Category: 112-63-0

Robinson, Henry; Oatley, Steven A.; Rowedder, James E.; Slade, Pawel; Macdonald, Simon J. F.; Argent, Stephen P.; Hirst, Jonathan D.; McInally, Thomas; Moody, Christopher J. published the artcile< Late-Stage Functionalization by Chan-Lam Amination: Rapid Access to Potent and Selective Integrin Inhibitors>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is naphthyridinylpentanamide arylpropanoic acid boronate Chan Lam amination; aminophenylpropanoic tetrahydro naphthyridinylpentanamide preparation integrin inhibitor idiopathic pulmonary fibrosis; C−N coupling; integrin antagonists; late-stage functionalization; medicinal chemistry; β-amino acids.

A late-stage functionalization of the aromatic ring in amino acid derivatives was described. The key step was a copper-catalyzed diversification of a boronate ester I (X = 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl; R1 = Boc; R2 = t-Bu) by amination (Chan-Lam reaction) that can be carried out on a complex β-aryl-β-amino acid scaffold. This not only considerably extended the substrate scope of amination partners, but also delivered an array of potent and selective integrin inhibitors I (X = 1-pyrazolyl, 4-chloro-1-imidazolyl, 1-piperidinyl, 1,4-oxazepan-4-yl, etc.; R1 = R2 = H) as potential treatment agents of idiopathic pulmonary fibrosis (IPF). This versatile chem. strategy, which was amenable to high-throughput-array protocols, allows the installation of pharmaceutically valuable heteroaromatic fragments at a late stage by direct coupling to NH heterocycles, leading to compounds with drug-like attributed.

Chemistry – A European Journal published new progress about Amination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stroka, Joerg; von Holst, Christoph; Anklam, Elke; Reutter, Matthias published the artcile< Immunoaffinity column cleanup with liquid chromatography using post-column bromination for determination of aflatoxin B1 in cattle feed: Collaborative study>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aflatoxin feed analysis immunoaffinity LC bromination interlaboratory calibration.

A collaborative study was conducted to evaluate the effectiveness of an immunoaffinity column cleanup liquid chromatog. (LC) method for determination of aflatoxin B1 in cattle feed at a possible future European regulatory limit (1 ng/g). The test portion was extracted with acetone-water (85 + 15), filtered, diluted with water, and applied to an immunoaffinity column. The column was washed with water to remove interfering compounds, and the purified aflatoxin B1 was eluted with methanol. Aflatoxin B1 was separated and determined by reversed-phase liquid chromatog. (RP-LC) and detected by fluorescence after post column derivatization (PCD) involving bromination. PCD was achieved with either pyridinium hydrobromide perbromide (PBPB), used by 14 laboratories, or an electrochem. cell and addition of bromide to the mobile phase, used by 7 laboratories Both derivatization techniques were not significantly different when compared by the t-test; the method was statistically evaluated for all laboratories together (bromination and PBPB). The cattle feed samples, both spiked and naturally contaminated with aflatoxin B1, were sent to 21 laboratories in 14 different countries (United States, Japan, and Europe). Test portions were spiked at levels of 1.2 and 3.6 ng/g for aflatoxin B1. Recoveries ranged from 74 to 157%. Based on results for spiked samples (blind pairs at 2 levels) as well as naturally contaminated samples (blind pairs at 3 levels), the relative standard deviation for repeatability (RSDr) ranged from 5.9 to 8.7%. The relative standard deviation for reproducibility (RSDR) ranged from 17.5 to 19.6%. The method showed acceptable within- and between-laboratory precision for this matrix, as evidenced by HORRAT values, at the target levels of determination for aflatoxin B1. No major differences in RSD were observed, showing that the composition of the feeds was not a factor for the samples tested and that the method was applicable for all materials used.

Journal of AOAC International published new progress about Calibration, interlaboratory. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adachi, Shuji; Imaoka, Hanaho; Hasegawa, Yuri; Matsuno, Ryuichi published the artcile< Preparation of a water-in-oil-in-water (W/O/W) type microcapsules by a single-droplet-drying method and change in encapsulation efficiency of a hydrophilic substance during storage>, Quality Control of 112-63-0, the main research area is pyrenetetrasulfonate emulsion microcapsule stability.

Microcapsules of a water-in-oil-in-water (W/O/W) emulsion, which contained a hydrophilic substance, 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt (PTSA), in its inner aqueous phase, was prepared by hot-air-drying or freeze-drying the emulsion using a single-droplet-drying method. Pullulan, maltodextrin, or gum arabic was used as a wall material, and the oily phase was tricaprylin, oleic acid, olive oil, or a mixture of tricaprylin and olive oil. An encapsulation efficiency higher than 0.95 was reached except for the microcapsules prepared using gum arabic and oleic acid. The hot-air-dried microcapsules were generally more stable than the freeze-dried microcapsules at 37° and various relative humidities. The stability was higher for the microcapsules with tricaprylin as the oily phase than for the microcapsules with oleic acid. The higher stability of the microcapsules with tricaprylin would be ascribed to the lower partition coefficient of PTSA to the oily phase. There was a tendency for the stability to be higher at lower relative humidity for both the hot-air- and freeze-dried microcapsules. The volumetric fraction of olive oil in its mixture with tricaprylin did not significantly affect either the encapsulation efficiency or the stability of the hot-air-dried microcapsules.

Bioscience, Biotechnology, and Biochemistry published new progress about Air drying process. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tsunoda, Takashi; Yamazaki, Atsuki; Mase, Toshiyasu; Sakamoto, Shuichi published the artcile< A Scalable Process for the Synthesis of 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine Monohydrate and 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic Acid: Two New Key Intermediates for the Synthesis of the AVP Antagonist Conivaptan Hydrochloride>, HPLC of Formula: 112-63-0, the main research area is safety methyltetrahydroimidazo benzazepine intermediate preparation scale up green chem; biphenylylcarbonyl aminobenzoic acid intermediate preparation vasopressin receptor antagonist.

A process for the multikilogram synthesis of the dual vasopressin-receptor antagonist, conivaptan hydrochloride, was developed. This method relies on the introduction of operationally simple chem. during the final stages of the process when two key intermediates, isolated by crystallization, are reacted to assemble the final mol. A three-stage sequence was developed for the synthesis of the first key amine hydrate intermediate, and modifications of the original process are described. Major strategic improvements were achieved in defining the final route to the side chain precursor mol., which is the second key intermediate. These advances revolve around the acylation of an unprotected amino benzoic acid and subsequent high-yield telescoped processes for the synthesis of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid. This method leads to a 4-fold increase in the overall yield of the target materials, circumvents the restricted synthetic intermediates, and constitutes a safe, reliable, adaptable, environmentally friendly, and cost-effective approach with improved manipulability.

Organic Process Research & Development published new progress about Acid hydrolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Smith, Hilton A.; Fort, Tomlinson Jr. published the artcile< The kinetics of the base-catalyzed hydrolysis of the methyl esters of cyclohexanedicarboxylic acids>, Application of C19H34O2, the main research area is .

Saponifications involving the monomethyl esters and alkali are strictly 1st order with respect to alkali and 1st order with respect to ester. For the cis-1,2, trans-1,2, trans-1,3, and cis-1,4 forms of the dimethyl esters saponification of the 1st ester group was so much more rapid than for the 2nd that in the early stages of the reaction (up to some 20%) the kinetic behavior was 2nd order. For each ester there is a large decrease in the saponification rate of the 2nd ester group as compared with the 1st. On the basis of the ratios of the 1st- and 2nd-rate constants for saponification of the esters studied, the separation of the 2 ester groups shows the following order: trans-1,4 > cis-1,3 > cis-1,4 > trans-1,3 > trans-1,2 > cis-1,2. The relative entropies of activation for the saponification reactions based on the monomethyl ester of cis-1,2-cyclohexanedicarboxylic acid are given.

Journal of the American Chemical Society published new progress about Entropy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Miao-Miao; Li, Shi-Hong; Tu, Jia-Lin; Min, Qing-Qiang; Liu, Feng published the artcile< Metal-free iminyl radical-mediated C-C single bond cleavage/functionalization of redox-active oxime esters>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is distal cyano pyridine photochem preparation metal free; cycloketone oxime ester vinylpyridine radical mediated bond cleavage functionalization; cyano alkene distal photochem preparation metal free; allyl sulfone cycloketone oxime ester radical bond cleavage functionalization.

A visible-light-driven iminyl radical-mediated C-C bond cleavage and functionalization of cycloketone oxime esters have been accomplished to give distal cyano pyridines such as I [R1 = H, Me, Bn, etc.; R2 = H, Me, Ph, etc.; R3 = H, 4-Me, 5-Me; R4 = H, Ph, 4-ClC6H4; R5 = H, 4-MeC6H4; n = 1, 2, 3, etc.; X = O, CH(Ph), CH(OBn), etc.] and distal cyano alkenes such as II [R6 = COOEt, Ph, 2-naphthyl, etc.; R7 = H, Me, Bn, etc.; R8 = H, Me, Ph, etc.]. This protocol is simple and does not require expensive and toxic photoredox and/or transition-metal catalysis, providing a novel catalyst-free strategy for alkylation, allylation, vinylation and alkynylation through addition of C(sp3)-centered radicals to various unsaturated acceptors. The com. available and photoactive Hantzsch ester effectively serves as an electron donor, as well as a hydrogen atom source.

Organic Chemistry Frontiers published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation) (cyano). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Nan; Huang, Renxuan; Yang, Kunmeng; He, Yichun; Gao, Yufei; Dong, Delu published the artcile< Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioblastoma multiforme mitochondria oxidative phosphorylation temozolomide chemotherapy; AMPK; TP53; glioblastoma multiforme; mitochondrial dynamics; temozolomide.

Glioblastoma multiforme (GBM) is a primary tumor of the central nervous system (CNS) that exhibits the highest degree of malignancy. Radiotherapy and chemotherapy are essential to prolong the survival time of patients. However, clin. work has demonstrated that sensitivity of GBM to chemotherapy decreases with time. The phenomenon of multi-drug resistance (MDR) reminds us that there may exist some fundamental mechanisms in the process of chemo-resistance. We tried to explore the mechanism of GBM chemo-resistance from the perspective of energy metabolism First, we found that the oxidative phosphorylation (OXPHOS) level of SHG44 and U87 cells increased under TMZ treatment. In further studies, it was found that the expression of PINK1 and mitophagy flux downstream was downregulated in GBM cells, which were secondary to the upregulation of TP53 in tumor cells under TMZ treatment. At the same time, we examined the mitochondrial morphol. in tumor cells and found that the size of mitochondria in tumor cells increased under the treatment of TMZ, which originated from the regulation of AMPK on the subcellular localization of Drp1 under the condition of unbalanced energy supply and demand in tumor cells. The accumulation of mitochondrial mass and the optimization of mitochondrial quality accounted for the increased oxidative phosphorylation, and interruption of the mitochondrial fusion process downregulated the efficiency of oxidative phosphorylation and sensitized GBM cells to TMZ, which was also confirmed in the in vivo experiment What is more, interfering with this process is an innovative strategy to overcome the chemo-resistance of GBM cells.

Journal of Cellular and Molecular Medicine published new progress about Apoptosis-regulating proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sowers, Mark L.; Sowers, Lawrence C. published the artcile< Glioblastoma and Methionine Addiction>, Category: esters-buliding-blocks, the main research area is epigenetics; glioblastoma; metabolism; methionine; therapeutic development; tumor microenvironment.

Glioblastoma is a fatal brain tumor with a bleak prognosis. The use of chemotherapy, primarily the alkylating agent temozolomide, coupled with radiation and surgical resection, has provided some benefit. Despite this multipronged approach, average patient survival rarely extends beyond 18 mo. Challenges to glioblastoma treatment include the identification of functional pharmacol. targets as well as identifying drugs that can cross the blood-brain barrier. To address these challenges, current research efforts are examining metabolic differences between normal and tumor cells that could be targeted. Among the metabolic differences examined to date, the apparent addiction to exogenous methionine by glioblastoma tumors is a critical factor that is not well understood and may serve as an effective therapeutic target. Others have proposed this property could be exploited by methionine dietary restriction or other approaches to reduce methionine availability. However, methionine links the tumor microenvironment with cell metabolism, epigenetic regulation, and even mitosis. Therefore methionine depletion could result in complex and potentially undesirable responses, such as aneuploidy and the aberrant expression of genes that drive tumor progression. If methionine manipulation is to be a therapeutic strategy for glioblastoma patients, it is essential that we enhance our understanding of the role of methionine in the tumor microenvironment.

International Journal of Molecular Sciences published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hiscock, Jennifer R.; Gale, Philip A.; Hynes, Michael J. published the artcile< Tris-(2-aminoethyl)amine-based tripodal trisindolylureas: new receptors for sulphate>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is anion receptor urea amine preparation phosphate sulfate acetate benzoate.

Several TREN-based amide or urea linked tris-indole anion receptors have been synthesized and their anion complexation properties studied in DMSO-d6/water mixtures

Supramolecular Chemistry published new progress about Amidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alayande, Abayomi Babatunde; Hong, Seungkwan published the artcile< Ultraviolet light-activated peroxymonosulfate (UV/PMS) system for humic acid mineralization: Effects of ionic matrix and feasible application in seawater reverse osmosis desalination>, Reference of 112-63-0, the main research area is peroxymonosulfate humic acid mineralization seawater reverse osmosis desalination; Disinfection byproducts; Halides; Humic acid; Reactive halogen species; UV/PMS oxidation; Water treatment.

The use of membrane-based technol. has evolved into an important strategy for supplying freshwater from seawater and wastewater to overcome the problems of water scarcity around the world. However, the presence of natural organic matter (NOM), including humic substances affects the performance of the process. Here, we present a systematic report on the mineralization of humic acid (HA), as a model for NOM, in high concentration of salts using the UV light-activated peroxymonosulfate (UV/PMS) system as a potential alternative for HA elimination during membrane-based seawater desalination and water treatment processes. Effects of various parameters such as PMS concentration, solution type, pH, anions, and anion-cation matrix on HA mineralization were assessed. The results show that 100%, 78% and 58% of HA (2 mg/L TOC) were mineralized with rate constants of 0.085 min-1, 0.0073 min-1, and 0.0041 min-1 after 180 min reaction time at pH 7 when 0.5 mM PMS was used in deionized water, sodium chloride solution (35,000 ppm) and synthetic seawater, resp. The reduced efficiency under saline conditions was attributed to the presence of anions in the system that acted as sulfate and hydroxyl radicals scavengers. Furthermore, the safety of the treated synthetic seawater was evaluated by analyzing the residual transformed products. Overall, pretreatment with the UV/PMS system mitigated fouling on the RO membrane.

Environmental Pollution (Oxford, United Kingdom) published new progress about Fouling. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics