metal batteries (MMBs) as a forceful competitor for Li-metal batteries (LMBs) have the advantages of high-safety and high-volume energy d. Whereas, the MMBs still confronts two vital issues to be addressed, including the incompatibility of conventional TFSI-based electrolytes with the Mg electrode and the poor reversibility of the cathode. In this work, to satisfyingly settle the incompatibility, an artificial interphase was first pre-constructed by high-temperature displacement reaction of CuCl2 and Mg metal, responsible for the faster charge-transfer rate and the lower Mg plating/stripping overpotential (∼0.2 V) in Mg sym. cells. Regarding the Mg-Mo6S8 full cells, to enhance the reversibility and rate performance, Mg/Li hybrid batteries were designed. Consequently, the Mg-Mo6S8 battery can achieve excellent cycle stability and deliver a desirable capacity. Even as the c.d. increases to 1C, the battery still shows a desirable capacity of 92 mAh g-1 over 500 cycles.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Current density. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zeng, Kun; Xi, Wenqun; Qiao, Yuanjiao; Huang, Xiaosheng; Liu, Xinhua published the artcile< Paeoniflorin inhibits epithelial mesenchymal transformation and oxidative damage of lens epithelial cells in diabetic cataract via sirtuin 1 upregulation>, Quality Control of 112-63-0, the main research area is human EMT diabetic cataract lens epithelial cells paeoniflorin; EMT; Paeoniflorin; SIRT1; diabetic cataract; lens epithelial cells; oxidative damage.

Paeoniflorin (Pae) has been reported to serve an important role in complications associated with diabetes. To the best of our knowledge, the role of Pae in diabetic cataracts has not yet been reported. Human lens epithelial SRA01/04 cells were induced by high glucose (HG) and subsequently treated with Pae. Cell viability was detected using the MTT assay. Moreover, LDH levels were detected. Immunofluorescence (IF) and Western blotting were used to determine the protein expression levels of N-cadherin and E-cadherin. ELISA was performed to determine oxidative stress-related indicator levels. TUNEL and Western blotting detected the apoptotic rate. The mRNA and protein expression levels of sirtuin 1 (SIRT1) in SRA01/04 cells were measured via reverse transcription-quant. PCR and Western blotting, resp. Subsequently, cell transfection techniques were used to inhibit the expression of SIRT1 in cells. MTT, ELISA, IF, Western blotting and TUNEL assays were used to investigate the mechanisms of epithelial-mesenchymal transition (EMT) and oxidative damage with Pae in the diabetic cataract. Pae significantly increased cell viability and possibly inhibit the EMT and oxidative damage of SRA01/04 cells induced by HG. Pae was demonstrated to upregulate SIRT1 expression levels. The results therefore suggested that the downregulation of SIRT1 reversed the protective effect of Pae on EMT and oxidative damage in SRA01/04 cells induced by HG. In conclusion, Pae may inhibit EMT of lens epithelial cells and reduce oxidative damage in diabetic cataracts via the upregulation of SIRT1.

Bioengineered published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Badali, Mohammad; Khalafy, Jabbar; Alidoost, Elnaz; Aghazadeh, Masomeh published the artcile< Ammonium hydrotribromide salts as convenient and selective brominating agents of aryl methyl ketones>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aryl ketone ammonium hydrotribromide salt monobromination regioselective; bromo ketone preparation.

A simple and improved protocol for the α-monobromination of acetophenone and acetyl carbazole derivatives using different ammonium hydrotribromide salts under mild reaction condition was described.

Journal of the Chemical Society of Pakistan published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bradsher, C. K.; Gross, P. M.; Hobbs, M. E.; Kittila, R. S.; Rapoport, L.; Tarrant, P.; West, G. published the artcile< Chloro- and dichlorobis(trichloromethyl)benzenes>, Electric Literature of 112-63-0, the main research area is .

1,3-C6H4(CCl3)2 (I) (243 g.) and 0.25 g. Fe filings, chlorinated (5 hrs.) at 115-25°, give 73 g. 5-chloro-1,3-bis(trichloromethyl)benzene (II), m. 77-8°; hydrolysis gives 5,1,3-ClC6H3(CO2H)2, whose di-Me ester m. 79-80°. Dichlorination of I (10 hrs. at a temperature as high as 145°) or of II yields a di-Cl derivative, b9 184-9°, and a small quantity of 2,5,1,4-Cl2C6H2(CCl3)2, m. 191-2°. 2,1,3-ClC6H3Me2, chlorinated at 120-30° (Hg arc), gives 30% 2-chloro-1,3-bis(trichloromethyl)benzene (III), m. 136-7°. 4,1,3-ClC6H3Me2 yields 50% 4,1,3-ClC6H3(CCl3)2, b8.5 180-5°, and a small quantity of III. 4,1,3-FC6H3Me2 yields 82% 4-fluoro-1,3-bis(trichloromethyl)benzene, b11 157.5-9.5°. 2,1,4-ClC6H3Me2 yields 79% 2-chloro-1,4-bis(trichloromethyl)benzene, m. 78-80°.

Journal of the American Chemical Society published new progress about Chlorination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dong, Juan; Tian, Xin; Sun, Xiao-yi; Jiang, Wen-wei; Luo, Qin; Yang, Qin published the artcile< Study on synthesis technology of 4,6-dinitro-1,2,3-trichlorobenzene and waste acid recycling>, Reference of 112-63-0, the main research area is dinitrotrichlorobenzene waste acid recycling.

The nitration of 1,2,3-trichlorobenzene are studied in the binary system of sulfuric acid and nitric acid. The effect of molar ratio of raw materials, reaction temperature and reaction time on the yield are evaluated in the system of nitric acid/sulfuric acid. The optimum process parameters are selected in the system of 98% of sulfuric acid and 65% of nitric acid as follows: n(1,2,3-trichlorobenzene):n(sulfuric acid):n(nitric acid) = 1:11.3:2.3, reaction temperature 65°C and reaction time 4.5 h. The yield of 4,6-dinitro-1,2,3-trichlorbenzene is 93.95%. The concentration of waste acid can reach to about 95% by extracting and distilling in vacuo. Both the sulfuric acid and residue after recrystallization can be recycled as starting materials in another synthetic reaction of 4,6-dinitro-1,2,3-trichlorbenzene, the product is obtained in yields greater than about 94 mol percent with purity being greater than about 99w%, The structure of target product is characterized by IR, HPLC and Element anal.

Procedia Engineering published new progress about Nitrification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics